| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Laura España, Yolanda Fernández, Nuria Rubio, Angels Torregrosa, Jeronimo Blanco, Angels Sierr. Overexpression of Bcl-xL in human breast cancer cells enhances organ-selective lymph node metastasis. Breast cancer research and treatment. vol 87. issue 1. 2005-01-07. PMID:15377849. |
additionally, in vitro experiments show that in 435 cells bcl-xl-antisense can override the emergence of resistance to apoptosis induced by tnf- alpha and tgf- beta in cells overexpressing bcl-xl, increasing also adhesion to extracellular matrix proteins. |
2005-01-07 |
2023-08-12 |
mouse |
| João Carlos das Neves Pereira, Alecsander Guilharman Pereira da Silva, Fabiana Soares, Alexandre Muxfeldt Ab'Saber, Aurelino Schmidt, Olavo Ribeiro Rodrigues, Ana Garippo, Marisa Capelozzi, José Ribas Milanez de Campos, Tereza Takagaki, Fábio Biscegli Jatene, Sandro Martins, Vera Luiza Capelozz. Nuclear and environment morphometric profile in tumor size and nodal metastasis of resected typical pulmonary carcinoid. Pathology, research and practice. vol 200. issue 6. 2005-01-06. PMID:15310149. |
as the biologic behavior in lung tumors with neuroendocrine differentiation is highly dependent on cell death (apoptosis) and extracellular matrix invasion, bcl2 and extracellular matrix density have been targeted as potentially useful tumor markers. |
2005-01-06 |
2023-08-12 |
Not clear |
| H P Monteiro, E F Silva, A Ster. Nitric oxide: a potential inducer of adhesion-related apoptosis--anoikis. Nitric oxide : biology and chemistry. vol 10. issue 1. 2005-01-04. PMID:15050529. |
among the many initiating events that lead to apoptosis or programmed cell death, loss of contact between the cell and the extracellular matrix has been extensively studied. |
2005-01-04 |
2023-08-12 |
Not clear |
| Paulo Castro-Chaves, Adelino F Leite-Moreir. [Renin-angiotensin system and its role in cardiovascular physiopathology and therapy]. Revista portuguesa de cardiologia : orgao oficial da Sociedade Portuguesa de Cardiologia = Portuguese journal of cardiology : an official journal of the Portuguese Society of Cardiology. vol 23 Suppl 2. 2005-01-04. PMID:15222251. |
at these levels it is involved in cellular proliferation and apoptosis, cellular migration, inflammation, synthesis and release of various mediators such as platelet-derived growth factor and endothelin-1) and in the synthesis of extracellular matrix. |
2005-01-04 |
2023-08-12 |
Not clear |
| Dennis R Warner, Vasker Bhattacherjee, Xiaolong Yin, Saurabh Singh, Partha Mukhopadhyay, M Michele Pisano, Robert M Green. Functional interaction between Smad, CREB binding protein, and p68 RNA helicase. Biochemical and biophysical research communications. vol 324. issue 1. 2004-12-28. PMID:15464984. |
the transforming growth factors beta control a diversity of biological processes including cellular proliferation, differentiation, apoptosis, and extracellular matrix production, and are critical effectors of embryonic patterning and development, including that of the orofacial region. |
2004-12-28 |
2023-08-12 |
mouse |
| Martin P Playford, Michael D Schalle. The interplay between Src and integrins in normal and tumor biology. Oncogene. vol 23. issue 48. 2004-12-28. PMID:15489911. |
we will identify the key players in the integrin-mediated signaling pathways involved in cell motility and apoptosis, such as fak, paxillin and p130(cas), and discuss how src signaling affects the formation of focal adhesions and the extracellular matrix. |
2004-12-28 |
2023-08-12 |
human |
| Jonathan R Gree. Bisphosphonates: preclinical review. The oncologist. vol 9 Suppl 4. 2004-12-22. PMID:15459425. |
as a result of their biochemical effects on protein prenylation, n-bps induce caspase-dependent apoptosis, inhibit matrix metalloproteinase activity, and downregulate alpha(v)beta(3) and alpha(v)beta(5) integrins. |
2004-12-22 |
2023-08-12 |
Not clear |
| Ghassan M Saed, Michael P Diamon. Molecular characterization of postoperative adhesions: the adhesion phenotype. The Journal of the American Association of Gynecologic Laparoscopists. vol 11. issue 3. 2004-12-21. PMID:15559339. |
these events are reduced plasminogen activator activity, extracellular matrix deposition, increased cytokine production, increased angiogenesis, and reduced apoptosis (programmed cell death). |
2004-12-21 |
2023-08-12 |
Not clear |
| Tadaaki Miyazaki, Min Shen, Daisuke Fujikura, Noriko Tosa, Hyung-Ryong Kim, Shigeyuki Kon, Toshimitsu Uede, John C Ree. Functional role of death-associated protein 3 (DAP3) in anoikis. The Journal of biological chemistry. vol 279. issue 43. 2004-12-14. PMID:15302871. |
detachment of adherent epithelial cells from the extracellular matrix induces apoptosis, known as anoikis. |
2004-12-14 |
2023-08-12 |
Not clear |
| Mani Alikhani, Zoubin Alikhani, Markos Raptis, Dana T Grave. TNF-alpha in vivo stimulates apoptosis in fibroblasts through caspase-8 activation and modulates the expression of pro-apoptotic genes. Journal of cellular physiology. vol 201. issue 3. 2004-12-14. PMID:15389560. |
apoptosis of matrix producing cells is common among many inflammatory diseases. |
2004-12-14 |
2023-08-12 |
mouse |
