| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Fuxing Dong, Shuang Wang, Yiwen Wang, Xiao Yang, Jiali Jiang, Dejian Wu, Xuebin Qu, Hongbin Fan, Ruiqin Ya. Quercetin ameliorates learning and memory via the Nrf2-ARE signaling pathway in d-galactose-induced neurotoxicity in mice. Biochemical and biophysical research communications. vol 491. issue 3. 2017-09-11. PMID:28757412. |
quercetin also prevented changes in the neuronal cell morphology and apoptosis in the hippocampus as well as increased the expression of nrf2, ho-1 and sod in d-galactose-treated mice. |
2017-09-11 |
2023-08-13 |
mouse |
| Tao Zhang, Jianbo Gu, Liangmiao Wu, Ning Li, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhan. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. vol 118. 2017-09-05. PMID:28342896. |
tbn also attenuated the neuronal apoptosis and ameliorated accumulation of astrocytes in parietal cortex and ca1 region of hippocampus. |
2017-09-05 |
2023-08-13 |
rat |
| Liqun Liu, Lingjuan Liu, Jiayun Shi, Menglin Tan, Jie Xiong, Xingfang Li, Qingpeng Hu, Zhuwen Yi, Ding'an Ma. MicroRNA-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures. BMC neuroscience. vol 17. issue 1. 2017-08-23. PMID:27514646. |
microrna-34b mediates hippocampal astrocyte apoptosis in a rat model of recurrent seizures. |
2017-08-23 |
2023-08-13 |
rat |
| Julien Gibon, Nicolas Unsain, Karine Gamache, Rhalena A Thomas, Andres De Leon, Aaron Johnstone, Karim Nader, Philippe Séguéla, Philip A Barke. The X-linked inhibitor of apoptosis regulates long-term depression and learning rate. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 30. issue 9. 2017-08-22. PMID:27189977. |
in the present study, we examined the role of x-linked inhibitor of apoptosis (xiap), a putative endogenous casp inhibitor, in synaptic plasticity in the hippocampus. |
2017-08-22 |
2023-08-13 |
mouse |
| Yilong Dong, Allan V Kalueff, Cai Son. N-methyl-d-aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus. Journal of neuroimmunology. vol 307. 2017-08-17. PMID:28495142. |
n-methyl-d-aspartate receptor-mediated calcium overload and endoplasmic reticulum stress are involved in interleukin-1beta-induced neuronal apoptosis in rat hippocampus. |
2017-08-17 |
2023-08-13 |
rat |
| Gang Zhu, Lei Tao, Ronglin Wang, Ying Xue, Xingqin Wang, Shaosong Yang, Xude Sun, Guodong Gao, Zixu Mao, Qian Yan. Endoplasmic reticulum stress mediates distinct impacts of sevoflurane on different subfields of immature hippocampus. Journal of neurochemistry. vol 142. issue 2. 2017-08-10. PMID:28444766. |
terminal deoxynucleotidyl transferase-mediated dutp nick-end-labeling staining was used to detect cell apoptosis and electrophysiology was used to measure the intrinsic excitability of neurons in hippocampus. |
2017-08-10 |
2023-08-13 |
rat |
| Lili Jia, Fei Wang, Xiangqian Gu, Yiqi Weng, Mingwei Sheng, Gang Wang, Shipeng Li, Hongyin Du, Wenli Y. Propofol postconditioning attenuates hippocampus ischemia-reperfusion injury via modulating JAK2/STAT3 pathway in rats after autogenous orthotropic liver transplantation. Brain research. vol 1657. 2017-08-07. PMID:27998796. |
we evaluated histological damage, inflammation, oxidative stress and apoptosis in hippocampus using he staining, light microscope, real-time pcr and western blot. |
2017-08-07 |
2023-08-13 |
rat |
