| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wenji Xie, Wenqin Xie, Zhenming Kang, Changcheng Jiang, Naizhen Li. Hydromorphone protects CA1 neurons by activating mTOR pathway. Neuroscience letters. vol 687. 2019-03-11. PMID:30236878. |
preconditioning with hydromorphone significantly increased latency time, decreased apoptosis of hippocampal ca1 neurons and suppressed ir induced oxidative stress. |
2019-03-11 |
2023-08-13 |
mouse |
| Sherif Rashad, Kuniyasu Niizuma, Daisuke Saigusa, Xiaobo Han, Mika Sato-Maeda, Ritsumi Saito, Akira Uruno, Miki Fujimura, Shuntaro Ikawa, Masayuki Yamamoto, Teiji Tominag. Intracellular S1P Levels Dictate Fate of Different Regions of the Hippocampus following Transient Global Cerebral Ischemia. Neuroscience. vol 384. 2019-02-21. PMID:29782904. |
following transient global cerebral ischemia (tgci), only the ca1 subregion of the hippocampus undergoes apoptosis. |
2019-02-21 |
2023-08-13 |
rat |
| Yi-Ru Wang, Yi-Hui Zhang, Zhi-Yu Chen, Dong-Mei Xu, Xiang Chen, Xiao-Yan Zhang, Hai-Yan H. [Effect of Active Ingredients of Qingxin Kaiqiao Recipe on Spatial Learning and Memory Capacities, and Expressions of Bax, Bcl-2, Caspase-3, and PAPP in Hippocampus of AD Model Rats]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine. vol 37. issue 2. 2019-02-18. PMID:30650272. |
conclusion three active ingredients (spaonins, benzene, and polysaccharides) of qkr could improve spatial memory and learning capacities to different degrees, which might be possibly achieved by decreasing expressions of bax, caspase-3, papp in hippocampal ca1 region, elevating bcl-2 expression, and inhibiting apoptosis in hippocampus. |
2019-02-18 |
2023-08-13 |
rat |
| Ying-Bin Wang, Jian-Qin Xie, Wei Liu, Rong-Zhi Zhang, Sheng-Hui Huang, Yan-Hong Xin. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221701. |
apoptosis of the hippocampal ca1 region was observed by terminal deoxynucleotidyl transferase dutp nick‑end labeling staining. |
2019-01-29 |
2023-08-13 |
rat |
| Ying-Bin Wang, Jian-Qin Xie, Wei Liu, Rong-Zhi Zhang, Sheng-Hui Huang, Yan-Hong Xin. BACE1 gene silencing alleviates isoflurane anesthesia‑induced postoperative cognitive dysfunction in immature rats by activating the PI3K/Akt signaling pathway. Molecular medicine reports. vol 18. issue 5. 2019-01-29. PMID:30221701. |
furthermore, it was suggested that silencing bace1 may have promoted the activation of the pi3k/akt signaling pathway, thereby inhibiting the apoptosis of the hippocampal ca1 region. |
2019-01-29 |
2023-08-13 |
rat |
| Xiang Zhou, Yong Liu, Yang Huang, ShuiBo Zhu, Jian Zhu, RongPing Wan. Hypertonic saline infusion suppresses apoptosis of hippocampal cells in a rat model of cardiopulmonary resuscitation. Scientific reports. vol 7. issue 1. 2019-01-23. PMID:28724904. |
the apoptosis rate in hs was significantly lower than that in the ns and hes groups, suggesting hs treatment during resuscitation could effectively suppress neuronal cell apoptosis in hippocampal ca1 post-rosc and improve neuronal function. |
2019-01-23 |
2023-08-13 |
rat |
| Qin Weilan, Yan Yan, Liu Xuemei, Shen Wei, Liu Xiaohan, Ma Qingke, Wang Ying, Jin Xiangla. Effect of medicated thread moxibustion on apoptosis of hippocampal neurons in rat models of chronic cerebral ischemic vascular dementia. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 13. 2018-12-17. PMID:30403605. |
changes in related indexes such as bax, bc1-2 and c-fos of neuron apoptosis in hippocampus ca1 area were determined by immunohistochemistry, while protein expression was semi-quantitatively assayed using imaging analysis technique. |
