| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Natalie N Rizk, Javar Myatt-Jones, José Rafols, Joseph C Dunba. Insulin like growth factor-1 (IGF-1) decreases ischemia-reperfusion induced apoptosis and necrosis in diabetic rats. Endocrine. vol 31. issue 1. 2007-10-16. PMID:17709900. |
the lesion volume was used as an index of necrosis and the sensorimotor cortex (layers 5 and 6) as well as the ca1 and ca3 regions of the hippocampus were analyzed for apoptosis using tunel staining and caspase-3 immunoreactivity. |
2007-10-16 |
2023-08-12 |
rat |
| Hei-Jen Huang, Ken-Chen Liang, Chie-Pein Chen, Chiung-Mei Chen, Hsiu Mei Hsieh-L. Intrahippocampal administration of A beta(1-40) impairs spatial learning and memory in hyperglycemic mice. Neurobiology of learning and memory. vol 87. issue 4. 2007-07-16. PMID:17241793. |
a beta accumulation, oxidative stress, and apoptosis in the ca1 region were more intensive in hyperglycemic mice than that in normoglycemic mice after acute treatment with oligomer a beta(1-40) peptide treatment. |
2007-07-16 |
2023-08-12 |
mouse |
| Hei-Jen Huang, Ken-Chen Liang, Chie-Pein Chen, Chiung-Mei Chen, Hsiu Mei Hsieh-L. Intrahippocampal administration of A beta(1-40) impairs spatial learning and memory in hyperglycemic mice. Neurobiology of learning and memory. vol 87. issue 4. 2007-07-16. PMID:17241793. |
these results indicate that ca1 apoptosis was enhanced by oxidative stress resulting from accumulation of a beta. |
2007-07-16 |
2023-08-12 |
mouse |
| Georg Johannes Müller, Hans Lassmann, Flemming Fryd Johanse. Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17207631. |
correlating cell death morphologies (apoptosis-like and necrosis-like death) with immunohistochemistry (ihc), we investigated whether anti-apoptosis contributes to survival, compromises apoptosis effector functions and/or delays death in ca1 neurons 1-7 days after tfi. |
2007-05-17 |
2023-08-12 |
rat |
| Georg Johannes Müller, Hans Lassmann, Flemming Fryd Johanse. Anti-apoptotic signaling and failure of apoptosis in the ischemic rat hippocampus. Neurobiology of disease. vol 25. issue 3. 2007-05-17. PMID:17207631. |
heat shock protein 70 (hsp70), neuronal apoptosis inhibitory protein (naip) and manganese superoxide dismutase (mnsod) were upregulated in the majority of intact ca1 neurons paralleling the occurrence of ca1 neuronal death (days 3-7) as well as in a proportion of apoptosis-(<50%) and necrosis-like (<30%) ca1 neurons. |
2007-05-17 |
2023-08-12 |
rat |
| Yajun Liu, Paulus S Wang, Dongping Xie, Kejing Liu, Lianbi Che. Ghrelin reduces injury of hippocampal neurons in a rat model of cerebral ischemia/reperfusion. The Chinese journal of physiology. vol 49. issue 5. 2007-03-20. PMID:17294832. |
the results showed that i/r decreased the number of surviving neurons and induced apoptosis of the neurons in ca1 area of the hippocampus in rats. |
2007-03-20 |
2023-08-12 |
rat |
| Paul Vert, Jean-Luc Dava. [Cell death and neurogenesis after hypoxia: a brain repair mechanism in the developing rat?]. Bulletin de l'Academie nationale de medecine. vol 190. issue 2. 2006-12-19. PMID:17001873. |
in the ca1 subfield of the hippocampus, hypoxia reduced the total number of cells by 27 % on day 6-7 post-reoxygenation, and histopathological hallmarks of apoptosis were observed this cell deficit was followed by gradual recovery, starting on day 20, suggesting a repair mechanism. |
