| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nafisa M Jadavji, Liyuan Deng, Daniel Leclerc, Olga Malysheva, Barry J Bedell, Marie A Caudill, Rima Roze. Severe methylenetetrahydrofolate reductase deficiency in mice results in behavioral anomalies with morphological and biochemical changes in hippocampus. Molecular genetics and metabolism. vol 106. issue 2. 2012-09-18. PMID:22521626. |
they showed decreased whole brain and hippocampal volumes, reduced thickness of the pyramidal cell layer of ca1 and ca3, and increased apoptosis in hippocampus. |
2012-09-18 |
2023-08-12 |
mouse |
| Yue Zhang, Wenlong Yao, Jin Qiu, Wei Qian, Chang Zhu, Chuanhan Zhan. The involvement of down-regulation of Cdh1-APC in hippocampal neuronal apoptosis after global cerebral ischemia in rat. Neuroscience letters. vol 505. issue 2. 2012-08-16. PMID:21982804. |
we found that, compared with sham group, the expression of cdh1 in hippocampus was significantly decreased on 1 and 3 days of reperfusion in ischemia group (p<0.05), while neuronal apoptosis were found in hippocampal ca1 region and the two downstream substrates of cdh1-apc (snon and skp2) were significantly increased after global cerebral ischemia (p<0.05). |
2012-08-16 |
2023-08-12 |
rat |
| Xing Su, Chang-Lai Zhu, Wei Shi, Lan-Chun Ni, Jian-Hong Shen, Jian Che. Transient global cerebral ischemia induces up-regulation of MLTKα in hippocampal CA1 neurons. Journal of molecular histology. vol 43. issue 2. 2012-08-15. PMID:22146853. |
taken together, we hypothesized the up-regulation of mltkα played an essential role in the apoptosis of hippocampal ca1 neurons. |
2012-08-15 |
2023-08-12 |
rat |
| Yoshito Kinoshita, H Jürgen Wenzel, Chizuru Kinoshita, Philip A Schwartzkroin, Richard S Morriso. Acute, but reversible, kainic acid-induced DNA damage in hippocampal CA1 pyramidal cells of p53-deficient mice. Epilepsia. vol 53 Suppl 1. 2012-07-16. PMID:22612817. |
in wild-type animals, therefore, p53 appears to stimulate dna repair and also mediate apoptosis in ca1 neurons in this excitotoxicity model. |
2012-07-16 |
2023-08-12 |
mouse |
| Danielle L Meyer, Daniel R Davies, Jeffrey L Barr, Pasquale Manzerra, Gina L Forste. Mild traumatic brain injury in the rat alters neuronal number in the limbic system and increases conditioned fear and anxiety-like behaviors. Experimental neurology. vol 235. issue 2. 2012-06-28. PMID:22498103. |
findings suggest that mtbi was associated with significant neuronal cell loss in the ca1 region of the dorsal hippocampus and increased cell number in subregions of the amygdala, both of which appear to be related to alterations to apoptosis in these regions following mtbi. |
2012-06-28 |
2023-08-12 |
rat |
| Weiqiao Zhang, Baofeng Wang, Sanquan Zhou, Yongming Qi. The effect of ischemic post-conditioning on hippocampal cell apoptosis following global brain ischemia in rats. Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia. vol 19. issue 4. 2012-06-15. PMID:22300791. |
the hippocampal ca1 regions were analysed using the terminal deoxynucleotidyl transferase-mediated biotinylated deoxyuridine triphosphate nick end-labelling (tunel) staining technique for determining cell apoptosis. |
2012-06-15 |
2023-08-12 |
rat |
| Sule Çağlayan Sözmen, Semra Hız Kurul, Uluç Yiş, Kazım Tuğyan, Başak Baykara, Osman Yılma. Neuroprotective effects of recombinant human erythropoietin in the developing brain of rat after lithium-pilocarpine induced status epilepticus. Brain & development. vol 34. issue 3. 2012-06-04. PMID:21600713. |
it also diminished apoptosis in the ca1 and dentate gyrus regions of hippocampus. |
2012-06-04 |
2023-08-12 |
human |
| C-J Gao, L Niu, P-C Ren, W Wang, C Zhu, Y-Q Li, W Chai, X-D Su. Hypoxic preconditioning attenuates global cerebral ischemic injury following asphyxial cardiac arrest through regulation of delta opioid receptor system. Neuroscience. vol 202. 2012-05-18. PMID:22200548. |
in the asphyxial ca rat model, hpc improved the neurological deficit score (nds), inhibited neuronal apoptosis, and increased the number of viable hippocampal ca1 neurons at 24 h, 72 h, or 7 days after restoration of spontaneous circulation (rosc); however, the above-mentioned neuroprotection of hpc was attenuated by naltrindole (a selective dor antagonist). |
2012-05-18 |
2023-08-12 |
rat |
| N Uysal, K Tugyan, I Aksu, S Ozbal, D Ozdemir, A Dayi, S Gönenç, O Açikgö. Age-related changes in apoptosis in rat hippocampus induced by oxidative stress. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 87. issue 2. 2012-04-26. PMID:21281059. |
hippocampal ca1, ca2, ca3 and dentate gyrus apoptosis, and hippocampal superoxide dismutase (sod), glutathione peroxidase (gpx) enzyme activities and thiobarbituric acid reactive substances (tbars) levels were measured. |
2012-04-26 |
2023-08-12 |
rat |
| Wei-Zu Li, Wei-Ping Li, Da-Ke Huang, Hong-Wei Kan, Xin Wang, Wang-Yang Wu, Yan-Yan Yin, Yu-You Ya. Dexamethasone and Aβ₂₅-₃₅ accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22061800. |
