| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hisakazu Izumida, Hiroshi Takagi, Haruki Fujisawa, Naoko Iwata, Kohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Takashi Namba, Yukio Komatu, Kozo Kaibuchi, Yutaka Oiso, Hiroshi Arima, Yoshihisa Sugimur. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Experimental neurology. vol 287. issue Pt 1. 2017-05-08. PMID:27527984. |
selective apoptosis of granule cells in the hippocampal dentate gyrus (dg) of rats with bilateral adrenalectomy (adx) and in patients who died of adrenal insufficiency has been reported. |
2017-05-08 |
2023-08-13 |
rat |
| Hisakazu Izumida, Hiroshi Takagi, Haruki Fujisawa, Naoko Iwata, Kohtaro Nakashima, Seiji Takeuchi, Shintaro Iwama, Takashi Namba, Yukio Komatu, Kozo Kaibuchi, Yutaka Oiso, Hiroshi Arima, Yoshihisa Sugimur. NMDA receptor antagonist prevents cell death in the hippocampal dentate gyrus induced by hyponatremia accompanying adrenal insufficiency in rats. Experimental neurology. vol 287. issue Pt 1. 2017-05-08. PMID:27527984. |
although adrenal insufficiency is a common disease and is usually associated with hyponatremia, its effect on the central nervous system and in apoptosis in the hippocampus remain to be elucidated. |
2017-05-08 |
2023-08-13 |
rat |
| Yu Jie, Yang Xuefeng, Yang Mengxue, Yang Xuesong, Yang Jing, Tang Yin, Xu Ji. Mechanism of nonylphenol-induced neurotoxicity in F1 rats during sexual maturity. Wiener klinische Wochenschrift. vol 128. issue 11-12. 2017-05-05. PMID:26905877. |
the purpose of this study was to examine whether gestational and lactational exposure to environmental endocrine disrupting chemical, nonylphenol (np), in pregnant dams would lead to the alterations in hormone levels in the body, apoptosis and glial fibrillary acidic protein (gfap) in hippocampus during weaning and sexual maturity periods in pups of rats. |
2017-05-05 |
2023-08-13 |
rat |
| Yu-Fei Han, Christian Holscher, Zhao-Jun Wang, Jun Zhang, Li Yuan, Jia-Qing Tong, Dan-Dan Wang, Mei-Na Wu, Jin-Shun Q. [Neuroprotective effects of a novel antidiabetic drug (D-Ser2)Oxm on amyloid β protein-induced cytotoxicity]. Sheng li xue bao : [Acta physiologica Sinica]. vol 68. issue 3. 2017-05-01. PMID:27350199. |
in the present study, we investigated the neuroprotective effects of (d-ser2)oxm on the cultured primary hippocampal neurons by testing the cell viability, neuronal apoptosis, mitochondrial membrane potential and intracellular calcium concentration. |
2017-05-01 |
2023-08-13 |
rat |
| Yi Pang, Xuemei Dai, Anna Roller, Kathleen Carter, Ian Paul, Abhay J Bhatt, Rick C S Lin, Lir-Wan Fa. Early Postnatal Lipopolysaccharide Exposure Leads to Enhanced Neurogenesis and Impaired Communicative Functions in Rats. PloS one. vol 11. issue 10. 2017-04-28. PMID:27723799. |
this unique microglial response was associated with a marked decrease in naturally occurring apoptosis, but an increase in cell proliferation in the subventricular zone (svz) and the dentate gyrus (dg) of hippocampus. |
2017-04-28 |
2023-08-13 |
rat |
| Behnoosh BonakdarYazdi, Fariba Khodagholi, Fatemeh Shaerzadeh, Azadeh Sharifzadeh, Ramesh Ahmadi, Mehdi Sanati, Hajar Mehdizadeh, Borna Payandehmehr, Leila Vali, Mehrnoush Moghaddasi Jahromi, Ghorban Taghizadeh, Mohammad Sharifzade. The effect of arsenite on spatial learning: Involvement of autophagy and apoptosis. European journal of pharmacology. vol 796. 2017-04-28. PMID:27993642. |
moreover, we evaluated levels of lc3-ii, atg7 and atg12 as reliable biomarkers of autophagy and caspase-3 and bax/bcl-2 ratio as indicators of apoptosis in the hippocampus. |
2017-04-28 |
2023-08-13 |
rat |
| Yu Ri Kim, Ha Neui Kim, Ki Whan Hong, Hwa Kyoung Shin, Byung Tae Cho. Antidepressant Effects of Aripiprazole Augmentation for Cilostazol-Treated Mice Exposed to Chronic Mild Stress after Ischemic Stroke. International journal of molecular sciences. vol 18. issue 2. 2017-04-28. PMID:28208711. |
this treatment also significantly reduced atrophic changes in the striatum, cortex, and midbrain of cms-treated ischemic mice, and inhibited neuronal cell apoptosis, particularly in the striatum and the dentate gyrus of the hippocampus. |
2017-04-28 |
2023-08-13 |
mouse |
| Yue Tian, Xiuying Wu, Shanbin Guo, Ling Ma, Wei Huang, Xiaochun Zha. Minocycline attenuates sevoflurane-induced cell injury via activation of Nrf2. International journal of molecular medicine. vol 39. issue 4. 2017-04-28. PMID:28260081. |
in our in vivo experiments using rats, minocycline attenuated sevoflurane-induced neuronal degeneration and apoptosis in the rat hippocampus, and this effect was associated with the minocycline-mediated suppression of oxidative stress in the hippocampus. |
2017-04-28 |
2023-08-13 |
rat |
| Michaela Fredrich, Mareike Hampel, Kay Seidel, Elmar Christ, Horst-Werner Kor. Impact of melatonin receptor-signaling on Zeitgeber time-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus. Hippocampus. vol 27. issue 5. 2017-04-25. PMID:28100031. |
