| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R E Bachelder, M A Wendt, N Fujita, T Tsuruo, A M Mercuri. The cleavage of Akt/protein kinase B by death receptor signaling is an important event in detachment-induced apoptosis. The Journal of biological chemistry. vol 276. issue 37. 2001-10-11. PMID:11463786. |
epithelial cells undergo death receptor-dependent apoptosis when detached from matrix, a process termed anoikis. |
2001-10-11 |
2023-08-12 |
Not clear |
| H van der Kuip, A W Goetz, C Miething, J Duyster, W E Aulitzk. Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis. Blood. vol 98. issue 5. 2001-10-04. PMID:11520804. |
integrin-mediated adhesion to extracellular matrix molecules is critical for the regulation of growth and apoptosis. |
2001-10-04 |
2023-08-12 |
Not clear |
| R A Nowa. Identification of new therapies for leiomyomas: what in vitro studies can tell us. Clinical obstetrics and gynecology. vol 44. issue 2. 2001-09-20. PMID:11344996. |
these growth factors not only regulate the proliferation, apoptosis, and extra-cellular matrix production of the smcs but also regulate proliferation and migration of vascular endothelial cells. |
2001-09-20 |
2023-08-12 |
Not clear |
| R Chen, O Kim, J Yang, K Sato, K M Eisenmann, J McCarthy, H Chen, Y Qi. Regulation of Akt/PKB activation by tyrosine phosphorylation. The Journal of biological chemistry. vol 276. issue 34. 2001-09-20. PMID:11445557. |
these two yf mutants fail to block forkhead transcription factor activity in 293 cells and are unable to prevent apoptosis induced by matrix detachment. |
2001-09-20 |
2023-08-12 |
Not clear |
| M Jost, T M Huggett, C Kari, U Rodec. Matrix-independent survival of human keratinocytes through an EGF receptor/MAPK-kinase-dependent pathway. Molecular biology of the cell. vol 12. issue 5. 2001-09-13. PMID:11359940. |
normal epithelial cells undergo apoptosis when they are denied contact with the extracellular matrix, in a process termed "anoikis." |
2001-09-13 |
2023-08-12 |
human |
| F Aoudjit, K Vuor. Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene. vol 20. issue 36. 2001-09-13. PMID:11526484. |
in the present study, we demonstrate that in the mda-mb-231 and mda-mb-435 breast cancer cells, ligation of beta1 integrins by their extracellular matrix ligands inhibits significantly apoptosis induced by paclitaxel and vincristine, two microtubule-directed chemotherapeutic agents that are widely used in the therapy of breast cancer. |
2001-09-13 |
2023-08-12 |
Not clear |
| J A Davies, C E Fisher, M W Barnet. Glycosaminoglycans in the study of mammalian organ development. Biochemical Society transactions. vol 29. issue Pt 2. 2001-09-06. PMID:11356147. |
gags interact with a large number of proteins and can participate in matrix organization, cell adhesion, differentiation, growth and apoptosis. |
2001-09-06 |
2023-08-12 |
mouse |
| A Lesay, J A Hickman, R M Gibso. Disruption of focal adhesions mediates detachment during neuronal apoptosis. Neuroreport. vol 12. issue 10. 2001-09-06. PMID:11447317. |
the aim of this study was to investigate the mechanisms of detachment of neuronal cells from the extracellular matrix (ecm) during apoptosis. |
2001-09-06 |
2023-08-12 |
Not clear |
| A Gemma, K Takenaka, Y Hosoya, K Matuda, M Seike, F Kurimoto, Y Ono, K Uematsu, Y Takeda, S Hibino, A Yoshimura, M Shibuya, S Kudo. Altered expression of several genes in highly metastatic subpopulations of a human pulmonary adenocarcinoma cell line. European journal of cancer (Oxford, England : 1990). vol 37. issue 12. 2001-09-06. PMID:11506965. |
this analysis in subpopulations of a lung cancer cell line indicated that the highly metastatic potential of lung cancer may be induced not by an alteration in the expression of a single gene, but by the accumulation of alterations in the expression of several genes involved in extracellular matrix (ecm) adhesion disruption, ecm degradation, escape from apoptosis, and resistance to transforming growth factor-beta(1) (tgf-beta(1)). |
2001-09-06 |
2023-08-12 |
human |
| S M O'Connor, D A Stenger, K M Shaffer, W M. Survival and neurite outgrowth of rat cortical neurons in three-dimensional agarose and collagen gel matrices. Neuroscience letters. vol 304. issue 3. 2001-08-30. PMID:11343834. |
the results suggest that collagen, because it is a major extracellular matrix constituent, suppresses apoptosis and provides a suitable substrate for neuronal survival and differentiation. |
