| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Tao Zhang, Jianbo Gu, Liangmiao Wu, Ning Li, Yewei Sun, Pei Yu, Yuqiang Wang, Gaoxiao Zhang, Zaijun Zhan. Neuroprotective and axonal outgrowth-promoting effects of tetramethylpyrazine nitrone in chronic cerebral hypoperfusion rats and primary hippocampal neurons exposed to hypoxia. Neuropharmacology. vol 118. 2017-09-05. PMID:28342896. |
tbn also attenuated the neuronal apoptosis and ameliorated accumulation of astrocytes in parietal cortex and ca1 region of hippocampus. |
2017-09-05 |
2023-08-13 |
rat |
| Xinxin Zhang, Xuanji Xue, Liang Xian, Zengjun Guo, Yoichiro Ito, Wenji Su. Potential neuroprotection of protodioscin against cerebral ischemia-reperfusion injury in rats through intervening inflammation and apoptosis. Steroids. vol 113. 2017-07-05. PMID:27343977. |
what's more, an apparent decrease in neuron apoptosis detected in hippocampus ca1 and cortex of the ipsilateral hemisphere might attribute to alleviate the increase in caspase-3 and bax/bcl-2 ratio. |
2017-07-05 |
2023-08-13 |
rat |
| He-Ming Min, Yan Wang, Da-Yong Ren, Xue Cheng, Jian Li, Xing-Qian Jiang, Lian-Qiu Min, Cui-Fen Ba. Protective effect of 2-deoxy-D-glucose on the brain tissue in rat cerebral ischemia-reperfusion models by inhibiting Caspase-apoptotic pathway. Histology and histopathology. vol 32. issue 1. 2017-04-14. PMID:27109833. |
nerve cell apoptosis, and the expressions of mrna and protein of glucose regulated protein 78 (grp78), cleaved-caspase-9 and cleaved-caspase-3 were determined with tunel, western blotting and rt-pcr, respectively, in rat cerebral hippocampal ca1 area at each time point. |
2017-04-14 |
2023-08-13 |
rat |
| Bo Chen, Xiaoyuan Deng, Bin Wang, Hongliang Li. Persistent neuronal apoptosis and synaptic loss induced by multiple but not single exposure of propofol contribute to long-term cognitive dysfunction in neonatal rats. The Journal of toxicological sciences. vol 41. issue 5. 2017-04-10. PMID:27665772. |
in this study, we investigated dynamic changes of neuronal apoptosis, neuronal density, synaptic density in hippocampal ca1 region and the prelimbic cortex (prl), and long-term cognitive function after multiple or single exposure of propofol in neonatal rats. |
2017-04-10 |
2023-08-13 |
rat |
| Xiaochen Liu, Deyi Lu, Robert Bowser, Jian Li. Expression of Carbonic Anhydrase I in Motor Neurons and Alterations in ALS. International journal of molecular sciences. vol 17. issue 11. 2017-04-10. PMID:27809276. |
furthermore, long-term expression of ca1 in mammalian cells activates apoptosis. |
2017-04-10 |
2023-08-13 |
human |
| Xiang-Ru Wen, Man Tang, Da-Shi Qi, Xiao-Jing Huang, Hong-Zhi Liu, Fang Zhang, Jian Wu, Yi-Wen Wang, Xun-Bao Zhang, Ji-Qiang Guo, Shu-Ling Wang, Yong Liu, Yu-Lan Wang, Yuan-Jian Son. Butylphthalide Suppresses Neuronal Cells Apoptosis and Inhibits JNK-Caspase3 Signaling Pathway After Brain Ischemia /Reperfusion in Rats. Cellular and molecular neurobiology. vol 36. issue 7. 2017-03-15. PMID:27015680. |
immunohistochemical staining and western blotting were performed to examine the expression of related proteins, and tunel-staining was used to detect the percentage of neuronal apoptosis in the hippocampal ca1 region. |
2017-03-15 |
2023-08-13 |
rat |
| N Zepeda, S Solano, N Copitin, J L Chávez, A M Fernández, F García, P Tato, J L Molinar. Apoptosis of mouse hippocampal cells induced by Taenia crassiceps metacestode factor. Journal of helminthology. vol 91. issue 2. 2017-03-14. PMID:27018714. |
extensive and significant apoptosis was found in the experimental animals, mainly in the dentate gyrus, ca1, ca2, ca3 and neighbouring regions, in comparison with the apparently intact cells from control mice (p < 0.01). |
