| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Jun Xu, Yu Mei, Xue-Qing Shi, Yi-Fang Zhang, Xin-Yue Wang, Li Guan, Qi Wang, Hua-Feng Pa. Albiflorin ameliorates memory deficits in APP/PS1 transgenic mice via ameliorating mitochondrial dysfunction. Brain research. vol 1719. 2020-09-25. PMID:31150651. |
albiflorin inhibited the mitochondrial pathway of apoptosis by increasing the levels of bcl-2 and bcl-xl and decreasing the levels of bax, caspase-3 and cytochrome c in both the hippocampus and the cortex and by reducing the number of apoptotic cells in the anterior parietal cortex of the app/ps1 mice. |
2020-09-25 |
2023-08-13 |
mouse |
| Shi Yu, Hujing Zhang, Yue Hei, Xicai Yi, Andrius Baskys, Weiping Liu, Qianfa Lon. High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats. Brain research. vol 1717. 2020-09-24. PMID:30986405. |
blood-brain barrier (bbb) permeability, brain water content, hippocampal neuroinflammation and neuronal apoptosis were measured 24 h after the pilocarpine induction of status epilepticus (se) in sprague-dawley rats treated with boxa. |
2020-09-24 |
2023-08-13 |
rat |
| Shi Yu, Hujing Zhang, Yue Hei, Xicai Yi, Andrius Baskys, Weiping Liu, Qianfa Lon. High mobility group box-1 (HMGB1) antagonist BoxA suppresses status epilepticus-induced neuroinflammatory responses associated with Toll-like receptor 2/4 down-regulation in rats. Brain research. vol 1717. 2020-09-24. PMID:30986405. |
these changes were associated with decreased bbb permeability, reduced hippocampal neuronal apoptosis and reduction in hippocampal microglial activation. |
2020-09-24 |
2023-08-13 |
rat |
| Golo Kronenberg, Karen Gertz, Ria Uhlemann, Melanie T C Kuffner, Imke Kirste, Junfeng An, Nafisa M Jadavji, Bjoern H Schott, Thomas Scheffel, Matthias Endres, Rainer Hellweg, Christoph Harm. Reduced Hippocampal Neurogenesis in Mice Deficient in Apoptosis Repressor with Caspase Recruitment Domain (ARC). Neuroscience. vol 416. 2020-09-24. PMID:31356897. |
reduced hippocampal neurogenesis in mice deficient in apoptosis repressor with caspase recruitment domain (arc). |
2020-09-24 |
2023-08-13 |
mouse |
| Tiantian Huo, Yanqiu Jia, Chunli Yin, Xintong Luo, Jingru Zhao, Zhanqiang Wang, Peiyuan L. Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway. Brain research bulletin. vol 153. 2020-09-24. PMID:31542426. |
last, we tested the apoptosis of neurons in hippocampus. |
2020-09-24 |
2023-08-13 |
rat |
| Tiantian Huo, Yanqiu Jia, Chunli Yin, Xintong Luo, Jingru Zhao, Zhanqiang Wang, Peiyuan L. Iron dysregulation in vascular dementia: Focused on the AMPK/autophagy pathway. Brain research bulletin. vol 153. 2020-09-24. PMID:31542426. |
to sum up, our data suggested that iron deposition increased ampk/autophagy pathway associated molecules in the hippocampus and promoted neuronal apoptosis, which might be a new pathogenesis in vascular dementia. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed ht-22 cells via the ngf-akt/bad pathway. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
type 2 diabetes causes learning and memory deficits that might be mediated by hippocampus neuron apoptosis. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
studies found that taurine might improve cognitive deficits under diabetic condition because of its ability to prevent hippocampus neuron apoptosis. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
in this study, we explore the effect and mechanism of taurine on inhibiting hippocampus neuron apoptosis. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
taurine improved learning and memory ability and significantly decreased apoptosis of the hippocampus neurons in t2d rats. |
2020-09-24 |
2023-08-13 |
rat |
| Pingan Wu, Xiaoxia Shi, Mengxin Luo, Inam-U-Llah, Kaixin Li, Mengren Zhang, Jingran Ma, Yuan Li, Yanqing Liu, Cong Zhang, Xiaofang Liu, Shuangyue Li, Qiujuan Li, Xiaochi Chen, Xiangyu Che, Fengyuan Pia. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino acids. vol 52. issue 1. 2020-09-24. PMID:31875259. |