| Hongmei Zhang, Lijun Chang, Huajun Zhang, Jisheng Nie, Zhihong Zhang, Xiaorong Yang, Ann M Vuong, Zemin Wang, Aimin Chen, Qiao Ni. Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology letters. vol 277. 2017-08-07. PMID:28559121. |
in this study, we aimed to investigate the role of calpain/p35-p25/cdk5 pathway in bde-153-induced neuronal apoptosis in the hippocampus and primary neurons in rats. |
2017-08-07 |
2023-08-13 |
mouse |
| Hongmei Zhang, Lijun Chang, Huajun Zhang, Jisheng Nie, Zhihong Zhang, Xiaorong Yang, Ann M Vuong, Zemin Wang, Aimin Chen, Qiao Ni. Calpain-2/p35-p25/Cdk5 pathway is involved in the neuronal apoptosis induced by polybrominated diphenyl ether-153. Toxicology letters. vol 277. 2017-08-07. PMID:28559121. |
results showed that compared to the controls, neuronal apoptosis was significantly increased in vivo and ex vivo, as manifested by the increased hippocampus tunel-positive cell rates, apoptotic neurons in hoechst and ao/eb staining, and the increased ldh activity and percentage of annexin v-positive cells in rat hippocampus and primary neurons. |
2017-08-07 |
2023-08-13 |
mouse |
| Yishu Yang, Lili Wang, Yan Wu, Dongmei Su, Ning Wang, Jiedong Wang, Cuige Shi, Liping Lv, Shucheng Zhan. Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway. Brain research. vol 1646. 2017-07-18. PMID:27317635. |
our previous work showed that mammalian ste20-like kinase 1 (mst1) and the gene for a downstream transcription factor, foxo3, play major roles in lipopolysaccharide (lps)-induced apoptosis in hippocampal neurons. |
2017-07-18 |
2023-08-13 |
rat |
| Yishu Yang, Lili Wang, Yan Wu, Dongmei Su, Ning Wang, Jiedong Wang, Cuige Shi, Liping Lv, Shucheng Zhan. Tanshinol suppresses inflammatory factors in a rat model of vascular dementia and protects LPS-treated neurons via the MST1-FOXO3 signaling pathway. Brain research. vol 1646. 2017-07-18. PMID:27317635. |
lps induced apoptosis in hippocampal neurons and increasedmst1 and p-foxo3 protein expression, whereas mst1 sirna transfection almost completely reversed lps-induced neuronal apoptosis, indicating that lps-induced cytotoxicity in hippocampal neurons is associated with mst1. |
2017-07-18 |
2023-08-13 |
rat |
| Daiying Zuo, Li Lin, Yumiao Liu, Chengna Wang, Jingwen Xu, Feng Sun, Lin Li, Zengqiang Li, Yingliang W. Baicalin Attenuates Ketamine-Induced Neurotoxicity in the Developing Rats: Involvement of PI3K/Akt and CREB/BDNF/Bcl-2 Pathways. Neurotoxicity research. vol 30. issue 2. 2017-07-17. PMID:26932180. |
our results revealed that five continuous injections of ketamine (20 mg/kg) at 90-min intervals over 6 h induced obvious morphological damages of neuron by nissl staining and apoptosis by tunel assays in the prefrontal cortex and hippocampus of pnd7 rat pups. |
2017-07-17 |
2023-08-13 |
rat |
| He Huang, Cun-Ming Liu, Jie Sun, Ting Hao, Chun-Mei Xu, Dan Wang, Yu-Qing W. Ketamine Affects the Neurogenesis of the Hippocampal Dentate Gyrus in 7-Day-Old Rats. Neurotoxicity research. vol 30. issue 2. 2017-07-17. PMID:26966008. |
ketamine has been reported to cause neonatal neurotoxicity via a neuronal apoptosis mechanism; however, no in vivo research has reported whether ketamine could affect postnatal neurogenesis in the hippocampal dentate gyrus (dg). |
2017-07-17 |
2023-08-13 |
rat |
