| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katsunori Iwasaki, Kenichi Mishima, Nobuaki Egashira, Izzettin Hatip Al-Khatib, Daisuke Ishibashi, Keiichi Irie, Hirotoshi Kobayashi, Takashi Egawa, Michihiro Fujiwar. Effect of nilvadipine on the cerebral ischemia-induced impairment of spatial memory and hippocampal apoptosis in rats. Journal of pharmacological sciences. vol 93. issue 2. 2004-06-18. PMID:14578587. |
we investigated the effects of nilvadipine and amlodipine on the cerebral ischemia-induced impairment of spatial memory in 8-arm radial maze performance and hippocampal ca1 apoptosis in rats. |
2004-06-18 |
2023-08-12 |
rat |
| Cheng-Haung Wang, Chung-Ling Liang, Li-Tung Huang, Jong-Kang Liu, Pei-Hua Hung, Angel Sun, Kuo-Sheng Hun. Single intravenous injection of naked plasmid DNA encoding erythropoietin provides neuroprotection in hypoxia-ischemia rats. Biochemical and biophysical research communications. vol 314. issue 4. 2004-03-23. PMID:14751241. |
our data showed that the mechanisms of epo gene therapy were rescue of ca1 neurons from lethal h-i injury, prevention of neuronal apoptosis in ca1 region, and decrease of glial activation in corpus callosum. |
2004-03-23 |
2023-08-12 |
human |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
intermittent hypoxia (ih) during sleep induces temporally defined increases in apoptosis within vulnerable brain regions such as the hippocampal ca1 region in rats. |
2004-03-05 |
2023-08-12 |
rat |
| Aviv Goldbart, Zixi Jack Cheng, Kenneth R Brittian, David Goza. Intermittent hypoxia induces time-dependent changes in the protein kinase B signaling pathway in the hippocampal CA1 region of the rat. Neurobiology of disease. vol 14. issue 3. 2004-03-05. PMID:14678760. |
thus, ih induces time-dependent biphasic changes in akt survival pathways within the ca1 region that are temporally correlated with the initial increases and subsequent decreases in neuronal apoptosis. |
2004-03-05 |
2023-08-12 |
rat |
| A Goldbart, B W Row, L Kheirandish, A Schurr, E Gozal, S Z Guo, R S Payne, Z Cheng, K R Brittian, D Goza. Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates. Neuroscience. vol 122. issue 3. 2004-02-17. PMID:14622901. |
creb phosphorylation and dna binding, as well as the presence of apoptosis in the ca1 region of the hippocampus were examined in sprague-dawley male rats exposed to ih. |
2004-02-17 |
2023-08-12 |
rat |
| A Goldbart, B W Row, L Kheirandish, A Schurr, E Gozal, S Z Guo, R S Payne, Z Cheng, K R Brittian, D Goza. Intermittent hypoxic exposure during light phase induces changes in cAMP response element binding protein activity in the rat CA1 hippocampal region: water maze performance correlates. Neuroscience. vol 122. issue 3. 2004-02-17. PMID:14622901. |
the expression of cleaved caspase 3 (cc3) in the ca1, a marker of apoptosis, peaked at 3 days and returned to normoxic values at 14 days. |
2004-02-17 |
2023-08-12 |
rat |
| Tetsumori Yamashima, Anton B Tonchev, Toshiyuki Tsukada, Takaomi C Saido, Shinobu Imajoh-Ohmi, Takashi Momoi, Eiki Kominam. Sustained calpain activation associated with lysosomal rupture executes necrosis of the postischemic CA1 neurons in primates. Hippocampus. vol 13. issue 7. 2004-01-21. PMID:14620874. |
this study focused on nonhuman primates to determine which cascade necrosis or apoptosis is predominantly involved in the development of delayed (day 5) neuronal death in the hippocampal ca1 sector undergoing 20 min ischemia. |
2004-01-21 |
2023-08-12 |
Not clear |
