| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Imtiaz A Mawji, Craig D Simpson, Rose Hurren, Marcela Gronda, Moyo A Williams, Jorge Filmus, James Jonkman, Ralph S Da Costa, Brian C Wilson, Michael P Thomas, John C Reed, Gennadi V Glinsky, Aaron D Schimme. Critical role for Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein in anoikis resistance and distant tumor formation. Journal of the National Cancer Institute. vol 99. issue 10. 2007-07-12. PMID:17505076. |
normal epithelial cells undergo anoikis, or apoptosis on loss of anchorage to the extracellular matrix, by initiating the death receptor pathway of caspase activation. |
2007-07-12 |
2023-08-12 |
Not clear |
| Gunter Wolf, Fuad N Ziyade. Cellular and molecular mechanisms of proteinuria in diabetic nephropathy. Nephron. Physiology. vol 106. issue 2. 2007-07-10. PMID:17570945. |
tgf-beta1 causes podocyte apoptosis and an increase in extracellular matrix deposition. |
2007-07-10 |
2023-08-12 |
Not clear |
| Pål Aukrust, Arne Yndestad, Camilla Smith, Wiggo J Sandberg, Thor Ueland, Torgun Waehre, Bente Halvorsen, Lars Gullestad, Jan Kristian Damå. Potential role for immunomodulatory therapy in atherosclerotic plaque stabilisation. Expert opinion on pharmacotherapy. vol 6. issue 13. 2007-07-05. PMID:16218879. |
thus, inflammatory cytokines may attenuate interstitial collagen synthesis, increase matrix degradation and promote apoptosis in several atheroma-associated cell types, and all these cellular events may enhance plaque vulnerability. |
2007-07-05 |
2023-08-12 |
Not clear |
| Raed N Samara, Luciana M Laguinge, J Milburn Jessu. Carcinoembryonic antigen inhibits anoikis in colorectal carcinoma cells by interfering with TRAIL-R2 (DR5) signaling. Cancer research. vol 67. issue 10. 2007-07-03. PMID:17510406. |
carcinoembryonic antigen (cea) is a tumor marker that is associated with metastasis, poor response to chemotherapy of colorectal cancer (crc), and anoikis, a form of apoptosis caused by cell detachment from matrix that is dependent on trail-r2 (dr5) and caspase-8 activation in crc. |
2007-07-03 |
2023-08-12 |
Not clear |
| Christoph-E Heyde, Sven K Tschoeke, Markus Hellmuth, Arwed Hostmann, Wolfgang Ertel, Andreas Oberholze. Trauma induces apoptosis in human thoracolumbar intervertebral discs. BMC clinical pathology. vol 6. 2007-07-02. PMID:16719914. |
in this regard, apoptosis of ivd cells has been suggested to be involved in the critical changes of the extracellular matrix. |
2007-07-02 |
2023-08-12 |
human |
| C M Thomas, C J Fuller, C E Whittles, M Shari. Chondrocyte death by apoptosis is associated with cartilage matrix degradation. Osteoarthritis and cartilage. vol 15. issue 1. 2007-07-02. PMID:16859932. |
chondrocyte death by apoptosis is associated with cartilage matrix degradation. |
2007-07-02 |
2023-08-12 |
Not clear |
| Chi-Chun Fong, Qi Zhang, Yue-Feng Shi, Rudolf S S Wu, Wang-Fun Fong, Mengsu Yan. Effect of hypoxia on RAW264.7 macrophages apoptosis and signaling. Toxicology. vol 235. issue 1-2. 2007-06-22. PMID:17416447. |
furthermore, gene expression profiles of raw264.7 macrophages induced by hypoxia showed that hypoxia treatment may alter expression of genes related to apoptosis, survival, cell cycle, metabolism and structural matrix. |
2007-06-22 |
2023-08-12 |
Not clear |
| Arne Yndestad, Jan Kristian Damås, Erik Øie, Thor Ueland, Lars Gullestad, Pål Aukrus. Role of inflammation in the progression of heart failure. Current cardiology reports. vol 9. issue 3. 2007-06-19. PMID:17470337. |
