| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Sheng Peng, Zhongshen Kuang, Yan Zhang, Hang Xu, Qinghong Chen. The protective effects and potential mechanism of Calpain inhibitor Calpeptin against focal cerebral ischemia-reperfusion injury in rats. Molecular biology reports. vol 38. issue 2. 2011-05-26. PMID:20473717. |
calpeptin could reduce the neuronal apoptosis in hippocampal ca1 sector when the rats was subjected to the focal cerebral ischemia-reperfusion, the potential mechanism might be related to the inhibition of the expression of caspase-3 by calpeptin. |
2011-05-26 |
2023-08-12 |
rat |
| Takuro Tsuchiya, Helena P Bonner, Tobias Engel, Ina Woods, Satoshi Matsushima, Manus W Ward, Waro Taki, David C Henshall, Caoimhín G Concannon, Jochen H M Preh. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. The European journal of neuroscience. vol 33. issue 3. 2011-05-12. PMID:21198986. |
stereotactic intrahippocampal microinjection of the selective proteasome inhibitor epoxomicin (2.5 nmol) induced a delayed apoptosis within only the ca1 hippocampal neurons and not neurons within the ca3 or dentate gyrus regions, a selective vulnerability similar to that seen during ischaemia. |
2011-05-12 |
2023-08-12 |
Not clear |
| Takuro Tsuchiya, Helena P Bonner, Tobias Engel, Ina Woods, Satoshi Matsushima, Manus W Ward, Waro Taki, David C Henshall, Caoimhín G Concannon, Jochen H M Preh. Bcl-2 homology domain 3-only proteins Puma and Bim mediate the vulnerability of CA1 hippocampal neurons to proteasome inhibition in vivo. The European journal of neuroscience. vol 33. issue 3. 2011-05-12. PMID:21198986. |
in summary, we demonstrate that the bh3-only proteins puma and bim mediate the delayed apoptosis of ca1 hippocampal neurons induced by proteasome inhibition in vivo, and that either bh3-only protein can only partly compensate for the deficiency of the other. |
2011-05-12 |
2023-08-12 |
Not clear |
| Zane Zeier, Irina Madorsky, Ying Xu, William O Ogle, Lucia Notterpek, Thomas C Foste. Gene expression in the hippocampus: regionally specific effects of aging and caloric restriction. Mechanisms of ageing and development. vol 132. issue 1-2. 2011-05-09. PMID:21055414. |
region specific analyses indicated that ca1 was more susceptible to aging stress, exhibiting a greater number of altered genes relative to ca3 and the dentate gyrus (dg), and an enrichment of genes related to the immune response and apoptosis. |
2011-05-09 |
2023-08-12 |
Not clear |
| A Rami, M Kim, J Nique. Translocation of the serine protease Omi/HtrA2 from mitochondria into the cytosol upon seizure-induced hippocampal injury in the neonatal rat brain. Neurochemical research. vol 35. issue 12. 2011-04-28. PMID:21132459. |
in this study, we analyzed the contribution of serine protease omi/htra2, its substrate x-linked inhibitor of apoptosis protein (xiap) and the caspase-3 activation to damage of hippocamplal ca1 cells following lithium-pilocarpine se in p14 rat pups. |
2011-04-28 |
2023-08-12 |
rat |
| Nobuhiro Osada, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa It. Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia. Neurochemistry international. vol 57. issue 1. 2011-01-31. PMID:20362024. |
in addition to neuronal injury, astrocytes in area ca1 undergo apoptosis under ischemic conditions. |
2011-01-31 |
2023-08-12 |
mouse |
| Nobuhiro Osada, Yasuhiro Kosuge, Kumiko Ishige, Yoshihisa It. Characterization of neuronal and astroglial responses to ER stress in the hippocampal CA1 area in mice following transient forebrain ischemia. Neurochemistry international. vol 57. issue 1. 2011-01-31. PMID:20362024. |
