| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| M Dahmoun, T Bäckström, K Boman, S Cajande. Apoptosis, proliferation, and hormone receptors in endometrial carcinoma: results depending on methods of analysis. International journal of oncology. vol 22. issue 1. 2003-06-16. PMID:12469193. |
apoptosis and proliferation were studied in 29 endometrial adenocarcinomas of the endometrioid type and characterized by the immunohisto-chemical pattern of estrogen receptor (er) alpha and progesterone receptor (pr) expression. |
2003-06-16 |
2023-08-12 |
Not clear |
| Alexandra G Evstafieva, George A Belov, Yuri P Rubtsov, Markus Kalkum, Bertrand Joseph, Nina V Chichkova, Elena A Sukhacheva, Alexey A Bogdanov, Ralf F Pettersson, Vadim I Agol, Andrey B Vartapetia. Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha. Experimental cell research. vol 284. issue 2. 2003-06-16. PMID:12651154. |
we demonstrate also that ectopic production of human prothymosin alpha and its mutants with nuclear or nuclear-cytoplasmic localization confers increased resistance of hela cells toward the tumor necrosis factor-induced apoptosis. |
2003-06-16 |
2023-08-12 |
human |
| X-F Le, C R Varela, R C Bas. Heregulin-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 7. issue 6. 2003-06-13. PMID:12370490. |
the signaling molecules and pathways that regulate hrg-induced apoptosis, including the p38, jnk, mtor kinase, and pkc alpha kinase. |
2003-06-13 |
2023-08-12 |
Not clear |
| R Graf, M Freyberg, D Kaiser, P Fried. Mechanosensitive induction of apoptosis in fibroblasts is regulated by thrombospondin-1 and integrin associated protein (CD47). Apoptosis : an international journal on programmed cell death. vol 7. issue 6. 2003-06-13. PMID:12370491. |
under the influence of mechanical loading, the cells show little apoptosis whereas releasing of tension leads to an increase up to tenfold during the first 24 h and remains constant for further 48 h. an autocrine loop of the integrin alpha(v)beta(3)/cd47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis: the integrin alpha(v)beta(3) is expressed under mechanical loading as well as unloading whereas the cd47 could only be identified after the release of tension. |
2003-06-13 |
2023-08-12 |
Not clear |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
we have recently reported that the constitutive expression of hif-1 alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and glucose deprivation. |
2003-06-12 |
2023-08-12 |
mouse |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
we then established dominant-negative hif-1 alpha (dnhif-1 alpha) transfectants and examined their susceptibility to apoptosis and growth inhibition induced by hypoxia and glucose deprivation in vitro and their tumorigenicity in scid mice. |
2003-06-12 |
2023-08-12 |
mouse |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
as a result, dnhif-1 alpha rendered the pancreatic cancer cells sensitive to apoptosis and growth inhibition induced by hypoxia and glucose deprivation. |
2003-06-12 |
2023-08-12 |
mouse |
| Yan Xiang Guo, Ting Wei, Klara Dallmann, Jimmy Kwan. Induction of caspase-dependent apoptosis by betanodaviruses GGNNV and demonstration of protein alpha as an apoptosis inducer. Virology. vol 308. issue 1. 2003-06-09. PMID:12706091. |
induction of caspase-dependent apoptosis by betanodaviruses ggnnv and demonstration of protein alpha as an apoptosis inducer. |
2003-06-09 |
2023-08-12 |
Not clear |
| Christine Chao, Jihan Youssef, Mohammad Rezaiekhaleigh, Linda S Birnbaum, Mostafa Bad. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha. Mechanisms of ageing and development. vol 123. issue 11. 2003-05-29. PMID:12425954. |
however, as a heterodimer with retinoid x receptor alpha (rxr alpha), ppar alpha regulates transcription of genes involved in oxidative stress, cell proliferation and apoptosis. |
2003-05-29 |
2023-08-12 |
rat |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
