| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Guanghua Mao, Hongyang Liu, Yangyang Ding, Weijie Zhang, Hui Chen, Ting Zhao, Weiwei Feng, Xiangyang Wu, Liuqing Yan. Evaluation of combined developmental neurological toxicity of di (n-butyl) phthalates and lead using immature mice. Environmental science and pollution research international. vol 27. issue 9. 2020-07-06. PMID:31916169. |
thirdly, it induced apoptosis in mouse hippocampal cells. |
2020-07-06 |
2023-08-13 |
mouse |
| Åsa Jungner, Suvi Vallius Kvist, Olga Romantsik, Matteo Bruschettini, Claes Ekström, Ivo Bendix, Josephine Herz, Ursula Felderhoff-Mueser, Adnan Bibic, René In Apos T Zandt, Magnus Gram, David Le. White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model. Developmental neuroscience. vol 41. issue 3-4. 2020-06-30. PMID:31991415. |
consistent with previous studies, we found an increase in apoptosis of oligodendrocytes as determined by tunel+ staining in olig2+ cells in white matter, cortex, thalamus, and hippocampus following exposure to hyperoxia with no additional effect of cell-free hb. |
2020-06-30 |
2023-08-13 |
rat |
| Zhi-Long Zhang, Yu-Gang Gao, Pu Zang, Pei-Pei Gu, Yan Zhao, Zhong-Mei He, Hong-Yan Zh. [Research progress on mechanism of gastrodin and p-hydroxybenzyl alcohol on central nervous system]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 45. issue 2. 2020-06-23. PMID:32237313. |
they alleviate hippocampal neuronal toxicity mainly by regulating a variety of neurotransmitters, such as acetylcholine, glutamic acid(glu), γ-aminobutyric acid(gaba), serotonin(5-ht), dopamine(da), norepinephrine(ne), 5-indoleacetic acid(5-hiaa), high vanillic acid(hva) and dihydroxyphenylacetic acid(dopac), pro-inflammatory cell growth factors, such as il-1β, il-6 and tnf-α and relevant receptor functions, and exert neuropharmacological effects by effectively increasing mrna expressions of brain neurotrophic factors, such as bdnf and gdnf, and further inhibiting the apoptosis of damaged neurons. |
2020-06-23 |
2023-08-13 |
Not clear |
| Jin Zhi, Bin Duan, Jiwen Pei, Songdi Wu, Junli We. Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30260007. |
in addition, daphnetin inhibited oxidative stress and cell apoptosis in hippocampal neurons after ogd/r stimulation. |
2020-06-22 |
2023-08-13 |
Not clear |
| Jin Zhi, Bin Duan, Jiwen Pei, Songdi Wu, Junli We. Daphnetin protects hippocampal neurons from oxygen-glucose deprivation-induced injury. Journal of cellular biochemistry. vol 120. issue 3. 2020-06-22. PMID:30260007. |
in conclusion, these findings demonstrated that daphnetin attenuated oxidative stress and neuronal apoptosis after ogd/r injury through the activation of the nrf2/ho-1 signaling pathway in hippocampal neurons. |
2020-06-22 |
2023-08-13 |
Not clear |
| Meichun Yuan, Hezhong Zhu, Jiajuan Chen, Dan Zhao, Qi Wan, Zhifeng Zhan. A novel squaramide compound alleviates cognitive deficits through activation of Akt and Erk1/2 in a rat model of vascular dementia. Journal of integrative neuroscience. vol 18. issue 4. 2020-06-22. PMID:31912698. |
moreover, bisperoxovanadium (pyridin-2-squaramide) ultimately reduced neuronal apoptosis represented by the bax/bcl-2 ratio in the ca1 (cornu ammonis 1) region of the hippocampus. |
2020-06-22 |
2023-08-13 |
rat |
| Ye Wu, Aizhen Qiu, Zhongxiu Yang, Jie Wu, Xinjian Li, Kexiu Bao, Min Wang, Baoyu W. Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice. Journal of neuroimmunology. vol 336. 2020-06-17. PMID:31487612. |
furthermore, we found that ms extract also inhibited the lps-induced neuron apoptosis and astrogliosis both in the cortex and the ca1 region of hippocampus. |
2020-06-17 |
2023-08-13 |
mouse |
| Puntarik Keawtep, Wasana Pratchayasakul, Apiwan Arinno, Nattayaporn Apaijai, Titikorn Chunchai, Sasiwan Kerdphoo, Thidarat Jaiwongkum, Nipon Chattipakorn, Siriporn C Chattipakor. Combined dipeptidyl peptidase-4 inhibitor with low-dose testosterone exerts greater efficacy than monotherapy on improving brain function in orchiectomized obese rats. Experimental gerontology. vol 123. 2020-06-11. PMID:31125595. |
hippocampal oxidative stress, apoptosis, dendritic spine loss, microglial hyperactivity, and cognitive decline were found in orchiectomized nd-fed rats and sham-operated hfd-fed rats. |
2020-06-11 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
to identify the effect of mir-124 on neuron activities, the viability and apoptosis of hippocampal neurons were assessed. |