in this study, 12-month-old male rats were chronically treated with aβ(25-35) (10 μg/rat, hippocampal ca1 injection) and dexamethasone (dex, 1.5mg/kg) for 14 days to investigate the effects of dex and aβ(25-35) treatment on learning and memory impairments, pathological changes, neuronal ultrastructure, amyloid precursor protein (app) processing and neuronal cell apoptosis. |
2012-04-23 |
2023-08-12 |
rat |
| Wei-Zu Li, Wei-Ping Li, Da-Ke Huang, Hong-Wei Kan, Xin Wang, Wang-Yang Wu, Yan-Yan Yin, Yu-You Ya. Dexamethasone and Aβ₂₅-₃₅ accelerate learning and memory impairments due to elevate amyloid precursor protein expression and neuronal apoptosis in 12-month male rats. Behavioural brain research. vol 227. issue 1. 2012-04-23. PMID:22061800. |
furthermore, hoechst 33258 staining and aβ(1-40) elisa results showed that dex+aβ(25-35) treatment induced hippocampus ca1 neuron apoptosis and increased the level of aβ(1-40). |
2012-04-23 |
2023-08-12 |
rat |
| Kunio Satoh, Masayuki Niwa, Wael Goda, Nguyen Huy Binh, Masaya Nakashima, Manabu Takamatsu, Akira Har. Galectin-3 expression in delayed neuronal death of hippocampal CA1 following transient forebrain ischemia, and its inhibition by hypothermia. Brain research. vol 1382. 2011-11-15. PMID:21262205. |
the ischemic damage in the hippocampal ca1 sector following transient ischemia, delayed neuronal death, is a typical apoptosis, but the mechanism underlying the delayed neuronal death is still far from fully understood. |
2011-11-15 |
2023-08-12 |
Not clear |
| Qing Wang, Xiao-Hui Yin, Yong Liu, Guang-Yi Zhan. K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion. Journal of receptor and signal transduction research. vol 31. issue 4. 2011-11-14. PMID:21726169. |
k252a suppresses neuronal cells apoptosis through inhibiting the translocation of bax to mitochondria induced by the mlk3/jnk signaling after transient global brain ischemia in rat hippocampal ca1 subregion. |
2011-11-14 |
2023-08-12 |
rat |
| Qing Wang, Xiao-Hui Yin, Yong Liu, Guang-Yi Zhan. K252a suppresses neuronal cells apoptosis through inhibiting the translocation of Bax to mitochondria induced by the MLK3/JNK signaling after transient global brain ischemia in rat hippocampal CA1 subregion. Journal of receptor and signal transduction research. vol 31. issue 4. 2011-11-14. PMID:21726169. |
these findings imply that k252a induced neuroprotection against ischemia/reperfusion in rat hippocampal ca1 subregion via inhibiting the mitochondrial apoptosis pathway induced by jnk activation. |
2011-11-14 |
2023-08-12 |
rat |
| Feiyu Ma, Hu Wang, Bin Chen, Feng Wang, Haixiong X. Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Arquivos de neuro-psiquiatria. vol 69. issue 1. 2011-09-21. PMID:21359432. |
metallothionein 3 attenuated the apoptosis of neurons in the ca1 region of the hippocampus in the senescence-accelerated mouse/prone8 (samp8). |
2011-09-21 |
2023-08-12 |
mouse |
| Feiyu Ma, Hu Wang, Bin Chen, Feng Wang, Haixiong X. Metallothionein 3 attenuated the apoptosis of neurons in the CA1 region of the hippocampus in the senescence-accelerated mouse/PRONE8 (SAMP8). Arquivos de neuro-psiquiatria. vol 69. issue 1. 2011-09-21. PMID:21359432. |
here, we measured the zinc and copper content in the brains of senescence-accelerated mouse/prone8 (samp8) and sought to investigate the effect of mt-3 on the apoptosis of neurons in the hippocampal ca1 region of these mice. |
2011-09-21 |
2023-08-12 |
mouse |
| Ting Yang, Lei Zhuang, Niccolò Terrando, Xinmin Wu, Mark R Jonhson, Mervyn Maze, Daqing M. A clinically relevant model of perinatal global ischemic brain damage in rats. Brain research. vol 1383. 2011-08-02. PMID:21281606. |
apoptosis was increased with the duration of hypoxia with neuronal loss and cell shrinkage in the ca1 of hippocampus. |
2011-08-02 |
2023-08-12 |
rat |
| Bin Duan, Hongwei Cai, Wenjie Yan. [Effect of hemorrhage on cell apoptosis in hippocampal CA1 region of rats under controlled hypotension]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 35. issue 1. 2011-06-30. PMID:20130366. |
[effect of hemorrhage on cell apoptosis in hippocampal ca1 region of rats under controlled hypotension]. |
2011-06-30 |
2023-08-12 |
rat |
| Bin Duan, Hongwei Cai, Wenjie Yan. [Effect of hemorrhage on cell apoptosis in hippocampal CA1 region of rats under controlled hypotension]. Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences. vol 35. issue 1. 2011-06-30. PMID:20130366. |
to explore the effect of hemorrhage on cell apoptosis in the hippocampal ca1 region of rats under controlled hypotension (ch). |
2011-06-30 |
2023-08-12 |
rat |
| Sheng Peng, Zhongshen Kuang, Yan Zhang, Hang Xu, Qinghong Chen. The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats. Molecular biology reports. vol 38. issue 2. 2011-05-26. PMID:20473717. |
using this animal model, the effects of calpeptin on the neurological functions, infarction volume and infarction volume percentage of brain, caspase-3 expression and neuronal apoptosis in hippocampal ca1 sector after focal cerebral ischemia-reperfusion injury in rats were investigated. |
2011-05-26 |
2023-08-12 |
rat |