| Diane R Bielenberg, Yasuhiro Hida, Akio Shimizu, Arja Kaipainen, Michael Kreuter, Caroline Choi Kim, Michael Klagsbru. Semaphorin 3F, a chemorepulsant for endothelial cells, induces a poorly vascularized, encapsulated, nonmetastatic tumor phenotype. The Journal of clinical investigation. vol 114. issue 9. 2004-12-13. PMID:15520858. |
rather, the primary tumors resembled benign nevi characterized by large areas of apoptosis, diminished vascularity, inhibition of hyperplasia in overlying epidermal cells, and encapsulated tumor borders delineated by thick layers of fibroblasts and collagen matrix. |
2004-12-13 |
2023-08-12 |
mouse |
| Elizabeth W Newcom. Flavopiridol: pleiotropic biological effects enhance its anti-cancer activity. Anti-cancer drugs. vol 15. issue 5. 2004-12-07. PMID:15166614. |
flavopiridol possesses several important anti-angiogenic activities including induction of apoptosis of endothelial cells; inhibition of the hypoxic induction of vascular endothelial growth factor and/or its production under hypoxic conditions through inhibition of hif-1alpha transcription; and decreased secretion of matrix metalloproteinases that is linked with significant inhibition of invasive potential in matrigel assays. |
2004-12-07 |
2023-08-12 |
human |
| Rowan J Milner, James Farese, Carolyn J Henry, Kim Selting, Timothy M Fan, Louis-Philippe de Lorimie. Bisphosphonates and cancer. Journal of veterinary internal medicine. vol 18. issue 5. 2004-12-07. PMID:15515572. |
bisphosphonates also inhibit cancer cell proliferation, induce apoptosis in in vitro cultures, inhibit angiogenesis, inhibit matrix metalloproteinase, have effects on cytokine and growth factors, and are immunomodulatory. |
2004-12-07 |
2023-08-12 |
Not clear |
| Jack Lawler, Michael Detma. Tumor progression: the effects of thrombospondin-1 and -2. The international journal of biochemistry & cell biology. vol 36. issue 6. 2004-12-02. PMID:15094119. |
the normal suppression of angiogenesis by tsp-1 and -2 involves multiple mechanisms including direct interaction with vascular endothelial cell growth factor (vegf), inhibition of matrix metalloproteinase 9 (mmp9) activation, inhibition of endothelial cell migration and induction of endothelial cell apoptosis. |
2004-12-02 |
2023-08-12 |
Not clear |
| Silvia Selleri, Francesca Arnaboldi, Laura Vizzotto, Andrea Balsari, Cristiano Rumi. Epithelium-mesenchyme compartment interaction and oncosis on chemotherapy-induced hair damage. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 11. 2004-12-02. PMID:15378070. |
as a first sign of damage, significant apoptosis was detected in the proximal perifollicular connective tissue sheath and sporadically in the matrix, near the interface between matrix and follicular papilla. |
2004-12-02 |
2023-08-12 |
rat |
| Erika Suzuki, Kazuko Handa, Marcos S Toledo, Senitiroh Hakomor. Sphingosine-dependent apoptosis: a unified concept based on multiple mechanisms operating in concert. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 41. 2004-12-02. PMID:15466700. |
in addition, sph induces apoptosis through a separate process: the blocking of "survival signal" through the akt kinase pathway induced by alpha3beta1-mediated cell adhesion to laminin 10/11 in extracellular matrix. |
2004-12-02 |
2023-08-12 |
Not clear |
| Charles J Malemu. Protein kinases in chondrocyte signaling and osteoarthritis. Clinical orthopaedics and related research. issue 427 Suppl. 2004-12-02. PMID:15480058. |
protein kinases, particularly mitogen-activated protein kinases and receptor-tyrosine kinases play crucial roles in mammalian cellular metabolism by regulating intracellular signaling pathways that control proliferation, differentiation, cytokine gene induction and cytokine responsiveness, matrix metalloproteinase gene expression, mechanical transduction, as well as programmed cell death (apoptosis). |
2004-12-02 |
2023-08-12 |
Not clear |
| R Lane Smith, Dennis R Carter, David J Schurma. Pressure and shear differentially alter human articular chondrocyte metabolism: a review. Clinical orthopaedics and related research. issue 427 Suppl. 2004-12-02. PMID:15480081. |
application of shear stress to osteoarthritic chondrocytes increased the release of the proinflammatory mediator, nitric oxide, decreased aggrecan and type ii collagen expression, and induced molecular changes associated with apoptosis whereas hydrostatic pressure increased matrix macromolecule expression. |
2004-12-02 |
2023-08-12 |
human |
| Zhao-cai Zhang, Shuang-jie Li, Ying-zhen Yang, Rui-zhen Chen, Jun-bo Ge, Hao-zhu Che. Microarray analysis of extracellular matrix genes expression in myocardium of mouse with Coxsackie virus B3 myocarditis. Chinese medical journal. vol 117. issue 8. 2004-11-30. PMID:15361300. |
extracellular matrix (ecm) orchestrates cell behaviour including growth, death, apoptosis, adhesion, migration, and invasion by activating several signalling pathways. |
2004-11-30 |
2023-08-12 |
mouse |
| Stéphane Fouquet, Verónica-Haydée Lugo-Martínez, Anne-Marie Faussat, Flore Renaud, Philippe Cardot, Jean Chambaz, Martine Pinçon-Raymond, Sophie Thene. Early loss of E-cadherin from cell-cell contacts is involved in the onset of Anoikis in enterocytes. The Journal of biological chemistry. vol 279. issue 41. 2004-11-24. PMID:15292248. |
apoptosis induced by detachment from the extracellular matrix, is thought to be involved in the shedding of enterocytes at the tip of intestinal villi. |
2004-11-24 |
2023-08-12 |
Not clear |