| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ya-Ching Hsieh, Hsiao-Ching Jao, Rei-Cheng Yang, Hseng-Kuang Hsu, Chin Hs. Suppression of protein kinase Calpha triggers apoptosis through down-regulation of Bcl-xL in a rat hepatic epithelial cell line. Shock (Augusta, Ga.). vol 19. issue 6. 2004-02-24. PMID:12785016. |
inactivation of protein kinase c (pkc)alpha plays an important role in modulating hepatic failure and/or apoptosis during sepsis. |
2004-02-24 |
2023-08-12 |
rat |
| Tomohide Mukogawa, Fumikazu Koyama, Masaaki Tachibana, Atsushi Takayanagi, Nobuyoshi Shimizu, Hisao Fujii, Masato Ueno, Hiroshi Matsumoto, Taku Takeuchi, Yoshiyuki Nakajim. Adenovirus-mediated gene transduction of truncated I kappa B alpha enhances radiosensitivity in human colon cancer cells. Cancer science. vol 94. issue 8. 2004-02-24. PMID:12901803. |
furthermore, it was demonstrated that apoptosis was increased by adenovirus-mediated gene transduction of i kappa b alpha delta n in vitro and in vivo. |
2004-02-24 |
2023-08-12 |
mouse |
| Motoaki Imose, Masahito Nagaki, Takafumi Naiki, Yosuke Osawa, David A Brenner, Takahiko Asano, Hideki Hayashi, Tomohiro Kato, Hisataka Moriwak. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Liver international : official journal of the International Association for the Study of the Liver. vol 23. issue 5. 2004-02-23. PMID:14708901. |
inhibition of nuclear factor kappab and phosphatidylinositol 3-kinase/akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. |
2004-02-23 |
2023-08-12 |
mouse |
| Manjari Mohan, Tarvinder K Taneja, Sudhir Sahdev, Krishnaveni Mohareer, Rasheedunnisa Begum, Mohammad Athar, Nand K Sah, Seyed E Hasnai. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell biology international. vol 27. issue 6. 2004-02-19. PMID:12798776. |
the inhibitory effect of different antioxidants including scavengers of oxygen radicals such as butylated hydroxyanisole (bha), alpha tocopherol acetate, benzoate and reduced-glutathione (gsh) on ultra violet b (uvb)-induced apoptosis in cultured sf9 cells was assessed. |
2004-02-19 |
2023-08-12 |
Not clear |
| Manjari Mohan, Tarvinder K Taneja, Sudhir Sahdev, Krishnaveni Mohareer, Rasheedunnisa Begum, Mohammad Athar, Nand K Sah, Seyed E Hasnai. Antioxidants prevent UV-induced apoptosis by inhibiting mitochondrial cytochrome c release and caspase activation in Spodoptera frugiperda (Sf9) cells. Cell biology international. vol 27. issue 6. 2004-02-19. PMID:12798776. |
both, cytochrome c release as well as sf-caspase-1 activation was inhibited by pre-treatment with antioxidants such as bha and alpha tocopherol acetate, suggesting that these antioxidants inhibit apoptosis by acting quite upstream in the apoptosis cascade at the mitochondrial level, as well as downstream at the caspase level. |
2004-02-19 |
2023-08-12 |
Not clear |
| Sarah J Welsh, Garth Powi. Hypoxia inducible factor as a cancer drug target. Current cancer drug targets. vol 3. issue 6. 2004-02-10. PMID:14683498. |
hif-1 consists of an oxygen regulated alpha subunit and a constitutively expressed beta subunit, which bind and translocate to the nucleus to activate transcription of a range of genes involved in increasing glycolysis, inhibition of apoptosis and promotion of angiogenesis and metastasis. |
2004-02-10 |
2023-08-12 |
human |
| Fei Chen, Vince Castranova, Zhiwei Li, Michael Karin, Xianglin Sh. Inhibitor of nuclear factor kappaB kinase deficiency enhances oxidative stress and prolongs c-Jun NH2-terminal kinase activation induced by arsenic. Cancer research. vol 63. issue 22. 2004-02-09. PMID:14633691. |
