| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Xuemeng Xie, Jincheng Zhang, Di Chen, Hao Pan, Ziqian Wu, Dong Ge, Guangtian Yan. Effects of ghrelin on postresuscitation brain injury in a rat model of cardiac arrest. Shock (Augusta, Ga.). vol 43. issue 5. 2016-01-20. PMID:25692252. |
then, brain tissues were harvested and coronal brain sections were analyzed by hematoxylin and eosin (he) staining for neuronal viability and terminal deoxynucleotidyl transferase-mediated dutp nick end labeling staining for apoptosis in hippocampal ca1 sectors. |
2016-01-20 |
2023-08-13 |
rat |
| Chun-Sing Lam, George Lim Tipoe, Kwok-Fai So, Man-Lung Fun. Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PloS one. vol 10. issue 2. 2016-01-18. PMID:25714473. |
in addition, redox-sensitive nuclear factor kappa b (nfКb) canonical pathway was activated with a translocation of nfКb members (p65, p50) and increased expression levels of nfКb-dependent inflammatory cytokines and mediator (tnfα, il-1β, cox-2); also, a significantly elevated level of er stress (grp78/bip, perk, chop) and autophagic flux in the hypoxic group, leading to neuronal apoptosis in hippocampal subfields (dg, ca1, ca3). |
2016-01-18 |
2023-08-13 |
rat |
| Mingyue Fan, Chunfeng Song, Tianjun Wang, Ling Li, Yanhong Dong, Wei Jin, Peiyuan L. Protective effects of lithium chloride treatment on repeated cerebral ischemia-reperfusion injury in mice. Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology. vol 36. issue 2. 2015-12-31. PMID:25192664. |
pathological changes such as reduction in cell count and obvious pyknosis were seen in haematoxylin-eosin staining, and apoptosis was detected by tunel staining in hippocampal ca1 regions in the model group. |
2015-12-31 |
2023-08-13 |
mouse |
| S H Takada, C A Dos Santos Haemmerle, L C Motta-Teixeira, A V Machado-Nils, V Y Lee, L F Takase, R J Cruz-Rizzolo, A H Kihara, G F Xavier, I-S Watanabe, M I Nogueir. Neonatal anoxia in rats: hippocampal cellular and subcellular changes related to cell death and spatial memory. Neuroscience. vol 284. 2015-12-22. PMID:25305666. |
compared to their respective controls, p2 anoxic rats exhibited (1) higher tunel labeling in cornus ammonis (ca) 1 and the dentate gyrus (dg), (2) higher fjb-positive cells in the ca2-3, and (3) somato-dendritic swelling, mitochondrial injury and chromatin condensation in irregular bodies, as well as other subcellular features indicating apoptosis, necrosis, autophagy and excitotoxicity in the ca1, ca2-3 and dg, as revealed by tem. |
2015-12-22 |
2023-08-13 |
human |
| Huan Zhang, Rui Xu, Fei Xie, Wei Xu, Meng-Fei Zeng, Xin Wang, Ji Zh. Protective effects of perfluorooctyl-bromide nanoparticles on early brain injuries following subarachnoid hemorrhage in rats. American journal of translational research. vol 7. issue 8. 2015-09-23. PMID:26396671. |
the rate of neuronal apoptosis in rat hippocampal ca1 region was determined using tunel assay. |
2015-09-23 |
2023-08-13 |
rat |
| Huan Zhang, Rui Xu, Fei Xie, Wei Xu, Meng-Fei Zeng, Xin Wang, Ji Zh. Protective effects of perfluorooctyl-bromide nanoparticles on early brain injuries following subarachnoid hemorrhage in rats. American journal of translational research. vol 7. issue 8. 2015-09-23. PMID:26396671. |
tunel staining showed that neuronal apoptosis was significantly reduced in the hippocampal ca1 region (p<0.01). |
2015-09-23 |
2023-08-13 |
rat |
| Xiao Yuan, Xueling Guo, Yan Deng, Die Zhu, Jin Shang, Huiguo Li. Chronic intermittent hypoxia-induced neuronal apoptosis in the hippocampus is attenuated by telmisartan through suppression of iNOS/NO and inhibition of lipid peroxidation and inflammatory responses. Brain research. vol 1596. 2015-08-24. PMID:25463026. |
