| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Roderfeld, S Hemmann, E Roe. Mechanisms of fibrinolysis in chronic liver injury (with special emphasis on MMPs and TIMPs). Zeitschrift fur Gastroenterologie. vol 45. issue 1. 2007-03-15. PMID:17236118. |
regeneration from liver fibrosis is characterized by four essential events: 1. eradication of pathological agents, 2. apoptosis of activated hepatic stellate cells, 3. remodeling of extracellular matrix, and 4. regeneration of parenchyma and liver function. |
2007-03-15 |
2023-08-12 |
Not clear |
| Jan Marek Słomiński, Krzysztof Kedzior. [Is COPD an autoimmune disease caused by smoking?]. Przeglad lekarski. vol 63. issue 10. 2007-03-15. PMID:17288238. |
this reaction will proceed over time to damage the lung, producing peptides and modified proteins from matrix destruction, cell necrosis and cell apoptosis. |
2007-03-15 |
2023-08-12 |
Not clear |
| Kyu Yong Jung, Ka Chen, Matthias Kretzler, Chuanyue W. TGF-beta1 regulates the PINCH-1-integrin-linked kinase-alpha-parvin complex in glomerular cells. Journal of the American Society of Nephrology : JASN. vol 18. issue 1. 2007-03-14. PMID:17167118. |
because the pip complex promotes glomerular mesangial matrix deposition and protects podocytes from apoptosis, the tgf-beta1-induced up- and downregulation of the pip complex likely contribute to the pleiotropic effects of tgf-beta1 on different glomerular cell types and hence the progression of glomerular failure. |
2007-03-14 |
2023-08-12 |
Not clear |
| Antonela F A Siqueira, Dulcinéia S P Abdalla, Sandra R G Ferreir. [LDL: from metabolic syndrome to instability of the atherosclerotic plaque]. Arquivos brasileiros de endocrinologia e metabologia. vol 50. issue 2. 2007-03-08. PMID:16767300. |
in the atherosclerotic process, the action of mldl continues until plaque rupture and thrombogenesis, when it promotes apoptosis in endothelial and smooth muscle cells, and activates matrix metalloproteinases, weaken the fibrous cap, and further enhance the inflammatory process that ends in the thrombus formation. |
2007-03-08 |
2023-08-12 |
human |
| Michael L McCormick, Dan Gavrila, Neal L Weintrau. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 3. 2007-03-07. PMID:17218601. |
the inflammatory process leads to protease-mediated degradation of the extracellular matrix and apoptosis of smooth muscle cells (smc), which are the predominant matrix synthesizing cells of the vascular wall. |
2007-03-07 |
2023-08-12 |
Not clear |
| Michael L McCormick, Dan Gavrila, Neal L Weintrau. Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arteriosclerosis, thrombosis, and vascular biology. vol 27. issue 3. 2007-03-07. PMID:17218601. |
moreover, reactive oxygen species (ros) play a key role in regulation of matrix metalloproteinases and induction of smc apoptosis. |
2007-03-07 |
2023-08-12 |
Not clear |
| Eric P Pourmand, Itzhak Binderman, Stephen B Doty, Valery Kudryashov, Adele L Boske. Chondrocyte apoptosis is not essential for cartilage calcification: evidence from an in vitro avian model. Journal of cellular biochemistry. vol 100. issue 1. 2007-02-28. PMID:16888817. |
stimulation of apoptosis with 40-120 nm staurosporine prior to the onset of calcification resulted in inhibition of calcium accretion, with the extent of total calcium uptake significantly decreased, the amount of matrix deposition impaired, and the formation of abnormal mineral crystals. |
2007-02-28 |
2023-08-12 |
chicken |
| J-J Hu, T W Fossum, M W Miller, H Xu, J-C Liu, J D Humphre. Biomechanics of the porcine basilar artery in hypertension. Annals of biomedical engineering. vol 35. issue 1. 2007-02-28. PMID:17066325. |
