| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tsong-Hai Lee, Jen-Tsung Yang, Jr-Rung Lin, Chaur-Jong Hu, Wen-Hai Chou, Ching-Po Lin, Nai-Fang Ch. Protective effects of ischemic preconditioning against neuronal apoptosis and dendritic injury in the hippocampus are age-dependent. Journal of neurochemistry. vol 155. issue 4. 2021-03-10. PMID:32314365. |
ischemic preconditioning could improve neuronal apoptosis in ca1 area and dendritic integrity in both ca1 and dg areas with better improvement in adult gerbils than middle-aged gerbils. |
2021-03-10 |
2023-08-13 |
Not clear |
| Bin Wang, Xu Lin, Jiahui Zhou, Chunhui Xie, Chuan Li, Rui Dong, Gaofeng Zhang, Xiaopeng Sun, Mingshan Wang, Yanlin B. Insulin-like growth factor-1 improves postoperative cognitive dysfunction following splenectomy in aged rats. Experimental and therapeutic medicine. vol 21. issue 3. 2021-02-13. PMID:33574912. |
tunel staining revealed that administration of igf-1 significantly reduced neuronal apoptosis in the hippocampal ca1 region following splenectomy. |
2021-02-13 |
2023-08-13 |
rat |
| Walaa Fakih, Ali Mroueh, Houssein Salah, Ali H Eid, Makram Obeid, Firas Kobeissy, Hala Darwish, Ahmed F El-Yazb. Dysfunctional cerebrovascular tone contributes to cognitive impairment in a non-obese rat model of prediabetic challenge: Role of suppression of autophagy and modulation by anti-diabetic drugs. Biochemical pharmacology. vol 178. 2020-12-07. PMID:32439335. |
neuroinflammation and neuronal apoptosis were detected in the hippocampal ca1 area as increased cd68 and iba-1 staining, as well as increased tunel staining and caspase-3 activity, respectively. |
2020-12-07 |
2023-08-13 |
rat |
| Sherif Rashad, Daisuke Saigusa, Takahiro Yamazaki, Yotaro Matsumoto, Yoshihisa Tomioka, Ritsumi Saito, Akira Uruno, Kuniyasu Niizuma, Masayuki Yamamoto, Teiji Tominag. Metabolic basis of neuronal vulnerability to ischemia; an in vivo untargeted metabolomics approach. Scientific reports. vol 10. issue 1. 2020-11-30. PMID:32300196. |
using untargeted liquid chromatography-mass spectrometry, we analyzed temporal metabolomic changes in ca1 and ca3 hippocampal areas following tgci in rats till the setting of neuronal apoptosis. |
2020-11-30 |
2023-08-13 |
rat |
| Xianghui Zhang, Guan'en Zho. MiR-199a-5p inhibition protects cognitive function of ischemic stroke rats by AKT signaling pathway. American journal of translational research. vol 12. issue 10. 2020-11-17. PMID:33194051. |
tunel fluorescence staining was used to detect neuronal apoptosis in hippocampal ca1 region of rats. |
2020-11-17 |
2023-08-13 |
rat |
| Zhiwen Hong, Yujing Tian, Yibiao Yuan, Mengwen Qi, Yingchun Li, Yimei Du, Lei Chen, Ling Che. Enhanced Oxidative Stress Is Responsible for TRPV4-Induced Neurotoxicity. Frontiers in cellular neuroscience. vol 10. 2020-10-01. PMID:27799895. |
finally, gsk1016790a-induced neuronal death and apoptosis in the hippocampal ca1 area were markedly attenuated by administration of a ros scavenger trolox or arl-17477. |
2020-10-01 |
2023-08-13 |
cat |
| Meng-Jun Wu, Ya-Jie Zhang, Hai Yu, Bin Li. Emulsified isoflurane combined with therapeutic hypothermia improves survival and neurological outcomes in a rat model of cardiac arrest. Experimental and therapeutic medicine. vol 13. issue 3. 2020-10-01. PMID:28450915. |
