| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| William M Humphrey, HongXin Dong, Cynthia A Csernansky, John G Csernansk. Immediate and delayed hippocampal neuronal loss induced by kainic acid during early postnatal development in the rat. Brain research. Developmental brain research. vol 137. issue 1. 2002-10-16. PMID:12128249. |
the appearance of tunel-positive hippocampal neurons accompanied the delayed neuronal loss in both ca3 and ca1 and electron micrographs confirmed that neurons in these subfields were undergoing apoptosis. |
2002-10-16 |
2023-08-12 |
rat |
| Koji Fukui, Nao-Omi Omoi, Takahiro Hayasaka, Tadashi Shinnkai, Shozo Suzuki, Kouichi Abe, Shiro Uran. Cognitive impairment of rats caused by oxidative stress and aging, and its prevention by vitamin E. Annals of the New York Academy of Sciences. vol 959. 2002-06-04. PMID:11976202. |
this phenomenon is supported by the findings that the delayed-type apoptosis appeared in the ca1 region of the hippocampus of the young at five to seven days after the stress. |
2002-06-04 |
2023-08-12 |
rat |
| T Tsukada, M Watanabe, T Yamashim. Implications of CAD and DNase II in ischemic neuronal necrosis specific for the primate hippocampus. Journal of neurochemistry. vol 79. issue 6. 2002-01-16. PMID:11752060. |
these data altogether suggest that the post-ischemic ca1 neuronal death of the monkey occurs not by apoptosis but by necrosis with participations of lysosomal enzymes dnase ii and cathepsins as well as cad. |
2002-01-16 |
2023-08-12 |
monkey |
| M Niwa, A Hara, T Iwai, S Wang, K Hotta, H Mori, T Uemats. Caspase activation as an apoptotic evidence in the gerbil hippocampal CA1 pyramidal cells following transient forebrain ischemia. Neuroscience letters. vol 300. issue 2. 2001-08-09. PMID:11207385. |
after transient forebrain ischemia in gerbils, activation of apoptosis related caspase, including caspase-3, was apparent, and it preceded dna fragmentation in ca1 region. |
2001-08-09 |
2023-08-12 |
Not clear |
| D Gozal, J M Daniel, G P Dohanic. Behavioral and anatomical correlates of chronic episodic hypoxia during sleep in the rat. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 21. issue 7. 2001-06-28. PMID:11264318. |
marked increases in apoptosis occurred in the ca1 hippocampal region (sevenfold) and cortex (cx; eightfold) after 1-2 d of ehyp but not in ca3 and were followed by decreases toward normoxic levels by 14 d. double labeling for nmda nr1 and c-fos revealed marked architectural disorganization in ca1 and cx with increases in c-fos over time. |
2001-06-28 |
2023-08-12 |
rat |
| P J Lucassen, M B Müller, F Holsboer, J Bauer, A Holtrop, J Wouda, W J Hoogendijk, E R De Kloet, D F Swaa. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. The American journal of pathology. vol 158. issue 2. 2001-04-05. PMID:11159183. |
in 11 of 15 depressed patients, rare, but convincing apoptosis was found in entorhinal cortex, subiculum, dentate gyrus, ca1, and ca4. |
2001-04-05 |
2023-08-12 |
human |
| Y S Zeng, Z C X. Co-existence of necrosis and apoptosis in rat hippocampus following transient forebrain ischemia. Neuroscience research. vol 37. issue 2. 2000-07-19. PMID:10867174. |
these results demonstrate the co-existence of necrosis and apoptosis in the ca1 region after transient forebrain ischemia. |
2000-07-19 |
2023-08-12 |
rat |
| S Koponen, G Goldsteins, R Keinänen, J Koistinah. Induction of protein kinase Cdelta subspecies in neurons and microglia after transient global brain ischemia. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 20. issue 1. 2000-01-13. PMID:10616797. |
the delayed death of ca1 neurons after global brain ischemia is associated with induction of apoptosis genes and is inhibited by protein synthesis inhibitors, suggesting that the degeneration of ca1 pyramidal neurons is an active process that requires new gene expression. |
2000-01-13 |
2023-08-12 |
rat |
| A E Kingston, M J O'Neill, A Lam, K R Bales, J A Monn, D D Schoep. Neuroprotection by metabotropic glutamate receptor glutamate receptor agonists: LY354740, LY379268 and LY389795. European journal of pharmacology. vol 377. issue 2-3. 1999-10-27. PMID:10456425. |
in vivo studies showed that ly354740 was able to mediate a partial protection against apoptosis in ca1 hippocampal cells under ischaemic conditions where substantial ca1 cell loss occurred. |
1999-10-27 |
2023-08-12 |
rat |
| K Domańska-Janik, P Bong, A Bronisz-Kowalczyk, H Zajac, B Zablock. AP1 transcriptional factor activation and its relation to apoptosis of hippocampal CA1 pyramidal neurons after transient ischemia in gerbils. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467255. |
neuronal apoptosis, visualized by the terminal transferase dutp nick-end labelling (tunel) reaction, selectively appeared in the ca1 region of the pyramidal cell layer between the third and fourth days after the insult. |
1999-10-19 |
2023-08-12 |
Not clear |
