| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S T Williams, A N Smith, C D Cianci, J S Morrow, T L Brow. Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. Apoptosis : an international journal on programmed cell death. vol 8. issue 4. 2004-07-14. PMID:12815278. |
identification of the primary cleavage site for caspase 3 may help to elucidate the role of alpha ii-spectrin in membrane stability and apoptosis as well as provide new insights into alpha ii-spectrin autoantibody formation associated with the autoimmune disease, sjögren's syndrome. |
2004-07-14 |
2023-08-12 |
Not clear |
| Rajani S Bhat, Madhu Bhaskaran, Anil Mongia, Naoko Hitosugi, Pravin C Singha. Morphine-induced macrophage apoptosis: oxidative stress and strategies for modulation. Journal of leukocyte biology. vol 75. issue 6. 2004-07-12. PMID:15039469. |
in in vivo studies, administration of n-acetyl cysteine and preinduction of heme oxygenase activity and epoetin alpha prevented morphine-induced peritoneal macrophage apoptosis, thus further confirming the role of oxidative stress in morphine-induced macrophage apoptosis. |
2004-07-12 |
2023-08-12 |
Not clear |
| Katsunori Fujii, Erinn Hoag Goldman, Hae Ryoun Park, Lixin Zhang, Jing Chen, Haian F. Negative control of apoptosis signal-regulating kinase 1 through phosphorylation of Ser-1034. Oncogene. vol 23. issue 29. 2004-07-12. PMID:15094778. |
apoptosis signal-regulating kinase 1 (ask1) is a serine/threonine kinase that mediates cell stress signaling initiated by diverse stimuli, such as h(2)o(2) and tnf alpha. |
2004-07-12 |
2023-08-12 |
Not clear |
| Slavica Tudzarova-Trajkovska, Józefa Wesierska-Gade. Strong induction of p73 protein in vivo coincides with the onset of apoptosis in rat liver after treatment with the hepatocarcinogen N-nitrosomorpholine (NNM). Journal of cellular biochemistry. vol 90. issue 4. 2004-07-09. PMID:14587038. |
the increase of p73 alpha and beta occurred already 6 h after nnm administration and preceded the onset of apoptosis by 6 h. very strong p73 signals appeared 20 and 40 h post-treatment and persisted for a few days, whereas p53 was induced only transiently at 20 and 40 h post-treatment. |
2004-07-09 |
2023-08-12 |
rat |
| Xiaoying Zhou, Frank R Murphy, Nitu Gehdu, Junlong Zhang, John P Iredale, R Christopher Benyo. Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15044441. |
these alpha(v)beta(3) antagonists also increased apoptosis of cultured stellate cells, and this was associated with an increase in the bax/bcl-2 protein ratio, induction of nuclear dna fragmentation, and activation of intracellular caspase-3. |
2004-07-08 |
2023-08-12 |
human |
| Xiaoying Zhou, Frank R Murphy, Nitu Gehdu, Junlong Zhang, John P Iredale, R Christopher Benyo. Engagement of alphavbeta3 integrin regulates proliferation and apoptosis of hepatic stellate cells. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15044441. |
degradation of alpha(v)beta(3) ligands surrounding activated stellate cells during resolution of liver fibrosis might decrease alpha(v)beta(3) integrin ligation, suppressing stellate cell proliferation and inducing a fibrolytic, matrix metalloproteinase-secreting phenotype that may prime stellate cells for apoptosis. |
2004-07-08 |
2023-08-12 |
human |
| Lena Thyrell, Linn Hjortsberg, Velmurugesan Arulampalam, Theocharis Panaretakis, Sabine Uhles, Markus Dagnell, Boris Zhivotovsky, Ingo Leibiger, Dan Grandér, Katja Pokrovskaj. Interferon alpha-induced apoptosis in tumor cells is mediated through the phosphoinositide 3-kinase/mammalian target of rapamycin signaling pathway. The Journal of biological chemistry. vol 279. issue 23. 2004-07-08. PMID:15056668. |
