| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Adrian A Lobito, Marcela F Lopes, Michael J Lenard. Ectopic T cell receptor expression causes B cell immunodeficiency in transgenic mice. European journal of immunology. vol 34. issue 3. 2004-03-25. PMID:14991619. |
we now show data suggesting that this defect is due to the expression and accumulation of tcr alpha and beta chains inside b cells and induction of an endoplasmic reticulum stress response, causing apoptosis at the pre b-i and later b cell stage. |
2004-03-25 |
2023-08-12 |
mouse |
| Elizabeth J Horn, Amador Albor, Yuangang Liu, Sally El-Hizawi, Gretchen E Vanderbeek, Melissa Babcock, G Tim Bowden, Henry Hennings, Guillermina Lozano, Wendy C Weinberg, Molly Kulesz-Marti. RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Carcinogenesis. vol 25. issue 2. 2004-03-17. PMID:14578165. |
however, transduced trim32 inhibited the synergistic effect of tumor necrosis factor alpha (tnfalpha) on uvb-induced apoptosis of keratinocytes in vitro and the apoptotic response of keratinocyte grafts exposed to uvb-light in vivo. |
2004-03-17 |
2023-08-12 |
mouse |
| Vladimir Vukicevic, Katja Kampfinger, Helga Stoppe. Influence of altered apoptosis in human lymphoblastoid cell lines on micronucleus frequency. Toxicology letters. vol 147. issue 2. 2004-03-16. PMID:14757322. |
apoptosis was reduced by the addition of pifithrin (pft) alpha and enhanced by transient transfection with bcl-2 antisense-oligonucleotide in bcl-2-overexpressing cells. |
2004-03-16 |
2023-08-12 |
human |
| Zhiyan Wang, Kazuhiro Tamura, Mikihiro Yoshie, Hiroshi Tamura, Kazuhiko Imakawa, Hiroshi Kog. Prostaglandin F2alpha-induced functional regression of the corpus luteum and apoptosis in rodents. Journal of pharmacological sciences. vol 92. issue 1. 2004-03-11. PMID:12832851. |
we investigated the relationship between prostaglandin (pg) f(2)(alpha)-induced functional luteal regression and apoptosis in the rodent ovary. |
2004-03-11 |
2023-08-12 |
mouse |
| Magdalena Rechnio, Bogumiła Litwińsk. Differences in inhibition of apoptosis depending on the virulence of used herpes simplex virus type 1 strains. Function of interferon alpha in apoptotic death of virus infected cells. Acta microbiologica Polonica. vol 52. issue 3. 2004-03-04. PMID:14743979. |
all strains of hsv-1 didn't inhibit apoptosis in the presence of ifn alpha and apoptosis was inhibited by anti ifn alpha antibodies. |
2004-03-04 |
2023-08-12 |
mouse |
| James D Firth, Edward E Putnin. Keratinocyte growth factor 1 inhibits wound edge epithelial cell apoptosis in vitro. The Journal of investigative dermatology. vol 122. issue 1. 2004-03-04. PMID:14962112. |
tumor necrosis factor alpha (1-5 ng per ml) or escherichia coli lipopolysaccharide (10-50 ng per ml) exacerbated scrape-induced early apoptosis (1-4 h), but was largely ameliorated by coculture with keratinocyte growth factor 1. |
2004-03-04 |
2023-08-12 |
Not clear |
| Ya-Ching Hsieh, Hsiao-Ching Jao, Rei-Cheng Yang, Hseng-Kuang Hsu, Chin Hs. Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. Shock (Augusta, Ga.). vol 19. issue 6. 2004-02-24. PMID:12785016. |
inactivation of protein kinase c (pkc)alpha plays an important role in modulating hepatic failure and/or apoptosis during sepsis. |
2004-02-24 |
2023-08-12 |
rat |
| Tomohide Mukogawa, Fumikazu Koyama, Masaaki Tachibana, Atsushi Takayanagi, Nobuyoshi Shimizu, Hisao Fujii, Masato Ueno, Hiroshi Matsumoto, Taku Takeuchi, Yoshiyuki Nakajim. Adenovirus-mediated gene transduction of truncated I kappa B alpha enhances radiosensitivity in human colon cancer cells. Cancer science. vol 94. issue 8. 2004-02-24. PMID:12901803. |
furthermore, it was demonstrated that apoptosis was increased by adenovirus-mediated gene transduction of i kappa b alpha delta n in vitro and in vivo. |
2004-02-24 |
2023-08-12 |
mouse |
| Motoaki Imose, Masahito Nagaki, Takafumi Naiki, Yosuke Osawa, David A Brenner, Takahiko Asano, Hideki Hayashi, Tomohiro Kato, Hisataka Moriwak. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver international : official journal of the International Association for the Study of the Liver. vol 23. issue 5. 2004-02-23. PMID:14708901. |
inhibition of nuclear factor kappab and phosphatidylinositol 3-kinase/akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. |
2004-02-23 |
2023-08-12 |
mouse |
| Manjari Mohan, Tarvinder K Taneja, Sudhir Sahdev, Krishnaveni Mohareer, Rasheedunnisa Begum, Mohammad Athar, Nand K Sah, Seyed E Hasnai. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell biology international. vol 27. issue 6. 2004-02-19. PMID:12798776. |
