| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
here we show that pten phosphatase becomes activated during collagen matrix contraction and is responsible for antagonizing phosphatidylinositol 3-kinase activity and promoting a decline in phosphorylated akt and fibroblast apoptosis in response to collagen contraction. |
2006-12-11 |
2023-08-12 |
Not clear |
| Richard Seonghun Nho, Hong Xia, Deanna Diebold, Judy Kahm, Jill Kleidon, Eric White, Craig A Henk. PTEN regulates fibroblast elimination during collagen matrix contraction. The Journal of biological chemistry. vol 281. issue 44. 2006-12-11. PMID:16963781. |
pten null fibroblasts displayed enhanced levels of phosphorylated akt and were resistant to collagen matrix contraction-induced apoptosis. |
2006-12-11 |
2023-08-12 |
Not clear |
| Patrick Laplante, Marc-André Raymond, Andrée Labelle, Jun-Ichi Abe, Renato V Iozzo, Marie-Josée Héber. Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16882656. |
we have shown previously that apoptosis of ec triggers the proteolysis of extracellular matrix components and the release of a c-terminal fragment of perlecan, which in turn inhibits apoptosis of fibroblasts. |
2006-11-27 |
2023-08-12 |
Not clear |
| Patrick Laplante, Marc-André Raymond, Andrée Labelle, Jun-Ichi Abe, Renato V Iozzo, Marie-Josée Héber. Perlecan proteolysis induces an alpha2beta1 integrin- and Src family kinase-dependent anti-apoptotic pathway in fibroblasts in the absence of focal adhesion kinase activation. The Journal of biological chemistry. vol 281. issue 41. 2006-11-27. PMID:16882656. |
these results suggest that extracellular matrix fragments produced by apoptotic ec initiate a state of resistance to apoptosis in fibroblasts via an alpha2beta1 integrin/sfk (src and fyn)/phosphatidylinositol 3-kinase (pi3k)-dependent pathway. |
2006-11-27 |
2023-08-12 |
Not clear |
| Murray C H Clarke, Nichola Figg, Janet J Maguire, Anthony P Davenport, Martin Goddard, Trevor D Littlewood, Martin R Bennet. Apoptosis of vascular smooth muscle cells induces features of plaque vulnerability in atherosclerosis. Nature medicine. vol 12. issue 9. 2006-11-27. PMID:16892061. |
in contrast, vsmc apoptosis in atherosclerotic plaques of sm22alpha-hdtr apoe-/- mice induced marked thinning of fibrous cap, loss of collagen and matrix, accumulation of cell debris and intense intimal inflammation. |
2006-11-27 |
2023-08-12 |
mouse |
| Karim Si-Tayeb, Arnaud Monvoisin, Claire Mazzocco, Sébastien Lepreux, Marion Decossas, Gaëlle Cubel, Danièle Taras, Jean-Frédéric Blanc, Derrick R Robinson, Jean Rosenbau. Matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. The American journal of pathology. vol 169. issue 4. 2006-11-24. PMID:17003494. |
matrix metalloproteinase 3 is present in the cell nucleus and is involved in apoptosis. |
2006-11-24 |
2023-08-12 |
human |
| Andrew C Newb. Do metalloproteinases destabilize vulnerable atherosclerotic plaques? Current opinion in lipidology. vol 17. issue 5. 2006-11-20. PMID:16960505. |
alternatively, metalloproteinases could destabilize vulnerable plaques by promoting matrix destruction, angiogenesis, leucocyte infiltration, and apoptosis. |
2006-11-20 |
2023-08-12 |
mouse |
| P S Hodkinson, T Elliott, W S Wong, R C Rintoul, A C Mackinnon, C Haslett, T Seth. ECM overrides DNA damage-induced cell cycle arrest and apoptosis in small-cell lung cancer cells through beta1 integrin-dependent activation of PI3-kinase. Cell death and differentiation. vol 13. issue 10. 2006-11-08. PMID:16410797. |
we demonstrate that extracellular matrix (ecm) activates phosphatidyl inositol 3-kinase (pi3-kinase) signaling in sclc cells and prevents etoposide-induced caspase-3 activation and subsequent apoptosis in a beta1 integrin/pi3-kinase-dependent manner. |
2006-11-08 |
2023-08-12 |
Not clear |
| R M Moore, J M Mansour, R W Redline, B M Mercer, J J Moor. The physiology of fetal membrane rupture: insight gained from the determination of physical properties. Placenta. vol 27. issue 11-12. 2006-11-03. PMID:16516962. |
work in the rat model has demonstrated that collagen remodeling, with activation of matrix metalloproteinases (mmps), and apoptosis increase markedly in the amnion at end-gestation, suggesting that these processes are involved in fetal membrane weakening. |
2006-11-03 |
2023-08-12 |
rat |
| S Bondini, Z M Younoss. Non-alcoholic fatty liver disease and hepatitis C infection. Minerva gastroenterologica e dietologica. vol 52. issue 2. 2006-10-26. PMID:16557185. |
these factors include mediators of metabolic syndrome such as adipokines, inflammatory cytokines, factors associated with oxidative stress, lipid peroxidation products, as well as apoptosis and hepatic stellate cell activation with the resultant deposition of extracellular matrix. |