these results suggest that astrocytes as well as pyramidal neurons in area ca1 undergo apoptosis through an er stress-dependent mechanism after ischemia. |
2011-01-31 |
2023-08-12 |
mouse |
| Iu V Lebid', V Ie Dosenko, H H Skyb. [Expression of proteasome subunits PSMB5 and PSMB9 mRNA in hippocampal neurons in experimental diabetes mellitus: link with apoptosis and necrosis]. Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994). vol 56. issue 4. 2010-11-30. PMID:20968039. |
the goal of this work was to investigate the expression of proteasome subunits psmb5 and psmb9 mrna in ca1, ca2 and ca3 areas of hippocampus in parallel with processes of cell death (apoptosis and necrosis) in development dynamics of streptozotocine-induced diabetes. |
2010-11-30 |
2023-08-12 |
Not clear |
| Ye Peng, Shu-Fang Feng, Qiang Wang, Hua-Ning Wang, Wu-Gang Hou, Lize Xiong, Zhuo-Jing Luo, Qing-Rong Ta. Hyperbaric oxygen preconditioning ameliorates anxiety-like behavior and cognitive impairments via upregulation of thioredoxin reductases in stressed rats. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20493230. |
the results indicated that hbo-pc was able to significantly preserve viable neurons in the ca1 subfield of hippocampus following sps exposure, as evidenced by reduced amounts of ca1 neuronal apoptosis. |
2010-11-02 |
2023-08-12 |
rat |
| Shufang Feng, Qiang Wang, Huaning Wang, Ye Peng, Lei Wang, Yan Lu, Tianyao Shi, Lize Xion. Electroacupuncture pretreatment ameliorates hypergravity-induced impairment of learning and memory and apoptosis of hippocampal neurons in rats. Neuroscience letters. vol 478. issue 3. 2010-10-08. PMID:20457216. |
our results showed that +gz exposure significantly caused pyramidal neuronal damage, increased neuronal apoptosis and caspase-3 activity in hippocampal ca1 region, as well as resulted in an impairment of spatial learning and memory, as compared to the sham group animals. |
2010-10-08 |
2023-08-12 |
rat |
| Shufang Feng, Qiang Wang, Huaning Wang, Ye Peng, Lei Wang, Yan Lu, Tianyao Shi, Lize Xion. Electroacupuncture pretreatment ameliorates hypergravity-induced impairment of learning and memory and apoptosis of hippocampal neurons in rats. Neuroscience letters. vol 478. issue 3. 2010-10-08. PMID:20457216. |
furthermore, the ea pretreatment significantly attenuated the neuronal apoptosis, preserved neuronal morphology and inhibited the caspase-3 activity in hippocampal ca1 region resulted from +gz exposure. |
2010-10-08 |
2023-08-12 |
rat |
| Helena P Bonner, Caoimhín G Concannon, Caroline Bonner, Ina Woods, Manus W Ward, Jochen H M Preh. Differential expression patterns of Puma and Hsp70 following proteasomal stress in the hippocampus are key determinants of neuronal vulnerability. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20477911. |
genetic deletion of the pro-apoptotic p53 target gene, p53-upregulated modulator of apoptosis (puma), significantly reduced injury within the ca1 following proteasomal inhibition. |
2010-08-23 |
2023-08-12 |
Not clear |
| Hui-guo Liu, Zhi-feng Zhang, Zhen-xiang Zhang, Yong-ping Gao, Ru-ji Ni. [The change and mechanism of apoptosis in the hippocampal CA1 region of rats exposed to intermittent hypoxia]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 30. issue 5. 2010-08-17. PMID:17651645. |
[the change and mechanism of apoptosis in the hippocampal ca1 region of rats exposed to intermittent hypoxia]. |
2010-08-17 |
2023-08-12 |
rat |
