| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
because of this regulation of ef-1 alpha in various states of cell life, and its key position in protein synthesis as well as cytoskeletal organization, we chose to investigate the effect of its expression levels on apoptosis. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
investigation of the effect of altered levels of elongation factor-1 alpha on apoptosis is of particular interest since it may affect both protein synthesis and cytoskeletal organization. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
for example, reduction of ef-1 alpha leads to a reduced protein synthesis rate, which might reduce the presence of those "killer factors" triggering apoptosis. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
ef-1 alpha involvement in cytoskeletal organization is another example, since cytoskeletal organization undergoes dramatic changes during apoptosis. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
thus, this study has been planned to ascertain whether hypo- and hyperexpression of ef-1 alpha protein, achieved by constructing expression vectors with the ef-1 alpha cdna in its antisense or sense orientation under the control of a cytomegalovirus promoter, can produce stable transfectants with either heightened or reduced responsiveness to apoptosis stimuli. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
our results show the following: (1) induction of apoptosis by serum deprivation shows that antisense ef-1 alpha provides cells significant protection from apoptotic cell death and (2) ef-1 alpha overexpression causes a faster rate of cell death. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
therefore, changes in levels of ef-1 alpha may be one of the global pivotal regulators modulating the rate of apoptosis. |
1998-02-23 |
2023-08-12 |
Not clear |
| A Ortiz, C Lorz, S González-Cuadrado, R Garcia del Moral, F O'Valle, J Egid. Cytokines and Fas regulate apoptosis in murine renal interstitial fibroblasts. Journal of the American Society of Nephrology : JASN. vol 8. issue 12. 1998-02-13. PMID:9402086. |
tumor necrosis factor alpha (tnfalpha) and agonistic anti-fas antibodies induce apoptosis of renal fibroblasts in a time- and dose-dependent manner. |
1998-02-13 |
2023-08-12 |
Not clear |
| W Shao, M Fanelli, F F Ferrara, R Riccioni, A Rosenauer, K Davison, W W Lamph, S Waxman, P G Pelicci, F Lo Coco, G Avvisati, U Testa, C Peschle, C Gambacorti-Passerini, C Nervi, W H Mille. Arsenic trioxide as an inducer of apoptosis and loss of PML/RAR alpha protein in acute promyelocytic leukemia cells. Journal of the National Cancer Institute. vol 90. issue 2. 1998-02-10. PMID:9450572. |
arsenic trioxide as an inducer of apoptosis and loss of pml/rar alpha protein in acute promyelocytic leukemia cells. |
1998-02-10 |
2023-08-12 |
Not clear |
| K Mizuno, K Noda, T Araki, T Imaoka, Y Kobayashi, Y Akita, M Shimonaka, S Kishi, S Ohn. The proteolytic cleavage of protein kinase C isotypes, which generates kinase and regulatory fragments, correlates with Fas-mediated and 12-O-tetradecanoyl-phorbol-13-acetate-induced apoptosis. European journal of biochemistry. vol 250. issue 1. 1998-02-05. PMID:9431985. |
among the pkc isotypes expressed in different cell types, such as jurkat, hpb-all, u937, and hl60, all the npkc isotypes including npkcdelta, npkc epsilon, and npkctheta, but not cpkc alpha and betaii and apkczeta (n, c, and a represent novel, conventional and atypical, respectively), showed limited proteolytic cleavage during fas-mediated apoptosis. |
1998-02-05 |
2023-08-12 |
human |
| T Mizuno, Y Momoi, Y Endo, Y Nishimura, Y Goto, K Ohno, T Watari, H Tsujimoto, A Hasegaw. Apoptosis enhanced by soluble factor produced in feline immunodeficiency virus infection. The Journal of veterinary medical science. vol 59. issue 11. 1998-02-04. PMID:9409524. |
feline immunodeficiency virus (fiv)-infected cells have been shown to undergo apoptosis by treatment with tumor necrosis factor alpha (tnf-alpha). |
