| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zheng Cao, Peiyan Wang, Xiang Gao, Bing Shao, Shuchen Zhao, Yanfei L. Lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat. Journal of inorganic biochemistry. vol 193. 2020-05-05. PMID:30743053. |
lycopene attenuates aluminum-induced hippocampal lesions by inhibiting oxidative stress-mediated inflammation and apoptosis in the rat. |
2020-05-05 |
2023-08-13 |
rat |
| Maria C Olianas, Simona Dedoni, Pierluigi Onal. Inhibition of TNF-α-induced neuronal apoptosis by antidepressants acting through the lysophosphatidic acid receptor LPA Apoptosis : an international journal on programmed cell death. vol 24. issue 5-6. 2020-05-05. PMID:30840161. |
in the present study we found that tnf-α-induced apoptosis of ht22 hippocampal cells, a neuroblast-like cell line, was markedly attenuated by the antidepressants mianserin, mirtazapine and amitriptyline. |
2020-05-05 |
2023-08-13 |
Not clear |
| Yin Fu, Xiaoyang Hu, Chunyu Zheng, Guicai Sun, Jianyu Xu, Shanshan Luo, Peigang Ca. Intrahippocampal miR-342-3p inhibition reduces β-amyloid plaques and ameliorates learning and memory in Alzheimer's disease. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31134481. |
accumulation of extracellular amyloid-β (aβ) in hippocampal subregions is a hallmark of alzheimer's disease (ad), which promotes neuronal apoptosis, potentiates cognitive decline and play a causative role in ad pathogenesis. |
2020-04-30 |
2023-08-13 |
mouse |
| Yin Fu, Xiaoyang Hu, Chunyu Zheng, Guicai Sun, Jianyu Xu, Shanshan Luo, Peigang Ca. Intrahippocampal miR-342-3p inhibition reduces β-amyloid plaques and ameliorates learning and memory in Alzheimer's disease. Metabolic brain disease. vol 34. issue 5. 2020-04-30. PMID:31134481. |
these findings support the model that derangement of hippocampus signal transduction and subsequent neuronal apoptosis in ad arises as a consequence of increased aβ burden and chronic activation of the jnk mapk cascade in a mir-342-3p-dependent manner. |
2020-04-30 |
2023-08-13 |
mouse |
| Zeki Serdar Ataizi, Kemal Ertilav, Mustafa Nazıroğl. Mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, Ca Metabolic brain disease. vol 34. issue 4. 2020-04-30. PMID:31197678. |
mitochondrial oxidative stress-induced brain and hippocampus apoptosis decrease through modulation of caspase activity, ca docetaxel (doce) is widely used to treat several types of glioblastoma. |
2020-04-30 |
2023-08-13 |
Not clear |
| Rong-Hao Mu, Yuan-Zhi Tan, Li-Li Fu, Mohammad Nazmul Islam, Mei Hu, Hao Hong, Su-Su Tan. 1-Methylnicotinamide attenuates lipopolysaccharide-induced cognitive deficits via targeting neuroinflammation and neuronal apoptosis. International immunopharmacology. vol 77. 2020-04-24. PMID:31639616. |
in addition, mna treatment suppressed neuronal apoptosis by reducing the number of tunel-positive cells, caspase-3 activation and increasing the level of bcl-2/bax ratio in the hippocampus and frontal cortex. |
2020-04-24 |
2023-08-13 |
mouse |
| Juan Zhuang, Jun Lu, Xin Wang, Xinfeng Wang, Weicheng Hu, Fashui Hong, Xiang-Xiang Zhao, Yuan-Lin Zhen. Purple sweet potato color protects against high-fat diet-induced cognitive deficits through AMPK-mediated autophagy in mouse hippocampus. The Journal of nutritional biochemistry. vol 65. 2020-04-20. PMID:30616064. |
it is concluded that pspc has great potential to improve cognitive function in hfd-fed mice via ampk activation that restores autophagy and protects against hippocampal apoptosis. |
2020-04-20 |
2023-08-13 |
mouse |
| Lin Wang, Gui Fang Jin, He Han Yu, Xiao Hua Lu, Zhen Hua Zou, Jia Qi Liang, Hong Yan. Protective effects of tenuifolin isolated from Polygala tenuifolia Willd roots on neuronal apoptosis and learning and memory deficits in mice with Alzheimer's disease. Food & function. vol 10. issue 11. 2020-04-16. PMID:31664284. |
ten treatment reversed spatial learning and memory deficits, as well as neuronal apoptosis in hippocampal areas, in app/ps1 transgenic ad mice. |
2020-04-16 |
2023-08-13 |
mouse |
| Xing Li, Lu Zheng, Qian Xia, Lu Liu, Meng Mao, Huijuan Zhou, Yin Zhao, Jing Sh. A novel cell-penetrating peptide protects against neuron apoptosis after cerebral ischemia by inhibiting the nuclear translocation of annexin A1. Cell death and differentiation. vol 26. issue 2. 2020-04-07. PMID:29769639. |
the tat-nts peptide inhibited the transcriptional activity of p53, decreased bid expression, suppressed activation of the caspase-3 apoptosis pathway and improved the survival of hippocampal neurons subjected to oxygen-glucose deprivation and reperfusion in vitro. |
2020-04-07 |
2023-08-13 |
Not clear |
| Miao Sun, Xiaoming Shen, Yunzhi M. Rehmannioside A attenuates cognitive deficits in rats with vascular dementia (VD) through suppressing oxidative stress, inflammation and apoptosis. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-07. PMID:31593895. |
