| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R X Wang, L E Limbir. Distribution of mRNA encoding three alpha 2-adrenergic receptor subtypes in the developing mouse embryo suggests a role for the alpha 2A subtype in apoptosis. Molecular pharmacology. vol 52. issue 6. 1998-01-29. PMID:9415717. |
to test whether alpha 2a-ar can signal apoptotic events, the alpha 2a-ar subtype was introduced into two mouse mesenchymal cell lines, c3h/10t1/2 and nih-3t3; expression of the alpha 2a-ar correlated with accelerated apoptosis, as detected both by the tunel assay and the loss of cell viability. |
1998-01-29 |
2023-08-12 |
mouse |
| T Taniguchi, M Takata, A Ikeda, E Momotani, K Sekikaw. Failure of germinal center formation and impairment of response to endotoxin in tumor necrosis factor alpha-deficient mice. Laboratory investigation; a journal of technical methods and pathology. vol 77. issue 6. 1998-01-27. PMID:9426403. |
our results indicated an important role for tnf alpha in germinal center formation and in the sepsis-induced hepatocyte apoptosis that precedes liver failure. |
1998-01-27 |
2023-08-12 |
mouse |
| J L Herrmann, A W Beham, M Sarkiss, P J Chiao, M T Rands, E M Bruckheimer, S Brisbay, T J McDonnel. Bcl-2 suppresses apoptosis resulting from disruption of the NF-kappa B survival pathway. Experimental cell research. vol 237. issue 1. 1998-01-23. PMID:9417872. |
expression of two dominant-negative i kappa b alpha mutant proteins significantly enhanced tnf-alpha-induced apoptosis in control cells but not in cells expressing high levels of bcl-2 protein. |
1998-01-23 |
2023-08-12 |
Not clear |
| E Santoni-Rugiu, M R Jensen, S S Thorgeirsso. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Cancer research. vol 58. issue 1. 1998-01-20. PMID:9426068. |
disruption of the prb/e2f pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. |
1998-01-20 |
2023-08-12 |
mouse |
| K E Sullivan, C Wooten, B J Schmeckpeper, D Goldman, M A Petr. A promoter polymorphism of tumor necrosis factor alpha associated with systemic lupus erythematosus in African-Americans. Arthritis and rheumatism. vol 40. issue 12. 1998-01-14. PMID:9416858. |
the polymorphic tumor necrosis factor alpha (tnfalpha) gene encodes a cytokine involved in inflammation, angiogenesis, and apoptosis. |
1998-01-14 |
2023-08-12 |
Not clear |
| L Jia, R R Dourmashkin, A C Newland, S M Kelse. Mitochondrial ultracondensation, but not swelling, is involved in TNF alpha-induced apoptosis in human T-lymphoblastic leukaemic cells. Leukemia research. vol 21. issue 10. 1998-01-05. PMID:9403008. |
conformational alterations of mitochondria induced by tumour necrosis factor-alpha (tnf alpha), and the association with tnf alpha-induced apoptosis, were, therefore, studied in the human acute t-lymphoblastic leukaemia (t-all) cell line, ccrf-cem and its vinblastine-resistant cem/vlb100 cell line by transmission electron microscopy (tem). |
1998-01-05 |
2023-08-12 |
human |
| S Hashimoto, Y Jing, N Kawazoe, Y Masuda, S Nakajo, T Yoshida, Y Kuroiwa, K Nakay. Bufalin reduces the level of topoisomerase II in human leukemia cells and affects the cytotoxicity of anticancer drugs. Leukemia research. vol 21. issue 9. 1998-01-02. PMID:9393603. |
the results suggest that bufalin caused a marked decrease in the steady-state level of topo ii alpha mrna, which led to a decrease in the amount and activity of the enzyme and to the induction of apoptosis. |
1998-01-02 |
2023-08-12 |
human |
| J Gómez, C Martínez, M Giry, A García, A Reboll. Rho prevents apoptosis through Bcl-2 expression: implications for interleukin-2 receptor signal transduction. European journal of immunology. vol 27. issue 11. 1998-01-02. PMID:9394801. |
here we describe a rho-mediated apoptosis suppression pathway driven by bcl-2 expression in the interleukin (il)-4- or il-2-dependent murine t cell line ts1 alpha beta. |
1998-01-02 |
2023-08-12 |
Not clear |
| S L DeMeester, T G Buchman, Y Qiu, A K Jacob, K Dunnigan, R S Hotchkiss, I Karl, J P Cob. Heat shock induces IkappaB-alpha and prevents stress-induced endothelial cell apoptosis. Archives of surgery (Chicago, Ill. : 1960). vol 132. issue 12. 1998-01-02. PMID:9403531. |