2006-10-26 |
2023-08-12 |
Not clear |
| L Delgado, E R Parra, V L Capelozz. Apoptosis and extracellular matrix remodelling in human silicosis. Histopathology. vol 49. issue 3. 2006-10-25. PMID:16918975. |
apoptosis and extracellular matrix remodelling in human silicosis. |
2006-10-25 |
2023-08-12 |
human |
| Mala R Chinoy, Shane A Mille. Relevance of tenascin-C and matrix metalloproteinases in vascular abnormalities in murine hypoplastic lungs. Biology of the neonate. vol 90. issue 3. 2006-10-24. PMID:16699260. |
tenascin-c (tn-c), an extracellular matrix glycoprotein, is crucial to cell-migration, proliferation, apoptosis and remodeling of tissues, with a potential role in pathobiology of pulmonary hypertension. |
2006-10-24 |
2023-08-12 |
Not clear |
| Julie Rice, Donald L Courter, Cecilia M Giachelli, Marta Scaten. Molecular mediators of alphavbeta3-induced endothelial cell survival. Journal of vascular research. vol 43. issue 5. 2006-10-24. PMID:16888388. |
the alphavbeta3 integrin interaction with the extracellular matrix (ecm) plays an essential role in inhibiting apoptosis in endothelial cells. |
2006-10-24 |
2023-08-12 |
rat |
| Ki-Kyung Jung, Xu-Wen Liu, Rosemarie Chirco, Rafael Fridman, Hyeong-Reh Choi Ki. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. The EMBO journal. vol 25. issue 17. 2006-10-24. PMID:16917503. |
while mcf10a cells within a three-dimensional (3d) matrigel matrix form polarized acinar-like structures, timp-1 overexpression disrupted breast epithelial cell polarization and inhibited caspase-mediated apoptosis in centrally located cells, necessary for the formation and maintenance of the hollow acinar-like structures. |
2006-10-24 |
2023-08-12 |
human |
| Ki-Kyung Jung, Xu-Wen Liu, Rosemarie Chirco, Rafael Fridman, Hyeong-Reh Choi Ki. Identification of CD63 as a tissue inhibitor of metalloproteinase-1 interacting cell surface protein. The EMBO journal. vol 25. issue 17. 2006-10-24. PMID:16917503. |
cd63 downregulation also restored polarization and apoptosis of timp-1 overexpressing mcf10a cells within a 3d-matrigel matrix. |
2006-10-24 |
2023-08-12 |
human |
| Sandra Cottet, Lydia Michaut, Gaëlle Boisset, Ulrich Schlecht, Walter Gehring, Daniel F Schordere. Biological characterization of gene response in Rpe65-/- mouse model of Leber's congenital amaurosis during progression of the disease. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 20. issue 12. 2006-10-20. PMID:17012256. |
microarray analysis demonstrates altered expression of genes involved in phototransduction, apoptosis regulation, cytoskeleton organization, and extracellular matrix (ecm) constituents. |
2006-10-20 |
2023-08-12 |
mouse |
| Carsten Bergmann, Valeska Frank, Fabian Küpper, Dirk Kamitz, Jens Hanten, Peter Berges, Silke Mager, Markus Moser, Jutta Kirfel, Reinhard Büttner, Jan Senderek, Klaus Zerre. Diagnosis, pathogenesis, and treatment prospects in cystic kidney disease. Molecular diagnosis & therapy. vol 10. issue 3. 2006-10-16. PMID:16771602. |
recent findings have proven the cystogenic process to be compatible with cellular dedifferentiation, i. e. increased apoptosis and proliferation rates, altered protein sorting and secretory characteristics, as well as disorganization of the extracellular matrix. |
2006-10-16 |
2023-08-12 |
Not clear |
| Maike Gallwitz, Jenny M Reimer, Lars Hellma. Expansion of the mast cell chymase locus over the past 200 million years of mammalian evolution. Immunogenetics. vol 58. issue 8. 2006-10-05. PMID:16807745. |
functionally, these proteases are involved, e.g., in the induction of apoptosis, the recruitment of inflammatory cells, and the remodeling of extra-cellular matrix. |
2006-10-05 |
2023-08-12 |
cattle |
| Claudia María Valverde, Teresa Macarulla, Esther Casado, Francisco Javier Ramos, Erika Martinelli, Josep Taberner. Novel targets in gastric and esophageal cancer. Critical reviews in oncology/hematology. vol 59. issue 2. 2006-10-05. PMID:16829119. |
in this review we describe the current status of targeted therapies in the treatment of ec and gc, including egfr inhibitors, antiangiogenic agents, cell cycle inhibitors, apoptosis promoters and matrix metalloproteinases inhibitors. |
2006-10-05 |
2023-08-12 |
Not clear |
| Farshid Saadat, Mohammad Reza Khorramizadeh, Abbas Mirshafie. Chemoprevention by pyrimethamine. Immunopharmacology and immunotoxicology. vol 27. issue 2. 2006-09-28. PMID:16114507. |
the fibrosarcoma (wehi-164) cell line was used for evaluating cytotoxicity, matrix metalloproteinase 2 (mmp-2) activity, and apoptosis. |
2006-09-28 |
2023-08-12 |
Not clear |