importantly, experimental studies have shown that inflammatory cytokines such as tumor necrosis factor-alpha, interleukin-1b, and monocyte chemoattractant peptide-1 may contribute to the development and progression of hf by promoting myocardial hypertrophy, activating matrix metalloproteinases, provoking contractile dysfunction, and inducing apoptosis. |
2007-06-19 |
2023-08-12 |
Not clear |
| Christopher J Carbone, Xavier Graña, E Premkumar Reddy, Dale S Haine. p21 loss cooperates with INK4 inactivation facilitating immortalization and Bcl-2-mediated anchorage-independent growth of oncogene-transduced primary mouse fibroblasts. Cancer research. vol 67. issue 9. 2007-06-18. PMID:17483323. |
in addition, absence of prb function renders h-ras(v12) + c-myc-transduced fibroblasts prone to apoptosis when deprived of the extracellular matrix, and oncogene-induced anchorage-independent growth of pocket protein-deficient cells requires apoptotic suppression. |
2007-06-18 |
2023-08-12 |
mouse |
| Sudhiranjan Gupta, Biswajit Das, Subha Se. Cardiac hypertrophy: mechanisms and therapeutic opportunities. Antioxidants & redox signaling. vol 9. issue 6. 2007-06-18. PMID:17511580. |
many factors have been implicated in cardiac remodeling, including alterations in gene expression in myocytes, cardiomyocytes apoptosis, cytokines and growth factors that influence cardiac dynamics, and deficits in energy metabolism as well as alterations in cardiac extracellular matrix composition. |
2007-06-18 |
2023-08-12 |
Not clear |
| Ravi Dhurjati, Xiaomei Liu, Carol V Gay, Andrea M Mastro, Erwin A Vogle. Extended-term culture of bone cells in a compartmentalized bioreactor. Tissue engineering. vol 12. issue 11. 2007-06-18. PMID:17518620. |
cells in the bioreactor basically matched results obtained in tcps over a 15-day culture interval, but loss of insoluble extracellular matrix and an approximate doubling of apoptosis rates in tcps after 30 days indicated that progressive instability of cultures maintained in tcps with periodic refeeding but without subculture. |
2007-06-18 |
2023-08-12 |
mouse |
| Thomas Effert. Willmar Schwabe Award 2006: antiplasmodial and antitumor activity of artemisinin--from bench to bedside. Planta medica. vol 73. issue 4. 2007-06-14. PMID:17354163. |
the identified genes are from classes with diverse biological functions; for example, regulation of proliferation (bub3, cyclins, cdc25a), angiogenesis (vascular endothelial growth factor and its receptor, matrix metalloproteinase-9, angiostatin, thrombospondin-1) or apoptosis (bcl-2, bax, nf-kappab). |
2007-06-14 |
2023-08-12 |
mouse |
| b' Iva Orli\\xc4\\x87, Fran Borovecki, Petra Simi\\xc4\\x87, Slobodan Vukicevi\\xc4\\x8. Gene expression profiling in bone tissue of osteoporotic mice. Arhiv za higijenu rada i toksikologiju. vol 58. issue 1. 2007-06-12. PMID:17424779.' |
following ovx, genes involved in immune response, cell cycle regulation, growth, apoptosis and bone resorption were upregulated, while genes that are important for regular cell processes, mitosis, metabolism of carbohydrates, extracellular matrix structure, angiogenesis, skeletal development and morphogenesis were downregulated. |
2007-06-12 |
2023-08-12 |
mouse |
| Francisco García-Esteo, Gemma Pascual, Alberto Gallardo, Julio San-Román, Julia Buján, Juan Manuel Belló. A biodegradable copolymer for the slow release of growth hormone expedites scarring in diabetic rats. Journal of biomedical materials research. Part B, Applied biomaterials. vol 81. issue 2. 2007-06-11. PMID:16969827. |