2020-06-11 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
the isoflurane anesthesia damaged rats' spatial learning and memory ability, and reduced viability, and promoted apoptosis of hippocampal neurons. |
2020-06-11 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
the treatment of mir-124 agomir improved rats' spatial learning and memory ability and notably increased hippocampal neuron viability and resistance to apoptosis, corresponding to an increased brain-derived neurotrophic factor (bdnf) expression, inhibited expression of proapoptotic factors (cleaved-caspase-3 and bax), and enhanced the expression of antiapoptotic factor (bcl-2). |
2020-06-11 |
2023-08-13 |
rat |
| Wenqian Yang, Qulian Guo, Jingyi Li, Ximei Wang, Bingbing Pan, Yunjiao Wang, Lei Wu, Jianqin Yan, Zhigang Chen. microRNA-124 attenuates isoflurane-induced neurological deficits in neonatal rats via binding to EGR1. Journal of cellular physiology. vol 234. issue 12. 2020-06-11. PMID:31131895. |
upregulated mir-124 inhibited the expression of egr1, by which mechanism mir-124 reduced the neurological deficits induced by isoflurane in neonatal rats through inhibiting apoptosis of hippocampal neurons. |
2020-06-11 |
2023-08-13 |
rat |
| Suping Qin, Dexu Sun, Cheng Zhang, Yao Tang, Feng Zhou, Kuiyang Zheng, Renxian Tang, Yuanlin Zhen. Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice. Behavioural brain research. vol 367. 2020-06-08. PMID:30940514. |
downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice. |
2020-06-08 |
2023-08-13 |
mouse |
| Suping Qin, Dexu Sun, Cheng Zhang, Yao Tang, Feng Zhou, Kuiyang Zheng, Renxian Tang, Yuanlin Zhen. Downregulation of sonic hedgehog signaling in the hippocampus leads to neuronal apoptosis in high-fat diet-fed mice. Behavioural brain research. vol 367. 2020-06-08. PMID:30940514. |
obesity induces hippocampal neuronal apoptosis and leads to cognitive function deficits. |
2020-06-08 |
2023-08-13 |
mouse |
| Hui Huang, Guiyun Cui, Hai Tang, Lingwen Kong, Xiaopeng Wang, Chenchen Cui, Qihua Xiao, Huiming J. Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1. Molecular brain. vol 12. issue 1. 2020-06-08. PMID:31796120. |
then, neuronal damage and cell apoptosis in the cornu ammonis (ca) 1 and 3 regions of the hippocampus were assessed. |
2020-06-08 |
2023-08-13 |
rat |
| Hui Huang, Guiyun Cui, Hai Tang, Lingwen Kong, Xiaopeng Wang, Chenchen Cui, Qihua Xiao, Huiming J. Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1. Molecular brain. vol 12. issue 1. 2020-06-08. PMID:31796120. |
silencing of mirna-146a significantly alleviated the neuronal damage and cell apoptosis in the ca1 and ca3 regions of the hippocampus in tle rats and decreased mda, il-1β, il-6, and il-18 levels and increased sod levels in the hippocampus of tle rats. |
2020-06-08 |
2023-08-13 |
rat |
| Seokhwi Kim, Nury Kim, Jinsu Lee, Sungsoo Kim, Jongryul Hong, Seungkyu Son, Won Do He. Dynamic Fas signaling network regulates neural stem cell proliferation and memory enhancement. Science advances. vol 6. issue 17. 2020-06-06. PMID:32494656. |
activation of fas (cd95) is observed in various neurological disorders and can lead to both apoptosis and prosurvival outputs, yet how fas signaling operates dynamically in the hippocampus is poorly understood. |
2020-06-06 |
2023-08-13 |
mouse |
| Jinping Yang, Lei Yuan, Ying Wen, Haiyan Zhou, Wenhan Jiang, Dan Xu, Minling Wan. Protective Effects of Naringin in Cerebral Infarction and Its Molecular Mechanism. Medical science monitor : international medical journal of experimental and clinical research. vol 26. 2020-06-05. PMID:31901198. |
and naringin treatment reduced apoptosis of nerve cells in rat hippocampus and the secretion of inflammatory factor such as tnf-alpha and il-6. |
2020-06-05 |
2023-08-13 |
rat |
| Qin Sun, Qing-Cui Zeng, Yan-Qiu Chen, Min Zhang, Ling-Ling Wei, Ping Che. Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31081202. |
long intergenic noncoding rna p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microrna-221 through upregulation of fos. |
2020-06-01 |
2023-08-13 |
mouse |
| Qin Sun, Qing-Cui Zeng, Yan-Qiu Chen, Min Zhang, Ling-Ling Wei, Ping Che. Long intergenic noncoding RNA p21 suppresses the apoptosis of hippocampus neurons in streptozotocin-diabetic mice by sponging microRNA-221 through upregulation of FOS. Journal of cellular physiology. vol 234. issue 11. 2020-06-01. PMID:31081202. |
finally, the cell cycle and apoptosis of the hippocampus neurons were measured. |
2020-06-01 |
2023-08-13 |
mouse |