neuronal apoptosis in the hippocampal ca1 region, nos activity, no content, and the presence of inflammatory agents and radical oxygen species in the hippocampus were determined. |
2015-08-24 |
2023-08-13 |
rat |
| Dong Han, Erin L Scott, Yan Dong, Limor Raz, Ruimin Wang, Quanguang Zhan. Attenuation of mitochondrial and nuclear p38α signaling: a novel mechanism of estrogen neuroprotection in cerebral ischemia. Molecular and cellular endocrinology. vol 400. 2015-08-12. PMID:25462588. |
furthermore, administration of a p38 inhibitor was able to mimic the neuroprotective effects of e2 in the hippocampal ca1 region by preventing nuclear and mitochondrial translocation of p38α, loss of mitochondrial membrane potential, and neuronal apoptosis. |
2015-08-12 |
2023-08-13 |
rat |
| Ling Wang, Panpan Zhang, Hongyang Wang, Jiangtao Yu, Min Zhang, Xiaoqing Han, Lin Li, Chen Li. [Intermittent hypoxia promotes the expressions of rat hippocampal neuronal hypoxia-inducible factor-1 and survivin]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 31. issue 3. 2015-07-02. PMID:25744839. |
to establish an intermittent hypoxia (ih) animal model by simulating the features of obstructive sleep apnea-hypopnea syndrome and observe the expressions of hypoxia-inducible factor-1 (hif-1) and survivin and the occurrence of apoptosis in the hippocampal ca1 neuron of rats with early ih. |
2015-07-02 |
2023-08-13 |
rat |
| Jingzong Qi, Yizhao Li, Hongwei Zhang, Yanna Cheng, Yongfu Sung, Jichao Cao, Ying Zhao, Fengshan Wan. A novel conjugate of low-molecular-weight heparin and Cu,Zn-superoxide dismutase: study on its mechanism in preventing brain reperfusion injury after ischemia in gerbils. Brain research. vol 1260. 2015-03-30. PMID:19401175. |
immunohistochemical results indicated icam-1 positive staining was lighter, pyramidal cells of hippocampal ca1 region were more regular and the changes in cell edema were minor, and apoptosis of hippocampal cells was milder in lmwh−sod treated animals than in sod or lmwh+sod treated animals, untreated brii animals and sham-operated animals. |
2015-03-30 |
2023-08-12 |
Not clear |
| Hai-Dong Guo, Jin-Xin Tian, Jing Zhu, Li Li, Kui Sun, Shui-Jin Shao, Guo-Hong Cu. Electroacupuncture Suppressed Neuronal Apoptosis and Improved Cognitive Impairment in the AD Model Rats Possibly via Downregulation of Notch Signaling Pathway. Evidence-based complementary and alternative medicine : eCAM. vol 2015. 2015-03-26. PMID:25810743. |
ea obviously alleviated the cell apoptosis resulted by aβ infusion in hippocampus ca1 regions through upregulating the expression of bcl-2 and downregulating the expression of bax. |
2015-03-26 |
2023-08-13 |
rat |
| Qinhua Guo, Jin Lan, Weiqiao Zhang, Pin Guo, Liemei Guo, Zhiqiang Li, Yongming Qi. Dynamic expression of cerebral cortex and hippocampal glutamate transporters in a rat model of chest compression-induced global cerebral ischemia. Neural regeneration research. vol 7. issue 2. 2015-03-13. PMID:25767487. |
at 7 days post-ischemia, expression of excitatory amino acid carrier 1 decreased in the hippocampal ca1 region and cortex, and was accompanied by apoptosis. |
2015-03-13 |
2023-08-13 |
rat |
| Zhihong Chen, Yaqiang He, Chengjun Song, Zhijun Dong, Zhejun Su, Jingfeng Xu. Sericin can reduce hippocampal neuronal apoptosis by activating the Akt signal transduction pathway in a rat model of diabetes mellitus. Neural regeneration research. vol 7. issue 3. 2015-03-13. PMID:25767499. |