2006-12-19 |
2023-08-12 |
rat |
| Katsunori Iwasaki, Nobuaki Egashira, Izzettin Hatip-Al-Khatib, Yuki Akiyoshi, Takashi Arai, Yuki Takagaki, Takuya Watanabe, Kenichi Mishima, Michihiro Fujiwar. Cerebral ischemia combined with beta-amyloid impairs spatial memory in the eight-arm radial maze task in rats. Brain research. vol 1097. issue 1. 2006-10-06. PMID:16729978. |
moreover, combination of ischemia and abeta induced apoptosis of pyramidal neurons in the ca1 region of the hippocampus. |
2006-10-06 |
2023-08-12 |
rat |
| Qiu-Hua Guan, Dong-Sheng Pei, Xiao-Mei Liu, Xiao-Tian Wang, Tian-Le Xu, Guang-Yi Zhan. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain research. vol 1092. issue 1. 2006-09-19. PMID:16674927. |
here, we reported that sp600125, a potent, cell-permeable, selective, and reversible inhibitor of c-jun n-terminal kinase (jnk), potently decrease neuronal apoptosis induced by global ischemia/reperfusion in the vulnerable hippocampal ca1 subregion. |
2006-09-19 |
2023-08-12 |
rat |
| Qiu-Hua Guan, Dong-Sheng Pei, Xiao-Mei Liu, Xiao-Tian Wang, Tian-Le Xu, Guang-Yi Zhan. Neuroprotection against ischemic brain injury by SP600125 via suppressing the extrinsic and intrinsic pathways of apoptosis. Brain research. vol 1092. issue 1. 2006-09-19. PMID:16674927. |
thus, our findings imply that sp600125 can inhibit the activation of jnk signaling pathway and induce neuroprotection against ischemia/reperfusion in rat hippocampal ca1 region via suppressing the extrinsic and intrinsic pathways of apoptosis. |
2006-09-19 |
2023-08-12 |
rat |
| Natalie N Rizk, José A Rafols, Joseph C Dunba. Cerebral ischemia-induced apoptosis and necrosis in normal and diabetic rats: effects of insulin and C-peptide. Brain research. vol 1096. issue 1. 2006-09-08. PMID:16729987. |
two brain areas, the sensori-motor cortex (layers-5 and 6) and the ca1 and ca3 sectors (pyramidal cell layers) of the hippocampus, were analyzed for apoptosis using tunel and caspase-3 immunoreactivity. |
2006-09-08 |
2023-08-12 |
rat |
| Hong-Gang Zhao, Wen-Bin Li, Qing-Jun Li, Xiao-Ling Chen, Hui-Qing Liu, Rong-Fang Feng, Jie A. Limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the CA1 hippocampus induced by cerebral ischemia-reperfusion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 3. 2006-07-21. PMID:15224159. |
limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the ca1 hippocampus induced by cerebral ischemia-reperfusion in rats. |
2006-07-21 |
2023-08-12 |
rat |
| Hong-Gang Zhao, Wen-Bin Li, Qing-Jun Li, Xiao-Ling Chen, Hui-Qing Liu, Rong-Fang Feng, Jie A. Limb ischemic preconditioning attenuates apoptosis of pyramidal neurons in the CA1 hippocampus induced by cerebral ischemia-reperfusion in rats. Sheng li xue bao : [Acta physiologica Sinica]. vol 56. issue 3. 2006-07-21. PMID:15224159. |
the purpose of this study was to investigate the effects of limb ischemic preconditioning (lip) on apoptosis of pyramidal neurons in the ca1 hippocampus induced by global cerebral ischemia-reperfusion in rats. |
2006-07-21 |
2023-08-12 |
rat |
| Robert Strosznajder, Barbara Gajkowsk. Effect of 3-aminobenzamide on Bcl-2, Bax and AIF localization in hippocampal neurons altered by ischemia-reperfusion injury. the immunocytochemical study. Acta neurobiologiae experimentalis. vol 66. issue 1. 2006-06-28. PMID:16617673. |