2018-12-17 |
2023-08-13 |
rat |
| Qin Weilan, Yan Yan, Liu Xuemei, Shen Wei, Liu Xiaohan, Ma Qingke, Wang Ying, Jin Xiangla. Effect of medicated thread moxibustion on apoptosis of hippocampal neurons in rat models of chronic cerebral ischemic vascular dementia. Cellular and molecular biology (Noisy-le-Grand, France). vol 64. issue 13. 2018-12-17. PMID:30403605. |
medicated thread moxibustion alleviates hippocampal neuronal necrosis, inhibits neuron apoptosis in hippocampus ca1 area, protects nerves, and maintains relative equilibrium inbax/bcl-2 through down-regulation of c-fos and bax and up-regulation of bcl-2. |
2018-12-17 |
2023-08-13 |
rat |
| Jianguo Li, Deping Yan, Xiaoyan Liu, Ye Wang, Xin Zhao, Yu Zhang, Ce Zhan. U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors. Neurological research. vol 40. issue 4. 2018-08-20. PMID:29473447. |
u0126 protects hippocampal ca1 neurons against forebrain ischemia-induced apoptosis via the erk1/2 signaling pathway and nmda receptors. |
2018-08-20 |
2023-08-13 |
Not clear |
| Peng Wang, Yi Li, Zhengfei Yang, Tao Yu, Guanghui Zheng, Xiangshao Fang, Zitong Huang, Longyuan Jiang, Wanchun Tan. Inhibition of dynamin-related protein 1 has neuroprotective effect comparable with therapeutic hypothermia in a rat model of cardiac arrest. Translational research : the journal of laboratory and clinical medicine. vol 194. 2018-07-31. PMID:29351829. |
in addition, both drp1 inhibition and therapeutic hypothermia decreased cell injury, apoptosis in hippocampal cornu ammonis 1 region and brain mitochondrial dysfunction including adenosine triphosphate production, reactive oxygen species and mitochondrial membrane potential after cardiac arrest. |
2018-07-31 |
2023-08-13 |
rat |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
neuronal density and apoptosis were measured in the ca1 region, 72 h after i/r injury. |
2018-07-27 |
2023-08-13 |
Not clear |
| Maedeh Arabian, Nahid Aboutaleb, Mansoureh Soleimani, Marjan Ajami, Rouhollah Habibey, Yousef Rezaei, Hamidreza Pazoki-Toroud. Preconditioning with morphine protects hippocampal CA1 neurons from ischemia-reperfusion injury via activation of the mTOR pathway. Canadian journal of physiology and pharmacology. vol 96. issue 1. 2018-07-27. PMID:28881154. |
these results describe novel findings whereby chronic morphine preconditioning in hippocampal ca1 neurons is mediated by the mtor pathway, and through increased phosphorylation of mtor can alleviate oxidative stress and apoptosis, and eventually protect the hippocampus from i/r injury. |
2018-07-27 |
2023-08-13 |
Not clear |
| Takayuki Miura, Masanori Tachikawa, Hideo Ohtsuka, Koji Fukase, Shun Nakayama, Naoaki Sakata, Fuyuhiko Motoi, Takeshi Naitoh, Yu Katayose, Yasuo Uchida, Sumio Ohtsuki, Tetsuya Terasaki, Michiaki Unn. Application of Quantitative Targeted Absolute Proteomics to Profile Protein Expression Changes of Hepatic Transporters and Metabolizing Enzymes During Cholic Acid-Promoted Liver Regeneration. Journal of pharmaceutical sciences. vol 106. issue 9. 2018-04-30. PMID:28249806. |
the ca1 group showed the increased liver weight, cell proliferation index, and oxidative stress, but no increase in apoptosis. |
2018-04-30 |
2023-08-13 |
mouse |
| Yun-Hui Zhang, Jin Zhang, Jian-Nan Song, Xue Xu, Jin-Song Cai, Yang Zhou, Jin-Gui Ga. The PI3K-AKT-mTOR pathway activates recovery from general anesthesia. Oncotarget. vol 7. issue 27. 2018-01-12. PMID:27340771. |
he staining showed that anesthesia may induce cell apoptosis in rat hippocampal ca1 areas, and pi3k/akt agonists could inhibit apoptosis. |
