| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Georg Johannes Müller, Hans Lassmann, Flemming Fryd Johanse. Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17207631. |
heat shock protein 70 (hsp70), neuronal apoptosis inhibitory protein (naip) and manganese superoxide dismutase (mnsod) were upregulated in the majority of intact ca1 neurons paralleling the occurrence of ca1 neuronal death (days 3-7) as well as in a proportion of apoptosis-(<50%) and necrosis-like (<30%) ca1 neurons. |
2007-05-17 |
2023-08-12 |
rat |
| Yajun Liu, Paulus S Wang, Dongping Xie, Kejing Liu, Lianbi Che. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. The Chinese journal of physiology. vol 49. issue 5. 2007-03-20. PMID:17294832. |
the results showed that i/r decreased the number of surviving neurons and induced apoptosis of the neurons in ca1 area of the hippocampus in rats. |
2007-03-20 |
2023-08-12 |
rat |
| Paul Vert, Jean-Luc Dava. [Cell death and neurogenesis after hypoxia: a brain repair mechanism in the developing rat?]. Bulletin de l'Academie nationale de medecine. vol 190. issue 2. 2006-12-19. PMID:17001873. |
in the ca1 subfield of the hippocampus, hypoxia reduced the total number of cells by 27 % on day 6-7 post-reoxygenation, and histopathological hallmarks of apoptosis were observed this cell deficit was followed by gradual recovery, starting on day 20, suggesting a repair mechanism. |
2006-12-19 |
2023-08-12 |
rat |
| Katsunori Iwasaki, Nobuaki Egashira, Izzettin Hatip-Al-Khatib, Yuki Akiyoshi, Takashi Arai, Yuki Takagaki, Takuya Watanabe, Kenichi Mishima, Michihiro Fujiwar. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Brain research. vol 1097. issue 1. 2006-10-06. PMID:16729978. |
moreover, combination of ischemia and abeta induced apoptosis of pyramidal neurons in the ca1 region of the hippocampus. |
2006-10-06 |
2023-08-12 |
rat |
| Qiu-Hua Guan, Dong-Sheng Pei, Xiao-Mei Liu, Xiao-Tian Wang, Tian-Le Xu, Guang-Yi Zhan. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain research. vol 1092. issue 1. 2006-09-19. PMID:16674927. |
here, we reported that sp600125, a potent, cell-permeable, selective, and reversible inhibitor of c-jun n-terminal kinase (jnk), potently decrease neuronal apoptosis induced by global ischemia/reperfusion in the vulnerable hippocampal ca1 subregion. |
2006-09-19 |
2023-08-12 |
rat |
| Qiu-Hua Guan, Dong-Sheng Pei, Xiao-Mei Liu, Xiao-Tian Wang, Tian-Le Xu, Guang-Yi Zhan. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain research. vol 1092. issue 1. 2006-09-19. PMID:16674927. |
thus, our findings imply that sp600125 can inhibit the activation of jnk signaling pathway and induce neuroprotection against ischemia/reperfusion in rat hippocampal ca1 region via suppressing the extrinsic and intrinsic pathways of apoptosis. |
2006-09-19 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
two brain areas, the sensori-motor cortex (layers-5 and 6) and the ca1 and ca3 sectors (pyramidal cell layers) of the hippocampus, were analyzed for apoptosis using tunel and caspase-3 immunoreactivity. |
2006-09-08 |
2023-08-12 |
rat |
| Hong-Gang Zhao, Wen-Bin Li, Qing-Jun Li, Xiao-Ling Chen, Hui-Qing Liu, Rong-Fang Feng, Jie A. Limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the CA1 hippocampus induced by cerebral ischemia-reperfusion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 3. 2006-07-21. PMID:15224159. |
limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the ca1 hippocampus induced by cerebral ischemia-reperfusion in rats. |
2006-07-21 |
2023-08-12 |
rat |
| Hong-Gang Zhao, Wen-Bin Li, Qing-Jun Li, Xiao-Ling Chen, Hui-Qing Liu, Rong-Fang Feng, Jie A. Limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the CA1 hippocampus induced by cerebral ischemia-reperfusion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 3. 2006-07-21. PMID:15224159. |
the purpose of this study was to investigate the effects of limb ischemic preconditioning (lip) on apoptosis of pyramidal neurons in the ca1 hippocampus induced by global cerebral ischemia-reperfusion in rats. |
2006-07-21 |
2023-08-12 |
rat |
| Robert Strosznajder, Barbara Gajkowsk. Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study. Acta neurobiologiae experimentalis. vol 66. issue 1. 2006-06-28. PMID:16617673. |
in this study we investigated the effect of 3-ab on the localization and expression of apoptosis inducing factor (aif) and on two proteins from bcl-2 family: bcl-2 and bax in hippocampal area ca1, on the 4th day after 3 min of forebrain ischemia in gerbils. |
2006-06-28 |
2023-08-12 |
Not clear |
| Lianyan Huang, Wenjun Li, Boxing Li, Fei Zo. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neuroscience letters. vol 398. issue 1-2. 2006-05-10. PMID:16426753. |
