| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
molecular mechanisms underlying the observed effects could be at least partially related to the inhibition of neuronal apoptosis and oxidative stress in the hippocampus ca1 area of morphine-treated rats. |
2020-08-20 |
2023-08-13 |
rat |
| Meichun Yuan, Hezhong Zhu, Jiajuan Chen, Dan Zhao, Qi Wan, Zhifeng Zhan. A novel squaramide compound alleviates cognitive deficits through activation of Akt and Erk1/2 in a rat model of vascular dementia. Journal of integrative neuroscience. vol 18. issue 4. 2020-06-22. PMID:31912698. |
moreover, bisperoxovanadium (pyridin-2-squaramide) ultimately reduced neuronal apoptosis represented by the bax/bcl-2 ratio in the ca1 (cornu ammonis 1) region of the hippocampus. |
2020-06-22 |
2023-08-13 |
rat |
| Ye Wu, Aizhen Qiu, Zhongxiu Yang, Jie Wu, Xinjian Li, Kexiu Bao, Min Wang, Baoyu W. Malva sylvestris extract alleviates the astrogliosis and inflammatory stress in LPS-induced depression mice. Journal of neuroimmunology. vol 336. 2020-06-17. PMID:31487612. |
furthermore, we found that ms extract also inhibited the lps-induced neuron apoptosis and astrogliosis both in the cortex and the ca1 region of hippocampus. |
2020-06-17 |
2023-08-13 |
mouse |
| Hui Huang, Guiyun Cui, Hai Tang, Lingwen Kong, Xiaopeng Wang, Chenchen Cui, Qihua Xiao, Huiming J. Silencing of microRNA-146a alleviates the neural damage in temporal lobe epilepsy by down-regulating Notch-1. Molecular brain. vol 12. issue 1. 2020-06-08. PMID:31796120. |
silencing of mirna-146a significantly alleviated the neuronal damage and cell apoptosis in the ca1 and ca3 regions of the hippocampus in tle rats and decreased mda, il-1β, il-6, and il-18 levels and increased sod levels in the hippocampus of tle rats. |
2020-06-08 |
2023-08-13 |
rat |
| Donal T Skelly, Éadaoin W Griffin, Carol L Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J Nicholas Rawlins, David M Bannerman, Colm Cunningha. Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms. Molecular psychiatry. vol 24. issue 10. 2020-05-21. PMID:29875474. |
direct application of il-1β to ex vivo hippocampal slices induced non-synaptic depolarisation and irreversible loss of membrane potential in ca1 neurons from diseased animals and systemic lps increased apoptosis in the degenerating brain, in an il-1ri-dependent fashion. |
2020-05-21 |
2023-08-13 |
mouse |
| Donal T Skelly, Éadaoin W Griffin, Carol L Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J Nicholas Rawlins, David M Bannerman, Colm Cunningha. Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms. Molecular psychiatry. vol 24. issue 10. 2020-05-11. PMID:30890763. |
following publication of this article, the authors noticed an error in the abstract, where they incorrectly stated that: "direct application of il-1β to ex vivo hippocampal slices induced non-synaptic depolarisation and irreversible loss of membrane potential in ca1 neurons from diseased animals and systemic lps increased apoptosis in the degenerating brain, in an il-1ri-/--dependent fashion". |
2020-05-11 |
2023-08-13 |
Not clear |
| Donal T Skelly, Éadaoin W Griffin, Carol L Murray, Sarah Harney, Conor O'Boyle, Edel Hennessy, Marc-Andre Dansereau, Arshed Nazmi, Lucas Tortorelli, J Nicholas Rawlins, David M Bannerman, Colm Cunningha. Correction: Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms. Molecular psychiatry. vol 24. issue 10. 2020-05-11. PMID:30890763. |
this has now been corrected to: "direct application of il-1β to ex vivo hippocampal slices induced non-synaptic depolarisation and irreversible loss of membrane potential in ca1 neurons from diseased animals and systemic lps increased apoptosis in the degenerating brain, in an il-1ri-dependent fashion". |
2020-05-11 |
2023-08-13 |
Not clear |