our increasing understanding of vascular mechanobiology reveals that changes in mechanical stimuli, such as increased blood pressure, alter basic cellular functions including the production and degradation of extracellular matrix as well as proliferation, migration, and apoptosis. |
2007-02-28 |
2023-08-12 |
Not clear |
| Jia-Jun Liu, Dong-Jun Lin, Pei-Qing Liu, Min Huang, Xu-Dong Li, Ren-Wei Huan. Induction of apoptosis and inhibition of cell adhesive and invasive effects by tanshinone IIA in acute promyelocytic leukemia cells in vitro. Journal of biomedical science. vol 13. issue 6. 2007-02-22. PMID:16955348. |
in this study, the anti-proliferation and apoptosis inducing effects of tanshinone iia as well as its influence on cell adhesion to and invasion through the extracellular matrix (ecm) on acute promyelocytic leukemia (apl) nb4 cells in vitro were studied. |
2007-02-22 |
2023-08-12 |
Not clear |
| D Vallböhmer, H-J Len. Predictive and prognostic molecular markers in outcome of esophageal cancer. Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus. vol 19. issue 6. 2007-02-21. PMID:17069584. |
these factors include growth-factor receptors, enzymes of angiogenesis, tumor suppressor genes, cell cycle regulators, enzymes involved in the dna repair system, in apoptosis and in the degradation of extracellular matrix. |
2007-02-21 |
2023-08-12 |
Not clear |
| Maher N Younes, Young Wook Park, Yasemin Dakak Yazici, Meirong Gu, Alfredo A Santillan, Xiaolin Nong, Seungwon Kim, Samar A Jasser, Adel K El-Naggar, Jeffrey N Myer. Concomitant inhibition of epidermal growth factor and vascular endothelial growth factor receptor tyrosine kinases reduces growth and metastasis of human salivary adenoid cystic carcinoma in an orthotopic nude mouse model. Molecular cancer therapeutics. vol 5. issue 11. 2007-02-15. PMID:17121916. |
tumors of mice treated with aee788 and aee788 plus chemotherapy exhibited down-regulation of activated egfr and vegfr-2, increased tumor and endothelial cell apoptosis, and decreased microvessel density, which correlated with a decrease in the level of matrix metalloproteinase-9 and matrix metalloproteinase-2 expression and a decrease in the incidence of vascular metastasis. |
2007-02-15 |
2023-08-12 |
mouse |
| Jordi Monfort, Natalia Garcia-Giralt, María J López-Armada, Joan C Monllau, Angeles Bonilla, Pere Benito, Francisco J Blanc. Decreased metalloproteinase production as a response to mechanical pressure in human cartilage: a mechanism for homeostatic regulation. Arthritis research & therapy. vol 8. issue 5. 2007-02-09. PMID:16972994. |
alternatively, no differences in apoptosis levels between loading areas were found--evidence that mechanical load regulates cartilage matrix composition but does not affect chondrocyte viability. |
2007-02-09 |
2023-08-12 |
human |
| Eleonora Olivotto, Roberta Vitellozzi, Patricia Fernandez, Elisabetta Falcieri, Michela Battistelli, Sabrina Burattini, Annalisa Facchini, Flavio Flamigni, Spartaco Santi, Andrea Facchini, Rosa Maria Borzi\. Chondrocyte hypertrophy and apoptosis induced by GROalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin B. Journal of cellular physiology. vol 210. issue 2. 2007-02-09. PMID:17096385. |
chondrocyte hypertrophy and apoptosis induced by groalpha require three-dimensional interaction with the extracellular matrix and a co-receptor role of chondroitin sulfate and are associated with the mitochondrial splicing variant of cathepsin b. cxcr2 ligands contribute to chondrocyte hypertrophy and apoptosis, important determinants in cartilage pathophysiology. |
2007-02-09 |
2023-08-12 |
human |
