| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| R Kinscherf, R Claus, M Wagner, C Gehrke, H Kamencic, D Hou, O Nauen, W Schmiedt, G Kovacs, J Pill, J Metz, H P Deigne. Apoptosis caused by oxidized LDL is manganese superoxide dismutase and p53 dependent. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 12. issue 6. 1998-04-17. PMID:9535218. |
we found that induction of apoptosis in mphi by oxldl, c2-ceramide, tumor necrosis factor alpha (tnf-alpha), and hydrogen peroxide (h2o2) was associated with enhanced expression of manganese superoxide dismutase (mnsod) and p53. |
1998-04-17 |
2023-08-12 |
human |
| E V Maytin, J F Habene. Transcription factors C/EBP alpha, C/EBP beta, and CHOP (Gadd153) expressed during the differentiation program of keratinocytes in vitro and in vivo. The Journal of investigative dermatology. vol 110. issue 3. 1998-04-16. PMID:9506442. |
balb/mk keratinocytes incubated in 0.12 mm calcium medium undergo a differentiation program featuring growth-arrest at 24-48 h, keratin k10 gene expression beginning at 24 h, and apoptosis commencing at 48 h. within this framework, western immunoblot analysis and immunohistochemistry reveal that c/ebp alpha increases 5-fold at 1-2 d and remains elevated, c/ebp beta rises 2-fold at 2-4 d and gradually falls, and chop rises 9-fold in the first 24 h then returns rapidly to baseline. |
1998-04-16 |
2023-08-12 |
mouse |
| F F Isik, N S Gibran, Y C Jang, L Sandell, S M Schwart. Vitronectin decreases microvascular endothelial cell apoptosis. Journal of cellular physiology. vol 175. issue 2. 1998-04-16. PMID:9525473. |
though our data confirm that vitronectin may bind to more than one integrin receptor to reduce mec apoptosis, binding to the alpha(v) component appears to be the critical integrin subcomponent for reducing apoptosis. |
1998-04-16 |
2023-08-12 |
human |
| W Meikrantz, M A Bergom, A Memisoglu, L Samso. O6-alkylguanine DNA lesions trigger apoptosis. Carcinogenesis. vol 19. issue 2. 1998-03-24. PMID:9498291. |
o6alkg repair had no effect on apoptosis induced by tumor necrosis factor alpha or by gamma-irradiation. |
1998-03-24 |
2023-08-12 |
Not clear |
| R Nowack, L F Flores-Suárez, F J van der Woud. New developments in pathogenesis of systemic vasculitis. Current opinion in rheumatology. vol 10. issue 1. 1998-03-19. PMID:9448984. |
reports on hereditary alpha 1-antitrypsin deficiency, the link between systemic vasculitis and human leukocyte antigen molecules, and an animal model of spontaneous granulomatous arteritis in mice with a hereditary deficit in fas-mediated apoptosis, are some of the new data that strongly favor genetic predisposition. |
1998-03-19 |
2023-08-12 |
mouse |
| B Holzmann, U Gosslar, M Bittne. alpha 4 integrins and tumor metastasis. Current topics in microbiology and immunology. vol 231. 1998-03-16. PMID:9479864. |
however, as was documented for murine lymphoma cells alpha 4 integrins may also inhibit tumor cell growth either by inducing apoptosis or by reducing the proliferation rate. |
1998-03-16 |
2023-08-12 |
human |
| L Conti, G Rainaldi, P Matarrese, B Varano, R Rivabene, S Columba, A Sato, F Belardelli, W Malorni, S Gessan. The HIV-1 vpr protein acts as a negative regulator of apoptosis in a human lymphoblastoid T cell line: possible implications for the pathogenesis of AIDS. The Journal of experimental medicine. vol 187. issue 3. 1998-03-13. PMID:9449720. |
treatment of control clones with apoptotic stimuli (i.e., cycloheximide/tumor necrosis factor alpha (tnf-alpha), anti-fas antibody, or serum starvation) resulted in a massive cell death by apoptosis. |
1998-03-13 |
2023-08-12 |
human |
| K M Akmal, J M Dufour, M Vo, S Higginson, K H Ki. Ligand-dependent regulation of retinoic acid receptor alpha in rat testis: in vivo response to depletion and repletion of vitamin A. Endocrinology. vol 139. issue 3. 1998-03-12. PMID:9492059. |
these results indicate that rar alpha is either down-regulated or inactivated in ra-deficient testis and coincident with that, testes degenerate by apoptosis or selective loss of germ cells. |
1998-03-12 |
2023-08-12 |
rat |
| E Z Tchilian, J J Owen, E J Jenkinso. Anti-alpha 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells. Immunology. vol 92. issue 3. 1998-03-09. PMID:9486103. |
we have shown that an antibody (9c10) to the alpha 4 integrin induces apoptosis in murine immature cd4+ cd8+ thymocytes and in activated (but not resting) mature lymph node t cells. |
