| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kazuhiro Tanaka, Claire E Kelly, Ket Yin Goh, Kim Buay Lim, Carlos F Ibáñe. Death Domain Signaling by Disulfide-Linked Dimers of the p75 Neurotrophin Receptor Mediates Neuronal Death in the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 20. 2017-06-26. PMID:27194337. |
proneurotrophins induced apoptosis of cultured hippocampal and cortical neurons from wild-type mice, but mutant neurons lacking p75(ntr), only the p75(ntr) dd, or just cys(259) were all equally resistant to proneurotrophin-induced neuronal death. |
2017-06-26 |
2023-08-13 |
mouse |
| Wen-Chong Sun, Ling Pe. rno-miR-665 targets BCL2L1 (Bcl-xl) and increases vulnerability to propofol in developing astrocytes. Journal of neurochemistry. vol 138. issue 2. 2017-06-23. PMID:27121046. |
the single dose of propofol 30 mg/kg triggered dose-dependent apoptosis of developing hippocampal astrocytes. |
2017-06-23 |
2023-08-13 |
rat |
| Chun-Sing Lam, George Lim Tipoe, Johnny Kong-Ching Wong, Moussa B H Youdim, Man-Lung Fun. M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus. PloS one. vol 11. issue 11. 2017-06-23. PMID:27870896. |
cort-treated rats exhibited depressive-like behavior with significant elevated levels of mao activities, serotonin turnover, oxidative stress, neuroinflammation and apoptosis in the hippocampus with significant losses of synaptic proteins when compared to the control. |
2017-06-23 |
2023-08-13 |
rat |
| Oihane Abiega, Sol Beccari, Irune Diaz-Aparicio, Agnes Nadjar, Sophie Layé, Quentin Leyrolle, Diego Gómez-Nicola, María Domercq, Alberto Pérez-Samartín, Víctor Sánchez-Zafra, Iñaki Paris, Jorge Valero, Julie C Savage, Chin-Wai Hui, Marie-Ève Tremblay, Juan J P Deudero, Amy L Brewster, Anne E Anderson, Laura Zaldumbide, Lara Galbarriatu, Ainhoa Marinas, Maria dM Vivanco, Carlos Matute, Mirjana Maletic-Savatic, Juan M Encinas, Amanda Sierr. Neuronal Hyperactivity Disturbs ATP Microgradients, Impairs Microglial Motility, and Reduces Phagocytic Receptor Expression Triggering Apoptosis/Microglial Phagocytosis Uncoupling. PLoS biology. vol 14. issue 5. 2017-06-21. PMID:27228556. |
recent findings suggest that in the adult hippocampal neurogenic niche, where the excess of newborn cells undergo apoptosis in physiological conditions, phagocytosis is efficiently executed by surveillant, ramified microglia. |
2017-06-21 |
2023-08-13 |
mouse |
| Yan Sun, Lulu Ke, Xiangren Zheng, Tao Li, Wei Ouyang, Zigui Zhan. Effects of Different Levels of Calcium Intake on Brain Cell Apoptosis in Fluorosis Rat Offspring and Its Molecular Mechanism. Biological trace element research. vol 176. issue 2. 2017-06-19. PMID:27655243. |
we determined the blood/urine fluoride, the blood/urine calcium, the apoptosis in the hippocampus, and the expression levels of apoptosis-related genes, namely bcl-2, caspase 12, and jnk. |
2017-06-19 |
2023-08-13 |
human |
| Anne Günther, Vince Luczak, Ted Abel, Arnd Bauman. Caspase-3 and GFAP as early markers for apoptosis and astrogliosis in shRNA-induced hippocampal cytotoxicity. The Journal of experimental biology. vol 220. issue Pt 8. 2017-06-16. PMID:28167801. |
caspase-3 and gfap as early markers for apoptosis and astrogliosis in shrna-induced hippocampal cytotoxicity. |
2017-06-16 |
2023-08-13 |
mouse |
| Xu-Hua Ge, Guo-Ji Zhu, De-Qin Geng, Han-Zhi Zhang, Juan-Mei He, Ai-Zhen Guo, Lin-Lin Ma, De-Hua Y. Metformin protects the brain against ischemia/reperfusion injury through PI3K/Akt1/JNK3 signaling pathways in rats. Physiology & behavior. vol 170. 2017-06-13. PMID:28017679. |