eiso, th and eiso plus th yielded significant improvements in survival rates, neural deficit score and cognitive function, and ameliorated hippocampal ca1 region cell injury and apoptosis at 1 day and 7 days after rosc compared with the cpr group. |
2020-10-01 |
2023-08-13 |
rat |
| Yangyang Shan, Fan Yang, Zhiyin Tang, Congjie Bi, Shiwei Sun, Yongfang Zhang, Hongtao Li. Dexmedetomidine Ameliorates the Neurotoxicity of Sevoflurane on the Immature Brain Through the BMP/SMAD Signaling Pathway. Frontiers in neuroscience. vol 12. 2020-10-01. PMID:30618586. |
in our study, pregnant rats on gestational day 20 (g20) were exposed to 3% sevoflurane for 2 h or 4 h, and the neuronal apoptosis in hippocampal ca1 region of the offspring rats was detected by quantification of tunel positive cells and cleaved-caspase3 (cl-caspase3). |
2020-10-01 |
2023-08-13 |
rat |
| Elahe Mirarab, Vida Hojati, Golamhassan Vaezi, Abdolhossein Shiravi, Mehdi Khaksar. Obestatin inhibits apoptosis and astrogliosis of hippocampal neurons following global cerebral ischemia reperfusion via antioxidant and anti-inflammatory mechanisms. Iranian journal of basic medical sciences. vol 22. issue 6. 2020-10-01. PMID:31231488. |
this study aimed at examining the protective impact of obestatin on apoptosis, protein expression and reactive astrogliosis level in hippocampal ca1 region of rat following transient global cerebral ischemia. |
2020-10-01 |
2023-08-13 |
rat |
| Ji-Eun Kim, Tae-Cheon Kan. PKC, AKT and ERK1/2-Mediated Modulations of PARP1, NF-κB and PEA15 Activities Distinctly Regulate Regional Specific Astroglial Responses Following Status Epilepticus. Frontiers in molecular neuroscience. vol 12. 2020-10-01. PMID:31396050. |
akt inhibition deteriorated dentate astroglial loss and led to ca1 astroglial apoptosis following se, which were ameliorated by akt activation. |
2020-10-01 |
2023-08-13 |
Not clear |
| Xiao Li, Rui-Zhen Liu, Qi Zeng, Zhi-Hua Huang, Jian-Dong Zhang, Zong-Liang Liu, Jing Zeng, Hai Xia. 3'-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127116. |
tunel assay was used to analyze apoptosis in the hippocampal ca1, ca3 regions and dentate gyrus. |
2020-09-30 |
2023-08-13 |
rat |
| Xiao Li, Rui-Zhen Liu, Qi Zeng, Zhi-Hua Huang, Jian-Dong Zhang, Zong-Liang Liu, Jing Zeng, Hai Xia. 3'-Daidzein sulfonate sodium protects against memory impairment and hippocampal damage caused by chronic cerebral hypoperfusion. Neural regeneration research. vol 13. issue 9. 2020-09-30. PMID:30127116. |
results showed that dss treatment greatly improved the learning and memory deficits of rats with cch, reduced apoptosis of neurons in the hippocampal ca1, ca3 regions and dentate gyrus, and increased the phosphorylation of pka, erk1/2, and creb in the hippocampus. |
2020-09-30 |
2023-08-13 |
rat |
| Filippo Ugolini, Daniele Lana, Pamela Nardiello, Daniele Nosi, Daniela Pantano, Fiorella Casamenti, Maria Grazia Giovannin. Different Patterns of Neurodegeneration and Glia Activation in CA1 and CA3 Hippocampal Regions of TgCRND8 Mice. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30483118. |
in ca1 sp, we found decrease of volume and number of pyramidal neurons, paralleled by increase of apoptosis, and, consequently, shrinkage of ca1 sp. |
2020-09-30 |
2023-08-13 |
mouse |
| Bin Xu, Li-Min Lang, Shuai Lian, Jing-Ru Guo, Jian-Fa Wang, Huan-Min Yang, Shi-Ze L. Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure. Brain sciences. vol 9. issue 10. 2020-09-28. PMID:31614701. |