by using wild-type and ikkbeta gene knockout (ikkbeta(-/-)) mouse embryo fibroblasts, we found that ikkbeta deficiency results in prolongation of arsenic-induced jnk activation, which was not due to the decreased expression of gadd45beta or x-linked inhibitor of apoptosis (xiap), as suggested previously for rela(-/-) cells treated with tumor necrosis factor alpha. |
2004-02-09 |
2023-08-12 |
mouse |
| Noboru Yamaguchi, Chie Kubo, Yoshikazu Masuhiro, Edward T Lally, Toshihiko Koga, Shigemasa Hanazaw. Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. Infection and immunity. vol 72. issue 1. 2004-02-02. PMID:14688105. |
tumor necrosis factor alpha enhances actinobacillus actinomycetemcomitans leukotoxin-induced hl-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. |
2004-02-02 |
2023-08-12 |
human |
| Noboru Yamaguchi, Chie Kubo, Yoshikazu Masuhiro, Edward T Lally, Toshihiko Koga, Shigemasa Hanazaw. Tumor necrosis factor alpha enhances Actinobacillus actinomycetemcomitans leukotoxin-induced HL-60 cell apoptosis by stimulating lymphocyte function-associated antigen 1 expression. Infection and immunity. vol 72. issue 1. 2004-02-02. PMID:14688105. |
of the cytokines tested, tumor necrosis factor alpha (tnf-alpha) significantly enhanced the ltx-induced cell apoptosis. |
2004-02-02 |
2023-08-12 |
human |
| Douglas M Yau, Nobuhiko Yokoyama, Yoshio Goshima, Zeba K Siddiqui, Shahid S Siddiqui, Tohru Kozas. Identification and molecular characterization of the G alpha12-Rho guanine nucleotide exchange factor pathway in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 25. 2004-01-23. PMID:14657363. |
g alpha 12/13-mediated pathways have been shown to be involved in various fundamental cellular functions in mammalian cells such as axonal guidance, apoptosis, and chemotaxis. |
2004-01-23 |
2023-08-12 |
caenorhabditis_elegans |
| William J Murdoch, Michelle L Gottsc. Proteolytic mechanisms in the ovulatory folliculo-luteal transformation. Connective tissue research. vol 44. issue 1. 2004-01-22. PMID:12945804. |
tumor necrosis factor alpha progressively induces matrix metalloproteinase gene expression, apoptosis, and inflammatory necrosis. |
2004-01-22 |
2023-08-12 |
Not clear |
| Paolo Monti, Biagio Eugenio Leone, Federica Marchesi, Gianpaolo Balzano, Alessandro Zerbi, Francesca Scaltrini, Claudio Pasquali, Giliola Calori, Francesca Pessi, Cosimo Sperti, Valerio Di Carlo, Paola Allavena, Lorenzo Piemont. The CC chemokine MCP-1/CCL2 in pancreatic cancer progression: regulation of expression and potential mechanisms of antimalignant activity. Cancer research. vol 63. issue 21. 2004-01-16. PMID:14612545. |
moreover, other proinflammatory cytokines such as tumor necrosis factor alpha and ifn-gamma appeared able to induce apoptosis and to reduce the proliferative rate of pancreatic cancer. |
2004-01-16 |
2023-08-12 |
human |
| Carmen C Solorzano, Rosa Hwang, Cheryl H Baker, Corazon D Bucana, Peter W Pisters, Douglas B Evans, Jerald J Killion, Isaiah J Fidle. Administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. Clinical cancer research : an official journal of the American Association for Cancer Research. vol 9. issue 5. 2004-01-12. PMID:12738744. |
administration of optimal biological dose and schedule of interferon alpha combined with gemcitabine induces apoptosis in tumor-associated endothelial cells and reduces growth of human pancreatic carcinoma implanted orthotopically in nude mice. |
