| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Vyacheslav A Adarichev, Rita Vaiskunaite, Jiaxin Niu, Irina V Balyasnikova, Tatyana A Voyno-Yasenetskay. G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity. American journal of physiology. Cell physiology. vol 285. issue 4. 2003-10-23. PMID:12736137. |
here, we analyzed which signaling pathways are required for g alpha 13-induced mitogenesis or apoptosis using a novel mutant of g alpha 13. |
2003-10-23 |
2023-08-12 |
human |
| Vyacheslav A Adarichev, Rita Vaiskunaite, Jiaxin Niu, Irina V Balyasnikova, Tatyana A Voyno-Yasenetskay. G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity. American journal of physiology. Cell physiology. vol 285. issue 4. 2003-10-23. PMID:12736137. |
we found that g alpha 13-t lost its ability to promote proliferation and transformation but retained its ability to induce apoptosis. |
2003-10-23 |
2023-08-12 |
human |
| Vyacheslav A Adarichev, Rita Vaiskunaite, Jiaxin Niu, Irina V Balyasnikova, Tatyana A Voyno-Yasenetskay. G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity. American journal of physiology. Cell physiology. vol 285. issue 4. 2003-10-23. PMID:12736137. |
importantly, truncated g alpha 13 retained its ability to stimulate apoptosis signal-regulated kinase ask1 and c-jun terminal kinase, jnk. |
2003-10-23 |
2023-08-12 |
human |
| Vyacheslav A Adarichev, Rita Vaiskunaite, Jiaxin Niu, Irina V Balyasnikova, Tatyana A Voyno-Yasenetskay. G alpha 13-mediated transformation and apoptosis are permissively dependent on basal ERK activity. American journal of physiology. Cell physiology. vol 285. issue 4. 2003-10-23. PMID:12736137. |
interestingly, the apoptosis induced by g alpha 13-t was inhibited by dominant-negative ask1 or by sb-203580. |
2003-10-23 |
2023-08-12 |
human |
| Dwayne M Baxa, Fayth K Yoshimur. Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha. Biochemical pharmacology. vol 66. issue 6. 2003-10-16. PMID:12963487. |
generation of the repressive activity of delta i kappa b alpha on nf-kappa b is a novel mechanism for the reduction of this transcription factor by genistein and the possible effect this may have on the ability of genistein to induce apoptosis in tumor cells. |
2003-10-16 |
2023-08-12 |
Not clear |
| Stephan F Schlosser, Markus Schuler, Christoph P Berg, Kirsten Lauber, Klaus Schulze-Osthoff, Friedrich Wilhelm Schmahl, Sebastian Wesselbor. Ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. Antimicrobial agents and chemotherapy. vol 47. issue 6. 2003-10-07. PMID:12760867. |
ribavirin and alpha interferon enhance death receptor-mediated apoptosis and caspase activation in human hepatoma cells. |
2003-10-07 |
2023-08-12 |
human |
| Yuichi Tanaka, M Veronica Gavrielides, Yasuhiro Mitsuuchi, Teruhiko Fujii, Marcelo G Kazaniet. Protein kinase C promotes apoptosis in LNCaP prostate cancer cells through activation of p38 MAPK and inhibition of the Akt survival pathway. The Journal of biological chemistry. vol 278. issue 36. 2003-10-07. PMID:12824193. |
activation of protein kinase c (pkc) by phorbol esters or diacylglycerol mimetics induces apoptosis in androgen-dependent prostate cancer cells, an effect that involves both the activation of the classic pkc alpha and the novel pkc delta isozymes (fujii, t., garcía-bermejo, m. l., bernabó, j. l., caamaño, j., ohba, m., kuroki, t., li, l., yuspa, s. h., and kazanietz, m. g. (2000) j. biol. |
2003-10-07 |
2023-08-12 |
Not clear |
| Amnon Zisman, Allan J Pantuck, Matthew H T Bui, Jonathan W Said, Randy R Caliliw, Nagesh Rao, Peter Shintaku, Frank Berger, Sanjiv S Gambhir, Arie S Belldegru. LABAZ1: A metastatic tumor model for renal cell carcinoma expressing the carbonic anhydrase type 9 tumor antigen. Cancer research. vol 63. issue 16. 2003-09-24. PMID:12941820. |
