| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xiangdan Li, Vikash Giri, Yunmei Cui, Mingji Yin, Zhemin Xian, Jinzi L. LncRNA FTX inhibits hippocampal neuron apoptosis by regulating miR-21-5p/SOX7 axis in a rat model of temporal lobe epilepsy. Biochemical and biophysical research communications. vol 512. issue 1. 2020-02-10. PMID:30871773. |
collectively, our study for the first time demonstrated the anti-apoptosis ability of ftx during epileptogenesis and uncovered a novel ftx-mediated mechanism in se-induced neural apoptosis by targeting mir-21-5p/sox7 axis, which provides a new target in developing lncrna-based strategies to reduce se-induced hippocampal neuron apoptosis. |
2020-02-10 |
2023-08-13 |
rat |
| Shuzhi Zhong, Dong Pei, Lei Shi, Yong Cui, Zongyuan Hon. Ephrin-B2 inhibits Aβ Neuroscience letters. vol 704. 2020-02-05. PMID:30936033. |
the aim of this study was to investigate the effect of the efnb2-activated eph/efn forward signaling pathway on aβ-induced ht22 hippocampal cell apoptosis using recombination mouse ephrin b2-fc chimera protein (efnb2-fc). |
2020-02-05 |
2023-08-13 |
mouse |
| Fei Chen, Can-Can Zhou, Yin Yang, Jian-Wen Liu, Chong-Huai Ya. GM1 Ameliorates Lead-Induced Cognitive Deficits and Brain Damage Through Activating the SIRT1/CREB/BDNF Pathway in the Developing Male Rat Hippocampus. Biological trace element research. vol 190. issue 2. 2020-02-04. PMID:30414004. |
in conclusion, our study demonstrated that gm1 exerts a protective effect on lead-induced cognitive deficits via antioxidant activity, preventing apoptosis, and activating sirt1/creb/bdnf in the developing rat hippocampus, implying a novel potential assistant therapy for lead poisoning. |
2020-02-04 |
2023-08-13 |
rat |
| Jennifer Mytych, Przemyslaw Solek, Anna Tabecka-Lonczynska, Marek Koziorowsk. Klotho-Mediated Changes in Shelterin Complex Promote Cytotoxic Autophagy and Apoptosis in Amitriptyline-Treated Hippocampal Neuronal Cells. Molecular neurobiology. vol 56. issue 10. 2020-01-30. PMID:30945158. |
klotho-mediated changes in shelterin complex promote cytotoxic autophagy and apoptosis in amitriptyline-treated hippocampal neuronal cells. |
2020-01-30 |
2023-08-13 |
mouse |
| Li-Li Wu, Dan-Na Lin, Li-Hua Yu, Li-Hua Yan. Endoplasmic reticulum stress plays an important role in methotrexate-related cognitive impairment in adult rats. International journal of clinical and experimental pathology. vol 10. issue 10. 2020-01-26. PMID:31966359. |
thus we hypothesized that mtx-induced apoptosis of hippocampal neurons via activating endoplasmic reticulum stress (ers) pathway, which leads to cognitive impairment in adult rats. |
2020-01-26 |
2023-08-13 |
rat |
| Li Wang, Yansong Zheng, Xiaoxiao Gao, Yingchun Liu, Xiaoqing Yo. Retinoid X receptor ligand regulates RXRα/Nur77-dependent apoptosis via modulating its nuclear export and mitochondrial targeting. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966420. |
thus, we detected the changes of the expression and subcellular localization of rxrα/nur77 and the apoptotic rate of neuroblastoma cells, sh-sy5y cells and nerve cells in c57bl/6 mouse hippocampus in alzheimer's disease pathologic condition, and investigated the effect of rxrα exporting inhibition caused by 9-cis-ra on the apoptosis of neurons. |
2020-01-26 |
2023-08-13 |
mouse |
| Haijie Xia, Yongliang Li, Guowen Zhu, Xuzhong Zhan. Activation of mitochondria apoptotic pathway is involved in the sevoflurane-induced hippocampal neuronal HT22 cells toxicity through miR-145/Binp3 axis. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966430. |
