| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
pmn apoptosis was detected by dna fragmentation, and ultraviolet and light microscopy, and was quantified by flow cytometry; superoxide release was measured by superoxide dismutase-inhibitable reduction of ferricytochrome c. incubation of pmn with 20 ng/ml tumor necrosis factor (tnf)alpha induced superoxide release (8.8 +/- 7.5 nmol o2-/30 min, n = 7) in normal pmn and also resulted in apoptosis within 2 h, whereas a subactivating dose of 2 ng/ml tnf alpha, which did not trigger superoxide release (3.1 +/- 1.7 nmol o2-, n = 10), did facilitate apoptosis, although to a lesser degree. |
1997-09-24 |
2023-08-12 |
Not clear |
| R Kettritz, R J Falk, J C Jennette, M L Gaid. Neutrophil superoxide release is required for spontaneous and FMLP-mediated but not for TNF alpha-mediated apoptosis. Journal of the American Society of Nephrology : JASN. vol 8. issue 7. 1997-09-24. PMID:9219158. |
pmn cultured under nonstimulating conditions underwent apoptotic cell death after 8 h. exogenous superoxide dismutase did not inhibit apoptosis induced by 20 ng/ml tnf alpha. |
1997-09-24 |
2023-08-12 |
Not clear |
| L Benassi, D Ottani, F Fantini, A Marconi, C Chiodino, A Giannetti, C Pincell. 1,25-dihydroxyvitamin D3, transforming growth factor beta1, calcium, and ultraviolet B radiation induce apoptosis in cultured human keratinocytes. The Journal of investigative dermatology. vol 109. issue 3. 1997-09-24. PMID:9284090. |
apoptosis was analyzed after stimulation with 1,25-dihydroxyvitamin d3 [1,25(oh)2d3], transforming growth factor beta1 (tgfbeta1), calcium, uvb, or tumor necrosis factor alpha (tnfalpha). |
1997-09-24 |
2023-08-12 |
human |
| V Dangles, F Féménia, V Lainé, M Berthelemy, D Le Rhun, M F Poupon, D Levy, I Schwartz-Corni. Two- and three-dimensional cell structures govern epidermal growth factor survival function in human bladder carcinoma cell lines. Cancer research. vol 57. issue 16. 1997-09-09. PMID:9269996. |
conversely, egf and transforming growth factor alpha prevented apoptosis when the same serum-starved cells were cultured as three-dimensional spheroids. |
1997-09-09 |
2023-08-12 |
human |
| P N Huynh, R M Lori. Contrasting effects of alpha- and beta-androstenediol on oncogenic myeloid cell lines in vitro. Journal of leukocyte biology. vol 62. issue 2. 1997-09-04. PMID:9261340. |
at 50 nm or above, 17 alpha aed induced apoptosis in raw cells and hl-60 as detected by transmission electron microscopy and tunel assays. |
1997-09-04 |
2023-08-12 |
human |
| J Gómez, C Martínez, B Fernández, A García, A Reboll. Ras activation leads to cell proliferation or apoptotic cell death upon interleukin-2 stimulation or lymphokine deprivation, respectively. European journal of immunology. vol 27. issue 7. 1997-08-25. PMID:9247568. |
we describe that lymphokine deprivation of the interleukin (il)-2- or il-4-dependent mouse t cell line ts1 alpha beta induces ras activation which plays a role in programmed cell death, since blocking ras activity reduces the induction of apoptosis. |
1997-08-25 |
2023-08-12 |
mouse |
| J E Saavedra, T R Billiar, D L Williams, Y M Kim, S C Watkins, L K Keefe. Targeting nitric oxide (NO) delivery in vivo. Design of a liver-selective NO donor prodrug that blocks tumor necrosis factor-alpha-induced apoptosis and toxicity in the liver. Journal of medicinal chemistry. vol 40. issue 13. 1997-08-07. PMID:9207935. |
of five cell types examined, only cultured hepatocytes metabolized o2-vinyl 1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (v-pyrro/no) to no, triggering cyclic guanosine 3',5'-monophosphate (cgmp) synthesis and protecting the hepatocytes from apoptotic cell death induced by treatment with tumor necrosis factor-alpha (tnf alpha) plus actinomycin d. in vivo, v-pyrro/no increased liver cgmp levels while minimally affecting systemic hemodynamics, protecting rats dosed with tnf alpha plus galactosamine from apoptosis and hepatotoxicity. |
1997-08-07 |
2023-08-12 |
rat |
| D R Brison, R M Schult. Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha. Biology of reproduction. vol 56. issue 5. 1997-07-28. PMID:9160705. |
apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha. |
1997-07-28 |
2023-08-12 |
mouse |
| C A Baumann, M Badamchian, A L Goldstei. Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways. Mechanisms of ageing and development. vol 94. issue 1-3. 1997-07-23. PMID:9147362. |
thymosin alpha 1 antagonizes dexamethasone and cd3-induced apoptosis of cd4+ cd8+ thymocytes through the activation of camp and protein kinase c dependent second messenger pathways. |
1997-07-23 |
2023-08-12 |
Not clear |
| C A Baumann, M Badamchian, A L Goldstei. Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways. Mechanisms of ageing and development. vol 94. issue 1-3. 1997-07-23. PMID:9147362. |
t alpha 1 treatment of thymocytes delays the production of free radicals and the subsequent consumption of glutathione, that is observed during both dex and cd3 induced apoptosis. |
1997-07-23 |
2023-08-12 |
Not clear |