| Hui-guo Liu, Zhi-feng Zhang, Zhen-xiang Zhang, Yong-ping Gao, Ru-ji Ni. [The change and mechanism of apoptosis in the hippocampal CA1 region of rats exposed to intermittent hypoxia]. Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases. vol 30. issue 5. 2010-08-17. PMID:17651645. |
to investigate the effect of intermittent hypoxia on rat hippocampal oxidative stress and neuron apoptosis in the hippocampal ca1 region. |
2010-08-17 |
2023-08-12 |
rat |
| In Koo Hwang, Ki-Yeon Yoo, Dae Won Kim, Choong Hyun Lee, Jung Hoon Choi, Young-Guen Kwon, Young-Myeong Kim, Soo Young Choi, Moo-Ho Wo. Changes in the expression of mitochondrial peroxiredoxin and thioredoxin in neurons and glia and their protective effects in experimental cerebral ischemic damage. Free radical biology & medicine. vol 48. issue 9. 2010-06-16. PMID:20156553. |
these results suggest that changes in the expression of prx3 and trx2 in the hippocampal ca1 region after i/r may be associated with the delayed neuronal death of ca1 pyramidal cells induced by transient cerebral ischemia, and that treatment with prx3 or prx3/trx2 in ischemic brains shows a potent neuroprotective effect against ischemic damage by reducing lipid peroxidation and mitochondrial-mediated apoptosis by i/r. |
2010-06-16 |
2023-08-12 |
Not clear |
| Xiang-Rong Zheng, Shan-Shan Zhang, Yu-Jia Yang, Fei Yin, Xia Wang, Le Zhong, Xiao-He Y. Adenoviral vector-mediated transduction of VEGF improves neural functional recovery after hypoxia-ischemic brain damage in neonatal rats. Brain research bulletin. vol 81. issue 4-5. 2010-05-06. PMID:19945513. |
the better performs by the animals that received vegf vectors may be directly linked to the inhibitory effect of vegf on neuronal apoptosis because the animals had less neural loss in the cortex and hippocampal ca1 region as compared with pbs group. |
2010-05-06 |
2023-08-12 |
human |
| Jun-Li Liu, Dai-Shi Tian, Zai-Wang Li, Wen-Sheng Qu, Yan Zhan, Min-Jie Xie, Zhi-Yuan Yu, Wei Wang, Gang W. Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo. Brain research. vol 1316. 2010-05-06. PMID:20044983. |
furthermore, wbi led to microglial activation and reactive astrogliosis in the cerebral cortex and neuronal apoptosis in the ca1 hippocampus at day 3 post-radiation. |
2010-05-06 |
2023-08-12 |
Not clear |
| Shouping Wang, Kelly Peretich, Yifan Zhao, Ge Liang, Qingcheng Meng, Huafeng We. Anesthesia-induced neurodegeneration in fetal rat brains. Pediatric research. vol 66. issue 4. 2010-02-05. PMID:20016413. |
fetal brains were then evaluated for apoptosis, using caspase-3 immunohistochemistry in the ca1 region of the hippocampus and the retrosplenial cortex (rs). |
2010-02-05 |
2023-08-12 |
rat |
| T Yawno, J J Hirst, M Castillo-Melendez, D W Walke. Role of neurosteroids in regulating cell death and proliferation in the late gestation fetal brain. Neuroscience. vol 163. issue 3. 2010-01-14. PMID:19591903. |
finasteride treatment significantly increased apoptosis (activated caspase-3 expression) in hippocampal ca3 and ca1, and cerebellar molecular and granular layers, an effect abolished by co-infusion of alfaxalone and finasteride. |
2010-01-14 |
2023-08-12 |
Not clear |
| b' S H Kurul, U Yi\\xc5\\x9f, A Kumral, K Tu\\xc4\\x9fyan, S Cilaker, E Kolatan, O Yilmaz, S Gen\\xc3\\xa. Protective effects of topiramate against hyperoxic brain injury in the developing brain. Neuropediatrics. vol 40. issue 1. 2009-10-16. PMID:19639524.' |
histopathological examination showed that topiramate significantly diminished apoptosis in the ca1 region and dentate gyrus of hippocampus. |
2009-10-16 |
2023-08-12 |
rat |