micrornas (mirnas) play critical roles in multiple cells apoptosis, including hippocampal neural. |
2020-01-26 |
2023-08-13 |
Not clear |
| Haijie Xia, Yongliang Li, Guowen Zhu, Xuzhong Zhan. Activation of mitochondria apoptotic pathway is involved in the sevoflurane-induced hippocampal neuronal HT22 cells toxicity through miR-145/Binp3 axis. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966430. |
the present study, therefore, was aimed to investigate the mir-145 function on the hippocampal neural apoptosis induced by sevoflurane exposure. |
2020-01-26 |
2023-08-13 |
Not clear |
| Haijie Xia, Yongliang Li, Guowen Zhu, Xuzhong Zhan. Activation of mitochondria apoptotic pathway is involved in the sevoflurane-induced hippocampal neuronal HT22 cells toxicity through miR-145/Binp3 axis. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966430. |
results showed that sevoflurane could significantly induce the hippocampal neural cell apoptosis via mitochondria apoptotic pathway. |
2020-01-26 |
2023-08-13 |
Not clear |
| Haijie Xia, Yongliang Li, Guowen Zhu, Xuzhong Zhan. Activation of mitochondria apoptotic pathway is involved in the sevoflurane-induced hippocampal neuronal HT22 cells toxicity through miR-145/Binp3 axis. International journal of clinical and experimental pathology. vol 10. issue 11. 2020-01-26. PMID:31966430. |
therefore, it concluded that mir-145 could protect against sevoflurane-induced hippocampal apoptosis through the mitochondrial pathway at least by directly inhibiting its target gene-bnip3 expression in hippocampal neural cell lines. |
2020-01-26 |
2023-08-13 |
Not clear |
| Yongliang Li, Haijie Xia, Liangliang Chen, Xuzhong Zhan. Sevoflurane induces endoplasmic reticulum stress mediated apoptosis inmouse hippocampal neuronal HT22 cells via modulating miR-15b-5p/Rab1A signaling pathway. International journal of clinical and experimental pathology. vol 10. issue 8. 2020-01-26. PMID:31966678. |
sevoflurane induces endoplasmic reticulum stress mediated apoptosis inmouse hippocampal neuronal ht22 cells via modulating mir-15b-5p/rab1a signaling pathway. |
2020-01-26 |
2023-08-13 |
Not clear |
| Birsen Elibol, Merve Beker, Cigdem Dilek Sahbaz, Ulkan Kilic, Ewa Jakubowska-Doğr. Prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus. Acta neurobiologiae experimentalis. vol 79. issue 2. 2020-01-23. PMID:31342950. |
prenatal ethanol intoxication and maternal intubation stress alter cell survival and apoptosis in the postnatal development of rat hippocampus. |
2020-01-23 |
2023-08-13 |
rat |
| Jing Zhang, Ying Han, Yang Zhao, Qin-Rui Li, Hong-Fang Jin, Jun-Bao Du, Jiong Qi. Role of endoplasmic reticulum stress-associated gene TRIB3 in rats following kainic acid-induced seizures. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-01-17. PMID:31933865. |
in a rat model of kainic acid-induced seizures, neuronal excitotoxic injury and apoptosis, and increases in the expression of trib3 and er stress markers glucose-regulated protein 78 (grp78) and c/ebp homologous binding protein (chop) were observed in the hippocampus by 24 h to 30 d after ka administration. |
2020-01-17 |
2023-08-13 |
rat |
| Jing Zhang, Ying Han, Yang Zhao, Qin-Rui Li, Hong-Fang Jin, Jun-Bao Du, Jiong Qi. Role of endoplasmic reticulum stress-associated gene TRIB3 in rats following kainic acid-induced seizures. International journal of clinical and experimental pathology. vol 12. issue 2. 2020-01-17. PMID:31933865. |
these results indicate that er stress, trib3 and akt signaling are involved in the acute and prolonged hippocampal injury following ka induced seizure, suggesting that the er stress-associated gene trib3 plays an important role in neuronal apoptosis after seizure. |