| Takeshi Hayashi, Atsushi Saito, Shuzo Okuno, Michel Ferrand-Drake, Robert L Dodd, Tatsuro Nishi, Carolina M Maier, Hiroyuki Kinouchi, Pak H Cha. Oxidative damage to the endoplasmic reticulum is implicated in ischemic neuronal cell death. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 23. issue 10. 2003-11-12. PMID:14526222. |
phosphorylated forms of eukaryotic initiation factor 2 alpha (eif2 alpha) and rna-dependent protein kinase-like er eif2 alpha kinase (perk), both of which play active roles in apoptosis, were increased in hippocampal ca1 neurons after ischemia but to a lesser degree in the transgenic animals. |
2003-11-12 |
2023-08-12 |
rat |
| Morten Blaabjerg, Liwei Fang, Jens Zimmer, Andrius Basky. Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. Experimental neurology. vol 183. issue 2. 2003-10-31. PMID:14552898. |
using caspase-3 activity to monitor the presence of apoptosis, failed to demonstrate this type of cell death in ca1 after nmda application. |
2003-10-31 |
2023-08-12 |
rat |
| Jon B Klein, David Gozal, William M Pierce, Visith Thongboonkerd, Janice A Scherzer, Leroy R Sachleben, Shang Z Guo, Jian Cai, Evelyne Goza. Proteomic identification of a novel protein regulated in CA1 and CA3 hippocampal regions during intermittent hypoxia. Respiratory physiology & neurobiology. vol 136. issue 2-3. 2003-09-29. PMID:12853002. |
using proteomic analysis we have previously demonstrated that acute (6 h) ih-mediated ca1 injury results from complex interactions between pathways involving increased metabolism, induction of stress-induced proteins and apoptosis, and ultimately disruption of structural proteins and cell integrity. |
2003-09-29 |
2023-08-12 |
Not clear |
| Xiao-Ming Li, Xiao-Chun Bai, Lu-Ning Qin, Hao Huang, Zhong-Ju Xiao, Tian-Ming Ga. Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats. Neuroscience letters. vol 346. issue 1-2. 2003-09-02. PMID:12850540. |
our results suggest that an inhibition of caspase-3 and apoptosis by byhwd may partially account for its neuroprotection against ischemic injury in the hippocampal ca1 region. |
2003-09-02 |
2023-08-12 |
rat |
| Mi-Hyeon Jang, Min-Chul Shin, Taeck-Hyun Lee, Baek-Vin Lim, Mal-Soon Shin, Byung-Il Min, Hong Kim, Sonhae Cho, Ee-Hwa Kim, Chang-Ju Ki. Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neuroscience letters. vol 347. issue 1. 2003-08-21. PMID:12865128. |
acupuncture suppresses ischemia-induced increase in c-fos expression and apoptosis in the hippocampal ca1 region in gerbils. |
2003-08-21 |
2023-08-12 |
Not clear |
| Mi-Hyeon Jang, Min-Chul Shin, Taeck-Hyun Lee, Baek-Vin Lim, Mal-Soon Shin, Byung-Il Min, Hong Kim, Sonhae Cho, Ee-Hwa Kim, Chang-Ju Ki. Acupuncture suppresses ischemia-induced increase in c-Fos expression and apoptosis in the hippocampal CA1 region in gerbils. Neuroscience letters. vol 347. issue 1. 2003-08-21. PMID:12865128. |
in the present study, the effects of acupuncture on the c-fos expression and apoptosis in the hippocampal ca1 region of gerbils following transient global ischemia were investigated via immunohistochemistry for c-fos and caspase-3 and terminal deoxynucleotidyl transferase-mediated dutp nick end labeling (tunel) assay. |
2003-08-21 |
2023-08-12 |
Not clear |
| Andrea B Page, Cheri R Owen, Rita Kumar, Janet M Miller, José A Rafols, Blaine C White, Donald J DeGracia, Gary S Kraus. Persistent eIF2alpha(P) is colocalized with cytoplasmic cytochrome c in vulnerable hippocampal neurons after 4 hours of reperfusion following 10-minute complete brain ischemia. Acta neuropathologica. vol 106. issue 1. 2003-08-11. PMID:12687390. |
