| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Zu Li, Wang-Yang Wu, Huan Huang, Yang-Yang Wu, Yan-Yan Yi. Protective effect of bilobalide on learning and memory impairment in rats with vascular dementia. Molecular medicine reports. vol 8. issue 3. 2014-04-07. PMID:23835946. |
these results suggest that bb provides protection against learning and memory impairment by reducing free radical injury and inhibiting neuronal apoptosis in the brain cortex and hippocampal ca1 region in vd rats. |
2014-04-07 |
2023-08-12 |
rat |
| Hai-Ling Fan, Shui-Gui Yin, Pu Lou, Su-Wei Ren, Sheng Huang, Xiang Che. [Expressions of P-JNK in nerve cell apoptosis of A2AR knockout newborn mice after hypoxia/ischemia brain damage]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 29. issue 2. 2014-01-23. PMID:23833981. |
to investigate the effect of adenosine a2a receptor knockout (a(2a)rko) on relationship between continuous activation of phospho-c-jun n-terminal kinase (p-jnk) and expression of nerve cell apoptosis in hippocampus ca1 domain of newborn mice after hypoxia/ischemia brain damage(hibd) and its potential mechanism. |
2014-01-23 |
2023-08-12 |
mouse |
| Yanyan Yin, Yuguo Ren, Wangyang Wu, Yuchan Wang, Mingcheng Cao, Zhengyi Zhu, Mingming Wang, Weizu L. Protective effects of bilobalide on Aβ(25-35) induced learning and memory impairments in male rats. Pharmacology, biochemistry, and behavior. vol 106. 2013-12-26. PMID:23537729. |
besides, bb (4, 8 mg/kg) was able to attenuate the neuronal damage and apoptosis in frontal cortex and hippocampus ca1 in rats. |
2013-12-26 |
2023-08-12 |
rat |
| María Irene Ayuso, Emma Martínez-Alonso, Cristina Cid, Maria Alonso de Leciñana, Alberto Alcáza. The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23591646. |
upon reperfusion, a selective neuronal apoptosis in the hippocampal cornu ammonis 1 (ca1) region was induced, while it did not occur in the cerebral cortex. |
2013-10-22 |
2023-08-12 |
rat |
| María Irene Ayuso, Emma Martínez-Alonso, Cristina Cid, Maria Alonso de Leciñana, Alberto Alcáza. The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23591646. |
furthermore, the binding of a 4e-bp2 peptide to eif4e induced neuronal apoptosis in the ca1 region. |
2013-10-22 |
2023-08-12 |
rat |
| María Irene Ayuso, Emma Martínez-Alonso, Cristina Cid, Maria Alonso de Leciñana, Alberto Alcáza. The translational repressor eIF4E-binding protein 2 (4E-BP2) correlates with selective delayed neuronal death after ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 33. issue 8. 2013-10-22. PMID:23591646. |
finally, pharmacological-induced protection of ca1 neurons inhibited neuronal apoptosis, decreased 4e-bp2/eif4e association, and recovered translation. |
2013-10-22 |
2023-08-12 |
rat |
| C Lin, C-J Wu, I-H Wei, M-H Tsai, N-W Chang, T-T Yang, Y-M Ku. Chronic treadmill running protects hippocampal neurons from hypobaric hypoxia-induced apoptosis in rats. Neuroscience. vol 231. 2013-07-25. PMID:23219906. |
four weeks of treadmill ex before hypoxia treatment significantly reduced the hypoxia-induced apoptosis (p<0.001, n=3) in the hippocampal ca1 neurons. |
2013-07-25 |
2023-08-12 |
rat |
| Hamid Kalalian-Moghaddam, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Fatemeh Goshadrou, Abdolaziz Ronagh. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23099256. |
this study was conducted to evaluate the effect of berberine on hippocampal ca1 neuronal apoptosis, synaptic plasticity and learning and memory of streptozotocin (stz)-diabetic rats. |
2013-06-10 |
2023-08-12 |
rat |
| Hamid Kalalian-Moghaddam, Tourandokht Baluchnejadmojarad, Mehrdad Roghani, Fatemeh Goshadrou, Abdolaziz Ronagh. Hippocampal synaptic plasticity restoration and anti-apoptotic effect underlie berberine improvement of learning and memory in streptozotocin-diabetic rats. European journal of pharmacology. vol 698. issue 1-3. 2013-06-10. PMID:23099256. |
restored ps amplitude and fepsp and ameliorated learning and memory impairment and attenuated apoptosis of pyramidal neurons in the ca1 area, as determined by the terminal deoxynucleotidyl transferase (tdt)-mediated dutp nick end-labeling method. |
2013-06-10 |
2023-08-12 |
rat |
| Jesús F Torres-Peraza, Tobias Engel, Raquel Martín-Ibáñez, Amaya Sanz-Rodríguez, M Rosario Fernández-Fernández, Miriam Esgleas, Josep M Canals, David C Henshall, José J Luca. Protective neuronal induction of ATF5 in endoplasmic reticulum stress induced by status epilepticus. Brain : a journal of neurology. vol 136. issue Pt 4. 2013-05-30. PMID:23518711. |
interestingly, atf5 upregulation occurred mainly in hippocampal neuronal fields that do not undergo apoptosis in this status epilepticus model such as ca1 and dentate gyrus, thus suggesting a neuroprotective role. |