rea group significantly reduced oxidative stress, inflammatory response and apoptosis in the hippocampus of rats with vd, which was linked to the activation of nuclear erythroid related factor-2 (nrf2), while the inactivation of nuclear factor-κb (nf-κb) and caspase-3. |
2020-04-07 |
2023-08-13 |
rat |
| Jing Meng, Dong-Ming Wang, Li-Ling Lu. CTRP3 acts as a novel regulator in depressive-like behavior associated inflammation and apoptosis by meditating p38 and JNK MAPK signaling. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie. vol 120. 2020-04-07. PMID:31629950. |
next, in cums-exposed mice with ctrp3 deficiency, suppressing p38 and jnk markedly alleviated depressive-like behavior,hippocampal neuron death, apoptosis and inflammation. |
2020-04-07 |
2023-08-13 |
mouse |
| Ling Zhang, Zheng-Wen Chen, Shu-Fen Yang, Muyasi Shaer, Ying Wang, Jun-Jie Dong, Beili Jiapae. MicroRNA-219 decreases hippocampal long-term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing the NMDAR signaling pathway. CNS neuroscience & therapeutics. vol 25. issue 1. 2020-04-06. PMID:29804319. |
microrna-219 decreases hippocampal long-term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing the nmdar signaling pathway. |
2020-04-06 |
2023-08-13 |
mouse |
| Ling Zhang, Zheng-Wen Chen, Shu-Fen Yang, Muyasi Shaer, Ying Wang, Jun-Jie Dong, Beili Jiapae. MicroRNA-219 decreases hippocampal long-term potentiation inhibition and hippocampal neuronal cell apoptosis in type 2 diabetes mellitus mice by suppressing the NMDAR signaling pathway. CNS neuroscience & therapeutics. vol 25. issue 1. 2020-04-06. PMID:29804319. |
hence, this study aimed to examine the effects of microrna-219 (mir-219) on inhibition of long-term potentiation (ltp) and apoptosis of hippocampal neuronal cells in t2dm mice through the n-methyl-d-aspartate receptor (nmdar) signaling pathway regulation. |
2020-04-06 |
2023-08-13 |
mouse |
| Maryam Kamarehei, Sussan Kabudanian Ardestani, Masoumeh Firouzi, Hamid Zahednasab, Hossein Keyvani, Mohammad Hossein Harirchia. Increased expression of endoplasmic reticulum stress-related caspase-12 and CHOP in the hippocampus of EAE mice. Brain research bulletin. vol 147. 2020-04-06. PMID:30738137. |
higher levels of caspase-12/chop in hippocampal oligodendrocytes as compared with microglia and astrocytes denote that oligodendrocytes are particularly sensitive to er-mediated apoptosis. |
2020-04-06 |
2023-08-13 |
mouse |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
ethanol increases manganese-induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. |
2020-04-06 |
2023-08-13 |
rat |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
the results indicate that mn and etoh exposure induces spatial learning and memory deficits, increase oxidative/nitrosative stress, neuro-inflammation resulting in enhanced hippocampal apoptosis. |
2020-04-06 |
2023-08-13 |
rat |
| Kpobari W Nkpaa, Benjamin A Amadi, Matthew O Wegwu, Ebenezer O Faromb. Ethanol increases manganese-Induced spatial learning and memory deficits via oxidative/nitrosative stress induced p53 dependent/independent hippocampal apoptosis. Toxicology. vol 418. 2020-04-06. PMID:30844427. |
collectively, etoh increases mn - induced oxidative/nitrosative stress, neuro-inflammation and hippocampal apoptosis via mechanism involving oxidative damages of cellular constituents, neuronal inflammation and subsequent upregulation of bax and caspase-3 and downregulation of bcl-2 protein expression via p53 dependent/independent pathways to induced hippocampal apoptosis associated with impaired spatial learning and memory. |
2020-04-06 |
2023-08-13 |
rat |
| Lu Ouyang, Wei Zhang, Guihua Du, Haizhen Liu, Jie Xie, Junwang Gu, Shuyun Zhang, Fankun Zhou, Lijian Shao, Chang Feng, Guangqin Fa. Lead exposure-induced cognitive impairment through RyR-modulating intracellular calcium signaling in aged rats. Toxicology. vol 419. 2020-04-06. PMID:30905827. |
mechanistically, the exposure of aged rats to lead resulted in increasing free calcium concentration, reactive oxygen species, and apoptosis in the hippocampal neurons. |
2020-04-06 |
2023-08-13 |
rat |
| Ruijun Wang, Ruonan Wang, Xiaoying Niu, Ying Cheng, Xiaona Shang, Yachen Li, Shuangyue Li, Xiaohui Liu, Jing Sha. Role of astrocytes-derived d-serine in PFOS-induced neurotoxicity through NMDARs in the rat primary hippocampal neurons. Toxicology. vol 422. 2020-04-03. PMID:31004706. |
in the present study, astrocytes-derived d-serine was shown to be involved in pfos-induced apoptosis and death in the rat primary hippocampal neurons. |
2020-04-03 |
2023-08-13 |
human |
| H Yeşil, I Tuğl. The relation of oxidative stress and apoptosis to histopathologic alterations in the lungs as a result of global cerebral ischemia. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 94. issue 8. 2020-04-03. PMID:31373845. |
following ischemia, we found evidence of gliosis induced oxidative stress and apoptosis in the hippocampus. |
2020-04-03 |
2023-08-13 |
rat |