2004-01-12 |
2023-08-12 |
mouse |
| Kwang-Hyun Cho, Sung-Young Shin, Hyeon-Woo Lee, Olaf Wolkenhaue. Investigations into the analysis and modeling of the TNF alpha-mediated NF-kappa B-signaling pathway. Genome research. vol 13. issue 11. 2004-01-12. PMID:14559780. |
tumor necrosis factor alpha (tnfalpha) is a potent proinflammatory cytokine that plays an important role in immunity and inflammation, in the control of cell proliferation, differentiation, and apoptosis. |
2004-01-12 |
2023-08-12 |
Not clear |
| Mounira K Chelbi-alix, Pierre Bobé, Gerard Benoit, Antony Canova, Richard Pin. Arsenic enhances the activation of Stat1 by interferon gamma leading to synergistic expression of IRF-1. Oncogene. vol 22. issue 57. 2004-01-07. PMID:14668793. |
in non-apl cells, interferon (ifn) alpha and 1 microm as2o3 act synergistically to induce apoptosis. |
2004-01-07 |
2023-08-12 |
Not clear |
| Sei-Jung Lee, Kyung-Sun Heo, Phil-Sun Oh, Kwang Lim, Kye-Taek Li. Glycoprotein isolated from Ulmus davidiana Nakai inhibits TPA-induced apoptosis through nuclear factor-kappa B in NIH/3T3 cells. Toxicology letters. vol 146. issue 2. 2004-01-06. PMID:14643968. |
to investigate the anti-apoptotic effects of udn glycoprotein, we investigated the activity of protein kinase c alpha (pkcalpha), the dna-binding activation of nuclear factor-kappa b (nf-kappab), the production of nitric oxide (no) and apoptosis in 12-o-tetradecanoylphorbol 13-acetate (tpa)-stimulated nih/3t3 cells using a western blot analysis, electrophoretic mobility shift assays (emsa) and no assays. |
2004-01-06 |
2023-08-12 |
Not clear |
| Satoshi Kokura, Norimasa Yoshida, Miho Ueda, Eiko Imamoto, Takeshi Ishikawa, Tomohisa Takagi, Yuji Naito, Takeshi Okanoue, Toshikazu Yoshikaw. Hyperthermia enhances tumor necrosis factor alpha-induced apoptosis of a human gastric cancer cell line. Cancer letters. vol 201. issue 1. 2004-01-05. PMID:14580690. |
we have investigated the effects of hyperthermia on the apoptosis induced by tumor necrosis factor alpha (tnf-alpha). |
2004-01-05 |
2023-08-12 |
human |
| J Dong, M Naito, S Dan, T Tsuru. Establishment of a mutant from human monocytic leukaemia U937 that exhibits a genetically dominant resistance to TNF alpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 3. issue 4. 2003-12-23. PMID:14646488. |
tumour necrosis factor-alpha (tnf alpha) is a cytokine that induces apoptosis in various cell systems by binding to a tnf receptor (tnfr). |
2003-12-23 |
2023-08-12 |
human |
| J Dong, M Naito, S Dan, T Tsuru. Establishment of a mutant from human monocytic leukaemia U937 that exhibits a genetically dominant resistance to TNF alpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 3. issue 4. 2003-12-23. PMID:14646488. |
to study tnf alpha-induced apoptosis, we isolated and characterized a novel tnf alpha resistant variant, u937/tnf clone ii-5, from human monocytic leukaemia u937 cells. |
2003-12-23 |
2023-08-12 |
human |
| J Dong, M Naito, S Dan, T Tsuru. Establishment of a mutant from human monocytic leukaemia U937 that exhibits a genetically dominant resistance to TNF alpha-induced apoptosis. Apoptosis : an international journal on programmed cell death. vol 3. issue 4. 2003-12-23. PMID:14646488. |
the ii-5 cells resist apoptosis by tnf alpha and anti-fas antibody but not by anticancer drugs, such as vp-16 and ara-c. somatic cell hybridization between u937 and ii-5 showed that the apoptosis resistance to tnf alpha in ii-5 was genetically dominant. |
2003-12-23 |
2023-08-12 |
human |