taurine could inhibit hippocampus neuron apoptosis via ngf-akt/bad pathway. |
2020-09-24 |
2023-08-13 |
rat |
| Li-Mei Zhang, Li-Li Jia, Wen-Li Y. [Serum exosomes of rats with hepatic ischemia-reperfusion injury induce the damage of hippocampus and cerebral cortex]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820307. |
the morphology and size of exosomes were observed by transmission electron microscope, the expression of exosomes markers cd63 and cd9 was detected by western blot, and the damage of liver and brain, levels of apoptosis and oxidative stress response in hippocampus and cerebral cortex were observed by serological and histological indexes. |
2020-09-24 |
2023-08-13 |
rat |
| Li-Mei Zhang, Li-Li Jia, Wen-Li Y. [Serum exosomes of rats with hepatic ischemia-reperfusion injury induce the damage of hippocampus and cerebral cortex]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820307. |
there was no significance in the degree of brain damage, apoptosis and oxidative stress in hippocampus and cerebral cortex between s group and es group. |
2020-09-24 |
2023-08-13 |
rat |
| Li-Mei Zhang, Li-Li Jia, Wen-Li Y. [Serum exosomes of rats with hepatic ischemia-reperfusion injury induce the damage of hippocampus and cerebral cortex]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 4. 2020-09-24. PMID:32820307. |
compared with those in s group and es group, the serum levels of brain injury markers, apoptosis index (ai) and oxidative stress in hippocampus and cerebral cortex increased in i/r group and ei group (p < 0.05). |
2020-09-24 |
2023-08-13 |
rat |
| Aihua Wang, Zhihua Si, Ping Xue, Xiaolin Li, Jinzhi Li. Tacrolimus protects hippocampal neurons of rats with status epilepticus through suppressing oxidative stress and inhibiting mitochondrial pathway of apoptosis. Brain research. vol 1715. 2020-09-18. PMID:30831086. |
tacrolimus protects hippocampal neurons of rats with status epilepticus through suppressing oxidative stress and inhibiting mitochondrial pathway of apoptosis. |
2020-09-18 |
2023-08-13 |
rat |
| Ahad Banagozar Mohammadi, Mohammadali Torbati, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad E J Golzari, Javad Mahmoud. Sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. Brain research. vol 1715. 2020-09-18. PMID:30898675. |
sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. |
2020-09-18 |
2023-08-13 |
mouse |
| Ahad Banagozar Mohammadi, Mohammadali Torbati, Fereshteh Farajdokht, Saeed Sadigh-Eteghad, Seyyed Mohammad Bagher Fazljou, Seyed Mehdi Vatandoust, Samad E J Golzari, Javad Mahmoud. Sericin alleviates restraint stress induced depressive- and anxiety-like behaviors via modulation of oxidative stress, neuroinflammation and apoptosis in the prefrontal cortex and hippocampus. Brain research. vol 1715. 2020-09-18. PMID:30898675. |
this study was aimed to examine the effects of sericin administration on restraint stress induced anxiety- and depressive-like behaviors, oxidative stress, inflammation and apoptosis in the prefrontal cortex (pfc) and hippocampus (hip) of mice. |
2020-09-18 |
2023-08-13 |
mouse |
| Qiang Duan, Erwang S. MicroRNA-25 aggravates Aβ1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31144355. |
when the mice were induced by aβ1-42, proliferation was suppressed while apoptosis was promoted in hippocampal neurons as evidenced by lower levels of klf2, nrf2, haem oxygenase, glutathione s transferase α1, glutathione, thioredoxin, and b-cell lymphoma-2 along with higher bax level. |
2020-09-18 |
2023-08-13 |
mouse |
| Qiang Duan, Erwang S. MicroRNA-25 aggravates Aβ1-42-induced hippocampal neuron injury in Alzheimer's disease by downregulating KLF2 via the Nrf2 signaling pathway in a mouse model. Journal of cellular biochemistry. vol 120. issue 9. 2020-09-18. PMID:31144355. |
these findings indicate that mir-25 may inhibit hippocampal neuron proliferation while promoting apoptosis, thereby aggravating hippocampal neuron injury through downregulation of klf2 via the nrf2 signaling pathway. |
2020-09-18 |
2023-08-13 |
mouse |