2018-01-12 |
2023-08-13 |
rat |
| Jingquan Gao, Hongmei Wu, Yonggang Cao, Shuang Liang, Caihong Sun, Peng Wang, Ji Wang, Hongli Sun, Lijie W. Maternal DHA supplementation protects rat offspring against impairment of learning and memory following prenatal exposure to valproic acid. The Journal of nutritional biochemistry. vol 35. 2017-10-23. PMID:27469996. |
the results showed that maternal feeding of dha to the prenatal exposed to vpa (1) prevented vpa-induced learning and memory impairment but did not change social-related behavior, (2) increased total dha content in offspring plasma and hippocampus, (3) rescued vpa-induced neuronal loss and apoptosis of pyramidal cells in hippocampal ca1, (4) influenced the content of malondialdehyde and glutathione and the activities of superoxide dismutase and glutathione in the hippocampus, (5) altered levels of apoptosis-related proteins (bcl-2, bax and caspase-3) and inhibited the activity of caspase-3 in offspring hippocampus and (6) enhanced relative levels of p-camkii and p-creb proteins in the hippocampus. |
2017-10-23 |
2023-08-13 |
rat |
| Jingjing Fan, Shenquan Cai, Hao Zhong, Liangbin Cao, Kangli Hui, Miaomiao Xu, Manlin Duan, Jianguo X. Therapeutic hypothermia attenuates global cerebral reperfusion-induced mitochondrial damage by suppressing dynamin-related protein 1 activation and mitochondria-mediated apoptosis in a cardiac arrest rat model. Neuroscience letters. vol 647. 2017-10-06. PMID:28242326. |
moreover, therapeutic hypothermia could decrease the histopathological damage, inhibit the apoptosis of ca1 neurons and improve the survival and neurological outcomes at 72h after cardiac arrest. |
2017-10-06 |
2023-08-13 |
rat |
| Tao Zhang, Jianbo Gu, Liangmiao Wu, Ning Li, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhan. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. vol 118. 2017-09-05. PMID:28342896. |
tbn also attenuated the neuronal apoptosis and ameliorated accumulation of astrocytes in parietal cortex and ca1 region of hippocampus. |
2017-09-05 |
2023-08-13 |
rat |
| Xinxin Zhang, Xuanji Xue, Liang Xian, Zengjun Guo, Yoichiro Ito, Wenji Su. Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis. Steroids. vol 113. 2017-07-05. PMID:27343977. |
what's more, an apparent decrease in neuron apoptosis detected in hippocampus ca1 and cortex of the ipsilateral hemisphere might attribute to alleviate the increase in caspase-3 and bax/bcl-2 ratio. |
2017-07-05 |
2023-08-13 |
rat |
| He-Ming Min, Yan Wang, Da-Yong Ren, Xue Cheng, Jian Li, Xing-Qian Jiang, Lian-Qiu Min, Cui-Fen Ba. Protective effect of 2-deoxy-D-glucose on the brain tissue in rat cerebral ischemia-reperfusion models by inhibiting Caspase-apoptotic pathway. Histology and histopathology. vol 32. issue 1. 2017-04-14. PMID:27109833. |
nerve cell apoptosis, and the expressions of mrna and protein of glucose regulated protein 78 (grp78), cleaved-caspase-9 and cleaved-caspase-3 were determined with tunel, western blotting and rt-pcr, respectively, in rat cerebral hippocampal ca1 area at each time point. |
2017-04-14 |
2023-08-13 |
rat |
| Bo Chen, Xiaoyuan Deng, Bin Wang, Hongliang Li. Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats. The Journal of toxicological sciences. vol 41. issue 5. 2017-04-10. PMID:27665772. |
in this study, we investigated dynamic changes of neuronal apoptosis, neuronal density, synaptic density in hippocampal ca1 region and the prelimbic cortex (prl), and long-term cognitive function after multiple or single exposure of propofol in neonatal rats. |
2017-04-10 |
2023-08-13 |
rat |