| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Takeshi Hayashi, Atsushi Saito, Shuzo Okuno, Michel Ferrand-Drake, Robert L Dodd, Pak H Cha. Damage to the endoplasmic reticulum and activation of apoptotic machinery by oxidative stress in ischemic neurons. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 25. issue 1. 2005-03-28. PMID:15678111. |
in ischemic, wild-type brains, expression of atf-4 and chop was increased in the hippocampal ca1 neurons that would later undergo apoptosis. |
2005-03-28 |
2023-08-12 |
mouse |
| M D Siegelin, L S Kossatz, J Winckler, A Ram. Regulation of XIAP and Smac/DIABLO in the rat hippocampus following transient forebrain ischemia. Neurochemistry international. vol 46. issue 1. 2005-02-22. PMID:15567514. |
we demonstrate that ca1 neuronal loss induced by ischemia (10 min) is preceded by a selective and marked elevation of catalytically active caspase-3 in these neurons, indicative of apoptosis. |
2005-02-22 |
2023-08-12 |
rat |
| Jean-Luc Daval, Paul Ver. Apoptosis and neurogenesis after transient hypoxia in the developing rat brain. Seminars in perinatology. vol 28. issue 4. 2005-02-15. PMID:15565785. |
in vivo, hypoxia induced cell damage in the ca1 subfield of the hippocampus, where the total number of cells was reduced by 27% at days 6-7 postreoxygenation, with histopathological hallmarks of apoptosis. |
2005-02-15 |
2023-08-12 |
rat |
| Ralphiel S Payne, Aviv Goldbart, David Gozal, Avital Schur. Effect of intermittent hypoxia on long-term potentiation in rat hippocampal slices. Brain research. vol 1029. issue 2. 2005-01-24. PMID:15542074. |
the expression of cleaved caspase 3 in the hippocampal ca1, a marker of apoptosis, peaked at 3 days of ih and returned to normoxic values at 14 days of ih. |
2005-01-24 |
2023-08-12 |
rat |
| Sebnem Atici, Leyla Cinel, Ismail Cinel, Nurcan Doruk, Mustafa Aktekin, Almila Akca, Handan Camdeviren, Ugur Ora. Opioid neurotoxicity: comparison of morphine and tramadol in an experimental rat model. The International journal of neuroscience. vol 114. issue 8. 2005-01-10. PMID:15527204. |
the presence and the number of red neurons, which are a histologic marker of apoptosis, were investigated in the parietal, frontal, temporal, occipital, entorhinal, pyriform, and hippocampal ca1, ca2, ca3 regions. |
2005-01-10 |
2023-08-12 |
rat |
| Dan-Qing Li, Yan-Long Duan, Yong-Ming Bao, Chui-Ping Liu, Ying Liu, Li-Jia A. Neuroprotection of catalpol in transient global ischemia in gerbils. Neuroscience research. vol 50. issue 2. 2004-12-22. PMID:15380324. |
it was shown that catalpol significantly attenuated apoptosis, rescued hippocampal ca1 neurons and reduced cognitive impairment. |
2004-12-22 |
2023-08-12 |
Not clear |
| Jean-Luc Daval, Grégory Pourié, Stéphanie Grojean, Valerie Lièvre, Catherine Strazielle, Sébastien Blaise, Paul Ver. Neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat CA1 hippocampus. Pediatric research. vol 55. issue 4. 2004-11-16. PMID:14739363. |
neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat ca1 hippocampus. |
2004-11-16 |
2023-08-12 |
rat |
| Jean-Luc Daval, Grégory Pourié, Stéphanie Grojean, Valerie Lièvre, Catherine Strazielle, Sébastien Blaise, Paul Ver. Neonatal hypoxia triggers transient apoptosis followed by neurogenesis in the rat CA1 hippocampus. Pediatric research. vol 55. issue 4. 2004-11-16. PMID:14739363. |
therefore, transient hypoxia in the newborn rat triggered apoptosis in the ca1 hippocampus followed by increased neurogenesis and apparent anatomical recovery, suggesting that the developing brain may have a high capacity for self-repair. |
2004-11-16 |
2023-08-12 |
rat |
| Li Zhou, Keith Del Villar, Zhaohui Dong, Carol A Mille. Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms. Brain research. vol 1021. issue 1. 2004-11-08. PMID:15328027. |
hypoxic stress induces apoptosis of hippocampal ca1 neurons while selectively sparing those in ca2-3. |
2004-11-08 |
2023-08-12 |
rat |
| Li Zhou, Keith Del Villar, Zhaohui Dong, Carol A Mille. Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms. Brain research. vol 1021. issue 1. 2004-11-08. PMID:15328027. |
jnks and erks were maximally activated by 4 h, returning approximately to basal levels by 6 h. apoptosis of ca1 neurons was maximal by 6-h hypoxia, although jnk activation had returned to basal levels. |