in this study we investigated the effect of 3-ab on the localization and expression of apoptosis inducing factor (aif) and on two proteins from bcl-2 family: bcl-2 and bax in hippocampal area ca1, on the 4th day after 3 min of forebrain ischemia in gerbils. |
2006-06-28 |
2023-08-12 |
Not clear |
| Lianyan Huang, Wenjun Li, Boxing Li, Fei Zo. Activation of ATP-sensitive K channels protects hippocampal CA1 neurons from hypoxia by suppressing p53 expression. Neuroscience letters. vol 398. issue 1-2. 2006-05-10. PMID:16426753. |
specifically, we show that ca1 neurons undergo apoptosis when depleted of oxygen for 12 or 24 h. a katp channels agonist diazoxide inhibits the observed apoptosis. |
2006-05-10 |
2023-08-12 |
Not clear |
| Koji Fukui, Hirokatsu Takatsu, Tadashi Shinkai, Shozo Suzuki, Kouichi Abe, Shiro Uran. Appearance of amyloid beta-like substances and delayed-type apoptosis in rat hippocampus CA1 region through aging and oxidative stress. Journal of Alzheimer's disease : JAD. vol 8. issue 3. 2006-04-14. PMID:16340088. |
appearance of amyloid beta-like substances and delayed-type apoptosis in rat hippocampus ca1 region through aging and oxidative stress. |
2006-04-14 |
2023-08-12 |
rat |
| Ting-Jie Zhang, Jian Hang, Da-Xiang Wen, Yan-Nan Hang, Frederick E Siebe. Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats. Anesthesia and analgesia. vol 102. issue 4. 2006-04-13. PMID:16551891. |
in group 1 ca1 hippocampus neurons, ultra-structural changes consistent with apoptosis occurred. |
2006-04-13 |
2023-08-12 |
rat |
| Ting-Jie Zhang, Jian Hang, Da-Xiang Wen, Yan-Nan Hang, Frederick E Siebe. Hippocampus bcl-2 and bax expression and neuronal apoptosis after moderate hypothermic cardiopulmonary bypass in rats. Anesthesia and analgesia. vol 102. issue 4. 2006-04-13. PMID:16551891. |
in rats, moderate hypothermic cpb with hemodilution is associated with ca1 hippocampus bax and bcl-2 gene expression and neuronal apoptosis during the early post-cpb recovery period. |
2006-04-13 |
2023-08-12 |
rat |
| Abdullah Kumral, Kazim Tugyan, Sevil Gonenc, Kursat Genc, Sermin Genc, Ulker Sonmez, Osman Yilmaz, Nuray Duman, Nazan Uysal, Hasan Ozka. Protective effects of erythropoietin against ethanol-induced apoptotic neurodegenaration and oxidative stress in the developing C57BL/6 mouse brain. Brain research. Developmental brain research. vol 160. issue 2. 2006-02-07. PMID:16236368. |
histopathological evaluation demonstrated that epo significantly diminished apoptosis in the cerebellum, prefrontal cortex, and hippocampus and also spared hippocampal ca1, ca2, and ca3 neurons. |
2006-02-07 |
2023-08-12 |
mouse |
| Qun Wang, Sue Yu, Agnes Simonyi, Grace Y Sun, Albert Y Su. Kainic acid-mediated excitotoxicity as a model for neurodegeneration. Molecular neurobiology. vol 31. issue 1-3. 2006-01-24. PMID:15953808. |
kainic acid (ka) is an agonist for a subtype of ionotropic glutamate receptor, and administration of ka has been shown to increase production of reactive oxygen species, mitochondrial dysfunction, and apoptosis in neurons in many regions of the brain, particularly in the hippocampal subregions of ca1 and ca3, and in the hilus of dentate gyrus (dg). |
2006-01-24 |
2023-08-12 |
rat |