| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
ach administration also ameliorated apoptosis and oxidative stress indicator levels in hippocampal ca1 of morphine‑treated animals. |
2022-07-14 |
2023-08-14 |
human |
| Nazanin Mozafari, Jalal Hassanshahi, Hamid Ostadebrahimi, Ali Shamsizadeh, Fatemeh Ayoobi, Elham Hakimizadeh, Mohammad Pak-Hashemi, Ayat Kaeid. Neuroprotective effect of Achillea millefolium aqueous extract against oxidative stress and apoptosis induced by chronic morphine in rat hippocampal CA1 neurons. Acta neurobiologiae experimentalis. vol 82. issue 2. 2022-07-14. PMID:35833817. |
based on the present study, ach improved spatial learning and memory defects, and reduced oxidative stress and apoptosis in the hippocampus ca1 region, in chronic morphine‑treated animals. |
2022-07-14 |
2023-08-14 |
human |
| Jikun Du, Jierong Liu, Xiaoman Huang, Yuanhua Li, Daibo Song, Qin Li, Jiantao Lin, Baohong Li, Li L. Catalpol Ameliorates Neurotoxicity in N2a/APP695swe Cells and APP/PS1 Transgenic Mice. Neurotoxicity research. 2022-06-14. PMID:35699892. |
likewise, tunel staining also manifested that catalpol significantly reduced apoptosis in hippocampal ca1 region of app/ps1 mice. |
2022-06-14 |
2023-08-14 |
mouse |
| Ashif Iqubal, Mohammad Kashif Iqubal, Sumit Sharma, Mohd Wasim, Mohamed A Alfaleh, Shadab Md, Sanjula Baboota, Javed Ali, Syed Ehtaishamul Haqu. Pathogenic mechanisms and therapeutic promise of phytochemicals and nanocarriers based drug delivery against radiotherapy-induced neurotoxic manifestations. Drug delivery. vol 29. issue 1. 2022-05-11. PMID:35543534. |
based on the preclinical and clinical investigations, the profound role of increased oxidative stress, nuclear translocation of nf-kb, production of proinflammatory cytokines such as tnf-α, il-6, il-β, increased level of mmps, increased apoptosis, reduced angiogenesis, neurogenesis, and histological aberrations in ca1, ca2, ca3 and dg region of the hippocampus have been reported. |
2022-05-11 |
2023-08-13 |
Not clear |
| Qian Chen, Yichen Cai, Xiaoyu Zhu, Jing Wang, Feng Gao, Mingfeng Yang, Leilei Mao, Zongyong Zhang, Baoliang Su. Edaravone Dexborneol Treatment Attenuates Neuronal Apoptosis and Improves Neurological Function by Suppressing 4-HNE-Associated Oxidative Stress After Subarachnoid Hemorrhage. Frontiers in pharmacology. vol 13. 2022-05-09. PMID:35529450. |
our results showed that a post-sah therapeutic regimen with edaravone dexborneol helped improve neurological function up to 21 days after sah surgery and demonstrated a greater beneficial effect than edaravone alone, accompanied by an obvious inhibition of neuronal apoptosis in the ca1 hippocampus and basal cortex regions. |
2022-05-09 |
2023-08-13 |
human |
| Zhu-Qing He, Peng-Fei Huan, Li Wang, Jian-Cheng H. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metabolic brain disease. 2022-03-01. PMID:35230626. |
additionally, pf improved 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp)-induced neuronal injury by inhibiting apoptosis in hippocampal neurons of the ca1 and ca3, and upregulating psd-95 as well as syn protein levels. |
2022-03-01 |
2023-08-13 |
mouse |
| Behzad Dehqanizadeh, Ziya Fallah Mohammadi, Abdol Hossein Taheri Kalani, Seyed Javad Mirghan. Effect of Early Exercise on Inflammatory Parameters and Apoptosis in CA1 Area of the Hippocampus Following Cerebral Ischemia-reperfusion in Rats. Brain research bulletin. 2022-02-21. PMID:35189318. |
effect of early exercise on inflammatory parameters and apoptosis in ca1 area of the hippocampus following cerebral ischemia-reperfusion in rats. |
2022-02-21 |
2023-08-13 |
rat |
| Behzad Dehqanizadeh, Ziya Fallah Mohammadi, Abdol Hossein Taheri Kalani, Seyed Javad Mirghan. Effect of Early Exercise on Inflammatory Parameters and Apoptosis in CA1 Area of the Hippocampus Following Cerebral Ischemia-reperfusion in Rats. Brain research bulletin. 2022-02-21. PMID:35189318. |
the purpose of this study was to evaluate the effect of early exercise on inflammatory parameters and apoptosis in the ca1 area of the hippocampus following cerebral i/r in adult male rats. |
2022-02-21 |
2023-08-13 |
rat |
| Fan Wu, Chunlin L. KLF2 up-regulates IRF4/HDAC7 to protect neonatal rats from hypoxic-ischemic brain damage. Cell death discovery. vol 8. issue 1. 2022-01-29. PMID:35091544. |
next, neuronal damage, morphological changes, and neuronal apoptosis were documented in the vulnerable hippocampal ca1 region and evaluated using nissl staining, h&e staining, and tunel assay, respectively. |
2022-01-29 |
2023-08-13 |
rat |
| Zhongcheng Wang, Yaxin Su, Lei Zhang, Ting Lan, Li Li, Suhua Q. GSK-126 Protects CA1 Neurons from H3K27me3-Mediated Apoptosis in Cerebral Ischemia. Molecular neurobiology. 2022-01-29. PMID:35091962. |
gsk-126 protects ca1 neurons from h3k27me3-mediated apoptosis in cerebral ischemia. |