in 293 cell clones, in which pp2c alpha expression is regulated by a tetracycline-inducible promoter, pp2c alpha overexpression led to g(2)/m cell cycle arrest and apoptosis. |
2003-05-22 |
2023-08-12 |
human |
| Phoebe Lin, Richard D Y. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12586833. |
rescue from g2a-induced apoptosis was achieved by co-expression of a g alpha(12/13)-specific inhibitor, p115rgs (regulator of g protein signaling), in combination with 2',5'-dideoxyadenosine treatment. |
2003-05-22 |
2023-08-12 |
Not clear |
| Phoebe Lin, Richard D Y. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12586833. |
these results demonstrate the ability of g2a to activate a specific combination of g proteins, and that g2a/lpc-induced apoptosis involves both g alpha(13)- and g alpha(s)-mediated pathways. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
protein kinase c alpha and zeta regulate nitric oxide-induced nf-kappa b activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
no-induced apoptosis and dedifferentiation are mediated by p38 kinase activity and p38 kinase-independent and -dependent inhibition of protein kinase c (pkc)alpha and zeta. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
taken together, our results indicate that no-induced inhibition of pkc alpha and zeta activity is required for the nf-kappa b activity that regulates apoptosis and cox-2 expression but not dedifferentiation in articular chondrocytes. |
2003-05-22 |
2023-08-12 |
Not clear |
| Wen-Shu Wu, Zhi-Xiang Xu, Walter N Hittelman, Paolo Salomoni, Pier Paolo Pandolfi, Kun-Sang Chan. Promyelocytic leukemia protein sensitizes tumor necrosis factor alpha-induced apoptosis by inhibiting the NF-kappaB survival pathway. The Journal of biological chemistry. vol 278. issue 14. 2003-05-19. PMID:12540841. |
in this study we found that ectopic expression of pml potentiates cell death by apoptosis in the tumor necrosis factor alpha (tnfalpha)-resistant cell line u2os and other cell lines. |
2003-05-19 |
2023-08-12 |
mouse |
| Naoki Murai, Kiyohito Nagai, Hideyuki Fujisawa, Ko Hatanaka, Michiko Kawamura, Yoshiteru Harad. Concurrent evolution and resolution in an acute inflammatory model of rat carrageenin-induced pleurisy. Journal of leukocyte biology. vol 73. issue 4. 2003-05-15. PMID:12660220. |
the characteristic ladder pattern of neutrophil dna was observed from 5 h. tumor necrosis factor alpha was detectable on the start, and the levels of interleukin-10 and transforming growth factor-beta1 rose together with signs of neutrophil apoptosis and the following ingestion by mononuclear leukocytes. |
2003-05-15 |
2023-08-12 |
rat |
| Sung-Yu Hong, Hyeryung Lee, Weon-Kyoo You, Kwang-Hoe Chung, Doo-Sik Kim, Kiwon Son. The snake venom disintegrin salmosin induces apoptosis by disassembly of focal adhesions in bovine capillary endothelial cells. Biochemical and biophysical research communications. vol 302. issue 3. 2003-05-13. PMID:12615062. |
these observations strongly suggest that salmosin disorganizes focal contacts to detach cells by competing with the extracellular matrix (ecm) for direct binding to integrin alpha(v)beta(3) on the cell surface, eventually leading to apoptosis. |
2003-05-13 |
2023-08-12 |
cattle |
| D Gibellini, M C Re, F Vitone, N Rizzo, C Maldini, M La Placa, G Zaul. Selective up-regulation of functional CXCR4 expression in erythroid cells by HIV-1 Tat protein. Clinical and experimental immunology. vol 131. issue 3. 2003-05-09. PMID:12605695. |
moreover, addition of sdf-1 alpha (200 ng/ml) induced a significant higher rate of apoptosis in tat-treated erythroid cells in comparison with control cells. |
2003-05-09 |
2023-08-12 |
Not clear |
| Roger M Lori. Immune up-regulation and tumor apoptosis by androstene steroids. Steroids. vol 67. issue 12. 2003-05-07. PMID:12398992. |
in contrast, 17 alpha androstenediol inhibits proliferation and mediates apoptosis in tumor cells of murine and human origin. |
2003-05-07 |
2023-08-12 |
human |