| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| James R Berenson, Lakshmi Rajdev, Michael Brode. Treatment strategies for skeletal complications of cancer. Cancer biology & therapy. vol 5. issue 9. 2007-04-20. PMID:16969118. |
these agents are potent inhibitors of osteoclast activity that bind to the bone matrix, are released during bone resorption, and are subsequently internalized by osteoclasts, where they interfere with biochemical pathways and induce osteoclast apoptosis. |
2007-04-20 |
2023-08-12 |
Not clear |
| Ilpo Koskivirta, Otto Rahkonen, Mikko Mäyränpää, Sari Pakkanen, Michael Husheem, Annele Sainio, Harri Hakovirta, Jukka Laine, Eero Jokinen, Eero Vuorio, Petri Kovanen, Hannu Järveläine. Tissue inhibitor of metalloproteinases 4 (TIMP4) is involved in inflammatory processes of human cardiovascular pathology. Histochemistry and cell biology. vol 126. issue 3. 2007-04-10. PMID:16521002. |
in advanced atherosclerotic lesions, timp4 was detected around necrotic lipid cores, whereas timp3 and caspase 3 resided within and around the core regions, indicating different roles for timp3 and timp4 in inflammation-induced apoptosis and in matrix turnover. |
2007-04-10 |
2023-08-12 |
human |
| F Hess, D Estrugo, A Fischer, C Belka, N Corde. Integrin-linked kinase interacts with caspase-9 and -8 in an adhesion-dependent manner for promoting radiation-induced apoptosis in human leukemia cells. Oncogene. vol 26. issue 10. 2007-04-10. PMID:16936772. |
integrin-mediated adhesion of leukemia cells to extracellular matrix proteins reduces apoptosis following radiation-induced genotoxic injury. |
2007-04-10 |
2023-08-12 |
human |
| James S Forrester, Peter Libb. The inflammation hypothesis and its potential relevance to statin therapy. The American journal of cardiology. vol 99. issue 5. 2007-04-10. PMID:17317382. |
these mediators, including tumor necrosis factor, interleukins, and matrix metalloproteinases and transforming growth factor-beta are also prominent in other chronic progressive diseases characterized by cell apoptosis and tissue fibrosis. |
2007-04-10 |
2023-08-12 |
Not clear |
| Chia-Ning Shen, Anita Marguerie, Chiao-Yun Chien, Clive Dickson, Jonathan M W Slack, David Tos. All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation; research in biological diversity. vol 75. issue 1. 2007-04-03. PMID:17244022. |
in contrast, the suppressive effect of ra on exocrine differentiation may be due to a combination of two mechanisms (i) up-regulation of the extracellular matrix component laminin and (ii) enhancement of apoptosis. |
2007-04-03 |
2023-08-12 |
mouse |
| Miao Y Lai, Henry Wing C Leung, Wen H Yang, Wen H Chen, Hong Z Le. Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. Anticancer research. vol 27. issue 1A. 2007-03-29. PMID:17352226. |
up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. |
2007-03-29 |
2023-08-12 |
human |
| Miao Y Lai, Henry Wing C Leung, Wen H Yang, Wen H Chen, Hong Z Le. Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. Anticancer research. vol 27. issue 1A. 2007-03-29. PMID:17352226. |
in this study, there was a significant increase in the gene expression of matrix metalloproteinase (mmp)-1, -2 -3, -9 and -10 in h460 cells after treatment with 10 microm ursolic acid for 24 h. under these experimental conditions, it was found that ursolic acid induced h460 cell apoptosis. |
2007-03-29 |
2023-08-12 |
human |
| Miao Y Lai, Henry Wing C Leung, Wen H Yang, Wen H Chen, Hong Z Le. Up-regulation of matrix metalloproteinase family gene involvement in ursolic acid-induced human lung non-small carcinoma cell apoptosis. Anticancer research. vol 27. issue 1A. 2007-03-29. PMID:17352226. |
these results indicated that matrix metalloproteinase family members are involved not only in invasion, but also in apoptosis of cancer cells. |
2007-03-29 |
2023-08-12 |
human |
| Xiaojuan Lin, Xiancheng Chen, Yuquan Wei, Jumei Zhao, Linyu Fan, Yanjun Wen, Hongbo Wu, Xia Zha. Efficient inhibition of intraperitoneal human ovarian cancer growth and prolonged survival by gene transfer of vesicular stomatitis virus matrix protein in nude mice. Gynecologic oncology. vol 104. issue 3. 2007-03-27. PMID:17112567. |
vesicular stomatitis virus (vsv) matrix protein (mp) has been reported to be capable of inducing apoptosis in vitro in the absence of other viral components. |
2007-03-27 |
2023-08-12 |
mouse |
| Catherine C Net. Cranberry and its phytochemicals: a review of in vitro anticancer studies. The Journal of nutrition. vol 137. issue 1 Suppl. 2007-03-27. PMID:17182824. |
possible chemopreventive mechanisms of action by cranberry phytochemicals include induction of apoptosis in tumor cells, reduced ornithine decarboxylase activity, decreased expression of matrix metalloproteinases associated with prostate tumor metastasis, and antiinflammatory activities including inhibition of cyclooxygenases. |
2007-03-27 |
2023-08-12 |
Not clear |
| Céline Van Themsche, Isabelle Mathieu, Sophie Parent, Eric Asseli. Transforming growth factor-beta3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of X-linked inhibitor of apoptosis and protein kinase c-dependent induction of matrix metalloproteinase-9. The Journal of biological chemistry. vol 282. issue 7. 2007-03-26. PMID:17150964. |