2013-05-30 |
2023-08-12 |
mouse |
| Xi-Ji Shu, Wei Liu, Lei Zhang, Rong Yang, Hui-Ling Yi, Chang-Lei Li, Yan-Jie Ye, Yong-Xun A. Effect of bis(7)-tacrine on cognition in rats with chronic cerebral ischemia. Neuroscience letters. vol 512. issue 2. 2013-05-07. PMID:22330749. |
immunohistochemical results showed that b7t reduced neuronal apoptosis in the hippocampal ca1 region as compared with ischemia rats, and b7t treatment increased neurogenesis in the hippocampus. |
2013-05-07 |
2023-08-12 |
rat |
| Simon J Fung, MingChu Xi, JianHua Zhang, Sharon Sampogna, Michael H Chas. Apnea produces excitotoxic hippocampal synapses and neuronal apoptosis. Experimental neurology. vol 238. issue 2. 2013-01-21. PMID:22921462. |
morphologically, the deleterious effect of recurrent apnea was substantiated by the finding of apoptosis in ca1 neurons of apneic (but not normoxic) animals. |
2013-01-21 |
2023-08-12 |
rat |
| J G Zhou, J C Liu, Y Q Fan. [Study on the effect of hyperbaric oxygen on apoptosis in the CA1 region of hippocampus following forebrain ischemia reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 17. issue 1. 2012-12-03. PMID:21171452. |
[study on the effect of hyperbaric oxygen on apoptosis in the ca1 region of hippocampus following forebrain ischemia reperfusion]. |
2012-12-03 |
2023-08-12 |
Not clear |
| J G Zhou, J C Liu, Y Q Fan. [Study on the effect of hyperbaric oxygen on apoptosis in the CA1 region of hippocampus following forebrain ischemia reperfusion]. Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology. vol 17. issue 1. 2012-12-03. PMID:21171452. |
to study the mechanism of hyperbaric oxygen (hbo) on the treatment of cerebral ischemia, and to provide theoretical basis for hyperbaric oxygen treatment (hbot), we examined the effect of 0.15 mpa and 0.25 mpa hbo treatment (60 min/d, for 3 successive days ) on ischemia reperfusion - induced apoptosis in gerbil hippocampus ca1 using tunel staining method. |
2012-12-03 |
2023-08-12 |
Not clear |
| Fei-Juan Kong, Lei-Lei Ma, Wen-Wen Hu, Wen-Na Wang, Hui-Shun Lu, Shu-Ping Che. Fetal exposure to high isoflurane concentration induces postnatal memory and learning deficits in rats. Biochemical pharmacology. vol 84. issue 4. 2012-10-08. PMID:22705347. |
the apoptosis was evaluated by caspase-3 immunohistochemistry in the hippocampal ca1 region. |
2012-10-08 |
2023-08-12 |
rat |
| Guangyu Li, Fei Cai, Wei Yan, Cairong Li, Jianghua Wan. A proteomic analysis of MCLR-induced neurotoxicity: implications for Alzheimer's disease. Toxicological sciences : an official journal of the Society of Toxicology. vol 127. issue 2. 2012-09-24. PMID:22430071. |
this was found to lead to impairment of learning and memory, accompanied by severe histological damage and neuronal apoptosis in the hippocampal ca1 regions of rats. |
2012-09-24 |
2023-08-12 |
rat |
| Nafisa M Jadavji, Liyuan Deng, Daniel Leclerc, Olga Malysheva, Barry J Bedell, Marie A Caudill, Rima Roze. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Molecular genetics and metabolism. vol 106. issue 2. 2012-09-18. PMID:22521626. |
they showed decreased whole brain and hippocampal volumes, reduced thickness of the pyramidal cell layer of ca1 and ca3, and increased apoptosis in hippocampus. |
2012-09-18 |
2023-08-12 |
mouse |
| Yue Zhang, Wenlong Yao, Jin Qiu, Wei Qian, Chang Zhu, Chuanhan Zhan. The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat. Neuroscience letters. vol 505. issue 2. 2012-08-16. PMID:21982804. |
we found that, compared with sham group, the expression of cdh1 in hippocampus was significantly decreased on 1 and 3 days of reperfusion in ischemia group (p<0.05), while neuronal apoptosis were found in hippocampal ca1 region and the two downstream substrates of cdh1-apc (snon and skp2) were significantly increased after global cerebral ischemia (p<0.05). |
2012-08-16 |
2023-08-12 |
rat |
| Xing Su, Chang-Lai Zhu, Wei Shi, Lan-Chun Ni, Jian-Hong Shen, Jian Che. Transient global cerebral ischemia induces up-regulation of MLTKα in hippocampal CA1 neurons. Journal of molecular histology. vol 43. issue 2. 2012-08-15. PMID:22146853. |
taken together, we hypothesized the up-regulation of mltkα played an essential role in the apoptosis of hippocampal ca1 neurons. |
2012-08-15 |
2023-08-12 |
rat |
| Yoshito Kinoshita, H Jürgen Wenzel, Chizuru Kinoshita, Philip A Schwartzkroin, Richard S Morriso. Acute, but reversible, kainic acid-induced DNA damage in hippocampal CA1 pyramidal cells of p53-deficient mice. Epilepsia. vol 53 Suppl 1. 2012-07-16. PMID:22612817. |
in wild-type animals, therefore, p53 appears to stimulate dna repair and also mediate apoptosis in ca1 neurons in this excitotoxicity model. |
2012-07-16 |
2023-08-12 |
mouse |