| Gillian E Begg, Lyle Carrington, Philippa H Stokes, Jacqueline M Matthews, Merridee A Wouters, Ahsan Husain, Laszlo Lorand, Siiri E Iismaa, Robert M Graha. Mechanism of allosteric regulation of transglutaminase 2 by GTP. Proceedings of the National Academy of Sciences of the United States of America. vol 103. issue 52. 2007-02-08. PMID:17179049. |
here, we investigated the allosteric mechanism by which gtp inhibits cross-linking activity of transglutaminase 2 (tg2), a multifunctional protein, with postulated roles in receptor signaling, extracellular matrix assembly, and apoptosis. |
2007-02-08 |
2023-08-12 |
Not clear |
| Gisela Schieren, Brigitta Rumberger, Marinella Klein, Clemens Kreutz, Jochen Wilpert, Marcel Geyer, Daniel Faller, Jens Timmer, Ivo Quack, Lars Christian Rump, Gerd Walz, Johannes Donaue. Gene profiling of polycystic kidneys. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. vol 21. issue 7. 2007-02-01. PMID:16520345. |
fluid secretion with cyst expansion and reactive changes in the extracellular matrix composition combined with increased apoptosis and proliferation rates have been implicated in cystogenesis. |
2007-02-01 |
2023-08-12 |
Not clear |
| Kelly A Harradine, Rosemary J Akhurs. Mutations of TGFbeta signaling molecules in human disease. Annals of medicine. vol 38. issue 6. 2007-01-30. PMID:17008304. |
the transforming growth factor beta (tgfbeta) signaling pathway regulates several biological processes including cellular proliferation, differentiation, apoptosis, migration, and extracellular matrix deposition. |
2007-01-30 |
2023-08-12 |
human |
| Inka Brockhausen, Xiaojing Yang, Mark Harriso. Analysis of the glycodynamics of primary osteoblasts and bone cancer cells. Methods in molecular biology (Clifton, N.J.). vol 347. 2007-01-30. PMID:17072013. |
bone cells produce a variety of glycoproteins that contribute to bone health, and function in cell adhesion, stabilizing the extracellular matrix, promoting growth and differentiation, and the induction of apoptosis. |
2007-01-30 |
2023-08-12 |
Not clear |
| Y Yang, T Ikezoe, C Nishioka, K Bandobashi, T Takeuchi, Y Adachi, M Kobayashi, S Takeuchi, H P Koeffler, H Taguch. NFV, an HIV-1 protease inhibitor, induces growth arrest, reduced Akt signalling, apoptosis and docetaxel sensitisation in NSCLC cell lines. British journal of cancer. vol 95. issue 12. 2007-01-30. PMID:17133272. |
hiv-1 protease inhibitor (pi), nelfinavir (nfv) induced growth arrest and apoptosis of nci-h460 and -h520, a549, ebc-1 and abc-1 non-small-cell lung cancer (nsclc) cells in association with upregulation of p21waf1, p27kip1 and p53, and downregulation of bcl-2 and matrix metalloproteinase (mmp)-2 proteins. |
2007-01-30 |
2023-08-12 |
mouse |
| Cory J Xian, Johanna C Cool, Tim Pyragius, Bruce K Foste. Damage and recovery of the bone growth mechanism in young rats following 5-fluorouracil acute chemotherapy. Journal of cellular biochemistry. vol 99. issue 6. 2007-01-23. PMID:16888818. |
therefore, 5-fu chemotherapy affects bone growth directly by inducing apoptosis and inhibiting proliferation at growth plate cartilage and metaphyseal bone; after the acute damage, bone growth mechanism can recover, which is associated with upregulated expression of matrix proteins and growth factors. |
2007-01-23 |
2023-08-12 |
rat |
| Diane Proudfoot, Catherine M Shanaha. Molecular mechanisms mediating vascular calcification: role of matrix Gla protein. Nephrology (Carlton, Vic.). vol 11. issue 5. 2007-01-18. PMID:17014561. |
it potentially acts in several ways to regulate calcium deposition including: (i) binding calcium ions and crystals; (ii) antagonizing bone morphogenetic protein and altering cell differentiation; (iii) binding to extracellular matrix components; and (iv) regulating apoptosis. |
2007-01-18 |
2023-08-12 |
Not clear |