| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michelle P Bendeck, Michelle Conte, Mingyu Zhang, Nafiseh Nili, Bradley H Strauss, Stephanie M Farwel. Doxycycline modulates smooth muscle cell growth, migration, and matrix remodeling after arterial injury. The American journal of pathology. vol 160. issue 3. 2002-04-02. PMID:11891205. |
the tetracyclines function as antibiotics by inhibiting bacterial protein synthesis, but recent work has shown that they are pluripotent drugs that affect many mammalian cell functions including proliferation, migration, apoptosis, and matrix remodeling. |
2002-04-02 |
2023-08-12 |
rat |
| Carlos L Arteaga, Fadlo Khuri, Geoffrey Krystal, Said Sebt. Overview of rationale and clinical trials with signal transduction inhibitors in lung cancer. Seminars in oncology. vol 29. issue 1 Suppl 4. 2002-04-02. PMID:11894010. |
most cellular proto-oncogenes encode proteins that participate in signaling pathways by which cells receive and execute instructions that lead to mitogenesis, differentiation, lineage determination, cell migration, extracellular matrix production, and apoptosis, among others. |
2002-04-02 |
2023-08-12 |
Not clear |
| M Cattaruzza, M M Berger, M Ochs, A Fayyazi, L Füzesi, J Richter, M Hecke. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cell death and differentiation. vol 9. issue 2. 2002-03-27. PMID:11840172. |
isolated smc from these rabbit blood vessels as well as from the aorta and vena cava of the rat, when cultured on a collagen or laminin matrix, uniformly revealed an etb-r-mediated increase in apoptosis upon exposure to mechanical deformation plus exogenous et-1 (10 nmol/l). |
2002-03-27 |
2023-08-12 |
rat |
| M Cattaruzza, M M Berger, M Ochs, A Fayyazi, L Füzesi, J Richter, M Hecke. Deformation-induced endothelin B receptor-mediated smooth muscle cell apoptosis is matrix-dependent. Cell death and differentiation. vol 9. issue 2. 2002-03-27. PMID:11840172. |
however, when grown on a fibronectin matrix, the cultured smc did not respond with an increase in apoptosis under otherwise identical experimental conditions. |
2002-03-27 |
2023-08-12 |
rat |
| A Anwar, A A Zahid, K J Scheidegger, M Brink, P Delafontain. Tumor necrosis factor-alpha regulates insulin-like growth factor-1 and insulin-like growth factor binding protein-3 expression in vascular smooth muscle. Circulation. vol 105. issue 10. 2002-03-27. PMID:11889017. |
insulin-like growth factor-1 (igf-1) prevents apoptosis, promotes matrix formation, and can decrease tnf-alpha or il-1beta--induced proteoglycan degradation. |
2002-03-27 |
2023-08-12 |
Not clear |
| A Calender, C Vercherat, P Gaudray, J A Chayviall. Deregulation of genetic pathways in neuroendocrine tumors. Annals of oncology : official journal of the European Society for Medical Oncology. vol 12 Suppl 2. 2002-03-26. PMID:11762348. |
might be related to each step of the cell life, from mitosis to dna transcription, membrane receptor signalling and growth factor production, protein catabolism and extracellular matrix synthesis, and from transcription regulation to apoptosis and response to hypoxia and cellular stress. |
2002-03-26 |
2023-08-12 |
human |
| Oscar H L Bing, Chester H Conrad, Marvin O Boluyt, Kathleen G Robinson, Wesley W Brook. Studies of prevention, treatment and mechanisms of heart failure in the aging spontaneously hypertensive rat. Heart failure reviews. vol 7. issue 1. 2002-03-20. PMID:11790924. |
the roles of the extracellular matrix, apoptosis, intracellular calcium, beta-adrenergic stimulation, microtubules, and oxygen supply-demand relationships in ultimately mediating myocardial tissue dysfunction are reviewed. |
2002-03-20 |
2023-08-12 |
rat |
| D G Jayne, R M Heath, O Dewhurst, N Scott, P J Guillo. Extracellular matrix proteins and chemoradiotherapy: alpha5beta1 integrin as a predictive marker in rectal cancer. European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology. vol 28. issue 1. 2002-03-12. PMID:11869010. |
to investigate the effects of extracellular matrix (ecm) protein expression on the rates of apoptosis and proliferation in rectal cancers and subsequent response to chemoradiotherapy (crt). |
2002-03-12 |
2023-08-12 |
Not clear |
| Akihisa Matsuda, Yasuhiro Suzuki, Kazunao Kondo, Yasuhiko Ikeda, Kazuo Umemur. Hypercholesterolemia induces regression in neointimal thickening due to apoptosis of vascular smooth muscle cells in the hamster endothelial injury model. Cardiovascular research. vol 53. issue 2. 2002-03-11. PMID:11827703. |
although matrix metalloproteinase may play a key role in plaque rupture, apoptosis of vascular smooth muscle cells (vsmcs), which is induced by cholesterol and its oxides may also contribute to instability and rupture of plaque. |
2002-03-11 |