| K Domańska-Janik, P Bong, A Bronisz-Kowalczyk, H Zajac, B Zablock. AP1 transcriptional factor activation and its relation to apoptosis of hippocampal CA1 pyramidal neurons after transient ischemia in gerbils. Journal of neuroscience research. vol 57. issue 6. 1999-10-19. PMID:10467255. |
the early, survival-supporting ap1 response, located mainly in ischemia-resistant areas of ca2/3, is followed by the delayed phase, characteristic of massive neuronal apoptosis in ca1 with concomitant increase of phospho-c-jun in ap1 dimer. |
1999-10-19 |
2023-08-12 |
Not clear |
| A Hara, M Niwa, T Iwai, M Nakashima, Y Bunai, T Uematsu, N Yoshimi, H Mor. Neuronal apoptosis studied by a sequential TUNEL technique: a method for tract-tracing. Brain research. Brain research protocols. vol 4. issue 2. 1999-10-12. PMID:10446408. |
although this method can identify only the apical dendrites of cells that are undergoing apoptosis during the limited period, some projections of the gerbil hippocampal ca1 neurons undergoing apoptosis are clearly demonstrated. |
1999-10-12 |
2023-08-12 |
Not clear |
| T Nakamura, O Miyamoto, S Yamagami, T Toyoshima, T Negi, T Itano, S Naga. The chronic cell death with DNA fragmentation after post-ischaemic hypothermia in the gerbil hippocampus. Acta neurochirurgica. vol 141. issue 4. 1999-09-13. PMID:10352751. |
these data may indicate that cells in the ca1 area are very vulnerable to ischaemia and die after post-ischaemic hypothermia, and that their death is associated with apoptosis. |
1999-09-13 |
2023-08-12 |
Not clear |
| H D Wang, T Fukuda, T Suzuki, K Hashimoto, S Y Liou, T Momoi, T Kosaka, K Yamamoto, H Nakanish. Differential effects of Bcl-2 overexpression on hippocampal CA1 neurons and dentate granule cells following hypoxic ischemia in adult mice. Journal of neuroscience research. vol 57. issue 1. 1999-08-04. PMID:10397630. |
the electron microscopic studies showed that morphological changes of the degenerating ca1 neurons from both groups were clearly distinct from ordinary apoptosis. |
1999-08-04 |
2023-08-12 |
mouse |
| H D Wang, T Fukuda, T Suzuki, K Hashimoto, S Y Liou, T Momoi, T Kosaka, K Yamamoto, H Nakanish. Differential effects of Bcl-2 overexpression on hippocampal CA1 neurons and dentate granule cells following hypoxic ischemia in adult mice. Journal of neuroscience research. vol 57. issue 1. 1999-08-04. PMID:10397630. |
these results indicate that the overexpression of bcl-2 effectively suppressed dentate granule cell apoptosis but only delayed cell death of the ca1 neurons induced by hypoxic ischemia, suggesting the occurrence of a non-apoptotic, caspase-3-independent mechanism for neuronal death in the ca1 subfield. |
1999-08-04 |
2023-08-12 |
mouse |
| D Xu, Y Bureau, D C McIntyre, D W Nicholson, P Liston, Y Zhu, W G Fong, S J Crocker, R G Korneluk, G S Robertso. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366635. |
we demonstrate that ca1 neuronal loss induced by 4-vo (12 min) is preceded by a selective and marked elevation of catalytically active caspase-3 in these neurons, indicative of apoptosis. |
1999-06-28 |
2023-08-12 |
rat |
| D Xu, Y Bureau, D C McIntyre, D W Nicholson, P Liston, Y Zhu, W G Fong, S J Crocker, R G Korneluk, G S Robertso. Attenuation of ischemia-induced cellular and behavioral deficits by X chromosome-linked inhibitor of apoptosis protein overexpression in the rat hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 12. 1999-06-28. PMID:10366635. |
virally mediated overexpression of the anti-apoptotic gene x chromosome-linked inhibitor of apoptosis protein (xiap) prevented both the production of catalytically active caspase-3 and degeneration of ca1 neurons after transient forebrain ischemia. |
1999-06-28 |
2023-08-12 |
rat |
| F Colbourne, G R Sutherland, R N Aue. Electron microscopic evidence against apoptosis as the mechanism of neuronal death in global ischemia. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 19. issue 11. 1999-06-16. PMID:10341224. |
it has been repeatedly claimed that neuronal death in the hippocampal ca1 sector after untreated global ischemia occurs via apoptosis. |
1999-06-16 |
2023-08-12 |
Not clear |
| K Iwasaki, E H Chung, M Fujiwar. [Apoptosis in the repeated cerebral ischemia--behavioral & histochemical study]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica. vol 112 Suppl 1. 1999-05-10. PMID:10190141. |
furthermore repeated cerebral ischemia-induced disruption of spatial cognition and apoptosis in the hippocampal ca1 area were inhibited by ym-90 k(15 mg/kg,i.p. |
1999-05-10 |
2023-08-12 |
rat |
| H Ozawa, S Shioda, K Dohi, H Matsumoto, H Mizushima, C J Zhou, H Funahashi, Y Nakai, S Nakajo, K Matsumot. Delayed neuronal cell death in the rat hippocampus is mediated by the mitogen-activated protein kinase signal transduction pathway. Neuroscience letters. vol 262. issue 1. 1999-05-06. PMID:10076872. |
transient global ischemia caused by 5 min of cardiac arrest induced delayed neuronal cell death (apoptosis) in the ca1 region of the rat hippocampus. |
1999-05-06 |
2023-08-12 |
rat |