2022-01-29 |
2023-08-13 |
rat |
| Liwei Gao, Xin Guo, Shan Liu, Qiang Sun, Xuejiao Qin, Peiyuan Lv, Ming Hu, Jing Xu, Yanhong Don. Neuroprotective role of DL-3-n-butylphthalide via the Nrf2/SIRT3 pathway in a mouse model of vascular dementia. Brain research. 2022-01-15. PMID:35032442. |
the results indicated that nbp treatment ameliorated learning and memory deficits, attenuated pathological damage in the ca1 regions, and reduced autophagy and apoptosis via the nrf2/sirt3 pathway after repeated cerebral i/r. |
2022-01-15 |
2023-08-13 |
mouse |
| Liangliang Zhang, Wei Liang, Yiling Li, Jie Yan, Jingwen Xue, Qinyue Guo, Lan Gao, Hao Li, Qindong Sh. Mild therapeutic hypothermia improves neurological outcomes in a rat model of cardiac arrest. Brain research bulletin. vol 173. 2021-12-09. PMID:34022286. |
neuronal injury and apoptosis in the ca1 region of the hippocampus, assessed using neun immunofluorescence and terminal deoxynucleotidyl transferase-mediated dutp nick-end labeling assays, were significantly reduced in the hypothermia group 1 week after ca. |
2021-12-09 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. Tamoxifen offers long-term neuroprotection after hippocampal silent infarct in male rats. Hormones and behavior. vol 136. 2021-11-29. PMID:34749277. |
in the present study, we induced si in the dorsal hippocampal ca1 region of rats and assessed the effects of systemic administration of tamoxifen (5 mg/kg, twice) 21 days after injury on cognitive and pathophysiological measures, including cell loss, apoptosis, gliosis and estrogen receptors (ers). |
2021-11-29 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. Tamoxifen offers long-term neuroprotection after hippocampal silent infarct in male rats. Hormones and behavior. vol 136. 2021-11-29. PMID:34749277. |
we found that tamoxifen protected against the si-induced cognitive dysfunction on the hippocampal-dependent, place recognition task, cell and er loss, and increased apoptosis and gliosis in the ca1. |
2021-11-29 |
2023-08-13 |
rat |
| Caitlin A Finney, Margaret J Morris, R Frederick Westbrook, Nicole M Jone. Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model. Behavioural brain research. vol 401. 2021-11-15. PMID:33358919. |
si did not result in any detectable cell or synaptophysin loss, but did increase apoptosis, gliosis and inflammation in the ca1. |
2021-11-15 |
2023-08-13 |
rat |
| Caitlin A Finney, Margaret J Morris, R Frederick Westbrook, Nicole M Jone. Hippocampal silent infarct leads to subtle cognitive decline that is associated with inflammation and gliosis at twenty-four hours after injury in a rat model. Behavioural brain research. vol 401. 2021-11-15. PMID:33358919. |
principal component analysis indicated the main variables associated with hippocampal si included increased time spent with the unmoved object, gliosis, apoptosis and inflammation as well as decreased exploration proportion and ca1 cells. |
2021-11-15 |
2023-08-13 |
rat |
| Ying Huang, Xiangping Liao, Huaiwei Wang, Jianghong Luo, Shanquan Zhong, Ziliang Zhang, Fang Zhang, Jianping Chen, Fuhua Xi. Effects of imperatorin on apoptosis and synaptic plasticity in vascular dementia rats. Scientific reports. vol 11. issue 1. 2021-11-12. PMID:33883654. |
we revealed that 2vo-induced cognitive impairment, hippocampus ca1 neuron damage, apoptosis and synaptic damage. |
2021-11-12 |
2023-08-13 |
rat |
| Golshad Kowsari, Soraya Mehrabi, Sara Soleimani Asl, Mahsa Pourhamzeh, Kazem Mousavizadeh, Mehdi Mehdizade. Nicotine and modafinil combination protects against the neurotoxicity induced by 3,4-Methylenedioxymethamphetamine in hippocampal neurons of male rats. Journal of chemical neuroanatomy. vol 116. 2021-11-10. PMID:34119664. |
by tunel test and cresyl violet staining we evaluated neuronal loss and apoptosis in the hippocampal ca1 and found increased neuronal viability in the nmc group. |
2021-11-10 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats. Hormones and behavior. vol 134. 2021-11-01. PMID:34242875. |
we induced si in the dorsal hippocampal ca1 of rats and assessed whether tamoxifen is protective 24 h later against cognitive deficits and injury responses including gliosis, apoptosis, inflammation and changes in estrogen receptors (ers). |
2021-11-01 |
2023-08-13 |
rat |
| Caitlin A Finney, Artur Shvetcov, R Frederick Westbrook, Margaret J Morris, Nicole M Jone. The selective estrogen receptor modulator tamoxifen protects against subtle cognitive decline and early markers of injury 24 h after hippocampal silent infarct in male Sprague-Dawley rats. Hormones and behavior. vol 134. 2021-11-01. PMID:34242875. |
tamoxifen mitigates apoptosis, gliosis, and inflammation and normalization of er levels in the ca1, leading to improved cognitive outcomes after hippocampal si. |
2021-11-01 |
2023-08-13 |
rat |