| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Zhixiong Zhang, Rong Li, Xiaoyan Zhang, Yaxuan Wei, Hongbing Ma, Ling Zhu, Rong Yi. Voluntary exercise promotes neurotrophic factor and suppresses apoptosis in hippocampal ischemia. Journal of integrative neuroscience. vol 18. issue 1. 2019-12-23. PMID:31091850. |
results indicate that voluntary wheel running promote hippocampal brain derived neurotrophic factor and inhibit cell apoptosis in ischemia-induced impairment. |
2019-12-23 |
2023-08-13 |
rat |
| Xiaojuan Wu, Yajie Wang, Zhenrong Sun, Shouchen Ren, Weili Yang, Yaxian Deng, Chaoxia Tian, Yazhen Yu, Baoqin Ga. Molecular expression and functional analysis of genes in children with temporal lobe epilepsy. Journal of integrative neuroscience. vol 18. issue 1. 2019-12-23. PMID:31091851. |
hippocampal slices from either normal (control) children or children with temporal lobe epilepsy were used to detect the expression of mir-135a-5p and its target gene caspase activity and apoptosis inhibitor 1. |
2019-12-23 |
2023-08-13 |
rat |
| Xiangyu Guo, Yu Shi, Ping Du, Jiahui Wang, Yelei Han, Bei Sun, Jing Fen. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life sciences. vol 239. 2019-12-23. PMID:31678553. |
hmgb1/tlr4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with osa. |
2019-12-23 |
2023-08-13 |
mouse |
| Xiangyu Guo, Yu Shi, Ping Du, Jiahui Wang, Yelei Han, Bei Sun, Jing Fen. HMGB1/TLR4 promotes apoptosis and reduces autophagy of hippocampal neurons in diabetes combined with OSA. Life sciences. vol 239. 2019-12-23. PMID:31678553. |
we previously reported that cognitive impairment is exacerbated in kkay mice exposed to intermittent hypoxia (ih), during which the dna binding protein hmgb1 mediates hippocampal neuronal apoptosis by maintaining microglia-associated neuroinflammation, but the underlying mechanism remains largely unknown. |
2019-12-23 |
2023-08-13 |
mouse |
| Ahmad H Alhowail, Jenna Bloemer, Mohammed Majrashi, Priyanka D Pinky, Subhrajit Bhattacharya, Zhang Yongli, Dwipayan Bhattacharya, Matthew Eggert, Lauren Woodie, Manal A Buabeid, Nathaniel Johnson, Alyssa Broadwater, Bruce Smith, Muralikrishnan Dhanasekaran, Robert D Arnold, Vishnu Suppiramania. Doxorubicin-induced neurotoxicity is associated with acute alterations in synaptic plasticity, apoptosis, and lipid peroxidation. Toxicology mechanisms and methods. vol 29. issue 6. 2019-12-18. PMID:31010378. |
this data indicates that acute dox exposure dose-dependently impairs synaptic processes associated with hippocampal neurotransmission, induces apoptosis, and increases lipid peroxidation leading to neurotoxicity. |
2019-12-18 |
2023-08-13 |
Not clear |
| Biao Yan, Yanling Sun, Jie Zeng, Yingying Chen, Chongyao Li, Peng Song, Lin Zhang, Xu Yang, Yang Wu, Ping M. Combined use of vitamin E and nimodipine ameliorates dibutyl phthalate-induced memory deficit and apoptosis in mice by inhibiting the ERK 1/2 pathway. Toxicology and applied pharmacology. vol 368. 2019-12-16. PMID:30776390. |
studies have shown that the erk 1/2 pathway is closely related to apoptosis of hippocampal neurons. |
2019-12-16 |
2023-08-13 |
mouse |
| Biao Yan, Yanling Sun, Jie Zeng, Yingying Chen, Chongyao Li, Peng Song, Lin Zhang, Xu Yang, Yang Wu, Ping M. Combined use of vitamin E and nimodipine ameliorates dibutyl phthalate-induced memory deficit and apoptosis in mice by inhibiting the ERK 1/2 pathway. Toxicology and applied pharmacology. vol 368. 2019-12-16. PMID:30776390. |