transforming growth factor-beta3 increases the invasiveness of endometrial carcinoma cells through phosphatidylinositol 3-kinase-dependent up-regulation of x-linked inhibitor of apoptosis and protein kinase c-dependent induction of matrix metalloproteinase-9. |
2007-03-26 |
2023-08-12 |
human |
| Hongwei Jiang, Hanyu Zhu, Xiangmei Chen, Youming Peng, Jianzhong Wang, Fuyou Liu, Suozhu Shi, Bo Fu, Yang Lu, Quan Hong, Zhe Feng, Kai Hou, Xuefeng Sun, Guangyan Cai, Xueguang Zhang, Yuansheng Xi. TIMP-1 transgenic mice recover from diabetes induced by multiple low-dose streptozotocin. Diabetes. vol 56. issue 1. 2007-03-26. PMID:17192464. |
tissue inhibitor of metalloproteinase (timp)-1 inhibits matrix metalloproteinase activity and regulates proliferation and apoptosis of a variety of cells types, depending on the context. |
2007-03-26 |
2023-08-12 |
mouse |
| Claudia Hofmann, Florian Obermeier, Monika Artinger, Martin Hausmann, Werner Falk, Juergen Schoelmerich, Gerhard Rogler, Johannes Grossman. Cell-cell contacts prevent anoikis in primary human colonic epithelial cells. Gastroenterology. vol 132. issue 2. 2007-03-26. PMID:17258732. |
colonic epithelial cells (cecs) receive important survival signals from the extracellular matrix and undergo detachment-induced apoptosis (anoikis) as soon as they lose their cell-matrix anchorage. |
2007-03-26 |
2023-08-12 |
human |
| T John, B Kohl, A Mobasheri, W Ertel, M Shakibae. Interleukin-18 induces apoptosis in human articular chondrocytes. Histology and histopathology. vol 22. issue 5. 2007-03-23. PMID:17330802. |
the effects of il-18 on the cartilage-specific matrix protein collagen type ii, the cytoskeletal protein vinculin, the cell matrix signal transduction receptor beta-integrin, key signalling proteins of the mapkinase pathway (such as shc (sarc homology collagen) and activated mapkinase [erk-1/-2]), the pro-inflammatory enzyme cyclo-oxygenase-2 (cox-2) and the apoptosis marker activated caspase-3 were evaluated by western blot analysis and immunofluorescence labelling. |
2007-03-23 |
2023-08-12 |
human |
| T John, B Kohl, A Mobasheri, W Ertel, M Shakibae. Interleukin-18 induces apoptosis in human articular chondrocytes. Histology and histopathology. vol 22. issue 5. 2007-03-23. PMID:17330802. |
taken together, the results of the present study underline key catabolic events mediated by il-18 signalling in chondrocytes such as loss of cartilage-specific matrix and apoptosis. |
2007-03-23 |
2023-08-12 |
human |
| Shizhong Zheng, Anping Che. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. American journal of physiology. Gastrointestinal and liver physiology. vol 292. issue 1. 2007-03-22. PMID:16959952. |
we previously demonstrated that curcumin induced gene expression of ppar-gamma in activated hsc, leading to reducing cell proliferation, inducing apoptosis and suppressing expression of extracellular matrix genes. |
2007-03-22 |
2023-08-12 |
rat |
| Pamela Renate Moll, Veronika Sander, Anna-Maria Frischauf, Klaus Richte. Expression profiling of vitamin D treated primary human keratinocytes. Journal of cellular biochemistry. vol 100. issue 3. 2007-03-20. PMID:16960875. |
targets identified are involved in intracellular signaling, transcription, cell cycle, metabolism, cellular growth, constitution of the extracellular matrix or the cytoskeleton and apoptosis, immune responses, and dna repair, respectively. |
2007-03-20 |
2023-08-12 |
human |
| Ray Saunders, Krysia H Szymczyk, Irving M Shapiro, Christopher S Adam. Matrix regulation of skeletal cell apoptosis III: mechanism of ion pair-induced apoptosis. Journal of cellular biochemistry. vol 100. issue 3. 2007-03-20. PMID:17006955. |
matrix regulation of skeletal cell apoptosis iii: mechanism of ion pair-induced apoptosis. |
2007-03-20 |
2023-08-12 |
Not clear |
| Kwang Seok Ahn, Gautam Sethi, Bharat B Aggarwa. Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1. Journal of immunology (Baltimore, Md. : 1950). vol 178. issue 4. 2007-03-20. PMID:17277159. |
this effect of simvastatin correlated with down-regulation of various gene products that mediate cell proliferation (cyclin d1 and cyclooxygenase-2), cell survival (bcl-2, bcl-x(l), cellular flip, inhibitor of apoptosis protein 1, inhibitor of apoptosis protein 2, and survivin), invasion (matrix mellatoproteinase-9 and icam-1), and angiogenesis (vascular endothelial growth factor); all known to be regulated by the nf-kappab. |
2007-03-20 |
2023-08-12 |
Not clear |
| M Kelly Nicholas, Rimas V Lukas, Nazia F Jafri, Leonardo Faoro, Ravi Salgi. Epidermal growth factor receptor - mediated signal transduction in the development and therapy of gliomas. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 12. issue 24. 2007-03-15. PMID:17189397. |
they are associated with a variety of molecular abnormalities affecting signal transduction, transcription factors, apoptosis, angiogensesis, and the extracellular matrix. |
2007-03-15 |
2023-08-12 |
Not clear |