interferon (ifn) alpha induces a caspase-dependent apoptosis that is associated with activation of the proapoptotic bak and bax, loss of mitochondrial membrane potential, and release of cytochrome c. in addition to the onset of the classical jak-stat pathway, ifnalpha also induced phosphoinositide 3-kinase (pi3k) activity. |
2004-07-08 |
2023-08-12 |
Not clear |
| Jin He, Lung-Ji Chan. Functional characterization of hepatoma-specific stem cell antigen-2. Molecular carcinogenesis. vol 40. issue 2. 2004-07-08. PMID:15170814. |
interestingly, inhibition of sca-2 induced rapid hepatoma cell apoptosis, and the survival sca-2-negative hepatoma cells exhibited high sensitivity to extrinsic tumor necrosis factor alpha (tnf-alpha) apoptosis signal but not intrinsic apoptosis signal. |
2004-07-08 |
2023-08-12 |
Not clear |
| Katia Vandenbulcke, Filip De Vos, Fritz Offner, Jan Philippé, Christos Apostolidis, Roger Molinet, Tuomo K Nikula, Klaus Bacher, Virginie de Gelder, Anne Vral, Christophe Lahorte, Hubert Thierens, Rudi A Dierckx, Guido Sleger. In vitro evaluation of 213Bi-rituximab versus external gamma irradiation for the treatment of B-CLL patients: relative biological efficacy with respect to apoptosis induction and chromosomal damage. European journal of nuclear medicine and molecular imaging. vol 30. issue 10. 2004-07-02. PMID:12845484. |
we assessed the relative biological efficacy (rbe) of alpha rit (in vitro) compared to external gamma irradiation with respect to induction of apoptosis in b chronic lymphocytic leukaemia (b-cll) and induction of chromosomal damage in healthy donor b and t lymphocytes. |
2004-07-02 |
2023-08-12 |
human |
| Ronen R Leker, Michal Aharonowiz, Nigel H Greig, Haim Ovadi. The role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. Experimental neurology. vol 187. issue 2. 2004-06-30. PMID:15144874. |
the role of p53-induced apoptosis in cerebral ischemia: effects of the p53 inhibitor pifithrin alpha. |
2004-06-30 |
2023-08-12 |
Not clear |
| Rajeev Mallipeddi, Vesarat Wessagowit, Andrew P South, Alistair M Robson, Guy E Orchard, Robin A J Eady, John A McGrat. Reduced expression of insulin-like growth factor-binding protein-3 (IGFBP-3) in Squamous cell carcinoma complicating recessive dystrophic epidermolysis bullosa. The Journal of investigative dermatology. vol 122. issue 5. 2004-06-25. PMID:15140235. |
igfbp-3 has an important role in cancer cell apoptosis mediated via the nuclear retinoid x receptor alpha (rxralpha). |
2004-06-25 |
2023-08-12 |
Not clear |
| Erik Z Yu, Ying-Yue Li, Xiu-Huai Liu, Elliott Kagan, Richard M McCarro. Antiapoptotic action of hypoxia-inducible factor-1 alpha in human endothelial cells. Laboratory investigation; a journal of technical methods and pathology. vol 84. issue 5. 2004-06-17. PMID:15064771. |
in this study, we evaluated the effects of rna interference (rnai) targeting hif-1 alpha messenger rna (mrna) on apoptosis in primary cultured human umbilical vascular endothelial cells (huvecs) exposed to anoxia and reoxygenation (a/r). |
2004-06-17 |
2023-08-12 |
human |
| B Nelson Chau, Tung-Ti Chen, Yisong Y Wan, James DeGregori, Jean Y J Wan. Tumor necrosis factor alpha-induced apoptosis requires p73 and c-ABL activation downstream of RB degradation. Molecular and cellular biology. vol 24. issue 10. 2004-06-17. PMID:15121862. |
we have previously shown that rb degradation is required for tumor necrosis factor alpha (tnf-alpha) to induce apoptosis. |