our findings indicate that gh induces cell proliferation, enhances cd4(+) infiltration; increases extracellular matrix protein deposition; stimulates angiogenesis; and diminishes apoptosis at the diabetic wound site. |
2007-06-11 |
2023-08-12 |
rat |
| Giacomo Finocchiaro, Francesco Mattia Mancuso, Davide Cittaro, Heiko Mulle. Graph-based identification of cancer signaling pathways from published gene expression signatures using PubLiME. Nucleic acids research. vol 35. issue 7. 2007-06-05. PMID:17389643. |
the identified communities consist of cell cycle, apoptosis, phosphorylation cascade, extra cellular matrix, interferon and immune response regulators as well as communities of unknown function. |
2007-06-05 |
2023-08-12 |
Not clear |
| Masaki Fujita, Yoichi Nakanish. The pathogenesis of COPD: lessons learned from in vivo animal models. Medical science monitor : international medical journal of experimental and clinical research. vol 13. issue 2. 2007-05-31. PMID:17261992. |
several important factors such as matrix metalloproteinases, apoptosis, protease-antiprotease imbalance, are considered to contribute to the development of copd. |
2007-05-31 |
2023-08-12 |
Not clear |
| M L Bowie, M M Troch, J Delrow, E C Dietze, G R Bean, C Ibarra, G Pandiyan, V L Seewald. Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells. Oncogene. vol 26. issue 14. 2007-05-23. PMID:17016442. |
interferon regulatory factor-1 regulates reconstituted extracellular matrix (recm)-mediated apoptosis in human mammary epithelial cells. |
2007-05-23 |
2023-08-12 |
human |
| J-P Upton, A J Valentijn, L Zhang, A P Gilmor. The N-terminal conformation of Bax regulates cell commitment to apoptosis. Cell death and differentiation. vol 14. issue 5. 2007-05-23. PMID:17273174. |
using anoikis as a model, we have shown that bax translocation does not commit cells to apoptosis, and they can be rescued by reattachment to extracellular matrix within a specific time. |
2007-05-23 |
2023-08-12 |
Not clear |
| Ajaikumar B Kunnumakkara, Sushovan Guha, Sunil Krishnan, Parmeswaran Diagaradjane, Juri Gelovani, Bharat B Aggarwa. Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. Cancer research. vol 67. issue 8. 2007-05-23. PMID:17440100. |
in vivo, tumors from nude mice injected with pancreatic cancer cells and treated with a combination of curcumin and gemcitabine showed significant reductions in volume (p = 0.008 versus control; p = 0.036 versus gemcitabine alone), ki-67 proliferation index (p = 0.030 versus control), nf-kappab activation, and expression of nf-kappab-regulated gene products (cyclin d1, c-myc, bcl-2, bcl-xl, cellular inhibitor of apoptosis protein-1, cyclooxygenase-2, matrix metalloproteinase, and vascular endothelial growth factor) compared with tumors from control mice treated with olive oil only. |
2007-05-23 |
2023-08-12 |
mouse |
| Peter V N Bodine, Barry S Kom. Wnt signaling and osteoblastogenesis. Reviews in endocrine & metabolic disorders. vol 7. issue 1-2. 2007-05-22. PMID:16960757. |
studies of knockout and transgenic mouse models for wnt pathway components like wnt-10b, lrp-5/6, secreted frizzled-related protein-1, dickkopf-2, axin-2 and beta-catenin have demonstrated that canonical signaling modulates most aspects of osteoblast physiology including proliferation, differentiation, bone matrix formation/mineralization and apoptosis as well as coupling to osteoclastogenesis and bone resorption. |
2007-05-22 |
2023-08-12 |
mouse |