| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert A Gatenby, Edward T Gawlinski, Arthur F Gmitro, Brant Kaylor, Robert J Gillie. Acid-mediated tumor invasion: a multidisciplinary study. Cancer research. vol 66. issue 10. 2006-07-18. PMID:16707446. |
this chronic exposure of peritumoral normal tissue to an acidic microenvironment produces toxicity by: (a) normal cell death caused by the collapse of the transmembrane h(+) gradient inducing necrosis or apoptosis and (b) extracellular matrix degradation through the release of cathepsin b and other proteolytic enzymes. |
2006-07-18 |
2023-08-12 |
Not clear |
| Irfan Rahman, Iain Kilt. Antioxidant therapeutic targets in COPD. Current drug targets. vol 7. issue 6. 2006-07-14. PMID:16787173. |
oxidative stress has important consequences for several elements of lung physiology and for the pathogenesis of copd, including oxidative inactivation of antiproteases and surfactants, mucus hypersecretion, membrane lipid peroxidation, alveolar epithelial injury, remodeling of extracellular matrix, and apoptosis. |
2006-07-14 |
2023-08-12 |
Not clear |
| H A Golpon, N F Voelke. The vasculature as a target in the treatment of pulmonary emphysema. Current drug targets. vol 7. issue 6. 2006-07-14. PMID:16787175. |
the interplay between inflammation, matrix proteolysis, oxidative stress and apoptosis might account for the irreversible progression of the disease. |
2006-07-14 |
2023-08-12 |
Not clear |
| M E Taube, X-W Liu, R Fridman, H-R C Ki. TIMP-1 regulation of cell cycle in human breast epithelial cells via stabilization of p27(KIP1) protein. Oncogene. vol 25. issue 21. 2006-07-07. PMID:16407831. |
increasing evidence suggests that tissue inhibitor of metalloproteinases-1 (timp-1) can directly regulate cell growth and apoptosis independent of its matrix metalloproteinases (mmps)-inhibitory activity. |
2006-07-07 |
2023-08-12 |
human |
| Zaiping Liu, Hongbing Li, Mathieu Derouet, Alexander Berezkin, Takehiko Sasazuki, Senji Shirasawa, Kirill Rose. Oncogenic Ras inhibits anoikis of intestinal epithelial cells by preventing the release of a mitochondrial pro-apoptotic protein Omi/HtrA2 into the cytoplasm. The Journal of biological chemistry. vol 281. issue 21. 2006-07-07. PMID:16461771. |
resistance of cancer cells to anoikis, apoptosis induced by cell detachment from the extracellular matrix, is thought to represent a critical feature of the malignant phenotype. |
2006-07-07 |
2023-08-12 |
Not clear |
| Nicola Normanno, William J Gullic. Epidermal growth factor receptor tyrosine kinase inhibitors and bone metastases: different mechanisms of action for a novel therapeutic application? Endocrine-related cancer. vol 13. issue 1. 2006-07-06. PMID:16601275. |
anti-egfr agents have a direct activity on tumour cells in which they produce growth inhibition, apoptosis, and reduced invasive capacity through the inhibition of molecules associated with tissue invasion such as urokinase-type plasminogen activator (upa) and matrix metalloproteinase (mmp)-9. |
2006-07-06 |
2023-08-12 |
Not clear |
| Xiong Zhi Wu, Dan Chen, Guang Ru Xi. Extracellular matrix remodeling in hepatocellular carcinoma: effects of soil on seed? Medical hypotheses. vol 66. issue 6. 2006-06-29. PMID:16504415. |
on the other hand, hepatocarcinoma cells create a permissive soil by extracellular matrix remodeling, result in high proliferation, low differentiation, apoptosis block, invasion and metastasis. |
2006-06-29 |
2023-08-12 |
Not clear |
| Francesco De Luc. Impaired growth plate chondrogenesis in children with chronic illnesses. Pediatric research. vol 59. issue 5. 2006-06-23. PMID:16627871. |
growth plate chondrocyte proliferation, hypertrophy/differentiation, apoptosis, and cartilage matrix synthesis all contribute to chondrogenesis or cartilage formation, a process tightly coupled to the simultaneous remodeling of the cartilage into bone at the metaphyseal border of the growth plate. |
2006-06-23 |
2023-08-12 |
Not clear |
| Francesco Gorreta, Timothy P Runfola, Amy J VanMeter, Dagania Barzaghi, Vikas Chandhoke, Luca Del Giacc. Identification of thioredoxin reductase 1-regulated genes using small interference RNA and cDNA microarray. Cancer biology & therapy. vol 4. issue 10. 2006-06-22. PMID:16096367. |
we identified trxr1-dependent genes with functions related to several cellular processes such as apoptosis (sox4), ubiquitination (ubiquitin d, f-box protein 25), organization of cytoskeletal/extracellular matrix (keratin 19, fibronectin 1) and transport (cystine/glutamate transporter). |
2006-06-22 |
2023-08-12 |
Not clear |
| Ya-Huey Chen, Hua-Lin Wu, Ching Li, Yi-Hsien Huang, Chi-Wu Chiang, Ming-Ping Wu, Li-Wha W. Anti-angiogenesis mediated by angiostatin K1-3, K1-4 and K1-4.5. Involvement of p53, FasL, AKT and mRNA deregulation. Thrombosis and haemostasis. vol 95. issue 4. 2006-06-22. PMID:16601838. |
more than 70% of these genes participate in growth, inflammation, apoptosis, migration and extracellular matrix. |
2006-06-22 |
2023-08-12 |
human |
