| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nanhui Yu, Yongpan Huang, Yu Jiang, Lianhong Zou, Xiehong Liu, Sulai Liu, Fang Chen, Jun Luo, Yimin Zh. Ganoderma lucidum Triterpenoids (GLTs) Reduce Neuronal Apoptosis via Inhibition of ROCK Signal Pathway in APP/PS1 Transgenic Alzheimer's Disease Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-09-17. PMID:32089787. |
apoptosis of the hippocampal neurons in mouse brain tissue was determined by tunel staining. |
2020-09-17 |
2023-08-13 |
mouse |
| Haci Ömer Osmanlıoğlu, Mustafa Kemal Yıldırım, Yener Akyuva, Kenan Yıldızhan, Mustafa Nazıroğl. Correction to: Morphine Induces Apoptosis, Inflammation, and Mitochondrial Oxidative Stress via Activation of TRPM2 Channel and Nitric Oxide Signaling Pathways in the Hippocampus. Molecular neurobiology. vol 57. issue 8. 2020-09-17. PMID:32572759. |
correction to: morphine induces apoptosis, inflammation, and mitochondrial oxidative stress via activation of trpm2 channel and nitric oxide signaling pathways in the hippocampus. |
2020-09-17 |
2023-08-13 |
Not clear |
| Xiangyong Feng, Wei Xiong, Mingqiong Yuan, Jian Zhan, Xiankun Zhu, Zhijie Wei, Xidong Chen, Xianbing Chen. Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1. Cell cycle (Georgetown, Tex.). vol 18. issue 22. 2020-09-16. PMID:31571517. |
inhibited mir-183 could up-regulate foxp1, inhibited mir-183 together with up-regulated foxp1 could repress hippocampal neuron injury, promote neuron proliferation, suppress neuron apoptosis, and inactivate the jak/stat signaling pathway, resulting in an attenuation of ep progression. |
2020-09-16 |
2023-08-13 |
rat |
| Xiangyong Feng, Wei Xiong, Mingqiong Yuan, Jian Zhan, Xiankun Zhu, Zhijie Wei, Xidong Chen, Xianbing Chen. Down-regulated microRNA-183 mediates the Jak/Stat signaling pathway to attenuate hippocampal neuron injury in epilepsy rats by targeting Foxp1. Cell cycle (Georgetown, Tex.). vol 18. issue 22. 2020-09-16. PMID:31571517. |
our study implies that inhibited mir-183 could up-regulate foxp1, resulting in an inactivation of the jak/stat signaling pathway and promotion of neuron proliferation, as well as inhibition of apoptosis of hippocampal neurons in ep rats, by which the hippocampal neuron injury and ep progression could be repressed. |
2020-09-16 |
2023-08-13 |
rat |
| Youbo Zuo, Xingping Hu, Qiuyan Yang, Lei Zhao, Xueli Chen, Jiangtao Lin, Tiande Yan. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 373. 2020-09-14. PMID:31340174. |
the levels of endoplasmic reticulum (er) stress markers and apoptosis related proteins in the hippocampus were examined by western blot analysis. |
2020-09-14 |
2023-08-13 |
rat |
| Youbo Zuo, Xingping Hu, Qiuyan Yang, Lei Zhao, Xueli Chen, Jiangtao Lin, Tiande Yan. Preoperative vitamin-rich carbohydrate loading alleviates postoperative cognitive dysfunction in aged rats. Behavioural brain research. vol 373. 2020-09-14. PMID:31340174. |
furthermore, preoperative cho loading reduced er stress and neuronal apoptosis in the hippocampus of aged rats, as indicated by the protein biomarkers of grp78, eif2a, beclin1, bax, and bcl-2. |
2020-09-14 |
2023-08-13 |
rat |
| Leila Hosseini, Fatemeh Farokhi-Sisakht, Reza Badalzadeh, Aytak Khabbaz, Javad Mahmoudi, Saeed Sadigh-Etegha. Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus. Neuroscience. vol 423. 2020-09-14. PMID:31678348. |
nicotinamide mononucleotide and melatonin alleviate aging-induced cognitive impairment via modulation of mitochondrial function and apoptosis in the prefrontal cortex and hippocampus. |
2020-09-14 |
2023-08-13 |
rat |
| Leila Hosseini, Fatemeh Farokhi-Sisakht, Reza Badalzadeh, Aytak Khabbaz, Javad Mahmoudi, Saeed Sadigh-Etegha. Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus. Neuroscience. vol 423. 2020-09-14. PMID:31678348. |
also, apoptosis and alterations in mitochondrial function including reactive oxygen species (ros) and atp levels as well as mitochondrial membrane potential were assessed in both prefrontal cortex (pfc) and hippocampus (hip) regions. |
2020-09-14 |
2023-08-13 |
rat |
| Shanglin Guo, Yongqing Zhang, Chaoping Wei, Lu Shi, Yugong Fen. The E3 Ubiquitin Ligase MARCH8 Regulates TNF-α-Induced Apoptosis in Hippocampal Neurons by Targeting Myosin Light Chain 2 for Degradation. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 12. 2020-09-11. PMID:31443122. |
the e3 ubiquitin ligase march8 regulates tnf-α-induced apoptosis in hippocampal neurons by targeting myosin light chain 2 for degradation. |
2020-09-11 |
2023-08-13 |
rat |