1998-03-09 |
2023-08-12 |
Not clear |
| E Z Tchilian, J J Owen, E J Jenkinso. Anti-alpha 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells. Immunology. vol 92. issue 3. 1998-03-09. PMID:9486103. |
in both cases, apoptosis is blocked by the highly selective protein kinase c (pkc) inhibitor ro31.8425, suggesting that 9c10 induces signalling through the alpha 4 integrin resulting in pkc activation leading to apoptosis. |
1998-03-09 |
2023-08-12 |
Not clear |
| E Z Tchilian, J J Owen, E J Jenkinso. Anti-alpha 4 integrin antibody induces apoptosis in murine thymocytes and staphylococcal enterotoxin B-activated lymph node T cells. Immunology. vol 92. issue 3. 1998-03-09. PMID:9486103. |
overall, our results indicate the potential role of the alpha 4 integrin-mediated interactions in apoptosis induction during t-cell development and following mature t-cell activation. |
1998-03-09 |
2023-08-12 |
Not clear |
| R Kettritz, M L Gaido, H Haller, F C Luft, C J Jennette, R J Fal. Interleukin-8 delays spontaneous and tumor necrosis factor-alpha-mediated apoptosis of human neutrophils. Kidney international. vol 53. issue 1. 1998-03-05. PMID:9453003. |
both il-8 and gro alpha attenuated apoptosis, although il-8 was more effective than gro alpha. |
1998-03-05 |
2023-08-12 |
human |
| S P Srivastava, K U Kumar, R J Kaufma. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. The Journal of biological chemistry. vol 273. issue 4. 1998-03-03. PMID:9442091. |
expression of a trans-dominant negative, catalytically inactive mutant pkr protected nih3t3 cells from apoptosis in response to either treatment with tumor necrosis factor alpha (tnf alpha), serum deprivation. |
1998-03-03 |
2023-08-12 |
Not clear |
| S P Srivastava, K U Kumar, R J Kaufma. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. The Journal of biological chemistry. vol 273. issue 4. 1998-03-03. PMID:9442091. |
tnf alpha-induced apoptosis correlated with increased phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (eif-2 alpha), the primary physiological substrate of the pkr. |
1998-03-03 |
2023-08-12 |
Not clear |
| S P Srivastava, K U Kumar, R J Kaufma. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. The Journal of biological chemistry. vol 273. issue 4. 1998-03-03. PMID:9442091. |
furthermore, forced expression of a nonphosphorylatable s51a mutant eif-2 alpha partially protected cells from tnf alpha-induced apoptosis, and expression of a s51d mutant eif-2 alpha, a mutant that mimics phosphorylated eif-2 alpha, was sufficient to induce apoptosis. |
1998-03-03 |
2023-08-12 |
Not clear |
| S P Srivastava, K U Kumar, R J Kaufma. Phosphorylation of eukaryotic translation initiation factor 2 mediates apoptosis in response to activation of the double-stranded RNA-dependent protein kinase. The Journal of biological chemistry. vol 273. issue 4. 1998-03-03. PMID:9442091. |
taken together, these studies identify a novel requirement for pkr in stress-induced apoptosis that is mediated through eif-2 alpha phosphorylation. |
1998-03-03 |
2023-08-12 |
Not clear |
| R A Roberts, N H James, N J Woodyatt, N Macdonald, J D Tugwoo. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis. vol 19. issue 1. 1998-02-27. PMID:9472691. |
evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (ppar alpha). |
1998-02-27 |
2023-08-12 |
human |
| R A Roberts, N H James, N J Woodyatt, N Macdonald, J D Tugwoo. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis. vol 19. issue 1. 1998-02-27. PMID:9472691. |
here, we investigate whether activation of ppar alpha mediates the suppression of rat hepatocyte apoptosis induced by pps. |
1998-02-27 |
2023-08-12 |
human |
| R A Roberts, N H James, N J Woodyatt, N Macdonald, J D Tugwoo. Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis. vol 19. issue 1. 1998-02-27. PMID:9472691. |
when introduced into primary rat liver cell cultures by transient transfection, hppar alpha-6/29 prevented the suppression of hepatocyte apoptosis by the pp nafenopin, but not that seen in response to phenobarbitone (pb), a nongenotoxic carcinogen whose action does not involve ppar alpha. |
1998-02-27 |
2023-08-12 |
human |
| A Duttaroy, D Bourbeau, X L Wang, E Wan. Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. Experimental cell research. vol 238. issue 1. 1998-02-23. PMID:9457069. |
apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. |
1998-02-23 |
2023-08-12 |
Not clear |