2004-06-17 |
2023-08-12 |
mouse |
| Annie Abadie, Juana Wietzerbi. Involvement of TNF-related apoptosis-inducing ligand (TRAIL) induction in interferon gamma-mediated apoptosis in Ewing tumor cells. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033706. |
we investigated the effect of ifn gamma or ifn gamma/ifn alpha and ifn gamma/tnf treatment on the apoptosis of ewing tumor cells (sk-n-mc). |
2004-06-15 |
2023-08-12 |
Not clear |
| Annie Abadie, Juana Wietzerbi. Involvement of TNF-related apoptosis-inducing ligand (TRAIL) induction in interferon gamma-mediated apoptosis in Ewing tumor cells. Annals of the New York Academy of Sciences. vol 1010. 2004-06-15. PMID:15033706. |
the results reported here are consistent with the notion that cell-associated and secreted trail contribute in an autocrine or paracrine manner to the triggering of ewing cell apoptosis induced by ifn gamma alone or combined with ifn alpha or tnf. |
2004-06-15 |
2023-08-12 |
Not clear |
| Tetsuo Nakajima, Osami Yukawa, Chihiro Azuma, Harumi Ohyama, Bing Wang, Shuji Kojima, Isamu Hayata, Hiroko Hama-Inab. Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma(3SBH5) cells. Radiation research. vol 161. issue 5. 2004-06-15. PMID:15161371. |
in addition, gö6976, a classical pkc (cpkc) inhibitor, which specifically inhibits pkc (alpha and betai), also promoted apoptosis. |
2004-06-15 |
2023-08-12 |
human |
| Tetsuo Nakajima, Osami Yukawa, Chihiro Azuma, Harumi Ohyama, Bing Wang, Shuji Kojima, Isamu Hayata, Hiroko Hama-Inab. Involvement of protein kinase C-related anti-apoptosis signaling in radiation-induced apoptosis in murine thymic lymphoma(3SBH5) cells. Radiation research. vol 161. issue 5. 2004-06-15. PMID:15161371. |
our findings indicate that activation of cpkc (alpha or beta) soon after irradiation is critical to the understanding of the regulation of radiation-induced apoptosis in radiation-sensitive cells. |
2004-06-15 |
2023-08-12 |
human |
| Friederike Goepel, Pamela Weinmann, Jürgen Schymeinsky, Barbara Walzo. Identification of caspase-10 in human neutrophils and its role in spontaneous apoptosis. Journal of leukocyte biology. vol 75. issue 5. 2004-06-11. PMID:14761933. |
in the present study, we investigated the molecular mechanisms of spontaneous and tumor necrosis factor alpha (tnf-alpha)-mediated apoptosis of human polymorphonuclear neutrophils (pmn). |
2004-06-11 |
2023-08-12 |
human |
| T Tanaka, B L Dancheck, L C Trifiletti, R E Birnkrant, B J Taylor, S H Garfield, U Thorgeirsson, L M De Luc. Altered localization of retinoid X receptor alpha coincides with loss of retinoid responsiveness in human breast cancer MDA-MB-231 cells. Molecular and cellular biology. vol 24. issue 9. 2004-06-10. PMID:15082790. |
infecting mda-mb-231 cells with adenoviral rxr alpha induced nucleoplasmic overexpression of rxr alpha and resulted in apoptosis upon treatment with an rxr ligand. |
2004-06-10 |
2023-08-12 |
human |
| Pierre-François Cartron, Lisa Oliver, Philippe Juin, Khaled Meflah, François M Vallett. The p18 truncated form of Bax behaves like a Bcl-2 homology domain 3-only protein. The Journal of biological chemistry. vol 279. issue 12. 2004-05-27. PMID:14681224. |
we have shown recently that the first alpha helix (halpha1) of p21(bax) contained a mitochondrial addressing sequence, which appeared to be necessary for p21(bax)-induced apoptosis (cartron, p. f., priault, m., oliver, l., meflah, k., manon, s., and vallette, f. m. (2003) j. biol. |
2004-05-27 |
2023-08-12 |
Not clear |