| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| L Shen, R I Glaze. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochemical pharmacology. vol 55. issue 10. 1998-07-02. PMID:9634008. |
increased protein kinase c(alpha) (pkc(alpha)) expression in glioblastoma cells is associated with proliferation and resistance to drug-induced apoptosis by an undefined anti-apoptotic pathway. |
1998-07-02 |
2023-08-12 |
Not clear |
| L Shen, R I Glaze. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochemical pharmacology. vol 55. issue 10. 1998-07-02. PMID:9634008. |
to clarify the role of pkc in apoptosis, we have investigated the effect of the selective pkc inhibitor ro 31-8220 (3-[1-[3-(amidinothio)propyl]-3-indolyl]-4-(1-methyl-3-indolyl)-1h -pyrrole-2,5-dione methanesulfonate) in two glioblastoma cell lines whose proliferation is dependent on high levels of pkc(alpha). |
1998-07-02 |
2023-08-12 |
Not clear |
| L Shen, R I Glaze. Induction of apoptosis in glioblastoma cells by inhibition of protein kinase C and its association with the rapid accumulation of p53 and induction of the insulin-like growth factor-1-binding protein-3. Biochemical pharmacology. vol 55. issue 10. 1998-07-02. PMID:9634008. |
these results suggest that pkc(alpha) suppresses apoptosis in glioblastoma cells primarily by restricting the accumulation of p53 and the expression of insulin-like growth factor-1-binding protein, as well as by maintaining rb in an inactive hyperphosphorylated state. |
1998-07-02 |
2023-08-12 |
Not clear |
| A V Alesenko, A S Solov'ev, A A Terent'ev, A V Khreno. [The role of sphingomyelin cycle products in development of apoptosis mediated by Fas receptors and tumor necrosis factor alpha]. Izvestiia Akademii nauk. Seriia biologicheskaia. issue 2. 1998-06-30. PMID:9609949. |
[the role of sphingomyelin cycle products in development of apoptosis mediated by fas receptors and tumor necrosis factor alpha]. |
1998-06-30 |
2023-08-12 |
Not clear |
| I Jeremias, C Kupatt, B Baumann, I Herr, T Wirth, K M Debati. Inhibition of nuclear factor kappaB activation attenuates apoptosis resistance in lymphoid cells. Blood. vol 91. issue 12. 1998-06-30. PMID:9616159. |
death-inducing ligands (dils) such as tumor necrosis factor alpha (tnfalpha) or the cytotoxic drug doxorubicin have been shown to activate a nuclear factor kappab (nfkappab)-dependent program that may rescue cells from apoptosis induction. |
1998-06-30 |
2023-08-12 |
Not clear |
| T Takehara, N Hayashi, E Mita, T Kanto, T Tatsumi, Y Sasaki, A Kasahara, M Hor. Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of TNF alpha. Hepatology (Baltimore, Md.). vol 27. issue 6. 1998-06-30. PMID:9620338. |
delayed fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of tnf alpha. |
1998-06-30 |
2023-08-12 |
mouse |
| T Takehara, N Hayashi, E Mita, T Kanto, T Tatsumi, Y Sasaki, A Kasahara, M Hor. Delayed Fas-mediated hepatocyte apoptosis during liver regeneration in mice: hepatoprotective role of TNF alpha. Hepatology (Baltimore, Md.). vol 27. issue 6. 1998-06-30. PMID:9620338. |
these results indicate that fas-signaling events at the level or upstream of caspase-3-like protease are suppressed during liver regeneration, resulting in delayed hepatocyte apoptosis, and also that tnf alpha acts as one of the protective factors against fas-mediated hepatocyte apoptosis. |
1998-06-30 |
2023-08-12 |
mouse |
| K B Seydel, S L Stanle. Entamoeba histolytica induces host cell death in amebic liver abscess by a non-Fas-dependent, non-tumor necrosis factor alpha-dependent pathway of apoptosis. Infection and immunity. vol 66. issue 6. 1998-06-25. PMID:9596776. |
by studying infection in c57/bl6.lpr and c57/bl6.gld mice, we found that e. histolytica-induced apoptosis does not require the fas/fas ligand pathway of apoptosis, and by using mice with a targeted deletion of the tumor necrosis factor receptor i gene, we have shown that e. histolytica-induced apoptosis is not mediated by tumor necrosis factor alpha. |
1998-06-25 |
2023-08-12 |
mouse |
| O Williams, R Tarazona, A Wack, N Harker, K Roderick, D Kioussi. Interactions with multiple peptide ligands determine the fate of developing thymocytes. Proceedings of the National Academy of Sciences of the United States of America. vol 95. issue 10. 1998-06-19. PMID:9576948. |
we have previously shown that apoptosis of thymocytes from an alpha beta tcr-transgenic mouse (f5), induced by antigenic peptide, can be inhibited specifically by an antagonist peptide variant in an in vitro culture model. |
1998-06-19 |
2023-08-12 |
mouse |