2020-01-17 |
2023-08-13 |
rat |
| Chang Xu, Jiao-Jiao Niu, Jun-Fei Zhou, Yin-Sheng We. MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. Brain research bulletin. vol 144. 2020-01-16. PMID:30217735. |
the mrna and protein levels of igf1r, bcl-2, bax, and caspase-3 were measured followed by the determination of hippocampal neuron apoptosis. |
2020-01-16 |
2023-08-13 |
mouse |
| Chang Xu, Jiao-Jiao Niu, Jun-Fei Zhou, Yin-Sheng We. MicroRNA-96 is responsible for sevoflurane-induced cognitive dysfunction in neonatal rats via inhibiting IGF1R. Brain research bulletin. vol 144. 2020-01-16. PMID:30217735. |
our analyses indicated that 4% sevoflurane had a significantly stronger effect on reducing the levels of igf1r and bcl-2, while elevating the levels of mir-96, bax and caspase-3 more so than that of 1% or 2% sevoflurane, which resulted in increased hippocampal neuron apoptosis but diminished the learning and memory performance of the rats. |
2020-01-16 |
2023-08-13 |
mouse |
| Bruno Braga Sisnando da Costa, Isabela Costola Windlin, Edwin Koterba, Vitor Nagai Yamaki, Nícollas Nunes Rabelo, Davi Jorge Fontoura Solla, Manoel Jacobsen Teixeira, Eberval Gadelha Figueired. Glibenclamide in aneurysmatic subarachnoid hemorrhage (GASH): study protocol for a randomized controlled trial. Trials. vol 20. issue 1. 2020-01-14. PMID:31288831. |
the effect of glibenclamide blocking the sur1-trpm4 channel was examined in models of subarachnoid hemorrhage and stroke, with findings of significantly reduced tight-junction abnormalities, resulting in less edema formation and considerably reduced transsynaptic apoptosis of hippocampal neurons and significantly ameliorated impairments in spatial learning. |
2020-01-14 |
2023-08-13 |
Not clear |
| Ah-Ran Yu, Yeon Ju Jeong, Chi Yeon Hwang, Kyung-Sik Yoon, Wonchae Choe, Joohun Ha, Sung Soo Kim, Youngmi Kim Pak, Eui-Ju Yeo, Insug Kan. Alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-Src-, ROS-, MAPKs-, and arylhydrocarbon receptor-dependent pathways in HT22 hippocampal neuronal cells. Neurotoxicology. vol 71. 2020-01-09. PMID:30508555. |
alpha-naphthoflavone induces apoptosis through endoplasmic reticulum stress via c-src-, ros-, mapks-, and arylhydrocarbon receptor-dependent pathways in ht22 hippocampal neuronal cells. |
2020-01-09 |
2023-08-13 |
mouse |
| Kyosuke Yamanishi, Nobutaka Doe, Keiichiro Mukai, Kaoru Ikubo, Takuya Hashimoto, Noriko Uwa, Miho Sumida, Yosif El-Darawish, Naomi Gamachi, Wen Li, Sachi Kuwahara-Otani, Seishi Maeda, Yuko Watanabe, Tetsu Hayakawa, Hiromichi Yamanishi, Tomohiro Matsuyama, Hideshi Yagi, Haruki Okamura, Hisato Matsunag. Interleukin-18-deficient mice develop hippocampal abnormalities related to possible depressive-like behaviors. Neuroscience. vol 408. 2020-01-09. PMID:30981863. |
moreover, dm is associated with cognitive impairment and promotes apoptosis of hippocampal cells by activating pro-apoptotic and inhibiting anti-apoptotic factors. |
2020-01-09 |
2023-08-13 |
mouse |
| Żaneta Broniowska, Beata Bystrowska, Beata Starek-Świechowicz, Bartosz Pomierny, Weronika Krzyżanowska, Maria Walczak, Bogusława Budziszewsk. Benzophenone-2 Concentration and Its Effect on Oxidative Stress and Apoptosis Markers in Rat Brain. Neurotoxicity research. vol 36. issue 1. 2020-01-09. PMID:31006828. |
in the hippocampus, where bp-2 level was about 3.5-fold lower than in the frontal cortex, no significant changes in either oxidative stress and apoptosis markers were observed. |
2020-01-09 |
2023-08-13 |
rat |