| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shintaro Kinugawa, Hiroyuki Tsutsu. [Oxidative stress and heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 64. issue 5. 2006-06-15. PMID:16689364. |
the excessive reactive oxygen species (ros), produced by the electron leak in mitochondria of failing myocardium, play an important role in development and progression of heart failure (hf) and cardiac remodeling, which is associated with induction of myocyte hypertrophy and apoptosis and activation of matrix metalloproteinases. |
2006-06-15 |
2023-08-12 |
Not clear |
| Teru Hideshima, Paul G Richardson, Kenneth C Anderso. Current therapeutic uses of lenalidomide in multiple myeloma. Expert opinion on investigational drugs. vol 15. issue 2. 2006-06-12. PMID:16433596. |
it directly induces growth arrest and/or apoptosis of even drug-resistant mm cells; inhibits binding of mm cells to bone marrow extracellular matrix proteins and stromal cells; modulates cytokine secretion and inhibits angiogenesis in the bone marrow milieu; and augments host antitumour immunity. |
2006-06-12 |
2023-08-12 |
Not clear |
| Frank M Benge. Atherosclerosis imaging on the molecular level. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. vol 13. issue 1. 2006-06-12. PMID:16464725. |
a variety of approaches aiming at plaque inflammation, apoptosis, smooth muscle cell proliferation, extracellular matrix activation, or platelet binding have been introduced. |
2006-06-12 |
2023-08-12 |
Not clear |
| Rolf Schwarzer, Sybille Dames, Daniel Tondera, Anke Klippel, Joerg Kaufman. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Cellular signalling. vol 18. issue 6. 2006-06-09. PMID:16129579. |
however, in the absence of glucose overexpression of trb3 in pc-3 cells can interfere with apoptosis and restore growth on extracellular matrix. |
2006-06-09 |
2023-08-12 |
human |
| Markus J Leskinen, Hanna M Heikkilä, Mei Y Speer, Jukka K Hakala, Mika Laine, Petri T Kovanen, Ken A Lindsted. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16460729. |
chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (smcs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and akt dephosphorylation, which are necessary for cell adhesion and survival. |
2006-06-08 |
2023-08-12 |
human |
| Hae Jeong Park, Dong-Hoon Shin, Woo Jin Chung, Kanghyun Leem, Seo Hyun Yoon, Mee Suk Hong, Joo-Ho Chung, Jae-Hoon Bae, Jae Seok Hwan. Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells. Life sciences. vol 78. issue 24. 2006-06-05. PMID:16445947. |
cell detachment from extracellular matrix is closely related to induction of apoptosis. |
2006-06-05 |
2023-08-12 |
human |
| Jakob Richardson, Kasinath Viswanathan, Alexandra Luca. Serpins, the vasculature, and viral therapeutics. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16146796. |
serine protease inhibitors, termed serpins, are key regulators of numerous biological pathways that initiate inflammation, coagulation, angiogenesis, apoptosis, extra-cellular matrix composition and complement activation responses. |
2006-06-02 |
2023-08-12 |
mouse |
| Charles J Malemu. Matrix metalloproteinases: role in skeletal development and growth plate disorders. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16368549. |
among the mmps, mmp-13 (collagenase-3), mmp-9 (92-kda gelatinase; gelatinase b) and mmp-14 (mt1-mmp) are the most abundant proteinases that regulate cellular migration, alterations in the extracellular matrix and apoptosis in growth plate cartilage. |
2006-06-02 |
2023-08-12 |
human |
| G Oktem, S Vatansever, S Ayla, A Uysal, S Aktas, B Karabulut, A Bili. Effect of apoptosis and response of extracellular matrix proteins after chemotherapy application on human breast cancer cell spheroids. Oncology reports. vol 15. issue 2. 2006-06-01. PMID:16391851. |
effect of apoptosis and response of extracellular matrix proteins after chemotherapy application on human breast cancer cell spheroids. |
2006-06-01 |
2023-08-12 |
human |
| G Oktem, S Vatansever, S Ayla, A Uysal, S Aktas, B Karabulut, A Bili. Effect of apoptosis and response of extracellular matrix proteins after chemotherapy application on human breast cancer cell spheroids. Oncology reports. vol 15. issue 2. 2006-06-01. PMID:16391851. |
in this study, we examined the effect of apoptosis and proliferation of cells on the human breast cancer cell line, mcf-7, by using p53, bcl-2 and ki67 gene expression, and the tendency to metastasis with extracellular matrix proteins, laminin and type iv collagen after chemotherapy in the spheroid model. |
2006-06-01 |
2023-08-12 |
human |
| Randal A Wolff, Rita L Malinowski, Nicholas S Heaton, Debra A Hullett, John R Hoc. Transforming growth factor-beta1 antisense treatment of rat vein grafts reduces the accumulation of collagen and increases the accumulation of h-caldesmon. Journal of vascular surgery. vol 43. issue 5. 2006-05-30. PMID:16678700. |