on the basis of these links between lds, dbp and the erk 1/2 pathway, we explore whether dbp induces hippocampal neuron apoptosis and increases behavioral disorders in mice via the erk 1/2 pathway. |
2019-12-16 |
2023-08-13 |
mouse |
| Biao Yan, Yanling Sun, Jie Zeng, Yingying Chen, Chongyao Li, Peng Song, Lin Zhang, Xu Yang, Yang Wu, Ping M. Combined use of vitamin E and nimodipine ameliorates dibutyl phthalate-induced memory deficit and apoptosis in mice by inhibiting the ERK 1/2 pathway. Toxicology and applied pharmacology. vol 368. 2019-12-16. PMID:30776390. |
we looked at oxidative stress, examined the calcium signal, detected the erk 1/2 pathway and evaluated apoptosis as well as using histological observations, and found that dbp significantly increased oxidative damage and apoptosis in hippocampal neurons via the erk 1/2 pathway in mice. |
2019-12-16 |
2023-08-13 |
mouse |
| Changliang Wang, Xiaolong Wang, Yan Li, Zhixiu Xia, Yang Liu, Hao Yu, Guohui Xu, Xu Wu, Rui Zhao, Guohua Zhan. Chronic ethanol exposure reduces the expression of NCX3 in the hippocampus of male C57BL/6 mice. Neuroreport. vol 30. issue 6. 2019-12-16. PMID:30829960. |
chronic etoh exposure reduced the expression of ncx3 in the hippocampus of male c57bl/6 mice, increasing intracellular calcium and apoptosis, resulting in spatial memory impairment in mice. |
2019-12-16 |
2023-08-13 |
mouse |
| Jianguo Zhang, Chunzhi Tang, Wenyan Liao, Mingmin Zhu, Ming Liu, Ningning Su. The antiapoptotic and antioxidative stress effects of Zhisanzhen in the Alzheimer's disease model rat. Neuroreport. vol 30. issue 9. 2019-12-16. PMID:31095002. |
we found that zhisanzhen improved behavioral performance, reduced oxidative stress, increased the neurotransmitter acetylcholine concentration, reduced apoptosis in hippocampal neurons, and down-regulated the expression of apoptosis-related genes and proteins. |
2019-12-16 |
2023-08-13 |
rat |
| L-L Guo, D-S Wang, Y-Y Xu, K-G Cu. Effects of IL-1β on hippocampus cell apoptosis and learning ability of vascular dementia rats. European review for medical and pharmacological sciences. vol 22. issue 18. 2019-12-11. PMID:30280789. |
effects of il-1β on hippocampus cell apoptosis and learning ability of vascular dementia rats. |
2019-12-11 |
2023-08-13 |
rat |
| Mehtab Khan, Bart P F Rutten, Myeong Ok Ki. MST1 Regulates Neuronal Cell Death via JNK/Casp3 Signaling Pathway in HFD Mouse Brain and HT22 Cells. International journal of molecular sciences. vol 20. issue 10. 2019-12-03. PMID:31117242. |
our western blot and immunofluorescence results indicate that hfd and stress-induced hippocampal ht22 cells activate mst1/jnk/caspase-3 (casp-3) signaling, which regulates neuronal cell apoptosis and beta-amyloid-cleaving enzyme (bace1) expression and leads to impaired cognition. |
2019-12-03 |
2023-08-13 |
mouse |
| Qinghui Guo, Shangming Liu, Shandan Wang, Meiyan Wu, Zhaoxia Li, Yibiao Wan. Beta-hydroxybutyric acid attenuates neuronal damage in epileptic mice. Acta histochemica. vol 121. issue 4. 2019-12-02. PMID:30954274. |
it was found bhba improved epilepsy- caused learning deficiency and attenuated epilepsy-mediated neuron loss and cell apoptosis in the hippocampus. |
2019-12-02 |
2023-08-13 |
mouse |