| C A Baumann, M Badamchian, A L Goldstei. Thymosin alpha 1 antagonizes dexamethasone and CD3-induced apoptosis of CD4+ CD8+ thymocytes through the activation of cAMP and protein kinase C dependent second messenger pathways. Mechanisms of ageing and development. vol 94. issue 1-3. 1997-07-23. PMID:9147362. |
these data suggest that t alpha 1 exerts an influence on the development of a population of immature t-cells in the thymus by effecting the sensitivity of thymocytes to apoptosis during the pre-selection stages of thymic development. |
1997-07-23 |
2023-08-12 |
Not clear |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
recently, it was demonstrated that tumor necrosis factor alpha (tnf alpha) appears to be involved in the formation of sc since neutralization of tnf alpha both in vitro and in vivo reduced uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| A Schwarz, K Mahnke, T A Luger, T Schwar. Pentoxifylline reduces the formation of sunburn cells. Experimental dermatology. vol 6. issue 1. 1997-07-18. PMID:9067700. |
in summary, the data demonstrate that ptx can reduce the formation of sc both in vitro and in vivo and thus further support that tnf alpha is involved in uvb-induced apoptosis of keratinocytes. |
1997-07-18 |
2023-08-12 |
mouse |
| P J Fraker, W G Telfor. A reappraisal of the role of zinc in life and death decisions of cells. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.). vol 215. issue 3. 1997-07-16. PMID:9207857. |
interestingly, in attempting to determine if lower or more physiological concentrations of zinc could provide protection against apoptosis, it was found that 80-200 microm zinc could actually induce death in 40% of cd4+ cd8+ alpha beta tcr10cd3(10) thymocytes. |
1997-07-16 |
2023-08-12 |
Not clear |
| Z Szondy, U Reichert, J M Bernardon, S Michel, R Tóth, P Ancian, E Ajzner, L Fesu. Induction of apoptosis by retinoids and retinoic acid receptor gamma-selective compounds in mouse thymocytes through a novel apoptosis pathway. Molecular pharmacology. vol 51. issue 6. 1997-07-14. PMID:9187263. |
using various rar- and rxr-specific analogs and antagonists, it was demonstrated that stimulation of rar alpha inhibits the rargamma-specific death pathway (which explains the lack of apoptosis stimulatory effects of all-trans retinoic acid at physiological concentrations) and that costimulation of the rxr receptors (in the case of 9-cis retinoic acid) can neutralize this inhibitory effect. |
1997-07-14 |
2023-08-12 |
mouse |
| F Novelli, M M D'Elios, P Bernabei, L Ozmen, L Rigamonti, F Almerigogna, G Forni, G Del Pret. Expression and role in apoptosis of the alpha- and beta-chains of the IFN-gamma receptor on human Th1 and Th2 clones. Journal of immunology (Baltimore, Md. : 1950). vol 159. issue 1. 1997-07-14. PMID:9200456. |
apoptosis of both types of clones was mediated by autocrine or exogenous ifn-gamma through the up-regulation of fas-l expression, since anti-ifn-gammar alpha mab inhibited its expression on th1 and exogenous ifn-gamma increased its expression on th2. |
1997-07-14 |
2023-08-12 |
human |
| S Miscia, A Di Baldassarre, A Catald. Shift of DNA polymerase alpha nuclear distribution and activity in apoptotic human leukaemia cells. Biochemical and biophysical research communications. vol 234. issue 2. 1997-07-10. PMID:9177264. |
taken together, these results suggest that among the intracellular processes elicited by mtx-induced apoptosis in hl60 cells, the redistribution of dna polymerase alpha and the stimulation of dna polymerase beta activity might represent an extreme attempt of the cell to preserve the replicative machinery during fragmentation and chromatin margination. |
1997-07-10 |
2023-08-12 |
human |
| G S Salomons, H J Brady, M Verwijs-Janssen, J D Van Den Berg, A A Hart, H Van Den Berg, H Behrendt, K Hählen, L A Smet. The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. International journal of cancer. vol 71. issue 6. 1997-07-08. PMID:9185697. |
bcl-2 over-expression has been shown to inhibit apoptosis induced by a variety of stimuli, whereas a predominance of bax alpha to bcl-2 accelerates apoptosis upon apoptotic stimuli. |
1997-07-08 |
2023-08-12 |
Not clear |
| G S Salomons, H J Brady, M Verwijs-Janssen, J D Van Den Berg, A A Hart, H Van Den Berg, H Behrendt, K Hählen, L A Smet. The Bax alpha:Bcl-2 ratio modulates the response to dexamethasone in leukaemic cells and is highly variable in childhood acute leukaemia. International journal of cancer. vol 71. issue 6. 1997-07-08. PMID:9185697. |
results suggest that bax alpha:bcl-2, rather than bcl-2 alone is important for the survival of drug-induced apoptosis in leukemic cell lines and all. |
1997-07-08 |
2023-08-12 |
Not clear |
| M Wallén-Ohman, J W Larrick, R Carlsson, C A Borrebaec. Ligation of MHC class I induces apoptosis in human pre-B cell lines, in promyelocytic cell lines and in CD40-stimulated mature B cells. International immunology. vol 9. issue 4. 1997-07-01. PMID:9138021. |
the apoptotic response was not dependent on the epitope specificity, since other anti-mhc-i antibodies, reacting with different monomorphic determinants of the alpha chain or beta 2-microglobulin, also induced apoptosis in these cells. |
1997-07-01 |
2023-08-12 |
human |