following intragastric perfusion of sericin for 35 days, blood glucose levels significantly reduced, neuronal apoptosis in the hippocampal ca1 region decreased, hippocampal phosphorylated akt and nuclear factor kappa b expression were enhanced, but bcl-xl/bcl-2 associated death promoter expression decreased. |
2015-03-13 |
2023-08-13 |
rat |
| M Kiray, A R Sisman, U M Camsari, M Evren, A Dayi, B Baykara, I Aksu, M Ates, Nazan Uysa. Effects of carbon dioxide exposure on early brain development in rats. Biotechnic & histochemistry : official publication of the Biological Stain Commission. vol 89. issue 5. 2015-02-23. PMID:24476563. |
in addition, apoptosis was increased, while cell numbers were decreased in the ca1 regions of hippocampus and pfc after 0.3% co2 air exposure in adolescent rats. |
2015-02-23 |
2023-08-12 |
rat |
| Zhi Wang, Rongliang Xue, Xi Lei, Jianrui Lv, Gang Wu, Wei Li, Li Xue, Xiaoming Lei, Hongxia Zhao, Hui Gao, Xin We. Tea polyphenols increase X-ray repair cross-complementing protein 1 and apurinic/apyrimidinic endonuclease/redox factor-1 expression in the hippocampus of rats during cerebral ischemia/reperfusion injury. Neural regeneration research. vol 7. issue 30. 2014-12-24. PMID:25538760. |
we demonstrated that intraperitoneal injection of tea polyphenols immediately after reperfusion significantly reduced apoptosis in the hippocampal ca1 region; this effect started 6 hours following reperfusion. |
2014-12-24 |
2023-08-13 |
rat |
| W Wang, X D Yu, X Mo, H B Zhang, D M Zh. Limb ischemic preconditioning attenuates cerebral ischemic injury in rat model. Perfusion. vol 29. issue 3. 2014-12-09. PMID:24002779. |
therefore, potential protective effects of limb ischemic preconditioning (lip) on subsequent ischemic injury of the brain were investigated by evaluating anti-inflammatory effects and apoptosis of pyramidal neurons in the ca1 hippocampus. |
2014-12-09 |
2023-08-12 |
rat |
| Xiuli Chu, Yuwu Zhao, Fang Liu, Yajing Mi, Jie Shen, Xiyun Wang, Jianzhi Liu, Weilin Ji. Rapidly raise blood sugar will aggravate brain damage after severe hypoglycemia in rats. Cell biochemistry and biophysics. vol 69. issue 1. 2014-12-02. PMID:24248411. |
tunel and fjb staining were used to observe the apoptosis and necrosis in the rat hippocampus ca1 and dg regions and transmission electron microscopy for ultra-structures. |
2014-12-02 |
2023-08-12 |
rat |
| Xiuli Chu, Yuwu Zhao, Fang Liu, Yajing Mi, Jie Shen, Xiyun Wang, Jianzhi Liu, Weilin Ji. Rapidly raise blood sugar will aggravate brain damage after severe hypoglycemia in rats. Cell biochemistry and biophysics. vol 69. issue 1. 2014-12-02. PMID:24248411. |
however, apoptosis and necrosis in hippocampus ca1 and dg regions was not differed significantly among groups c, d, and e. all results were well supported by transmission electron microscopy. |
2014-12-02 |
2023-08-12 |
rat |
| Masatoshi Kakizaki, Hiromi Kashiwazaki, Rihito Watanab. Mutant murine hepatitis virus-induced apoptosis in the hippocampus. Japanese journal of infectious diseases. vol 67. issue 1. 2014-09-15. PMID:24451095. |
in contrast, in cl-2 infection, 10-20% of the infected mice exhibited apoptosis in the hippocampus, which was primarily observed in the ca1 subregion. |
2014-09-15 |
2023-08-12 |
mouse |
| Bin Liu, Jing Tang, Shiying Li, Yuqin Zhang, Yan Li, Xiaoliu Don. Involvement of the Wnt signaling pathway and cell apoptosis in the rat hippocampus following cerebral ischemia/reperfusion injury. Neural regeneration research. vol 8. issue 1. 2014-09-10. PMID:25206374. |
our results demonstrate that cell apoptosis increases in the ca1 region following ischemia/reperfusion. |
2014-09-10 |
2023-08-13 |
rat |