| Fernanda Huf, Solange Bandiera, Carolina B Müller, Luiza Gea, Fabiano B Carvalho, Francine L Rahmeier, Keli C Reiter, Lucas S Tortorelli, Rosane Gomez, Marilda da Cruz Fernande. Comparative study on the effects of cigarette smoke exposure, ethanol consumption and association: Behavioral parameters, apoptosis, glial fibrillary acid protein and S100β immunoreactivity in different regions of the rat hippocampus. Alcohol (Fayetteville, N.Y.). vol 77. 2020-05-06. PMID:30870710. |
the present study investigated the chronic effects of exposure to cigarette smoke and/or ethanol on behavioral parameters, apoptosis, and alteration in immunoreactivity of glial fibrillary acid protein (gfap) and s100β in the ca1, ca3, and dentate gyrus (dg) of the rat hippocampus. |
2020-05-06 |
2023-08-13 |
rat |
| Sara Chavoshinezhad, Homa Mohseni Kouchesfahani, Abolhassan Ahmadiani, Leila Dargah. Interferon beta ameliorates cognitive dysfunction in a rat model of Alzheimer's disease: Modulation of hippocampal neurogenesis and apoptosis as underlying mechanism. Progress in neuro-psychopharmacology & biological psychiatry. vol 94. 2020-03-30. PMID:31152860. |
moreover, in parallel with reducing apoptosis and neural loss in the hippocampal subfields, ifnβ decreased ectopic neurogenesis in the ca1 and ca3 regions of the ad rat hippocampus. |
2020-03-30 |
2023-08-13 |
rat |
| Yulin Zhu, Shihong Li, Jingying Liu, Qing Wen, Jingui Yu, Lingzhi Yu, Kun Xi. Role of JNK Signaling Pathway in Dexmedetomidine Post-Conditioning-Induced Reduction of the Inflammatory Response and Autophagy Effect of Focal Cerebral Ischemia Reperfusion Injury in Rats. Inflammation. vol 42. issue 6. 2020-03-30. PMID:31446520. |
tunel assay, he staining, and transmission electron microscopy were used to detect the apoptosis of neurons, neuro-cytopathic changes, and the formation of auto-phagosome in hippocampus ca1 region, respectively. |
2020-03-30 |
2023-08-13 |
rat |
| Yue Hei, Rong Chen, Xingang Mao, Jiancai Wang, Qianfa Long, Weiping Li. Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion. Behavioural brain research. vol 365. 2020-03-09. PMID:30826297. |
neuregulin1 attenuates cognitive deficits and hippocampal ca1 neuronal apoptosis partly via erbb4 receptor in a rat model of chronic cerebral hypoperfusion. |
2020-03-09 |
2023-08-13 |
rat |
| Yue Hei, Rong Chen, Xingang Mao, Jiancai Wang, Qianfa Long, Weiping Li. Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion. Behavioural brain research. vol 365. 2020-03-09. PMID:30826297. |
eight weeks post-surgery, cognitive impairment was analyzed using morris water maze (mwm) and radial arm water maze (rawm) tests, followed by histological assessment of the survival and apoptosis of hippocampal ca1 neurons using neun and tunel immunostaining respectively. |
2020-03-09 |
2023-08-13 |
rat |
| Yue Hei, Rong Chen, Xingang Mao, Jiancai Wang, Qianfa Long, Weiping Li. Neuregulin1 attenuates cognitive deficits and hippocampal CA1 neuronal apoptosis partly via ErbB4 receptor in a rat model of chronic cerebral hypoperfusion. Behavioural brain research. vol 365. 2020-03-09. PMID:30826297. |
the results showed that nrg1 significantly improved the performances in mwm (spatial learning and memory) and rawm (spatial working and reference memory), attenuated hippocampal ca1 neuronal loss and apoptosis, upregulated the expression of perbb4/erbb4 and the anti-apoptotic protein bcl-2, and downregulated the expression of pro-apoptotic proteins of cleaved (cl)-caspase3 and bax. |
2020-03-09 |
2023-08-13 |
rat |
| Chung-Hsin Wu, Ching-Lung Lin, Sheue-Er Wang, Chen-Wen L. Effects of imidacloprid, a neonicotinoid insecticide, on the echolocation system of insectivorous bats. Pesticide biochemistry and physiology. vol 163. 2020-02-21. PMID:31973875. |