| M Garzotto, M White-Jones, Y Jiang, D Ehleiter, W C Liao, A Haimovitz-Friedman, Z Fuks, R Kolesnic. 12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase. Cancer research. vol 58. issue 10. 1998-06-10. PMID:9605775. |
recent investigations showed that activation of pkc alpha by 12-o-tetradecanoylphorbol 13-acetate (tpa) induced apoptosis in lncap prostate cancer cells. |
1998-06-10 |
2023-08-12 |
Not clear |
| W Wuttke, L Pitzel, I Knoke, K Theiling, H Jarr. Immune-endocrine interactions affecting luteal function in pigs. Journal of reproduction and fertility. Supplement. vol 52. 1998-06-09. PMID:9602717. |
furthermore, tnf alpha stimulates programmed cell death (apoptosis) in luteal cells kept under culture conditions. |
1998-06-09 |
2023-08-12 |
Not clear |
| S Llanos, C Caelles, I Azorín, J Renau-Piqueras, J L Fernández-Luna, L Boscá, A Muño. The c-erbA alpha protooncogene induces apoptosis in glial cells via a protein kinase C- and bcl-2-suppressible mechanism. Journal of neurochemistry. vol 70. issue 6. 1998-06-05. PMID:9603196. |
the c-erba alpha protooncogene induces apoptosis in glial cells via a protein kinase c- and bcl-2-suppressible mechanism. |
1998-06-05 |
2023-08-12 |
Not clear |
| R D Whelan, P J Parke. Loss of protein kinase C function induces an apoptotic response. Oncogene. vol 16. issue 15. 1998-05-28. PMID:9591777. |
this relationship is shown to be causal in cos cells where expression of dominant negative pkc alpha is shown to induce apoptosis. |
1998-05-28 |
2023-08-12 |
Not clear |
| C DeLuca, H Kwon, N Pelletier, M A Wainberg, J Hiscot. NF-kappaB protects HIV-1-infected myeloid cells from apoptosis. Virology. vol 244. issue 1. 1998-05-22. PMID:9581775. |
the protective role of nf-kappab in blocking tnfalpha- and hiv-1-induced apoptosis was supported by studies in jurkat t cells engineered to express ikappab alpha repressor mutants (td-ikappab) under the control of a tetracycline-responsive promoter. |
1998-05-22 |
2023-08-12 |
Not clear |
| Z Chen, Z Y Wang, S J Che. Acute promyelocytic leukemia: cellular and molecular basis of differentiation and apoptosis. Pharmacology & therapeutics. vol 76. issue 1-3. 1998-05-21. PMID:9535176. |
these studies lead to a model in which pml-rar alpha could be the target of both atra differentiation therapy and as2o3 apoptosis therapy. |
1998-05-21 |
2023-08-12 |
human |
| J H Bauer, K D Liu, Y You, S Y Lai, M A Goldsmit. Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. The Journal of biological chemistry. vol 273. issue 15. 1998-05-14. PMID:9535918. |
heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to stat activation and prevention of apoptosis. |
1998-05-14 |
2023-08-12 |
Not clear |
| A K Yi, A M Krie. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 3. 1998-05-14. PMID:9570540. |
cpg dna rescue from anti-igm-induced wehi-231 b lymphoma apoptosis via modulation of i kappa b alpha and i kappa b beta and sustained activation of nuclear factor-kappa b/c-rel. |
1998-05-14 |
2023-08-12 |
Not clear |
| A K Yi, A M Krie. CpG DNA rescue from anti-IgM-induced WEHI-231 B lymphoma apoptosis via modulation of I kappa B alpha and I kappa B beta and sustained activation of nuclear factor-kappa B/c-Rel. Journal of immunology (Baltimore, Md. : 1950). vol 160. issue 3. 1998-05-14. PMID:9570540. |
these results indicate that cpg dna-mediated sustained activation of nfkappab depends on the degradation of ikappab alpha and ikappab beta and is required for the cpg dna-mediated anti-apoptosis gene expression and the protection against anti-igm-induced apoptosis of wehi-231 cells. |
1998-05-14 |
2023-08-12 |
Not clear |
| K Ruckdeschel, S Harb, A Roggenkamp, M Hornef, R Zumbihl, S Köhler, J Heesemann, B Rouo. Yersinia enterocolitica impairs activation of transcription factor NF-kappaB: involvement in the induction of programmed cell death and in the suppression of the macrophage tumor necrosis factor alpha production. The Journal of experimental medicine. vol 187. issue 7. 1998-05-08. PMID:9529323. |
analysis of different y. enterocolitica mutants revealed a striking correlation between the abilities of these strains to inhibit nf-kappab and to suppress the tumor necrosis factor alpha (tnf-alpha) production as well as to trigger macrophage apoptosis. |
1998-05-08 |
2023-08-12 |
Not clear |
| I Blasko, T L Schmitt, E Steiner, K Trieb, B Grubeck-Loebenstei. Tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. Neuroscience letters. vol 238. issue 1-2. 1998-05-04. PMID:9464644. |
tumor necrosis factor alpha augments amyloid beta protein (25-35) induced apoptosis in human cells. |
1998-05-04 |
2023-08-12 |
human |