impact of melatonin receptor-signaling on zeitgeber time-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus. |
2017-04-25 |
2023-08-13 |
mouse |
| Michaela Fredrich, Mareike Hampel, Kay Seidel, Elmar Christ, Horst-Werner Kor. Impact of melatonin receptor-signaling on Zeitgeber time-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus. Hippocampus. vol 27. issue 5. 2017-04-25. PMID:28100031. |
certain aspects of cell proliferation in the adult hippocampus are regulated by melatonin and accompanied by apoptosis to ensure proper tissue maintenance and function. |
2017-04-25 |
2023-08-13 |
mouse |
| Michaela Fredrich, Mareike Hampel, Kay Seidel, Elmar Christ, Horst-Werner Kor. Impact of melatonin receptor-signaling on Zeitgeber time-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus. Hippocampus. vol 27. issue 5. 2017-04-25. PMID:28100031. |
the present study investigated zeitgeber time (zt)-dependent changes in cell proliferation and apoptosis in the adult murine hippocampus and their regulation by melatonin receptor type1 and type2 (mt1/2)-mediated signaling. |
2017-04-25 |
2023-08-13 |
mouse |
| Ming Zhong, Wuhua Ma, Xiong Zhang, Yong Wang, Xiaoqiu Ga. Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28009855. |
tetramethyl pyrazine protects hippocampal neurons against anoxia/reoxygenation injury through inhibiting apoptosis mediated by jnk/mark signal pathway. |
2017-04-24 |
2023-08-13 |
rat |
| Ming Zhong, Wuhua Ma, Xiong Zhang, Yong Wang, Xiaoqiu Ga. Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28009855. |
the apoptosis rate, mkk4 and mkk7 mrna and jnk kinase protein levels (c-fos, c-jun, and p-jnk) of hippocampal neurons were detected. |
2017-04-24 |
2023-08-13 |
rat |
| Ming Zhong, Wuhua Ma, Xiong Zhang, Yong Wang, Xiaoqiu Ga. Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28009855. |
results the apoptosis rates of hippocampal neurons induced by a/r showed significant reduction after being pre-treated with jnk inhibitor, tmp 60 µg/ml, 200 µg/ml, and 800 µg/ml. |
2017-04-24 |
2023-08-13 |
rat |
| Ming Zhong, Wuhua Ma, Xiong Zhang, Yong Wang, Xiaoqiu Ga. Tetramethyl Pyrazine Protects Hippocampal Neurons Against Anoxia/Reoxygenation Injury Through Inhibiting Apoptosis Mediated by JNK/MARK Signal Pathway. Medical science monitor : international medical journal of experimental and clinical research. vol 22. 2017-04-24. PMID:28009855. |
conclusions tmp may produce a protective effect in anoxia/reoxygenation-induced primary hippocampal neuronal injury by inhibiting the apoptosis of the hippocampal neurons; the possible mechanism may be inhibition of the jnk signal pathway. |
2017-04-24 |
2023-08-13 |
rat |
| Jia-Jie Teoh, Tomohiko Iwano, Masataka Kunii, Nur Atik, Erda Avriyanti, Shin-Ichiro Yoshimura, Kenta Moriwaki, Akihiro Harad. BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain. PloS one. vol 12. issue 4. 2017-04-24. PMID:28414797. |
this apoptosis gradually progressed from the piriform cortex (pir), peaked in the neocortex, and then progressed into the hippocampus from embryonic day 13.5 (e13.5) to e17.5. |
2017-04-24 |
2023-08-13 |
mouse |
| Yueqi Zhang, Chengeng Liu, Jinling Wang, Qiliang Li, Hong Ping, Shichao Gao, Peichang Wan. MiR-299-5p regulates apoptosis through autophagy in neurons and ameliorates cognitive capacity in APPswe/PS1dE9 mice. Scientific reports. vol 6. 2017-04-21. PMID:27080144. |
furthermore, transfection of mir-299-5p into primary hippocampal neurons caused the attenuation of caspase-mediated apoptosis, which was reversed upon starvation-induced autophagy. |
2017-04-21 |
2023-08-13 |
mouse |
| Xue-Shan Zhao, Qi Wu, Juan Peng, Li-Hong Pan, Zhong Ren, Hui-Ting Liu, Zhi-Sheng Jiang, Gui-Xue Wang, Zhi-Han Tang, Lu-Shan Li. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28000893. |
hyperlipidemia-induced apoptosis of hippocampal neurons in apoe(-/-) mice may be associated with increased pcsk9 expression. |
2017-04-21 |
2023-08-13 |
mouse |
| Xue-Shan Zhao, Qi Wu, Juan Peng, Li-Hong Pan, Zhong Ren, Hui-Ting Liu, Zhi-Sheng Jiang, Gui-Xue Wang, Zhi-Han Tang, Lu-Shan Li. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Molecular medicine reports. vol 15. issue 2. 2017-04-21. PMID:28000893. |
plasma lipid levels, hippocampal lipid accumulation, hippocampal histology, and hippocampal neuronal apoptosis were all monitored for changes. |
2017-04-21 |
2023-08-13 |
mouse |
| Wei Zhao, Fang Han, Yuxiu Sh. IRE1α pathway of endoplasmic reticulum stress induces neuronal apoptosis in the locus coeruleus of rats under single prolonged stress. Progress in neuro-psychopharmacology & biological psychiatry. vol 69. 2017-04-10. PMID:27059130. |
our previous studies have shown evidence of endoplasmic reticulum (er) stress-induced apoptosis in the hippocampus and mpfc in an animal model of post- traumatic stress disorder (ptsd). |
2017-04-10 |
2023-08-13 |
rat |