the phenomena of oxidation stress, mapk signaling pathway activation, anti-oxidation protein release, neuronal apoptosis increases, and neuronal proliferation inhibition were demonstrated in the ca1 and ca3 regions of mouse hippocampal tissues following cold exposure. |
2020-09-28 |
2023-08-13 |
mouse |
| Gholam-Reza Mahmoudiasl, Hojjat Allah Abbaszadeh, Mostafa Rezaei-Tavirani, Mohammad-Amin Abdollahifar, Yousef Sadeghi, Maryam Sadat Khoramgah, Somayeh Niknazar, Shahram Darab. Postmortem Study of Molecular and Histological Changes in the CA1 Hippocampal Region of Chronic Methamphetamine User. Iranian journal of pharmaceutical research : IJPR. vol 18. issue 4. 2020-09-28. PMID:32184870. |
chronic meth use can induce gfap and iba-1 upregulation and neuronal apoptosis in the ca1 region of the postmortem hippocampus. |
2020-09-28 |
2023-08-13 |
human |
| Sara Sayad-Fathi, Arash Zaminy, Parvin Babaei, Fatemeh Yousefbeyk, Nasibeh Azizi, Ebrahim Nasir. The methanolic extract of Cinnamomum zeylanicum bark improves formaldehyde-induced neurotoxicity through reduction of phospho-tau (Thr231), inflammation, and apoptosis. EXCLI journal. vol 19. 2020-09-28. PMID:32536837. |
the nissl, hoechst, and bielschowsky silver staining methods were also used to assess apoptosis and neurofibrillary tangles (nfts) in the hippocampal ca1 region, respectively. |
2020-09-28 |
2023-08-13 |
rat |
| Juan Sun, Xiaomei Yang, Yan Zhang, Weiguang Zhang, Jianfei Lu, Qin Hu, Renyu Liu, Changman Zhou, Chunhua Che. Salvinorin A attenuates early brain injury through PI3K/Akt pathway after subarachnoid hemorrhage in rat. Brain research. vol 1719. 2020-09-25. PMID:31125530. |
we found that sa alleviated the neuronal morphological changes and apoptosis in ca1 area of hippocampus. |
2020-09-25 |
2023-08-13 |
rat |
| Jing Wang, Yabing Chen, Changliang Zhang, Zou Xiang, Jie Ding, Xiaodong Ha. Learning and memory deficits and alzheimer's disease-like changes in mice after chronic exposure to microcystin-LR. Journal of hazardous materials. vol 373. 2020-08-24. PMID:30947040. |
mc-lr exposure at this concentration induced dysfunction of learning and memory, accompanied with apoptosis of neuronal cells (with 10% reduction of the neurons in the ca1 region and 15% in the ca2 region), reduction of spine density, accumulation of β-amyloid plaques 1-42 (aβ1-42), and enhanced phosphorylation of tau (p-tau) in the brain, which is characteristic of alzheimer's disease (ad). |
2020-08-24 |
2023-08-13 |
mouse |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
in order to evaluate the cleaved caspase-3, bax, and bcl2 protein expression (as biochemical markers of apoptosis) in ca1 area of hippocampus tissue, the western blot test was used. |
2020-08-20 |
2023-08-13 |
rat |
| Farhad Shibani, Ali Sahamsizadeh, Iman Fatemi, Mohammad Allahtavakoli, Jalal Hasanshahi, Mohammadreza Rahmani, Mahdieh Azin, Mahsa Hassanipour, Nazanin Mozafari, Ayat Kaeid. Effect of oleuropein on morphine-induced hippocampus neurotoxicity and memory impairments in rats. Naunyn-Schmiedeberg's archives of pharmacology. vol 392. issue 11. 2020-08-20. PMID:31236657. |
also, oleuropein treatment decreased the apoptosis and oxidative stress levels in the hippocampus ca1 area of morphine-treated rats. |
2020-08-20 |
2023-08-13 |
rat |