subsequent xenograft generations have conserved immunohistochemical and ultrastructural properties typical for malignant renal epithelium-derived neoplasia (vimentin+, ck-19+, ca ix+ with hypoxia-inducible factor (hif)-1 alpha constitutive expression) and have demonstrated extensive proliferation, lack of apoptosis, severe genetic alterations, and molecular expression alterations; transforming growth factor beta 1 (tgf-beta 1), hepatocyte growth factor (hgf), proto-oncogene (c-met), matrix metalloproteinase (mmp)-1, and vascular endothelial growth factor (vegf) c and d were overexpressed, whereas human epidermal growth factor receptor (her)-2, mmp-2 and mmp-9, vegf-r3, p53, and p27 were severely down-regulated, suggesting a proangiogenic environment, local invasiveness, and facilitated lymphatic metastasis. |
2003-09-24 |
2023-08-12 |
mouse |
| Rosario Cambronero, Carmen Cámara, Eduardo López-Granados, Antonio Ferreira, Gumersindo Fontán, M Cruz García Rodrígue. [Autoimmune lymphoproliferative syndrome: molecular diagnosis in two families]. Medicina clinica. vol 120. issue 16. 2003-09-23. PMID:12732128. |
the autoimmune lymphoproliferative syndrome (alps) is a disorder caused by a defect in lymphocytes' apoptosis and characterized by non malignant lymphoproliferation, autoimmune features and increased tcr alpha + cd4cd8 cells. |
2003-09-23 |
2023-08-12 |
Not clear |
| E Ierardi, A Di Leo, M Barone, S Marangi, O Burattini, A Panarese, M Margiotta, R Francavilla, C Panella, A Francavilla, R Cuom. Tumor necrosis factor alpha and apoptosis in Helicobacter pylori related progressive gastric damage: a possible mechanism of immune system involvement in epithelial turnover regulation. Immunopharmacology and immunotoxicology. vol 25. issue 2. 2003-09-08. PMID:12784913. |
tumor necrosis factor alpha and apoptosis in helicobacter pylori related progressive gastric damage: a possible mechanism of immune system involvement in epithelial turnover regulation. |
2003-09-08 |
2023-08-12 |
human |
| E Ierardi, A Di Leo, M Barone, S Marangi, O Burattini, A Panarese, M Margiotta, R Francavilla, C Panella, A Francavilla, R Cuom. Tumor necrosis factor alpha and apoptosis in Helicobacter pylori related progressive gastric damage: a possible mechanism of immune system involvement in epithelial turnover regulation. Immunopharmacology and immunotoxicology. vol 25. issue 2. 2003-09-08. PMID:12784913. |
helicobacter pylori (hp) related inflammation is mediated by tumour necrosis factor alpha (tnfalpha), which "in vitro" increases epithelial apoptosis in response to infection. |
2003-09-08 |
2023-08-12 |
human |
| J A Menéndez, I Mehmi, D W Griggs, R Lup. The angiogenic factor CYR61 in breast cancer: molecular pathology and therapeutic perspectives. Endocrine-related cancer. vol 10. issue 2. 2003-09-04. PMID:12790776. |
moreover, we describe experimental evidence that establishes a novel role for cyr61 determining the protection of human breast cancer cells against chemotherapy-induced apoptosis through its interactions with the integrin receptor alpha(v)beta(3). |
2003-09-04 |
2023-08-12 |
human |
| Arti Shukla, Maria Stern, Karen M Lounsbury, Trisha Flanders, Brooke T Mossma. Asbestos-induced apoptosis is protein kinase C delta-dependent. American journal of respiratory cell and molecular biology. vol 29. issue 2. 2003-09-03. PMID:12626342. |
asbestos-induced apoptosis also was inhibited in cells stably expressing a dominant-negative kinase-deficient mutant of pkc delta (dnpkc delta), but not dnpkc alpha. |