through ischemia/reperfusion (i/r) rat model, we found that metformin could attenuate the deficits of hippocampal related behaviors and inhibit cell apoptosis. |
2017-06-13 |
2023-08-13 |
rat |
| Tianen Zhou, Yanran Liang, Longyuan Jiang, Tao Yu, Chaotao Zeng, Enxiang Ta. Mild hypothermia protects against oxygen glucose deprivation/reoxygenation-induced apoptosis via the Wnt/β-catenin signaling pathway in hippocampal neurons. Biochemical and biophysical research communications. vol 486. issue 4. 2017-06-12. PMID:28365156. |
mild hypothermia protects against oxygen glucose deprivation/reoxygenation-induced apoptosis via the wnt/β-catenin signaling pathway in hippocampal neurons. |
2017-06-12 |
2023-08-13 |
Not clear |
| Tianen Zhou, Yanran Liang, Longyuan Jiang, Tao Yu, Chaotao Zeng, Enxiang Ta. Mild hypothermia protects against oxygen glucose deprivation/reoxygenation-induced apoptosis via the Wnt/β-catenin signaling pathway in hippocampal neurons. Biochemical and biophysical research communications. vol 486. issue 4. 2017-06-12. PMID:28365156. |
our study provides evidence that mild hypothermia reactivates the wnt/β-catenin signaling pathway, which is suppressed by ogd/r injury, in hippocampal neurons and protects neurons from ogd/r-induced apoptosis via the reactivation of the wnt/β-catenin signaling pathway, ultimately suggesting that mild hypothermia could have therapeutic effects on ogd/r-induced apoptosis. |
2017-06-12 |
2023-08-13 |
Not clear |
| Ya-Nan Li, Qi Zhang, Chun-Ping Yin, Yang-Yang Guo, Shu-Ping Huo, Liang Wang, Qiu-Jun Wan. Effects of nimodipine on postoperative delirium in elderly under general anesthesia: A prospective, randomized, controlled clinical trial. Medicine. vol 96. issue 19. 2017-06-12. PMID:28489775. |
nimodipine is a clinical commonly used calcium antagonistscan lowering the apoptosis rate of hippocampal neuron to reduce the incidence of postoperative cognitive dysfunction (pocd). |
2017-06-12 |
2023-08-13 |
Not clear |
| Yifei Jiang, Dongyi Tong, Rylon D Hofacer, Andreas W Loepke, Qingquan Lian, Steve C Danze. Long-term Fate Mapping to Assess the Impact of Postnatal Isoflurane Exposure on Hippocampal Progenitor Cell Productivity. Anesthesiology. vol 125. issue 6. 2017-06-09. PMID:27655218. |
exposure to isoflurane increases apoptosis among postnatally generated hippocampal dentate granule cells. |
2017-06-09 |
2023-08-13 |
Not clear |
| Jae Hoon Oh, Sunghyun Choi, Jeehae Shin, Jong-Sang Par. Protective effect of recombinant soluble neprilysin against β-amyloid induced neurotoxicity. Biochemical and biophysical research communications. vol 477. issue 4. 2017-05-29. PMID:27395340. |
snep and aβ peptide co-treated hippocampal cells had a decreased level of aβ peptides shown by an increase in cell viability and decrease in apoptosis measured by the cck-8 and relative caspase-3 activity ratio assays, respectively. |
2017-05-29 |
2023-08-13 |
Not clear |
| Ewa Pius-Sadowska, Miłosz Piotr Kawa, Patrycja Kłos, Dorota Rogińska, Michał Rudnicki, Marek Boehlke, Piotr Waloszczyk, Bogusław Machalińsk. Alteration of Selected Neurotrophic Factors and their Receptor Expression in Mouse Brain Response to Whole-Brain Irradiation. Radiation research. vol 186. issue 5. 2017-05-26. PMID:27775476. |
using nissl staining of hippocampus slices to visualize morphological changes, and tunel assay and active caspase-3 detection to assess apoptotic cell death, we found evidence of apoptosis and degenerative changes in hippocampal tissue after wbi. |
2017-05-26 |
2023-08-13 |
mouse |
