| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hongwei Jiang, Hanyu Zhu, Xiangmei Chen, Youming Peng, Jianzhong Wang, Fuyou Liu, Suozhu Shi, Bo Fu, Yang Lu, Quan Hong, Zhe Feng, Kai Hou, Xuefeng Sun, Guangyan Cai, Xueguang Zhang, Yuansheng Xi. TIMP-1 transgenic mice recover from diabetes induced by multiple low-dose streptozotocin. Diabetes. vol 56. issue 1. 2007-03-26. PMID:17192464. |
tissue inhibitor of metalloproteinase (timp)-1 inhibits matrix metalloproteinase activity and regulates proliferation and apoptosis of a variety of cells types, depending on the context. |
2007-03-26 |
2023-08-12 |
mouse |
| Claudia Hofmann, Florian Obermeier, Monika Artinger, Martin Hausmann, Werner Falk, Juergen Schoelmerich, Gerhard Rogler, Johannes Grossman. Cell-cell contacts prevent anoikis in primary human colonic epithelial cells. Gastroenterology. vol 132. issue 2. 2007-03-26. PMID:17258732. |
colonic epithelial cells (cecs) receive important survival signals from the extracellular matrix and undergo detachment-induced apoptosis (anoikis) as soon as they lose their cell-matrix anchorage. |
2007-03-26 |
2023-08-12 |
human |
| T John, B Kohl, A Mobasheri, W Ertel, M Shakibae. Interleukin-18 induces apoptosis in human articular chondrocytes. Histology and histopathology. vol 22. issue 5. 2007-03-23. PMID:17330802. |
the effects of il-18 on the cartilage-specific matrix protein collagen type ii, the cytoskeletal protein vinculin, the cell matrix signal transduction receptor beta-integrin, key signalling proteins of the mapkinase pathway (such as shc (sarc homology collagen) and activated mapkinase [erk-1/-2]), the pro-inflammatory enzyme cyclo-oxygenase-2 (cox-2) and the apoptosis marker activated caspase-3 were evaluated by western blot analysis and immunofluorescence labelling. |
2007-03-23 |
2023-08-12 |
human |
| T John, B Kohl, A Mobasheri, W Ertel, M Shakibae. Interleukin-18 induces apoptosis in human articular chondrocytes. Histology and histopathology. vol 22. issue 5. 2007-03-23. PMID:17330802. |
taken together, the results of the present study underline key catabolic events mediated by il-18 signalling in chondrocytes such as loss of cartilage-specific matrix and apoptosis. |
2007-03-23 |
2023-08-12 |
human |
| Shizhong Zheng, Anping Che. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 1. 2007-03-22. PMID:16959952. |
we previously demonstrated that curcumin induced gene expression of ppar-gamma in activated hsc, leading to reducing cell proliferation, inducing apoptosis and suppressing expression of extracellular matrix genes. |
2007-03-22 |
2023-08-12 |
rat |
| Pamela Renate Moll, Veronika Sander, Anna-Maria Frischauf, Klaus Richte. Expression profiling of vitamin D treated primary human keratinocytes. Journal of cellular biochemistry. vol 100. issue 3. 2007-03-20. PMID:16960875. |
targets identified are involved in intracellular signaling, transcription, cell cycle, metabolism, cellular growth, constitution of the extracellular matrix or the cytoskeleton and apoptosis, immune responses, and dna repair, respectively. |
2007-03-20 |
2023-08-12 |
human |
| Ray Saunders, Krysia H Szymczyk, Irving M Shapiro, Christopher S Adam. Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. Journal of cellular biochemistry. vol 100. issue 3. 2007-03-20. PMID:17006955. |
matrix regulation of skeletal cell apoptosis iii: mechanism of ion pair-induced apoptosis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Kwang Seok Ahn, Gautam Sethi, Bharat B Aggarwa. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 4. 2007-03-20. PMID:17277159. |
this effect of simvastatin correlated with down-regulation of various gene products that mediate cell proliferation (cyclin d1 and cyclooxygenase-2), cell survival (bcl-2, bcl-x(l), cellular flip, inhibitor of apoptosis protein 1, inhibitor of apoptosis protein 2, and survivin), invasion (matrix mellatoproteinase-9 and icam-1), and angiogenesis (vascular endothelial growth factor); all known to be regulated by the nf-kappab. |
2007-03-20 |
2023-08-12 |
Not clear |
| M Kelly Nicholas, Rimas V Lukas, Nazia F Jafri, Leonardo Faoro, Ravi Salgi. Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 24. 2007-03-15. PMID:17189397. |
they are associated with a variety of molecular abnormalities affecting signal transduction, transcription factors, apoptosis, angiogensesis, and the extracellular matrix. |
2007-03-15 |
2023-08-12 |
Not clear |
| M Roderfeld, S Hemmann, E Roe. Mechanisms of fibrinolysis in chronic liver injury (with special emphasis on MMPs and TIMPs). Zeitschrift fur Gastroenterologie. vol 45. issue 1. 2007-03-15. PMID:17236118. |
regeneration from liver fibrosis is characterized by four essential events: 1. eradication of pathological agents, 2. apoptosis of activated hepatic stellate cells, 3. remodeling of extracellular matrix, and 4. regeneration of parenchyma and liver function. |