an early event in initiating apoptosis is the release of cytochrome c from mitochondria, and cytochrome c release corresponds to the selective vulnerability of hippocampal ca1 neurons in rats after transient global cerebral ischemia. |
2003-08-11 |
2023-08-12 |
rat |
| Barbara Zablocka, Joanna Dluzniewska, Halina Zajac, Krystyna Domańska-Janik, Joanna Duzniewsk. Opposite reaction of ERK and JNK in ischemia vulnerable and resistant regions of hippocampus: involvement of mitochondria. Brain research. Molecular brain research. vol 110. issue 2. 2003-07-28. PMID:12591160. |
these results are consistent with the theory that either long-lasting activation of jnk and/or contrasting erk and jnk activities in critical time of reperfusion, contribute to selective apoptosis of ca1 neurons. |
2003-07-28 |
2023-08-12 |
Not clear |
| C Cunningham, R Deacon, H Wells, D Boche, S Waters, C Picanco Diniz, H Scott, J N P Rawlins, V H Perr. Synaptic changes characterize early behavioural signs in the ME7 model of murine prion disease. The European journal of neuroscience. vol 17. issue 10. 2003-07-28. PMID:12786981. |
no increase in apoptosis or neuronal cell loss was detectable at this time, while in animals at 19 weeks postinjection there was 40% neuronal loss from ca1. |
2003-07-28 |
2023-08-12 |
mouse |
| Masayuki Shirakura, Masayuki Fukumura, Makoto Inoue, Satoshi Fujikawa, Mitsuyo Maeda, Kazuhiko Watabe, Shigeru Kyuwa, Yasuhiro Yoshikawa, Mamoru Hasegaw. Sendai virus vector-mediated gene transfer of glial cell line-derived neurotrophic factor prevents delayed neuronal death after transient global ischemia in gerbils. Experimental animals. vol 52. issue 2. 2003-07-28. PMID:12806886. |
tunel staining demonstrated that sev/gdnf treatment markedly reduced the number of apoptotic cells in the hippocampal ca1 neurons, indicating that sev/gdnf treatment prevented apoptosis. |
2003-07-28 |
2023-08-12 |
Not clear |
| Kiwamu Yamagishi, Kenichi Mishima, Yusuke Ohgami, Katsunori Iwasaki, Masayuki Jimbo, Hiroyuki Masuda, Yasuyuki Igarashi, Jin-ichi Inokuchi, Michihiro Fujiwar. A synthetic ceramide analog ameliorates spatial cognition deficit and stimulates biosynthesis of brain gangliosides in rats with cerebral ischemia. European journal of pharmacology. vol 462. issue 1-3. 2003-07-02. PMID:12591095. |
the first study showed significantly reduced spatial cognition deficit at 12 h after the final drug administration, and l-pdmp tended to attenuate apoptosis in hippocampal ca1. |
2003-07-02 |
2023-08-12 |
rat |
| Kenji Dohi, Hidekatsu Mizushima, Shigeo Nakajo, Hirokazu Ohtaki, Seiji Matsunaga, Tohru Aruga, Seiji Shiod. Pituitary adenylate cyclase-activating polypeptide (PACAP) prevents hippocampal neurons from apoptosis by inhibiting JNK/SAPK and p38 signal transduction pathways. Regulatory peptides. vol 109. issue 1-3. 2003-06-24. PMID:12409219. |
we have demonstrated that ischemic neuronal death (apoptosis) of rat ca1 region of the hippocampus was prevented by infusing pituitary adenylate cyclase-activating polypeptide (pacap) either intracerebroventricularly or intravenously. |
2003-06-24 |
2023-08-12 |
rat |
| Barry W Row, Rugao Liu, Wei Xu, Leila Kheirandish, David Goza. Intermittent hypoxia is associated with oxidative stress and spatial learning deficits in the rat. American journal of respiratory and critical care medicine. vol 167. issue 11. 2003-06-24. PMID:12615622. |
in the adult rat, exposure to intermittent hypoxia (ih), such as occurs in sleep-disordered breathing, is associated with neurobehavioral impairments and increased apoptosis in the hippocampal ca1 region and cortex. |
2003-06-24 |
2023-08-12 |
rat |