| Juan Antonio Marchal, Fernando Rodríguez-Serrano, Joaquín Campos, Roberto Madeddu, Houria Boulaiz, Antonio Martínez-Amat, Esmeralda Carrillo, Octavio Caba, José C Prados, Celia Vélez, Consolación Melguizo, Andrea Montella, Antonia Aráneg. Differentiation: an encouraging approach to anticancer therapy. Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia. vol 111. issue 1. 2006-06-22. PMID:16736717. |
cancer is a process in which changes in regulating circuits are produced, such as proliferation control, the balance between cellular survival and programmed cellular death (apoptosis), the communication with neighbouring cells and with the extracellular matrix, angiogenesis, and finally, the migration of the tumoural cell, the invasion and metastasic dissemination. |
2006-06-22 |
2023-08-12 |
Not clear |
| Yoko Otake, Alice Mims, Daniel J Fernande. Merbarone induces activation of caspase-activated DNase and excision of chromosomal DNA loops from the nuclear matrix. Molecular pharmacology. vol 69. issue 4. 2006-06-19. PMID:16434617. |
merbarone induced the release of high molecular weight dna fragments from the nuclear matrix of hl-60 leukemia cells, which preceded the internucleosomalsize dna fragmentation characteristic of late-stage apoptosis. |
2006-06-19 |
2023-08-12 |
Not clear |
| Shintaro Kinugawa, Hiroyuki Tsutsu. [Oxidative stress and heart failure]. Nihon rinsho. Japanese journal of clinical medicine. vol 64. issue 5. 2006-06-15. PMID:16689364. |
the excessive reactive oxygen species (ros), produced by the electron leak in mitochondria of failing myocardium, play an important role in development and progression of heart failure (hf) and cardiac remodeling, which is associated with induction of myocyte hypertrophy and apoptosis and activation of matrix metalloproteinases. |
2006-06-15 |
2023-08-12 |
Not clear |
| Teru Hideshima, Paul G Richardson, Kenneth C Anderso. Current therapeutic uses of lenalidomide in multiple myeloma. Expert opinion on investigational drugs. vol 15. issue 2. 2006-06-12. PMID:16433596. |
it directly induces growth arrest and/or apoptosis of even drug-resistant mm cells; inhibits binding of mm cells to bone marrow extracellular matrix proteins and stromal cells; modulates cytokine secretion and inhibits angiogenesis in the bone marrow milieu; and augments host antitumour immunity. |
2006-06-12 |
2023-08-12 |
Not clear |
| Frank M Benge. Atherosclerosis imaging on the molecular level. Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology. vol 13. issue 1. 2006-06-12. PMID:16464725. |
a variety of approaches aiming at plaque inflammation, apoptosis, smooth muscle cell proliferation, extracellular matrix activation, or platelet binding have been introduced. |
2006-06-12 |
2023-08-12 |
Not clear |
| Rolf Schwarzer, Sybille Dames, Daniel Tondera, Anke Klippel, Joerg Kaufman. TRB3 is a PI 3-kinase dependent indicator for nutrient starvation. Cellular signalling. vol 18. issue 6. 2006-06-09. PMID:16129579. |
however, in the absence of glucose overexpression of trb3 in pc-3 cells can interfere with apoptosis and restore growth on extracellular matrix. |
2006-06-09 |
2023-08-12 |
human |
| Markus J Leskinen, Hanna M Heikkilä, Mei Y Speer, Jukka K Hakala, Mika Laine, Petri T Kovanen, Ken A Lindsted. Mast cell chymase induces smooth muscle cell apoptosis by disrupting NF-kappaB-mediated survival signaling. Experimental cell research. vol 312. issue 8. 2006-06-08. PMID:16460729. |
chymase released from activated mast cells induces apoptosis of vascular smooth muscle cells (smcs) in vitro by degrading the pericellular matrix component fibronectin, so causing disruption of focal adhesion complexes and akt dephosphorylation, which are necessary for cell adhesion and survival. |
2006-06-08 |
2023-08-12 |
human |
| Hae Jeong Park, Dong-Hoon Shin, Woo Jin Chung, Kanghyun Leem, Seo Hyun Yoon, Mee Suk Hong, Joo-Ho Chung, Jae-Hoon Bae, Jae Seok Hwan. Epigallocatechin gallate reduces hypoxia-induced apoptosis in human hepatoma cells. Life sciences. vol 78. issue 24. 2006-06-05. PMID:16445947. |
cell detachment from extracellular matrix is closely related to induction of apoptosis. |
2006-06-05 |
2023-08-12 |
human |
| Jakob Richardson, Kasinath Viswanathan, Alexandra Luca. Serpins, the vasculature, and viral therapeutics. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16146796. |
serine protease inhibitors, termed serpins, are key regulators of numerous biological pathways that initiate inflammation, coagulation, angiogenesis, apoptosis, extra-cellular matrix composition and complement activation responses. |
2006-06-02 |
2023-08-12 |
mouse |
| Charles J Malemu. Matrix metalloproteinases: role in skeletal development and growth plate disorders. Frontiers in bioscience : a journal and virtual library. vol 11. 2006-06-02. PMID:16368549. |
among the mmps, mmp-13 (collagenase-3), mmp-9 (92-kda gelatinase; gelatinase b) and mmp-14 (mt1-mmp) are the most abundant proteinases that regulate cellular migration, alterations in the extracellular matrix and apoptosis in growth plate cartilage. |
2006-06-02 |
2023-08-12 |
human |