| Hualin Zhang, Zhongliu Zhou, Ziming Chen, Zhiyong Zhong, Zhong L. Ginsenoside Rg3 exerts anti-depressive effect on an NMDA-treated cell model and a chronic mild stress animal model. Journal of pharmacological sciences. vol 134. issue 1. 2017-07-13. PMID:28461003. |
in n-methyl-d-aspartic acid (nmda)-treated ht22 murine hippocampal neuronal cells, rg3 recovered proliferation and inhibited apoptosis by altering the cell cycle. |
2017-07-13 |
2023-08-13 |
Not clear |
| Ke Pan, Xiaojun Li, Yan Chen, Dan Zhu, Yuping Li, Guocai Tao, Zhiyi Zu. Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus. Neuropharmacology. vol 111. 2017-07-11. PMID:27608977. |
additional rats received deferoxamine or saline were used to determine hippocampal iron content, iron transport-related proteins (transferrin receptor, divalent metal transporter 1, ferroportin 1 and hepcidin), oxidative stress, microglial activation and brain cell apoptosis. |
2017-07-11 |
2023-08-13 |
rat |
| Ke Pan, Xiaojun Li, Yan Chen, Dan Zhu, Yuping Li, Guocai Tao, Zhiyi Zu. Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus. Neuropharmacology. vol 111. 2017-07-11. PMID:27608977. |
furthermore, deferoxamine sharply reduced the hippocampal reactive oxygen species, malondialdehyde concentration and ox-42 that is a marker of microglia, which might reduce postoperative brain cell apoptosis. |
2017-07-11 |
2023-08-13 |
rat |
| Ke Pan, Xiaojun Li, Yan Chen, Dan Zhu, Yuping Li, Guocai Tao, Zhiyi Zu. Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus. Neuropharmacology. vol 111. 2017-07-11. PMID:27608977. |
this study showed that deferoxamine may improve postoperative cognition of aged rats by ameliorating oxidative stress induced by hippocampal iron accumulation, microglial activation and brain cell apoptosis. |
2017-07-11 |
2023-08-13 |
rat |
| Shaffi Manchanda, Rachana Mishra, Rumani Singh, Taranjeet Kaur, Gurcharan Kau. Aqueous Leaf Extract of Withania somnifera as a Potential Neuroprotective Agent in Sleep-deprived Rats: a Mechanistic Study. Molecular neurobiology. vol 54. issue 4. 2017-07-07. PMID:27037574. |
at the molecular level, vsd rats showed acute change in the expression of proteins involved in synaptic plasticity, cell survival, and apoptosis in the hippocampus region of brain, which was suppressed by ash-wex treatment thus indicating decreased cellular stress and apoptosis in wsd group. |
2017-07-07 |
2023-08-13 |
rat |
| Shunichiro Shinagawa, Nobuyuki Kobayashi, Tomoyuki Nagata, Akira Kusaka, Hisashi Yamada, Kazuhiro Kondo, Kazuhiko Nakayam. DNA methylation in the NCAPH2/LMF2 promoter region is associated with hippocampal atrophy in Alzheimer's disease and amnesic mild cognitive impairment patients. Neuroscience letters. vol 629. 2017-06-29. PMID:27356276. |
our results suggest that dna methylation in the ncaph2/lmf2 promoter region is associated with hippocampal atrophy through apoptosis. |
2017-06-29 |
2023-08-13 |
human |
| Majid Motaghinejad, Manijeh Motevalian, Sulai Fatim. Mediatory role of NMDA, AMPA/kainate, GABA Life sciences. vol 179. 2017-06-29. PMID:28082019. |
the current study evaluates in vivo role of various doses of tpm (10, 30, 50, 70 and 100mg/kg) and its possible mechanisms against mph-induced hippocampal oxidative stress, inflammation and apoptosis, in absence and presence of different receptor agonists and antagonists. |
2017-06-29 |
2023-08-13 |
Not clear |