| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Miho Ueda, Satoshi Kokura, Eiko Imamoto, Yuji Naito, Osamu Handa, Tomohisa Takagi, Norimasa Yoshida, Toshikazu Yoshikaw. Blocking of NF-kappaB activation enhances the tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line. Cancer letters. vol 193. issue 2. 2003-06-27. PMID:12706875. |
this study investigated the mechanism by which human gastric cancer cells (mkn45) are resistant to apoptosis induced by tumor necrosis factor alpha (tnf-alpha). |
2003-06-27 |
2023-08-12 |
human |
| J V Partin, I E Anglin, N Kypriano. Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction. British journal of cancer. vol 88. issue 10. 2003-06-26. PMID:12771931. |
quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via tgf-beta signalling and i kappa b alpha induction. |
2003-06-26 |
2023-08-12 |
human |
| J V Partin, I E Anglin, N Kypriano. Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction. British journal of cancer. vol 88. issue 10. 2003-06-26. PMID:12771931. |
previous studies documented the ability of quinazoline-based alpha1-adrenoceptor antagonists to induce apoptosis in prostate cancer cells via an alpha 1-adrenoceptor-independent mechanism. |
2003-06-26 |
2023-08-12 |
human |
| J V Partin, I E Anglin, N Kypriano. Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction. British journal of cancer. vol 88. issue 10. 2003-06-26. PMID:12771931. |
these findings suggest that the quinazoline-based doxazosin mediates prostate cancer apoptosis by initially inducing the expression of tgf-beta1 signalling effectors and subsequently i kappa b alpha. |
2003-06-26 |
2023-08-12 |
human |
| Scott D Kobayashi, Jovanka M Voyich, Kevin R Braughton, Frank R DeLe. Down-regulation of proinflammatory capacity during apoptosis in human polymorphonuclear leukocytes. Journal of immunology (Baltimore, Md. : 1950). vol 170. issue 6. 2003-06-25. PMID:12626596. |
we used flow cytometry to confirm that il-8r beta (cxcr2) and il-1 alpha were significantly down-regulated during pmn apoptosis. |
2003-06-25 |
2023-08-12 |
human |
| M Dahmoun, T Bäckström, K Boman, S Cajande. Apoptosis, proliferation, and hormone receptors in endometrial carcinoma: results depending on methods of analysis. International journal of oncology. vol 22. issue 1. 2003-06-16. PMID:12469193. |
apoptosis and proliferation were studied in 29 endometrial adenocarcinomas of the endometrioid type and characterized by the immunohisto-chemical pattern of estrogen receptor (er) alpha and progesterone receptor (pr) expression. |
2003-06-16 |
2023-08-12 |
Not clear |
| Alexandra G Evstafieva, George A Belov, Yuri P Rubtsov, Markus Kalkum, Bertrand Joseph, Nina V Chichkova, Elena A Sukhacheva, Alexey A Bogdanov, Ralf F Pettersson, Vadim I Agol, Andrey B Vartapetia. Apoptosis-related fragmentation, translocation, and properties of human prothymosin alpha. Experimental cell research. vol 284. issue 2. 2003-06-16. PMID:12651154. |
we demonstrate also that ectopic production of human prothymosin alpha and its mutants with nuclear or nuclear-cytoplasmic localization confers increased resistance of hela cells toward the tumor necrosis factor-induced apoptosis. |
2003-06-16 |
2023-08-12 |
human |
| X-F Le, C R Varela, R C Bas. Heregulin-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 7. issue 6. 2003-06-13. PMID:12370490. |
the signaling molecules and pathways that regulate hrg-induced apoptosis, including the p38, jnk, mtor kinase, and pkc alpha kinase. |
2003-06-13 |
2023-08-12 |
Not clear |
| R Graf, M Freyberg, D Kaiser, P Fried. Mechanosensitive induction of apoptosis in fibroblasts is regulated by thrombospondin-1 and integrin associated protein (CD47). Apoptosis : an international journal on programmed cell death. vol 7. issue 6. 2003-06-13. PMID:12370491. |
under the influence of mechanical loading, the cells show little apoptosis whereas releasing of tension leads to an increase up to tenfold during the first 24 h and remains constant for further 48 h. an autocrine loop of the integrin alpha(v)beta(3)/cd47 receptor complex and thrombospondin-1 is identified as the molecular coupling device between mechanical loading and apoptosis: the integrin alpha(v)beta(3) is expressed under mechanical loading as well as unloading whereas the cd47 could only be identified after the release of tension. |