specifically, we show that ca1 neurons undergo apoptosis when depleted of oxygen for 12 or 24 h. a katp channels agonist diazoxide inhibits the observed apoptosis. |
2006-05-10 |
2023-08-12 |
Not clear |
| Koji Fukui, Hirokatsu Takatsu, Tadashi Shinkai, Shozo Suzuki, Kouichi Abe, Shiro Uran. Appearance of amyloid beta-like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. Journal of Alzheimer's disease : JAD. vol 8. issue 3. 2006-04-14. PMID:16340088. |
appearance of amyloid beta-like substances and delayed-type apoptosis in rat hippocampus ca1 region through aging and oxidative stress. |
2006-04-14 |
2023-08-12 |
rat |
| Ting-Jie Zhang, Jian Hang, Da-Xiang Wen, Yan-Nan Hang, Frederick E Siebe. Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats. Anesthesia and analgesia. vol 102. issue 4. 2006-04-13. PMID:16551891. |
in group 1 ca1 hippocampus neurons, ultra-structural changes consistent with apoptosis occurred. |
2006-04-13 |
2023-08-12 |
rat |
| Ting-Jie Zhang, Jian Hang, Da-Xiang Wen, Yan-Nan Hang, Frederick E Siebe. Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats. Anesthesia and analgesia. vol 102. issue 4. 2006-04-13. PMID:16551891. |
in rats, moderate hypothermic cpb with hemodilution is associated with ca1 hippocampus bax and bcl-2 gene expression and neuronal apoptosis during the early post-cpb recovery period. |
2006-04-13 |
2023-08-12 |
rat |
| Abdullah Kumral, Kazim Tugyan, Sevil Gonenc, Kursat Genc, Sermin Genc, Ulker Sonmez, Osman Yilmaz, Nuray Duman, Nazan Uysal, Hasan Ozka. Protective effects of erythropoietin against ethanol-induced apoptotic neurodegenaration and oxidative stress in the developing C57BL/6 mouse brain. Brain research. Developmental brain research. vol 160. issue 2. 2006-02-07. PMID:16236368. |
histopathological evaluation demonstrated that epo significantly diminished apoptosis in the cerebellum, prefrontal cortex, and hippocampus and also spared hippocampal ca1, ca2, and ca3 neurons. |
2006-02-07 |
2023-08-12 |
mouse |
| Qun Wang, Sue Yu, Agnes Simonyi, Grace Y Sun, Albert Y Su. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953808. |
kainic acid (ka) is an agonist for a subtype of ionotropic glutamate receptor, and administration of ka has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions of ca1 and ca3, and in the hilus of dentate gyrus (dg). |
2006-01-24 |
2023-08-12 |
rat |
| Sonia Carboni, Bruno Antonsson, Pascale Gaillard, Jean-Pierre Gotteland, Jean-Yves Gillon, Pierre-Alain Vitt. Control of death receptor and mitochondrial-dependent apoptosis by c-Jun N-terminal kinase in hippocampal CA1 neurones following global transient ischaemia. Journal of neurochemistry. vol 92. issue 5. 2005-04-28. PMID:15715656. |
control of death receptor and mitochondrial-dependent apoptosis by c-jun n-terminal kinase in hippocampal ca1 neurones following global transient ischaemia. |
2005-04-28 |
2023-08-12 |
Not clear |
| Katsunori Iwasaki, Izzettin Hatip-Al-Khatib, Nobuaki Egashira, Yuki Akiyoshi, Takashi Arai, Kenichi Mishima, Yuki Takagaki, Keiichiro Inui, Michihiro Fujiwar. Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats. Neurotoxicity research. vol 6. issue 4. 2005-04-22. PMID:15545013. |
ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nachr expression without induction of apoptosis in the hippocampus ca1 neurons of rats. |
2005-04-22 |
2023-08-12 |
rat |
| Katsunori Iwasaki, Izzettin Hatip-Al-Khatib, Nobuaki Egashira, Yuki Akiyoshi, Takashi Arai, Kenichi Mishima, Yuki Takagaki, Keiichiro Inui, Michihiro Fujiwar. Ovariectomy combined with amyloid beta(1-42) impairs memory by decreasing acetylcholine release and alpha 7nAChR expression without induction of apoptosis in the hippocampus CA1 neurons of rats. Neurotoxicity research. vol 6. issue 4. 2005-04-22. PMID:15545013. |
in this study, the effect of ovariectomy and amyloid beta(1-42) (abeta(1-42))on eight-armed radial maze performance, acetylcholine (ach) release, alpha7nach receptor (alpha7nachr), glyceraldehyde 3-phosphate dehydrogenase (gapdh) expression, and apoptosis of ca1 neurons in the dorsal hippocampus were investigated in rat. |
2005-04-22 |
2023-08-12 |
rat |
| Thor D Stein, Nicholas J Anders, Charles DeCarli, Sic L Chan, Mark P Mattson, Jeffrey A Johnso. Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 24. issue 35. 2005-04-05. PMID:15342738. |
chronic infusion of an antibody against transthyretin into the hippocampus of mice overexpressing app with the swedish mutation (app(sw)) leads to increased abeta, tau phosphorylation, and neuronal loss and apoptosis within the ca1 neuronal field. |
2005-04-05 |
2023-08-12 |
mouse |