1998-02-04 |
2023-08-12 |
Not clear |
| C Bozzo, G Bellomo, L Silengo, G Tarone, F Altrud. Soluble integrin ligands and growth factors independently rescue neuroblastoma cells from apoptosis under nonadherent conditions. Experimental cell research. vol 237. issue 2. 1998-02-03. PMID:9434628. |
the survival promoting effect of ecm was mediated by the integrin receptors, since (1) the protective effect of soluble collagen i was blocked by anti-integrin antibodies to beta 1 and alpha 1 subunits and (2) the antibody-induced clustering of alpha 1, alpha 3, alpha v, beta 1, and beta 3 integrins rescued sk-n-be cells cultured in suspension from apoptosis. |
1998-02-03 |
2023-08-12 |
human |
| C Hermann, A M Zeiher, S Dimmele. Shear stress inhibits H2O2-induced apoptosis of human endothelial cells by modulation of the glutathione redox cycle and nitric oxide synthase. Arteriosclerosis, thrombosis, and vascular biology. vol 17. issue 12. 1998-02-03. PMID:9437209. |
similar results were obtained when apoptosis was stimulated by tumor necrosis factor alpha (tnf alpha). |
1998-02-03 |
2023-08-12 |
human |
| K Inagaki-Ohara, T Sakai, G Koya, A Awaya, Y Yoshika. A thymic hormone protects mice from enteropathy during acute graft-versus-host disease. Microbiology and immunology. vol 41. issue 11. 1998-02-03. PMID:9444331. |
the infiltration of donor-derived tcr alpha beta i-iel bearing cd8 alpha beta was significantly inhibited in the small intestine of fts-treated mice, and the frequencies of apoptosis of crypt cells in the intestinal mucosa were decreased in these mice during acute gvhd. |
1998-02-03 |
2023-08-12 |
mouse |
| T Tsuj. [Cell-biological changes on the disordered tissues]. Nihon hoigaku zasshi = The Japanese journal of legal medicine. vol 51. issue 5. 1998-02-02. PMID:9436362. |
it seems that appearance of necrosis and apoptosis is caused by action of tnf alpha derived from neutrophils, since generation of tnf alpha was confirmed electron microscopically. |
1998-02-02 |
2023-08-12 |
rat |
| R X Wang, L E Limbir. Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis. Molecular pharmacology. vol 52. issue 6. 1998-01-29. PMID:9415717. |
distribution of mrna encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2a subtype in apoptosis. |
1998-01-29 |
2023-08-12 |
mouse |
| R X Wang, L E Limbir. Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis. Molecular pharmacology. vol 52. issue 6. 1998-01-29. PMID:9415717. |
to test whether alpha 2a-ar can signal apoptotic events, the alpha 2a-ar subtype was introduced into two mouse mesenchymal cell lines, c3h/10t1/2 and nih-3t3; expression of the alpha 2a-ar correlated with accelerated apoptosis, as detected both by the tunel assay and the loss of cell viability. |
1998-01-29 |
2023-08-12 |
mouse |
| T Taniguchi, M Takata, A Ikeda, E Momotani, K Sekikaw. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Laboratory investigation; a journal of technical methods and pathology. vol 77. issue 6. 1998-01-27. PMID:9426403. |
our results indicated an important role for tnf alpha in germinal center formation and in the sepsis-induced hepatocyte apoptosis that precedes liver failure. |
1998-01-27 |
2023-08-12 |
mouse |
| J L Herrmann, A W Beham, M Sarkiss, P J Chiao, M T Rands, E M Bruckheimer, S Brisbay, T J McDonnel. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Experimental cell research. vol 237. issue 1. 1998-01-23. PMID:9417872. |
expression of two dominant-negative i kappa b alpha mutant proteins significantly enhanced tnf-alpha-induced apoptosis in control cells but not in cells expressing high levels of bcl-2 protein. |
1998-01-23 |
2023-08-12 |
Not clear |
| E Santoni-Rugiu, M R Jensen, S S Thorgeirsso. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer research. vol 58. issue 1. 1998-01-20. PMID:9426068. |
disruption of the prb/e2f pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. |
1998-01-20 |
2023-08-12 |
mouse |