to determine whether prior heat shock would attenuate endothelial cell apoptosis and whether any effect of preemptive heat shock is mediated through a nuclear factor kappa b and inhibitor kappa b alpha mechanism. |
1998-01-02 |
2023-08-12 |
Not clear |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
tumour necrosis factor alpha (tnf alpha) suppresses apoptosis and induces dna synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
evidence suggests that the suppression of apoptosis by pps is mediated via activation of the peroxisome proliferator activated receptor-alpha (ppar alpha), a member of the nuclear hormone receptor superfamily. |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
rat recombinant tnf alpha was found to stimulate dna synthesis and suppress apoptosis in isolated rat hepatocyte monolayers (p < or = 0.01). |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
suppression of mouse hepatocyte apoptosis by tnf alpha was not detected, possibly because of the low levels of apoptosis under control conditions. |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
however, when the levels of mouse hepatocyte apoptosis were augmented using tgf beta1, tnf alpha caused a significant suppression (p < or = 0.01). |
1997-12-30 |
2023-08-12 |
mouse |
| M Rolfe, N H James, R A Robert. Tumour necrosis factor alpha (TNF alpha) suppresses apoptosis and induces DNA synthesis in rodent hepatocytes: a mediator of the hepatocarcinogenicity of peroxisome proliferators? Carcinogenesis. vol 18. issue 11. 1997-12-30. PMID:9395232. |
the neutralization of tnf alpha using anti-tnf alpha antibodies abrogated significantly (p < or = 0.01) the suppression of apoptosis by the pp, nafenopin. |
1997-12-30 |
2023-08-12 |
mouse |
| D J DeGracia, J M Sullivan, R W Neumar, S S Alousi, K R Hikade, J E Pittman, B C White, J A Rafols, G S Kraus. Effect of brain ischemia and reperfusion on the localization of phosphorylated eukaryotic initiation factor 2 alpha. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 17. issue 12. 1997-12-30. PMID:9397028. |
immunohistochemistry shows localization of eif-2(alpha p) to astrocytes in normal brains, a massive increase in eif-2(alpha p) in the cytoplasm of neurons within the first 10 minutes of reperfusion, accumulation of eif-2(alpha p) in the nuclei of selectively vulnerable neurons after 1 hour of reperfusion, and morphology suggesting pyknosis or apoptosis in neuronal nuclei that continue to display eif-2(alpha p) after 4 hours of reperfusion. |
1997-12-30 |
2023-08-12 |
rat |
| P Bellosta, Q Zhang, S P Goff, C Basilic. Signaling through the ARK tyrosine kinase receptor protects from apoptosis in the absence of growth stimulation. Oncogene. vol 15. issue 20. 1997-12-29. PMID:9395235. |
interestingly ark signaling protects from apoptosis induced by serum deprivation, myc overexpression, or by tnf alpha but not from u.v. |
1997-12-29 |
2023-08-12 |
mouse |
| C D Albright, R Liu, M H Mar, O H Shin, A S Vrablic, R I Salganik, S H Zeise. Diet, apoptosis, and carcinogenesis. Advances in experimental medicine and biology. vol 422. 1997-12-23. PMID:9361818. |
control (70 microm choline) and adapted cells, but not acutely deficient hepatocytes, could be induced to undergo apoptosis by neutralization of secreted tgf alpha. |
1997-12-23 |
2023-08-12 |
mouse |
| A Kumar, M Commane, T W Flickinger, C M Horvath, G R Star. Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science (New York, N.Y.). vol 278. issue 5343. 1997-12-18. PMID:9374464. |
as a consequence, stat1-null cells are resistant to apoptosis by tumor necrosis factor alpha (tnf-alpha). |
1997-12-18 |
2023-08-12 |
human |
| P Vito, T Ghayur, L D'Adami. Generation of anti-apoptotic presenilin-2 polypeptides by alternative transcription, proteolysis, and caspase-3 cleavage. The Journal of biological chemistry. vol 272. issue 45. 1997-12-12. PMID:9353287. |
we find that ps2s protects transfected cells from fas- and tumor necrosis factor alpha (tnfalpha)-induced apoptosis. |
1997-12-12 |
2023-08-12 |
Not clear |