transforming growth factor beta-1 (tgf-beta1) is a pleiotropic cytokine known to have powerful effects on cell growth, apoptosis, cell differentiation, and extracellular matrix synthesis. |
2006-05-30 |
2023-08-12 |
rat |
| Hsiu-Wen Chan, Nicola J Smith, Ross D Hannan, Walter G Thoma. Tackling the EGFR in pathological tissue remodelling. Pulmonary pharmacology & therapeutics. vol 19. issue 1. 2006-05-11. PMID:15979363. |
tissue remodelling is an adaptive physiological event initiated by physical and/or hormonal stimuli and characterised by extracellular matrix modifications, inflammation, cellular hypertrophy, proliferation and/or apoptosis. |
2006-05-11 |
2023-08-12 |
Not clear |
| L F A Huitema, A B Vaandrager, P R van Weeren, A Barneveld, J B Helms, C H A van de Les. The nitric oxide donor sodium nitroprusside inhibits mineralization in ATDC5 cells. Calcified tissue international. vol 78. issue 3. 2006-05-11. PMID:16523220. |
these findings indicate that snp can specifically inhibit matrix mineralization via a cgmp-independent pathway and that the effect is not mediated by inhibition of phosphate transport or apoptosis. |
2006-05-11 |
2023-08-12 |
Not clear |
| Soo Jung Cho, Min Jong Kang, Robert J Homer, Hye Ryun Kang, Xuchen Zhang, Patty J Lee, Jack A Elias, Chun Geun Le. Role of early growth response-1 (Egr-1) in interleukin-13-induced inflammation and remodeling. The Journal of biological chemistry. vol 281. issue 12. 2006-05-10. PMID:16439363. |
lastly, they provide insights into the mechanisms of these processes by demonstrating that il-13 stimulates select cc and cxc chemokines (mip-1alpha/ccl-3, mip-1beta/ccl-4, mip-2/cxcl2/3, mcp-1/ccl-2, mcp-2/ccl-8, mcp-3/ccl-7, mcp-5/ccl-12, kc/cxcl-1, and lix/cxcl-5), matrix metalloproteinase-9, tissue inhibitor of metalloproteinase-1, and apoptosis regulators (caspase-3, -6, -8, and -9 and bax) and activates transforming growth factor-beta1 and pulmonary caspases via egr-1-dependent pathways. |
2006-05-10 |
2023-08-12 |
mouse |
| Helen Kalirai, Moshe Phillip, Lars Savendahl, Jan-M Wi. The Fifth European Growth Plate Working Group Symposium. 21st September 2005, Lyon, France. Journal of pediatric endocrinology & metabolism : JPEM. vol 19. issue 2. 2006-05-05. PMID:16562594. |
the result of these events is calcification of the matrix, chondrocyte apoptosis, and the completion of endochondral bone formation. |
2006-05-05 |
2023-08-12 |
human |
| Shufang Wu, Yuji Yoshiko, Francesco De Luc. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. The Journal of biological chemistry. vol 281. issue 8. 2006-05-04. PMID:16377640. |
in cultured chondrocytes, rhstc increased phosphate uptake, reduced chondrocyte proliferation and matrix synthesis, and induced apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| Shufang Wu, Yuji Yoshiko, Francesco De Luc. Stanniocalcin 1 acts as a paracrine regulator of growth plate chondrogenesis. The Journal of biological chemistry. vol 281. issue 8. 2006-05-04. PMID:16377640. |
such growth inhibition, likely mediated by an increased chondrocyte phosphate uptake, results from suppressed chondrocyte proliferation, hypertrophy/differentiation, and matrix synthesis and by increased apoptosis. |
2006-05-04 |
2023-08-12 |
mouse |
| Shu Nakamura, Yuji Arai, Kenji A Takahashi, Ryu Terauchi, Suzuyo Ohashi, Osam Mazda, Jiro Imanishi, Atsuo Inoue, Hitoshi Tonomura, Toshikazu Kub. Hydrostatic pressure induces apoptosis of chondrocytes cultured in alginate beads. Journal of orthopaedic research : official publication of the Orthopaedic Research Society. vol 24. issue 4. 2006-05-04. PMID:16514637. |
excessively strong hp could evoke apoptosis when the extracellular matrix did not accumulate around the chondrocytes. |
2006-05-04 |
2023-08-12 |
rabbit |
| Jeremias Wohlschlaeger, Klaus J Schmitz, Christof Schmid, Kurt W Schmid, Petra Keul, Atsushi Takeda, Serge Weis, Bodo Levkau, Hideo A Bab. Reverse remodeling following insertion of left ventricular assist devices (LVAD): a review of the morphological and molecular changes. Cardiovascular research. vol 68. issue 3. 2006-05-03. PMID:16024006. |
aside from describing the morphological changes, this review focuses on the roles of signal transduction, transcriptional regulation, apoptosis, stress proteins, matrix remodeling, and neurohormonal signaling in the failing human heart before and after mechanical circulatory support. |
2006-05-03 |
2023-08-12 |
human |
| John R Davies, James H F Rudd, Peter L Weissberg, Jagat Narul. Radionuclide imaging for the detection of inflammation in vulnerable plaques. Journal of the American College of Cardiology. vol 47. issue 8 Suppl. 2006-05-01. PMID:16631511. |
tracer compounds capable of assessing macrophage recruitment, foam cell generation, matrix metalloproteinase production, macrophage apoptosis, and macrophage metabolism have been developed and tested in the carotid and peripheral circulation. |
2006-05-01 |
2023-08-12 |
Not clear |