| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tbccao-treated mice, and esc treatment regulated the expression of mitophagy-related factors, including bnip3, beclin1, pink1, and parkin, the lc-3 ii/i ratio, and apoptosis-related factors, including p53, bax, and caspase 3. |
2020-08-19 |
2023-08-13 |
mouse |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
taken together, our results suggest that esc treatment regulated hippocampal mitophagy and mitochondrial apoptosis triggered by mitochondrial stress via the mediation of mitochondrial fragmentation during transient cerebral ischaemia and reperfusion injury, which provides insight into the potential of esc for further therapeutic implications. |
2020-08-19 |
2023-08-13 |
mouse |
| Irune Diaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodríguez-Iglesias, Mar Márquez-Ropero, Sol Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, Carlos Matute, Irantzu Bernales, Angela Schulz, Lilla Otrokocsi, Beata Sperlagh, Kaisa E Happonen, Greg Lemke, Mirjana Maletic-Savatic, Jorge Valero, Amanda Sierr. Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31896673. |
during adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. |
2020-08-19 |
2023-08-13 |
mouse |
| Bei Li, Yuan Zhao, ManYu Song, HaiLin Cui, XiuJing Feng, TianYuan Yang, Hong-Gang Fa. Role of c-Myc/chloride intracellular channel 4 pathway in lipopolysaccharide-induced neurodegenerative diseases. Toxicology. vol 429. 2020-08-17. PMID:31693917. |
in an in vivo experiment, the results of he staining, transmission electron microscopic, immunofluorescence microscopy of cleaved caspase-3 and bax and the increasing expression of apoptotic pathway related proteins in mitochondria showed that lps (10 mg/kg) administration damaged mitochondrial and induced hippocampal neuron apoptosis. |
2020-08-17 |
2023-08-13 |
Not clear |
| Monruedee Sukprasansap, Pithi Chanvorachote, Tewin Tencomna. Cyanidin-3-glucoside activates Nrf2-antioxidant response element and protects against glutamate-induced oxidative and endoplasmic reticulum stress in HT22 hippocampal neuronal cells. BMC complementary medicine and therapies. vol 20. issue 1. 2020-08-17. PMID:32046712. |
in the present study, we investigated the neuroprotective effect and underlying mechanisms of c3g on the reduction of oxidative/er stress-induced apoptosis by glutamate in ht22 mouse hippocampal neuronal cells. |
2020-08-17 |
2023-08-13 |
mouse |
| Hua Fang, Hua-Feng Li, Ming-Hai He, Jian-Yong Yan, Miao Yang, Fang-Xiang Zhang, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhan. Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1. Brain research bulletin. vol 152. 2020-08-14. PMID:31185248. |
long non-coding rna malat1 sponges microrna-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating wnt1. |
2020-08-14 |
2023-08-13 |
mouse |
| Hua Fang, Hua-Feng Li, Ming-Hai He, Jian-Yong Yan, Miao Yang, Fang-Xiang Zhang, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhan. Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1. Brain research bulletin. vol 152. 2020-08-14. PMID:31185248. |
meanwhile, brain injury and hippocampal neuronal apoptosis were evaluated. |
2020-08-14 |
2023-08-13 |
mouse |
| Hua Fang, Hua-Feng Li, Ming-Hai He, Jian-Yong Yan, Miao Yang, Fang-Xiang Zhang, Ru-Rong Wang, Quan-Yun Wang, Jian-Ping Zhan. Long non-coding RNA MALAT1 sponges microRNA-429 to regulate apoptosis of hippocampal neurons in hypoxic-ischemic brain damage by regulating WNT1. Brain research bulletin. vol 152. 2020-08-14. PMID:31185248. |
in addition, it was confirmed that malat1 sponged mir-429 downregulating expression of mir-429, thereby promoting apoptosis of hippocampal neurons. |
2020-08-14 |
2023-08-13 |
mouse |
| Zahra Gholamnezhad, Mohammad Hossien Boskabady, Zahra Jahangir. Exercise and Dementia. Advances in experimental medicine and biology. vol 1228. 2020-08-12. PMID:32342466. |
the main positive effects suggested for exercise are less cognitive and behavioral impairment or decline, development of health-associated conditions (stress, sleep), reduction of dementia risk factors including chronic non-communicable disease (diabetes, cardiovascular disease), increase in neurotrophins, enhancement of brain blood flow, angiogenesis, neurogenesis, synaptogenesis and synaptic plasticity in the brain memory-related region (e.g., hippocampus), and reduction of neuroinflammation and apoptosis. |
2020-08-12 |
2023-08-13 |
human |
| Yu-Hui You, Zhi-Qiang Qin, Huan-Li Zhang, Zhao-Hong Yuan, Xin Y. MicroRNA-153 promotes brain-derived neurotrophic factor and hippocampal neuron proliferation to alleviate autism symptoms through inhibition of JAK-STAT pathway by LEPR. Bioscience reports. vol 39. issue 6. 2020-08-07. PMID:30975733. |