as suggested from immunohistochemistry and western blots evidences, we found that insectivorous bats after suffering imidacloprid toxicity may decrease vocal-related foxp2 expressions in the superior colliculus, auditory-related prestin expressions in the cochlea, and the auditory-related otoferlin expressions in the cochlea and the inferior colliculus, and cause inflammation and mitochondrial dysfunction-related apoptosis in the hippocampal ca1 and medial entorhinal cortex. |
2020-02-21 |
2023-08-13 |
bee |
| Jue Liu, Yangyang Huang, Fei Cai, Yao Dang, Chunsheng Liu, Jianghua Wan. MicroRNA-181a regulates endoplasmic reticulum stress in offspring of mice following prenatal microcystin-LR exposure. Chemosphere. vol 240. 2020-01-03. PMID:31563103. |
our results showed that mclr prenatal exposure led to the impairment of learning and memory function in offspring on postnatal days (pnd) 35, accompanied by endoplasmic reticulum (er) stress and neuronal apoptosis in hippocampal ca1 regions of mice. |
2020-01-03 |
2023-08-13 |
mouse |
| Xin-Rui Han, Xin Wen, Yong-Jian Wang, Shan Wang, Min Shen, Zi-Feng Zhang, Shao-Hua Fan, Qun Shan, Liang Wang, Meng-Qiu Li, Bin Hu, Chun-Hui Sun, Dong-Mei Wu, Jun Lu, Yuan-Lin Zhen. MicroRNA-140-5p elevates cerebral protection of dexmedetomidine against hypoxic-ischaemic brain damage via the Wnt/β-catenin signalling pathway. Journal of cellular and molecular medicine. vol 22. issue 6. 2019-11-25. PMID:29536658. |
apoptosis and pathological changes in the hippocampus ca1 region and expressions of the related genes of the wnt/β-catenin signalling pathway as well as the genes responsible of apoptosis were detected. |
2019-11-25 |
2023-08-13 |
rat |
| Xiang Zhou, Liu Yong, Yang Huang, ShuiBo Zhu, XiaoYang Song, BiXi Li, Jian Zhu, HaiBo Wan. The protective effects of distal ischemic treatment on apoptosis and mitochondrial permeability in the hippocampus after cardiopulmonary resuscitation. Journal of cellular physiology. vol 233. issue 9. 2019-09-30. PMID:29323705. |
the rate of apoptosis rate of hippocampal ca1 neurons in the pre-treatment and post-treatment groups were significantly lower than that of the model group. |
2019-09-30 |
2023-08-13 |
rat |
| Zi-Wei Han, Li-Cang Zhu, Yue-Chen Chang, Ying Zhou, Jia-An Zong, Ke-Tao Ma, Jun-Qiang Si, Li L. [G protein-coupled estrogen receptor alleviates cerebral ischemia-reperfusion injury through inhibiting endoplasmic reticulum stress]. Sheng li xue bao : [Acta physiologica Sinica]. vol 71. issue 4. 2019-09-26. PMID:31440749. |
the neurobehavioral score was assessed by the longa score method, the morphological changes of the neurons were observed by the nissl staining, the cerebral infarction was detected by the ttc staining, and the neural apoptosis in the hippocampal ca1 region was detected by tunel staining. |
2019-09-26 |
2023-08-13 |
rat |
| Dawei Sun, Wenying Wang, Xintao Wang, Yan Wang, Xiaotao Xu, Feng Ping, Yu Du, Wei Jiang, Derong Cu. bFGF plays a neuroprotective role by suppressing excessive autophagy and apoptosis after transient global cerebral ischemia in rats. Cell death & disease. vol 9. issue 2. 2019-08-01. PMID:29416039. |
in conclusion, these results demonstrate that bfgf could exert neuroprotective effects in the hippocampal ca1 region by suppressing excessive autophagy via the mtor pathway and inhibiting apoptosis by preventing p53 mitochondrial translocation. |
2019-08-01 |
2023-08-13 |
rat |
| Lu Xu, Ling Ding, Yuanqi Su, Ruyue Shao, Jie Liu, Yan Huan. Neuroprotective effects of curcumin against rats with focal cerebral ischemia-reperfusion injury. International journal of molecular medicine. vol 43. issue 4. 2019-07-30. PMID:30816425. |
transmission electron microscope was utilized to observe morphological changes of hippocampal neurons; hematoxylin and eosin staining was used to observe morphological changes of brain tissue; and the terminal deoxynucleotidyl transferase (tdt)‑mediated dutp nick end labeling method detected neurons apoptosis of hippocampal ca1. |
2019-07-30 |
2023-08-13 |
rat |