2003-06-13 |
2023-08-12 |
Not clear |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
we have recently reported that the constitutive expression of hif-1 alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and glucose deprivation. |
2003-06-12 |
2023-08-12 |
mouse |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
we then established dominant-negative hif-1 alpha (dnhif-1 alpha) transfectants and examined their susceptibility to apoptosis and growth inhibition induced by hypoxia and glucose deprivation in vitro and their tumorigenicity in scid mice. |
2003-06-12 |
2023-08-12 |
mouse |
| Jian Chen, Songji Zhao, Kunihiro Nakada, Yuji Kuge, Nagara Tamaki, Futoshi Okada, Jingxin Wang, Masanobu Shindo, Fumihiro Higashino, Kohji Takeda, Masahiro Asaka, Hiroyuki Katoh, Toshio Sugiyama, Masuo Hosokawa, Masanobu Kobayash. Dominant-negative hypoxia-inducible factor-1 alpha reduces tumorigenicity of pancreatic cancer cells through the suppression of glucose metabolism. The American journal of pathology. vol 162. issue 4. 2003-06-12. PMID:12651620. |
as a result, dnhif-1 alpha rendered the pancreatic cancer cells sensitive to apoptosis and growth inhibition induced by hypoxia and glucose deprivation. |
2003-06-12 |
2023-08-12 |
mouse |
| Yan Xiang Guo, Ting Wei, Klara Dallmann, Jimmy Kwan. Induction of caspase-dependent apoptosis by betanodaviruses GGNNV and demonstration of protein alpha as an apoptosis inducer. Virology. vol 308. issue 1. 2003-06-09. PMID:12706091. |
induction of caspase-dependent apoptosis by betanodaviruses ggnnv and demonstration of protein alpha as an apoptosis inducer. |
2003-06-09 |
2023-08-12 |
Not clear |
| Christine Chao, Jihan Youssef, Mohammad Rezaiekhaleigh, Linda S Birnbaum, Mostafa Bad. Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha. Mechanisms of ageing and development. vol 123. issue 11. 2003-05-29. PMID:12425954. |
however, as a heterodimer with retinoid x receptor alpha (rxr alpha), ppar alpha regulates transcription of genes involved in oxidative stress, cell proliferation and apoptosis. |
2003-05-29 |
2023-08-12 |
rat |
| Paula Ofek, Daniella Ben-Meir, Zehavit Kariv-Inbal, Moshe Oren, Sara Lav. Cell cycle regulation and p53 activation by protein phosphatase 2C alpha. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12514180. |
in 293 cell clones, in which pp2c alpha expression is regulated by a tetracycline-inducible promoter, pp2c alpha overexpression led to g(2)/m cell cycle arrest and apoptosis. |
2003-05-22 |
2023-08-12 |
human |
| Phoebe Lin, Richard D Y. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12586833. |
rescue from g2a-induced apoptosis was achieved by co-expression of a g alpha(12/13)-specific inhibitor, p115rgs (regulator of g protein signaling), in combination with 2',5'-dideoxyadenosine treatment. |
2003-05-22 |
2023-08-12 |
Not clear |
| Phoebe Lin, Richard D Y. The lysophospholipid receptor G2A activates a specific combination of G proteins and promotes apoptosis. The Journal of biological chemistry. vol 278. issue 16. 2003-05-22. PMID:12586833. |
these results demonstrate the ability of g2a to activate a specific combination of g proteins, and that g2a/lpc-induced apoptosis involves both g alpha(13)- and g alpha(s)-mediated pathways. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
protein kinase c alpha and zeta regulate nitric oxide-induced nf-kappa b activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
no-induced apoptosis and dedifferentiation are mediated by p38 kinase activity and p38 kinase-independent and -dependent inhibition of protein kinase c (pkc)alpha and zeta. |
2003-05-22 |
2023-08-12 |
Not clear |
| Song-Ja Kim, Jang-Soo Chu. Protein kinase C alpha and zeta regulate nitric oxide-induced NF-kappa B activation that mediates cyclooxygenase-2 expression and apoptosis but not dedifferentiation in articular chondrocytes. Biochemical and biophysical research communications. vol 303. issue 1. 2003-05-22. PMID:12646188. |
taken together, our results indicate that no-induced inhibition of pkc alpha and zeta activity is required for the nf-kappa b activity that regulates apoptosis and cox-2 expression but not dedifferentiation in articular chondrocytes. |
2003-05-22 |
2023-08-12 |
Not clear |