the inhibitory effect of different antioxidants including scavengers of oxygen radicals such as butylated hydroxyanisole (bha), alpha tocopherol acetate, benzoate and reduced-glutathione (gsh) on ultra violet b (uvb)-induced apoptosis in cultured sf9 cells was assessed. |
2004-02-19 |
2023-08-12 |
Not clear |
| Manjari Mohan, Tarvinder K Taneja, Sudhir Sahdev, Krishnaveni Mohareer, Rasheedunnisa Begum, Mohammad Athar, Nand K Sah, Seyed E Hasnai. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell biology international. vol 27. issue 6. 2004-02-19. PMID:12798776. |
both, cytochrome c release as well as sf-caspase-1 activation was inhibited by pre-treatment with antioxidants such as bha and alpha tocopherol acetate, suggesting that these antioxidants inhibit apoptosis by acting quite upstream in the apoptosis cascade at the mitochondrial level, as well as downstream at the caspase level. |
2004-02-19 |
2023-08-12 |
Not clear |
| Sarah J Welsh, Garth Powi. Hypoxia inducible factor as a cancer drug target. Current cancer drug targets. vol 3. issue 6. 2004-02-10. PMID:14683498. |
hif-1 consists of an oxygen regulated alpha subunit and a constitutively expressed beta subunit, which bind and translocate to the nucleus to activate transcription of a range of genes involved in increasing glycolysis, inhibition of apoptosis and promotion of angiogenesis and metastasis. |
2004-02-10 |
2023-08-12 |
human |
| Fei Chen, Vince Castranova, Zhiwei Li, Michael Karin, Xianglin Sh. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer research. vol 63. issue 22. 2004-02-09. PMID:14633691. |
by using wild-type and ikkbeta gene knockout (ikkbeta(-/-)) mouse embryo fibroblasts, we found that ikkbeta deficiency results in prolongation of arsenic-induced jnk activation, which was not due to the decreased expression of gadd45beta or x-linked inhibitor of apoptosis (xiap), as suggested previously for rela(-/-) cells treated with tumor necrosis factor alpha. |
2004-02-09 |
2023-08-12 |
mouse |
| Noboru Yamaguchi, Chie Kubo, Yoshikazu Masuhiro, Edward T Lally, Toshihiko Koga, Shigemasa Hanazaw. Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. Infection and immunity. vol 72. issue 1. 2004-02-02. PMID:14688105. |
tumor necrosis factor alpha enhances actinobacillus actinomycetemcomitans leukotoxin-induced hl-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. |
2004-02-02 |
2023-08-12 |
human |
| Noboru Yamaguchi, Chie Kubo, Yoshikazu Masuhiro, Edward T Lally, Toshihiko Koga, Shigemasa Hanazaw. Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. Infection and immunity. vol 72. issue 1. 2004-02-02. PMID:14688105. |
of the cytokines tested, tumor necrosis factor alpha (tnf-alpha) significantly enhanced the ltx-induced cell apoptosis. |
2004-02-02 |
2023-08-12 |
human |
| Douglas M Yau, Nobuhiko Yokoyama, Yoshio Goshima, Zeba K Siddiqui, Shahid S Siddiqui, Tohru Kozas. Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 25. 2004-01-23. PMID:14657363. |
g alpha 12/13-mediated pathways have been shown to be involved in various fundamental cellular functions in mammalian cells such as axonal guidance, apoptosis, and chemotaxis. |
2004-01-23 |
2023-08-12 |
caenorhabditis_elegans |
| William J Murdoch, Michelle L Gottsc. Proteolytic mechanisms in the ovulatory folliculo-luteal transformation. Connective tissue research. vol 44. issue 1. 2004-01-22. PMID:12945804. |
tumor necrosis factor alpha progressively induces matrix metalloproteinase gene expression, apoptosis, and inflammatory necrosis. |
2004-01-22 |
2023-08-12 |
Not clear |
| Paolo Monti, Biagio Eugenio Leone, Federica Marchesi, Gianpaolo Balzano, Alessandro Zerbi, Francesca Scaltrini, Claudio Pasquali, Giliola Calori, Francesca Pessi, Cosimo Sperti, Valerio Di Carlo, Paola Allavena, Lorenzo Piemont. The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity. Cancer research. vol 63. issue 21. 2004-01-16. PMID:14612545. |
moreover, other proinflammatory cytokines such as tumor necrosis factor alpha and ifn-gamma appeared able to induce apoptosis and to reduce the proliferative rate of pancreatic cancer. |
2004-01-16 |
2023-08-12 |
human |
| Carmen C Solorzano, Rosa Hwang, Cheryl H Baker, Corazon D Bucana, Peter W Pisters, Douglas B Evans, Jerald J Killion, Isaiah J Fidle. Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 5. 2004-01-12. PMID:12738744. |
administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. |
2004-01-12 |
2023-08-12 |
mouse |
| Kwang-Hyun Cho, Sung-Young Shin, Hyeon-Woo Lee, Olaf Wolkenhaue. Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome research. vol 13. issue 11. 2004-01-12. PMID:14559780. |
tumor necrosis factor alpha (tnfalpha) is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation, and apoptosis. |
2004-01-12 |
2023-08-12 |
Not clear |