2003-09-03 |
2023-08-12 |
Not clear |
| Wendy F Ochoa, Alejandro Torrecillas, Ignacio Fita, Nuria Verdaguer, Senena Corbalán-García, Juan C Gomez-Fernande. Retinoic acid binds to the C2-domain of protein kinase C(alpha). Biochemistry. vol 42. issue 29. 2003-09-03. PMID:12873138. |
protein kinase c(alpha) (pkc(alpha)) is a key enzyme regulating the physiology of cells and their growth, differentiation, and apoptosis. |
2003-09-03 |
2023-08-12 |
Not clear |
| Ikuo Inoue, Kenji Hayashi, Fumiharu Yagasaki, Koh-ichi Nakamura, Toshiyuki Matsunaga, Haiyuan Xu, Koh-ichi Inukai, Takuya Awata, Tsugikazu Komoda, Shigehiro Katayam. Apoptosis of endothelial cells may be mediated by genes of peroxisome proliferator-activated receptor gamma 1 (PPARgamma 1) and PPARalpha genes. Journal of atherosclerosis and thrombosis. vol 10. issue 2. 2003-08-29. PMID:12740484. |
apoptosis in human umbilical vein endothelial cells (huvecs) was prevented by transfection with the gene for the human full-length peroxisome proliferator-activated receptor alpha (pparalpha), or acyl-coenzyme a synthetase (acylcs) into huvecs. |
2003-08-29 |
2023-08-12 |
human |
| Arnaud Parcellier, Elise Schmitt, Sandeep Gurbuxani, Daphné Seigneurin-Berny, Alena Pance, Aurélie Chantôme, Stéphanie Plenchette, Saadi Khochbin, Eric Solary, Carmen Garrid. HSP27 is a ubiquitin-binding protein involved in I-kappaBalpha proteasomal degradation. Molecular and cellular biology. vol 23. issue 16. 2003-08-29. PMID:12897149. |
hsp27 is an atp-independent chaperone that confers protection against apoptosis through various mechanisms, including a direct interaction with cytochrome c. here we show that hsp27 overexpression in various cell types enhances the degradation of ubiquitinated proteins by the 26s proteasome in response to stressful stimuli, such as etoposide or tumor necrosis factor alpha (tnf-alpha). |
2003-08-29 |
2023-08-12 |
Not clear |
| Tom J M Smeets, Maarten C Kraan, Marieke E van Loon, Paul-Peter Ta. Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis and rheumatism. vol 48. issue 8. 2003-08-29. PMID:12905468. |
tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. |
2003-08-29 |
2023-08-12 |
Not clear |
| Tom J M Smeets, Maarten C Kraan, Marieke E van Loon, Paul-Peter Ta. Tumor necrosis factor alpha blockade reduces the synovial cell infiltrate early after initiation of treatment, but apparently not by induction of apoptosis in synovial tissue. Arthritis and rheumatism. vol 48. issue 8. 2003-08-29. PMID:12905468. |
to determine whether treatment with the chimeric anti-tumor necrosis factor alpha antibody infliximab could reduce cellularity by the induction of apoptosis in synovial tissue. |
2003-08-29 |
2023-08-12 |
Not clear |
| Yoshio Honma, Yuki Ishii, Yuri Yamamoto-Yamaguchi, Takeshi Sassa, Ken-ichi Asah. Cotylenin A, a differentiation-inducing agent, and IFN-alpha cooperatively induce apoptosis and have an antitumor effect on human non-small cell lung carcinoma cells in nude mice. Cancer research. vol 63. issue 13. 2003-08-25. PMID:12839956. |
neutralizing antibody to trail inhibited apoptosis, suggesting that cotylenin a and ifn alpha cooperatively induced apoptosis through the trail signaling system. |
2003-08-25 |
2023-08-12 |
mouse |
| Michelle Emily Weisfelner, Alice B Gottlie. The role of apoptosis in human epidermal keratinocytes. Journal of drugs in dermatology : JDD. vol 2. issue 4. 2003-08-19. PMID:12884460. |
both the passive and active apoptosis, including the tnf alpha and fas-mediated pathways are highlighted, with regards to utilization in normal human epidermal turnover. |
2003-08-19 |
2023-08-12 |
human |