therefore, we evaluate the ability of mir-153 to influence brain-derived neurotrophic factor (bdnf) of autism as well as proliferation and apoptosis of hippocampal neuron through the janus kinase-signal transducer and activator of transcription (jak-stat) signaling pathway by targeting leptin receptor (lepr). |
2020-08-07 |
2023-08-13 |
mouse |
| Xiangyang Yu, Lili Jia, Wenli Yu, Hongyin D. Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice. Brain research. vol 1711. 2020-08-04. PMID:30659828. |
what's more, mdivi-1 and fk506 restrained cytochrome c release and cleaved caspase-3 expression, ameliorated hippocampal neurons apoptosis, and decreased serum s100β/nse concentrations as well. |
2020-08-04 |
2023-08-13 |
mouse |
| Xiangyang Yu, Lili Jia, Wenli Yu, Hongyin D. Dephosphorylation by calcineurin regulates translocation of dynamin-related protein 1 to mitochondria in hepatic ischemia reperfusion induced hippocampus injury in young mice. Brain research. vol 1711. 2020-08-04. PMID:30659828. |
these data suggest that calcineurin mediated drp1 dephosphorylation and translocation to mitochondria play a crucial role in hir induced mitochondrial fragmentation and neurons apoptosis in hippocampus. |
2020-08-04 |
2023-08-13 |
mouse |
| Feng Xu, Guixing Zhang, Jiangwen Yin, Qingtong Zhang, Ming-Yue Ge, Li Peng, Sheng Wang, Yan L. Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus. Behavioural brain research. vol 370. 2020-07-30. PMID:31103751. |
fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ers-mediated neurons apoptosis in the hippocampus. |
2020-07-30 |
2023-08-13 |
rat |
| Feng Xu, Guixing Zhang, Jiangwen Yin, Qingtong Zhang, Ming-Yue Ge, Li Peng, Sheng Wang, Yan L. Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus. Behavioural brain research. vol 370. 2020-07-30. PMID:31103751. |
neurons apoptosis rate in the hippocampus was examined by the tunel assay. |
2020-07-30 |
2023-08-13 |
rat |
| Feng Xu, Guixing Zhang, Jiangwen Yin, Qingtong Zhang, Ming-Yue Ge, Li Peng, Sheng Wang, Yan L. Fluoxetine mitigating late-stage cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ERS-mediated neurons apoptosis in the hippocampus. Behavioural brain research. vol 370. 2020-07-30. PMID:31103751. |
fluoxetine treatment can mitigate cognition and neurobehavior impairment induced by cerebral ischemia reperfusion injury through inhibiting ers-mediated neurons apoptosis in the hippocampus. |
2020-07-30 |
2023-08-13 |
rat |
| Titikorn Chunchai, Nattayaporn Apaijai, Puntarik Keawtep, Duangkamol Mantor, Apiwan Arinno, Wasana Pratchayasakul, Nipon Chattipakorn, Siriporn C Chattipakor. Testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex. Acta physiologica (Oxford, England). vol 226. issue 1. 2020-07-28. PMID:30506942. |
testosterone deprivation intensifies cognitive decline in obese male rats via glial hyperactivity, increased oxidative stress, and apoptosis in both hippocampus and cortex. |
2020-07-28 |
2023-08-13 |
rat |
| Xi Li, Yingjie Sun, Qiang Jin, Dandan Song, Yugang Dia. Kappa opioid receptor agonists improve postoperative cognitive dysfunction in rats via the JAK2/STAT3 signaling pathway. International journal of molecular medicine. vol 44. issue 5. 2020-07-27. PMID:31545485. |
the kor agonists led to a significantly reduced inflammatory response and oxidative stress, as determined by elisa detection, and attenuated hippocampal neuronal apoptosis, as revealed by tunel staining and western blotting, compared with the results in the cpb group. |
2020-07-27 |
2023-08-13 |
rat |
| Rodrigo M Aroña, Edith Arnold, Fernando Macías, Fernando López-Casillas, Carmen Clapp, Gonzalo Martínez de la Escaler. Vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. American journal of physiology. Regulatory, integrative and comparative physiology. vol 318. issue 4. 2020-07-27. PMID:32048872. |
vasoinhibin generation and effect on neuronal apoptosis in the hippocampus of late mouse embryos. |
2020-07-27 |
2023-08-13 |
mouse |
| Qing-Guo Xu, Ling Jiang, Jun Hou, Shu-Jun Wang, Chun Chen, Xiang H. [Effect of electroacupuncture on cognitive functions, hippocampal HIF-1α and neurons apoptosis in postoperative cognitive dysfunction rats]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion. vol 40. issue 3. 2020-07-22. PMID:32270642. |
[effect of electroacupuncture on cognitive functions, hippocampal hif-1α and neurons apoptosis in postoperative cognitive dysfunction rats]. |
2020-07-22 |
2023-08-13 |
rat |