2023-08-12 |
Not clear |
| Delphine Javelaud, Marie-France Poupon, Juana Wietzerbin, Françoise Besanço. Inhibition of constitutive NF-kappa B activity suppresses tumorigenicity of Ewing sarcoma EW7 cells. International journal of cancer. vol 98. issue 2. 2002-03-07. PMID:11857407. |
it causes, however, a remarkable loss of their ability to generate tumors in nude mice that correlates with both a decrease in extracellular matrix (ecm) protein secretion and an acquisition of sensitivity to murine tumor necrosis factor alpha (tnf alpha)-induced apoptosis. |
2002-03-07 |
2023-08-12 |
mouse |
| J R Berenso. Advances in the biology and treatment of myeloma bone disease. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists. vol 58 Suppl 3. 2002-02-26. PMID:11757204. |
possible mechanisms include inducing apoptosis in tumor cells, inhibiting angiogenesis, and reducing adherence of cancer cells to the bone matrix. |
2002-02-26 |
2023-08-12 |
Not clear |
| E P Moiseev. Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovascular research. vol 52. issue 3. 2002-02-19. PMID:11738054. |
many functions of smcs, such as adhesion, migration, proliferation, contraction, differentiation and apoptosis are determined by surface adhesion receptors involved in cell-cell binding and interactions between cells and extracellular matrix (ecm) proteins. |
2002-02-19 |
2023-08-12 |
Not clear |
| N Mitsiades, V Poulaki, C S Mitsiades, K C Anderso. Induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug. Expert opinion on investigational drugs. vol 10. issue 6. 2002-02-14. PMID:11772236. |
induction of tumour cell apoptosis by matrix metalloproteinase inhibitors: new tricks from a (not so) old drug. |
2002-02-14 |
2023-08-12 |
human |
| Z Zhang, X M Yuan, L H Li, F P Xi. Transdifferentiation of neoplastic cells. Medical hypotheses. vol 57. issue 5. 2002-02-13. PMID:11735329. |
tumor cell transdifferentiation may be influenced or determined by cellular genetic instabilities, proliferation and apoptosis, as well as by extracellular matrix and growth factors. |
2002-02-13 |
2023-08-12 |
Not clear |
| M Yasuda, Y Tanaka, K Fujii, K Yasumot. CD44 stimulation down-regulates Fas expression and Fas-mediated apoptosis of lung cancer cells. International immunology. vol 13. issue 10. 2002-02-07. PMID:11581176. |
based on these findings, we postulate a new concept--that interaction of cd44 on lung cancer cells with fragments of extracellular hyaluronan present in the surrounding extracellular matrix reduces fas expression as well as fas-mediated apoptosis of cancer cells. |
2002-02-07 |
2023-08-12 |
Not clear |
| Carla Boccaccio, Margherita Ando', Paolo M Comogli. A differentiation switch for genetically modified hepatocytes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 16. issue 1. 2002-01-31. PMID:11709498. |
this process, defined as "branching morphogenesis," involves cell scatter and redistribution to form ramified hollow tubules within the extracellular matrix, and protection from apoptosis. |
2002-01-31 |
2023-08-12 |
mouse |
| N Yamaguchi, I R Kieba, J Korostoff, P S Howard, B J Shenker, E T Lall. Maintenance of oxidative phosphorylation protects cells from Actinobacillus actinomycetemcomitans leukotoxin-induced apoptosis. Cellular microbiology. vol 3. issue 12. 2002-01-31. PMID:11736993. |
the results indicate that ltx induces apoptosis through a mitochondrial pathway that involves decreased levels of the adp in the mitochondrial matrix, a lack of substrate for atp synthetase and arrest of oxidative phosphorylation. |
2002-01-31 |
2023-08-12 |
Not clear |
| H A Kim, D I Suh, Y W Son. Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage. The Journal of rheumatology. vol 28. issue 9. 2002-01-30. PMID:11550972. |
relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage. |
2002-01-30 |
2023-08-12 |
human |
| H A Kim, D I Suh, Y W Son. Relationship between chondrocyte apoptosis and matrix depletion in human articular cartilage. The Journal of rheumatology. vol 28. issue 9. 2002-01-30. PMID:11550972. |
since matrix degradation is important in the pathology of arthritis, we investigated the effect of matrix depletion on chondrocyte apoptosis. |
2002-01-30 |
2023-08-12 |
human |
| D A Flusberg, Y Numaguchi, D E Ingbe. Cooperative control of Akt phosphorylation, bcl-2 expression, and apoptosis by cytoskeletal microfilaments and microtubules in capillary endothelial cells. Molecular biology of the cell. vol 12. issue 10. 2002-01-22. PMID:11598193. |
this ability of the cytoskeleton to control capillary endothelial cell survival may be important for understanding the relationship among extracellular matrix turnover, cell shape changes, and apoptosis during angiogenesis inhibition. |
2002-01-22 |
2023-08-12 |
Not clear |