2017-03-14 |
2023-08-13 |
mouse |
| Chun-Jen Hsiao, Ching-Lung Lin, Tian-Yu Lin, Sheue-Er Wang, Chung-Hsin W. Imidacloprid toxicity impairs spatial memory of echolocation bats through neural apoptosis in hippocampal CA1 and medial entorhinal cortex areas. Neuroreport. vol 27. issue 6. 2016-12-20. PMID:26966783. |
imidacloprid toxicity impairs spatial memory of echolocation bats through neural apoptosis in hippocampal ca1 and medial entorhinal cortex areas. |
2016-12-20 |
2023-08-13 |
Not clear |
| Chun-Jen Hsiao, Ching-Lung Lin, Tian-Yu Lin, Sheue-Er Wang, Chung-Hsin W. Imidacloprid toxicity impairs spatial memory of echolocation bats through neural apoptosis in hippocampal CA1 and medial entorhinal cortex areas. Neuroreport. vol 27. issue 6. 2016-12-20. PMID:26966783. |
we further found that neural apoptosis in hippocampal ca1 and medial entorhinal cortex areas of echolocation bats that received imidacloprid treatment was significantly enhanced in comparison with echolocation bats that received sham treatment. |
2016-12-20 |
2023-08-13 |
Not clear |
| Chun-Jen Hsiao, Ching-Lung Lin, Tian-Yu Lin, Sheue-Er Wang, Chung-Hsin W. Imidacloprid toxicity impairs spatial memory of echolocation bats through neural apoptosis in hippocampal CA1 and medial entorhinal cortex areas. Neuroreport. vol 27. issue 6. 2016-12-20. PMID:26966783. |
thus, we suggest that imidacloprid toxicity may interfere with the spatial memory of echolocation bats through neural apoptosis in hippocampal ca1 and medial entorhinal cortex areas. |
2016-12-20 |
2023-08-13 |
Not clear |
| Yulong Ma, Hang Guo, Lixia Zhang, Liang Tao, Anqi Yin, Zhaoyu Liu, Yan Li, Hailong Dong, Lize Xiong, Wugang Ho. Estrogen replacement therapy-induced neuroprotection against brain ischemia-reperfusion injury involves the activation of astrocytes via estrogen receptor β. Scientific reports. vol 6. 2016-12-19. PMID:26891996. |
and 10 nm e2, dpn or e2+mpp (erα antagonist), but not ppt or e2+phtpp (erβ antagonist), significantly reduced neuronal apoptosis following the subjection of astrocyte and neuronal cocultures to ogd-r. we also found that either 50 μg/kg e2 or 8 mg/kg dpn replacement (3 weeks) significantly increased gfap expression and reduced gci-induced neuronal apoptosis in hippocampal ca1 region of ovariectomized mice. |
2016-12-19 |
2023-08-13 |
mouse |
| Guo-Hong Cui, Shui-Jin Shao, Jia-Jun Yang, Jian-Ren Liu, Hai-Dong Gu. Designer Self-Assemble Peptides Maximize the Therapeutic Benefits of Neural Stem Cell Transplantation for Alzheimer's Disease via Enhancing Neuron Differentiation and Paracrine Action. Molecular neurobiology. vol 53. issue 2. 2016-12-13. PMID:25586060. |
apoptosis levels in the ca1 region and aβ level in the hippocampus were significantly decreased in the group of nsc transplantation in dsp. |
2016-12-13 |
2023-08-13 |
rat |
| A Patricio-Martínez, L Mendieta, I Martínez, J Aguilera, I D Limó. The recombinant C-terminal fragment of tetanus toxin protects against cholinotoxicity by intraseptal injection of β-amyloid peptide (25-35) in rats. Neuroscience. vol 315. 2016-10-19. PMID:26687435. |
finally, capase-3, a marker of apoptosis, was examined in the ms. our results clearly demonstrate that the application of hc-tetx prevents the loss of cholinergic markers (chat and ache), the activation of capase-3, and neurodegeneration in the ms and the ca1 and ca3 subfields of the hippocampus. |
2016-10-19 |
2023-08-13 |
rat |
| Li Liu, Chang-jun Li, Yun Lu, Xian-gang Zong, Chao Luo, Jun Sun, Lian-jun Gu. Baclofen mediates neuroprotection on hippocampal CA1 pyramidal cells through the regulation of autophagy under chronic cerebral hypoperfusion. Scientific reports. vol 5. 2016-08-19. PMID:26412641. |