| Bing Pei, Miaomiao Yang, Xiaoyan Qi, Xin Shen, Xing Chen, Fayong Zhan. Quercetin ameliorates ischemia/reperfusion-induced cognitive deficits by inhibiting ASK1/JNK3/caspase-3 by enhancing the Akt signaling pathway. Biochemical and biophysical research communications. vol 478. issue 1. 2017-05-23. PMID:27450812. |
next, we examined the severity of apoptosis by staining hippocampal neurons by the cresyl violet method. |
2017-05-23 |
2023-08-13 |
mouse |
| Peng Wang, Yonggang Cao, Juan Yu, Ruxia Liu, Bing Bai, Hanping Qi, Qianlong Zhang, Wenguang Guo, Hui Zhu, Lihui Q. Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus. Brain research. vol 1642. 2017-05-22. PMID:27016057. |
we found that baicalin, a camkii inhibitor and knocking down the camkii prevented ogd-induced apoptosis of hippocampal or sh-sy5y cells in culture. |
2017-05-22 |
2023-08-13 |
Not clear |
| Peng Wang, Yonggang Cao, Juan Yu, Ruxia Liu, Bing Bai, Hanping Qi, Qianlong Zhang, Wenguang Guo, Hui Zhu, Lihui Q. Baicalin alleviates ischemia-induced memory impairment by inhibiting the phosphorylation of CaMKII in hippocampus. Brain research. vol 1642. 2017-05-22. PMID:27016057. |
therefore, these results suggested that baicalin improves learning and memory impairment induced by global cerebral ischemia/reperfusion in gerbils via attenuating the phosphorylation level of camkii and further preventing hippocampal neuronal apoptosis. |
2017-05-22 |
2023-08-13 |
Not clear |
| Gao-Ge Sun, Jui-Hu Shih, Shih-Hwa Chiou, Chen-Jee Hong, Shao-Wei Lu, Li-Heng Pa. Chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. Journal of ethnopharmacology. vol 193. 2017-05-17. PMID:27416803. |
chinese herbal medicines promote hippocampal neuroproliferation, reduce stress hormone levels, inhibit apoptosis, and improve behavior in chronically stressed mice. |
2017-05-17 |
2023-08-13 |
mouse |
| Xue Zhou, Dongfeng Xian, Jiehua Xia, Ying Tang, Wenda Li, Xiaohui Chen, Zhibin Zhou, Dihan Lu, Xia Fen. MicroRNA-34c is regulated by p53 and is involved in sevoflurane-induced apoptosis in the developing rat brain potentially via the mitochondrial pathway. Molecular medicine reports. vol 15. issue 4. 2017-05-15. PMID:28259954. |
in the present study, the mirna sequence that was most closely associated with sevoflurane‑induced apoptosis in the hippocampus of neonatal rat brains was identified. |
2017-05-15 |
2023-08-13 |
rat |
| Xue Zhou, Dongfeng Xian, Jiehua Xia, Ying Tang, Wenda Li, Xiaohui Chen, Zhibin Zhou, Dihan Lu, Xia Fen. MicroRNA-34c is regulated by p53 and is involved in sevoflurane-induced apoptosis in the developing rat brain potentially via the mitochondrial pathway. Molecular medicine reports. vol 15. issue 4. 2017-05-15. PMID:28259954. |
in conclusion, the results of the present study suggest that mirna‑34c may be regulated by p53 and is involved in sevoflurane‑induced neural apoptosis in the hippocampus of developing rat brains, potentially via the mitochondrial pathway. |
2017-05-15 |
2023-08-13 |
rat |
| Swati Agarwal, Anuradha Yadav, Shashi Kant Tiwari, Brashket Seth, Lalit Kumar Singh Chauhan, Puneet Khare, Ratan Singh Ray, Rajnish Kumar Chaturved. Dynamin-related Protein 1 Inhibition Mitigates Bisphenol A-mediated Alterations in Mitochondrial Dynamics and Neural Stem Cell Proliferation and Differentiation. The Journal of biological chemistry. vol 291. issue 31. 2017-05-08. PMID:27252377. |
we found that chronic exposure of synthetic xenoestrogen bisphenol a (bpa), a component of consumer plastic products, impaired autophagy-mediated mitochondrial turnover, leading to increased oxidative stress, mitochondrial fragmentation, and apoptosis in hippocampal neural stem cells (nscs). |
2017-05-08 |
2023-08-13 |
rat |