2007-03-15 |
2023-08-12 |
Not clear |
| Jan Marek Słomiński, Krzysztof Kedzior. [Is COPD an autoimmune disease caused by smoking?]. Przeglad lekarski. vol 63. issue 10. 2007-03-15. PMID:17288238. |
this reaction will proceed over time to damage the lung, producing peptides and modified proteins from matrix destruction, cell necrosis and cell apoptosis. |
2007-03-15 |
2023-08-12 |
Not clear |
| Kyu Yong Jung, Ka Chen, Matthias Kretzler, Chuanyue W. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. Journal of the American Society of Nephrology : JASN. vol 18. issue 1. 2007-03-14. PMID:17167118. |
because the pip complex promotes glomerular mesangial matrix deposition and protects podocytes from apoptosis, the tgf-beta1-induced up- and downregulation of the pip complex likely contribute to the pleiotropic effects of tgf-beta1 on different glomerular cell types and hence the progression of glomerular failure. |
2007-03-14 |
2023-08-12 |
Not clear |
| Antonela F A Siqueira, Dulcinéia S P Abdalla, Sandra R G Ferreir. [LDL: from metabolic syndrome to instability of the atherosclerotic plaque]. Arquivos brasileiros de endocrinologia e metabologia. vol 50. issue 2. 2007-03-08. PMID:16767300. |
in the atherosclerotic process, the action of mldl continues until plaque rupture and thrombogenesis, when it promotes apoptosis in endothelial and smooth muscle cells, and activates matrix metalloproteinases, weaken the fibrous cap, and further enhance the inflammatory process that ends in the thrombus formation. |
2007-03-08 |
2023-08-12 |
human |
| Michael L McCormick, Dan Gavrila, Neal L Weintrau. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 3. 2007-03-07. PMID:17218601. |
the inflammatory process leads to protease-mediated degradation of the extracellular matrix and apoptosis of smooth muscle cells (smc), which are the predominant matrix synthesizing cells of the vascular wall. |
2007-03-07 |
2023-08-12 |
Not clear |
| Michael L McCormick, Dan Gavrila, Neal L Weintrau. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 3. 2007-03-07. PMID:17218601. |
moreover, reactive oxygen species (ros) play a key role in regulation of matrix metalloproteinases and induction of smc apoptosis. |
2007-03-07 |
2023-08-12 |
Not clear |
| Eric P Pourmand, Itzhak Binderman, Stephen B Doty, Valery Kudryashov, Adele L Boske. Chondrocyte apoptosis is not essential for cartilage calcification: evidence from an in vitro avian model. Journal of cellular biochemistry. vol 100. issue 1. 2007-02-28. PMID:16888817. |
stimulation of apoptosis with 40-120 nm staurosporine prior to the onset of calcification resulted in inhibition of calcium accretion, with the extent of total calcium uptake significantly decreased, the amount of matrix deposition impaired, and the formation of abnormal mineral crystals. |
2007-02-28 |
2023-08-12 |
chicken |
| J-J Hu, T W Fossum, M W Miller, H Xu, J-C Liu, J D Humphre. Biomechanics of the porcine basilar artery in hypertension. Annals of biomedical engineering. vol 35. issue 1. 2007-02-28. PMID:17066325. |
our increasing understanding of vascular mechanobiology reveals that changes in mechanical stimuli, such as increased blood pressure, alter basic cellular functions including the production and degradation of extracellular matrix as well as proliferation, migration, and apoptosis. |
2007-02-28 |
2023-08-12 |
Not clear |
| Jia-Jun Liu, Dong-Jun Lin, Pei-Qing Liu, Min Huang, Xu-Dong Li, Ren-Wei Huan. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of biomedical science. vol 13. issue 6. 2007-02-22. PMID:16955348. |
in this study, the anti-proliferation and apoptosis inducing effects of tanshinone iia as well as its influence on cell adhesion to and invasion through the extracellular matrix (ecm) on acute promyelocytic leukemia (apl) nb4 cells in vitro were studied. |
2007-02-22 |
2023-08-12 |
Not clear |
| D Vallböhmer, H-J Len. Predictive and prognostic molecular markers in outcome of esophageal cancer. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 19. issue 6. 2007-02-21. PMID:17069584. |
these factors include growth-factor receptors, enzymes of angiogenesis, tumor suppressor genes, cell cycle regulators, enzymes involved in the dna repair system, in apoptosis and in the degradation of extracellular matrix. |
2007-02-21 |
2023-08-12 |
Not clear |
| Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myer. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121916. |
tumors of mice treated with aee788 and aee788 plus chemotherapy exhibited down-regulation of activated egfr and vegfr-2, increased tumor and endothelial cell apoptosis, and decreased microvessel density, which correlated with a decrease in the level of matrix metalloproteinase-9 and matrix metalloproteinase-2 expression and a decrease in the incidence of vascular metastasis. |
2007-02-15 |
2023-08-12 |
mouse |