2004-11-08 |
2023-08-12 |
rat |
| Li Zhou, Keith Del Villar, Zhaohui Dong, Carol A Mille. Neurogenesis response to hypoxia-induced cell death: map kinase signal transduction mechanisms. Brain research. vol 1021. issue 1. 2004-11-08. PMID:15328027. |
a neuroprotective protein, jnk-interacting protein 1 (jip1), an inhibitor of jnk-mediated apoptosis, was reduced by 6-h hypoxia and markedly decreased by 24-h reoxygenation in ca1 neurons as was denn/madd, which also modulates jnk-mediated cell death. |
2004-11-08 |
2023-08-12 |
rat |
| Izzettin Hatip-Al-Khatib, Katsunori Iwasaki, Eun-hee Chung, Nobuaki Egashira, Kenichi Mishima, Michihiro Fujiwar. Inhibition of poly (ADP-ribose) polymerase and caspase-3, but not caspase-1, prevents apoptosis and improves spatial memory of rats with twice-repeated cerebral ischemia. Life sciences. vol 75. issue 16. 2004-09-30. PMID:15306164. |
the results of this study showed that the repeated ischemia impaired memory and induced apoptosis in hippocampus ca1 field after 7 days. |
2004-09-30 |
2023-08-12 |
rat |
| De-Liang Zhang, Yue-Ting Zhang, Jun-Jie Yin, Bao-Lu Zha. Oral administration of Crataegus flavonoids protects against ischemia/reperfusion brain damage in gerbils. Journal of neurochemistry. vol 90. issue 1. 2004-08-06. PMID:15198680. |
more neurons survived and fewer cells suffered apoptosis in the hippocampal ca1 region of cf treated animal brain. |
2004-08-06 |
2023-08-12 |
Not clear |
| b' Xue-Mei Zong, Yin-Ming Zeng, Tie Xu, Jian-Nong L\\xc3\\xb. [Effects of D1 and D2 dopamine receptor agonists and antagonists on cerebral ischemia/reperfusion injury]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566405.' |
gerbil forebrain ischemia/reperfusion(i/r) injury model was used to study the effects of d(1) and d(2) receptor agonists and antagonists on neuronal apoptosis of hippocampal ca1 area. |
2004-07-22 |
2023-08-12 |
Not clear |
| b' Xue-Mei Zong, Yin-Ming Zeng, Tie Xu, Jian-Nong L\\xc3\\xb. [Effects of D1 and D2 dopamine receptor agonists and antagonists on cerebral ischemia/reperfusion injury]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566405.' |
forebrain ischemia for 5 min resulted in extensive ca1 apoptosis on the 3rd and 7th days after i/r injury. |
2004-07-22 |
2023-08-12 |
Not clear |
| b' Xue-Mei Zong, Yin-Ming Zeng, Tie Xu, Jian-Nong L\\xc3\\xb. [Effects of D1 and D2 dopamine receptor agonists and antagonists on cerebral ischemia/reperfusion injury]. Sheng li xue bao : [Acta physiologica Sinica]. vol 55. issue 5. 2004-07-22. PMID:14566405.' |
about 95% neurons in hippocampal ca1 area entered apoptosis and only 2%-7% pyramidal neurons stayed alive due to an inhibition of bcl-2 expression and an increase in bax expression. |
2004-07-22 |
2023-08-12 |
Not clear |
| Katsunori Iwasaki, Kenichi Mishima, Nobuaki Egashira, Izzettin Hatip Al-Khatib, Daisuke Ishibashi, Keiichi Irie, Hirotoshi Kobayashi, Takashi Egawa, Michihiro Fujiwar. Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578587. |
we investigated the effects of nilvadipine and amlodipine on the cerebral ischemia-induced impairment of spatial memory in 8-arm radial maze performance and hippocampal ca1 apoptosis in rats. |
2004-06-18 |
2023-08-12 |
rat |
| Cheng-Haung Wang, Chung-Ling Liang, Li-Tung Huang, Jong-Kang Liu, Pei-Hua Hung, Angel Sun, Kuo-Sheng Hun. Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia-ischemia rats. Biochemical and biophysical research communications. vol 314. issue 4. 2004-03-23. PMID:14751241. |
our data showed that the mechanisms of epo gene therapy were rescue of ca1 neurons from lethal h-i injury, prevention of neuronal apoptosis in ca1 region, and decrease of glial activation in corpus callosum. |
2004-03-23 |
2023-08-12 |
human |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
intermittent hypoxia (ih) during sleep induces temporally defined increases in apoptosis within vulnerable brain regions such as the hippocampal ca1 region in rats. |
2004-03-05 |
2023-08-12 |
rat |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
thus, ih induces time-dependent biphasic changes in akt survival pathways within the ca1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis. |
2004-03-05 |
2023-08-12 |
rat |