however, during chronic cerebral hypoperfusion, the changes of autophagy in the hippocampal ca1 area, the correlation between gaba receptors and autophagy, and their influences on hippocampal neuronal apoptosis have not been well established. |
2016-08-19 |
2023-08-13 |
rat |
| Yao-Chung Chuang, Jenq-Lin Yang, Ding-I Yang, Tsu-Kung Lin, Chia-Wei Liou, Shang-Der Che. Roles of Sestrin2 and Ribosomal Protein S6 in Transient Global Ischemia-Induced Hippocampal Neuronal Injury. International journal of molecular sciences. vol 16. issue 11. 2016-08-19. PMID:26556340. |
in this study, we hypothesized that sestrin2 may protect hippocampal ca1 neurons against transient global ischemia (tgi)-induced apoptosis by regulating rps6 phosphorylation in rats. |
2016-08-19 |
2023-08-13 |
rat |
| S-H Su, Y-F Wu, Q Lin, F Yu, J Ha. Cannabinoid receptor agonist WIN55,212-2 and fatty acid amide hydrolase inhibitor URB597 suppress chronic cerebral hypoperfusion-induced neuronal apoptosis by inhibiting c-Jun N-terminal kinase signaling. Neuroscience. vol 301. 2016-04-18. PMID:25795598. |
changes in neuronal number were examined by labeling neurons with an antibody against the neuronal nuclei antigen, and apoptosis of cortical and hippocampal ca1 neurons was detected by terminal deoxynucleotidyl transferase-mediated dutp-biotin nick end labeling. |
2016-04-18 |
2023-08-13 |
rat |
| N S Shcherbak, A G Rusakova, M M Galagudza, G Yu Yukina, Ye R Barantsevich, V V Thomson, Ye V Shlyakht. [CHANGE IN BCL-2 PROTEIN EXPRESSION IN NEURONS OF THE HIPPOCAMPAL AREAS AFTER THE APPLICATION OF ISCHEMIC CEREBRAL POSTCONDITIONING]. Morfologiia (Saint Petersburg, Russia). vol 148. issue 5. 2016-04-08. PMID:26987213. |
the results suggest that the cytoprotective effect of ipostc in hippocampal ca1 area is realized through a mechanism leading to increased expression of bcl-2 protein, i.e., by blocking apoptosis. |
2016-04-08 |
2023-08-13 |
Not clear |
| Shahid Ali Shah, Gwang Ho Yoon, Myeong Ok Ki. Protection of the developing brain with anthocyanins against ethanol-induced oxidative stress and neurodegeneration. Molecular neurobiology. vol 51. issue 3. 2016-03-10. PMID:24997566. |
anthocyanins also inhibited the ethanol-activated expression of phosphorylated c-jun n terminal kinase (p-jnk), phospho-nuclear factor kappa b (p-nf-κb), cyclooxygenase 2 (cox-2), as well as attenuating neuronal apoptosis in the hippocampal ca1, ca3 and dg regions of the developing rat brain. |
2016-03-10 |
2023-08-13 |
rat |
| Yang Liu, Pu Jiang, Min Du, Kun Chen, Amber Chen, Yang Wang, Fei Cao, Shixiong Deng, Ying X. Hyperoxia-induced immature brain injury through the TLR4 signaling pathway in newborn mice. Brain research. vol 1610. 2016-02-09. PMID:25801121. |
electron microscopy and terminal deoxynucleotidyl transferase-mediated biotinylated utp nick end labeling (tunel) assays showed a significant increase, compared to the wo2 mice, in neuronal apoptosis within the prefrontal cortex and hippocampal ca1 region in the wo2 mice. |
2016-02-09 |
2023-08-13 |
mouse |
| Pengcheng Huang, Cai Li, Tianli Fu, Dan Zhao, Zhen Yi, Qing Lu, Lianjun Guo, Xulin X. Flupirtine attenuates chronic restraint stress-induced cognitive deficits and hippocampal apoptosis in male mice. Behavioural brain research. vol 288. 2016-01-27. PMID:25869780. |
in addition, flupirtine (10mg/kg and 25mg/kg) treatment alleviated neuronal apoptosis and the reduction of dendritic spine density and synaptophysin expression in the hippocampal ca1 region of crs mice. |
2016-01-27 |
2023-08-13 |
mouse |