| Shanglin Guo, Yongqing Zhang, Chaoping Wei, Lu Shi, Yugong Fen. The E3 Ubiquitin Ligase MARCH8 Regulates TNF-α-Induced Apoptosis in Hippocampal Neurons by Targeting Myosin Light Chain 2 for Degradation. Anatomical record (Hoboken, N.J. : 2007). vol 302. issue 12. 2020-09-11. PMID:31443122. |
taken together, our data not only clarify the function of march8 in tnf-α-induced neurotoxicity, but also demonstrates that tnf-α promotes the march8-mlc2 mediated apoptosis of hippocampal neurons. |
2020-09-11 |
2023-08-13 |
rat |
| Min Kyoung Kam, Dong Gil Lee, Bokyung Kim, Hyun-Shik Lee, Sang-Rae Lee, Yong Chul Bae, Dong-Seok Le. Peroxiredoxin 4 ameliorates amyloid beta oligomer-mediated apoptosis by inhibiting ER-stress in HT-22 hippocampal neuron cells. Cell biology and toxicology. vol 35. issue 6. 2020-09-01. PMID:31147869. |
peroxiredoxin 4 ameliorates amyloid beta oligomer-mediated apoptosis by inhibiting er-stress in ht-22 hippocampal neuron cells. |
2020-09-01 |
2023-08-13 |
Not clear |
| Da-Peng Wang, Hang Yin, Qi Lin, Shu-Ping Fang, Jian-Hua Shen, Yi-Fang Wu, Shao-Hua Su, Jian Ha. Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 10. 2020-08-31. PMID:31187188. |
andrographolide enhances hippocampal bdnf signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion. |
2020-08-31 |
2023-08-13 |
rat |
| Yunyun Liu, Yuanpei Zhang, Jialing Peng, Hongxuan Wang, Xiangpen Li, Xiaoyu Li, Xiaoming Rong, Jingrui Pan, Ying Pen. Autophagy alleviates ethanol-induced memory impairment in association with anti-apoptotic and anti-inflammatory pathways. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31376498. |
further, ethanol-induced autophagy suppressed the nlrp3 inflammatory and apoptosis pathways in the hippocampus in mice and in vitro. |
2020-08-25 |
2023-08-13 |
mouse |
| Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Li. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31430517. |
in addition, the hippocampal cell apoptosis and cognitive impairment were observed in the hfhfd-fed rats. |
2020-08-25 |
2023-08-13 |
rat |
| Min Yu, He Huang, Shiyang Dong, Huanhuan Sha, Wei Wei, Cunming Li. High mobility group box-1 mediates hippocampal inflammation and contributes to cognitive deficits in high-fat high-fructose diet-induced obese rats. Brain, behavior, and immunity. vol 82. 2020-08-25. PMID:31430517. |
inhibiting hmgb1 by glycyrrhizin or hmgb1 mab suppressed the hippocampal inflammatory, alleviated the apoptosis and ameliorated the cognitive impairment in hfhfd-fed rats. |
2020-08-25 |
2023-08-13 |
rat |
| Panpan Chang, Yuzi Tian, Aaron M Williams, Umar F Bhatti, Baoling Liu, Yongqing Li, Hasan B Ala. Inhibition of Histone Deacetylase 6 Protects Hippocampal Cells Against Mitochondria-mediated Apoptosis in a Model of Severe Oxygen-glucose Deprivation. Current molecular medicine. vol 19. issue 9. 2020-08-21. PMID:31339071. |
inhibition of histone deacetylase 6 protects hippocampal cells against mitochondria-mediated apoptosis in a model of severe oxygen-glucose deprivation. |
2020-08-21 |
2023-08-13 |
Not clear |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
moreover, mitophagy and mitochondrial apoptosis were stimulated in response to the mitochondrial oxidative stress in the hippocampus of tbccao-treated mice, and esc treatment regulated the expression of mitophagy-related factors, including bnip3, beclin1, pink1, and parkin, the lc-3 ii/i ratio, and apoptosis-related factors, including p53, bax, and caspase 3. |
2020-08-19 |
2023-08-13 |
mouse |
| Bingru Xu, Liyang Zhu, Jin Chu, Zhanqiang Ma, Qiang Fu, Wei Wei, Xueyang Deng, Shiping M. Esculetin improves cognitive impairments induced by transient cerebral ischaemia and reperfusion in mice via regulation of mitochondrial fragmentation and mitophagy. Behavioural brain research. vol 372. 2020-08-19. PMID:31238056. |
taken together, our results suggest that esc treatment regulated hippocampal mitophagy and mitochondrial apoptosis triggered by mitochondrial stress via the mediation of mitochondrial fragmentation during transient cerebral ischaemia and reperfusion injury, which provides insight into the potential of esc for further therapeutic implications. |
2020-08-19 |
2023-08-13 |
mouse |
| Irune Diaz-Aparicio, Iñaki Paris, Virginia Sierra-Torre, Ainhoa Plaza-Zabala, Noelia Rodríguez-Iglesias, Mar Márquez-Ropero, Sol Beccari, Paloma Huguet, Oihane Abiega, Elena Alberdi, Carlos Matute, Irantzu Bernales, Angela Schulz, Lilla Otrokocsi, Beata Sperlagh, Kaisa E Happonen, Greg Lemke, Mirjana Maletic-Savatic, Jorge Valero, Amanda Sierr. Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 7. 2020-08-19. PMID:31896673. |
during adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. |
2020-08-19 |
2023-08-13 |
mouse |