2001-08-30 |
2023-08-12 |
rat |
| A Rangarajan, R Syal, S Selvarajah, O Chakrabarti, A Sarin, S Krishn. Activated Notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through PKB/Akt. Virology. vol 286. issue 1. 2001-08-23. PMID:11448155. |
activated notch1 signaling cooperates with papillomavirus oncogenes in transformation and generates resistance to apoptosis on matrix withdrawal through pkb/akt. |
2001-08-23 |
2023-08-12 |
human |
| N I Kozlova, G E Morozevich, A N Chubukina, A E Berma. Integrin alphavbeta3 promotes anchorage-dependent apoptosis in human intestinal carcinoma cells. Oncogene. vol 20. issue 34. 2001-08-23. PMID:11498793. |
this finding suggested that alphav-integrin generates a signal stimulating apoptosis of caco-2 cells upon their detachment from the extracellular matrix. |
2001-08-23 |
2023-08-12 |
human |
| M Jüllig, S Eriksso. Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11294860. |
apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase. |
2001-08-16 |
2023-08-12 |
human |
| M Jüllig, S Eriksso. Apoptosis induces efflux of the mitochondrial matrix enzyme deoxyguanosine kinase. The Journal of biological chemistry. vol 276. issue 26. 2001-08-16. PMID:11294860. |
the redistribution of dgk from the mitochondria to the cytosol may be of importance for the activation of apoptotic purine nucleoside cofactors such as datp and demonstrates that mitochondrial matrix proteins may selectively leak out during apoptosis. |
2001-08-16 |
2023-08-12 |
human |
| Y Nakamura, K Sato, N Wakimoto, F Kimura, A Okuyama, K Motoyosh. A new matrix metalloproteinase inhibitor SI-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to TNF alpha-induced apoptosis. Leukemia. vol 15. issue 8. 2001-08-16. PMID:11480563. |
a new matrix metalloproteinase inhibitor si-27 induces apoptosis in several human myeloid leukemia cell lines and enhances sensitivity to tnf alpha-induced apoptosis. |
2001-08-16 |
2023-08-12 |
human |
| J Bode, C Benham, E Ernst, A Knopp, R Marschalek, R Strick, P Strisse. Fatal connections: when DNA ends meet on the nuclear matrix. Journal of cellular biochemistry. Supplement. vol Suppl 35. 2001-08-09. PMID:11389527. |
then we review the different dna targets of recombination, and present recent evidence implicating the nuclear matrix in processes which can induce either repair, translocation, deletion, or apoptosis. |
2001-08-09 |
2023-08-12 |
human |
| b' V Lallemand-Breitenbach, J Zhu, F Puvion, M Koken, N Honor\\xc3\\xa9, A Doubeikovsky, E Duprez, P P Pandolfi, E Puvion, P Freemont, H de Th\\xc3\\xa. Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation. The Journal of experimental medicine. vol 193. issue 12. 2001-08-09. PMID:11413191.' |
promyelocytic leukemia (pml) is the organizer of nuclear matrix domains, pml nuclear bodies (nbs), with a proposed role in apoptosis control. |
2001-08-09 |
2023-08-12 |
Not clear |
| R Snoeck, G Andrei, E De Clerc. Cidofovir in the treatment of HPV-associated lesions. Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie. vol 63. issue 2. 2001-08-02. PMID:11436421. |
different parameters of apoptosis, i.e., (i) induction of cpp32 (caspase-3) protease activity, (ii) translocation of phosphatidylserine (ps) from the inner part of the plasma membrane to the outer layer, (iii) disintegration of the nuclear matrix protein (nmp), (iv) dna fragmentation, (v) number of cells in apoptotic phase following cell cycle analysis, showed that the mechanism of cell death following treatment with cdv is based on apoptosis. |
2001-08-02 |
2023-08-12 |
human |
| H Tohge, K Tsutsui, K Sano, S Isik, K Tsutsu. High incidence of antinuclear antibodies that recognize the matrix attachment region. Biochemical and biophysical research communications. vol 285. issue 1. 2001-08-02. PMID:11437373. |
recent studies suggest that nuclear matrix is altered in the process of apoptosis and presented to the immune system, leading to the production of autoantibodies against its protein components. |
2001-08-02 |
2023-08-12 |
human |
| D Proudfoot, J N Skepper, L Hegyi, A Farzaneh-Far, C M Shanahan, P L Weissber. The role of apoptosis in the initiation of vascular calcification. Zeitschrift fur Kardiologie. vol 90 Suppl 3. 2001-07-26. PMID:11374032. |
these observations suggest that apoptosis is involved in the development of vsmc calcification and that vsmc-derived abs have similarities with matrix vesicles. |
2001-07-26 |
2023-08-12 |
human |