| Yang Wang, Chun Wang, Yue Zhang, Guan Wang, Haitao Yan. Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice. Acta histochemica. vol 121. issue 4. 2019-12-02. PMID:31006528. |
we first examined the effects of luteoline on hippocampal neuron apoptosis, inflammation and oxidative stress 18 h post anesthesia. |
2019-12-02 |
2023-08-13 |
mouse |
| Yang Wang, Chun Wang, Yue Zhang, Guan Wang, Haitao Yan. Pre-administration of luteoline attenuates neonatal sevoflurane-induced neurotoxicity in mice. Acta histochemica. vol 121. issue 4. 2019-12-02. PMID:31006528. |
in summary, our findings confirm that the attenuation of luteoline on sevoflurane-induced spatial learning and memory impairment later is associated with inhibition of hippocampal neuron apoptosis, inflammation and oxidative stress early. |
2019-12-02 |
2023-08-13 |
mouse |
| Dengxin Zhang, Bingxin Xue, Jie You, Bin Zhang, Gaoshang Cha. Suberoylanilide hydroxamic acid reversed cognitive and synaptic plasticity impairments induced by sevoflurane exposure in adult mice. Neuroreport. vol 30. issue 4. 2019-11-29. PMID:30672888. |
the effect is related to inhibiting cell apoptosis and activating the brain-derived neurotrophic factor/tropomyosin-related kinase b/camp response element-binding signaling pathway in the hippocampus. |
2019-11-29 |
2023-08-13 |
mouse |
| Zi Chen, Sheng-Dan Nie, Min-Li Qu, Di Zhou, Liang-Yan Wu, Xia-Jie Shi, Ling-Ran Ma, Xin Li, Shan-Lei Zhou, Shan Wang, Jing W. The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes. Cell death & disease. vol 9. issue 7. 2019-11-25. PMID:29991726. |
the aim of this study was to delineate whether the autophagic degradation of cav-1 is involved in pa-induced apoptosis and inflammation in hippocampal astrocytes. |
2019-11-25 |
2023-08-13 |
rat |
| Zi Chen, Sheng-Dan Nie, Min-Li Qu, Di Zhou, Liang-Yan Wu, Xia-Jie Shi, Ling-Ran Ma, Xin Li, Shan-Lei Zhou, Shan Wang, Jing W. The autophagic degradation of Cav-1 contributes to PA-induced apoptosis and inflammation of astrocytes. Cell death & disease. vol 9. issue 7. 2019-11-25. PMID:29991726. |
in this study we found that: (1) pa caused apoptotic death and inflammation by autophagic induction; (2) cav-1 was degraded by pa-induced autophagy and pa induced autophagy in a cav-1-independent manner; (3) the degradation of cav-1 was responsible for pa-induced autophagy-dependent apoptotic cell death and inflammation; (4) chronic high-fat diet (hfd) induced cav-1 degradation, apoptosis, autophagy, and inflammation in the hippocampal astrocytes of rats. |
2019-11-25 |
2023-08-13 |
rat |
| Dongyi Tong, Christin M Godale, Feni K Kadakia, Zhiqing Gu, Cole S K Danzer, Alaa Alghamdi, Ping Zhao, Andreas W Loepke, Steve C Danze. Immature murine hippocampal neurones do not develop long-term structural changes after a single isoflurane exposure. British journal of anaesthesia. vol 123. issue 6. 2019-11-25. PMID:31570162. |
in the hippocampal dentate gyrus, the anaesthetic isoflurane induces selective apoptosis among roughly 10% of 2-week-old hippocampal granule cells in 21-day-old mice. |
2019-11-25 |
2023-08-13 |
mouse |
| Hornsby, Grootendorst, de Kloet E. Dexamethasone Does Not Prevent Seven-Day ADX-Induced Apoptosis in the Dentate Gyrus of the Rat Hippocampus. Stress (Amsterdam, Netherlands). vol 1. issue 1. 2019-11-20. PMID:9807061. |
dexamethasone does not prevent seven-day adx-induced apoptosis in the dentate gyrus of the rat hippocampus. |
2019-11-20 |
2023-08-12 |
rat |