| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John D Foley, Heidi Rosenbaum, Anne E Grie. Temporal regulation of VEID-7-amino-4-trifluoromethylcoumarin cleavage activity and caspase-6 correlates with organelle loss during lens development. The Journal of biological chemistry. vol 279. issue 31. 2004-09-10. PMID:15161922. |
by contrast, in extracts from alpha ae7 transgenic mouse lenses in which apoptosis was induced, strong devd-afc cleavage activity and activated caspase-3 protein were detected. |
2004-09-10 |
2023-08-12 |
mouse |
| Stéphane Gilbert, Anne Loranger, Normand Marcea. Keratins modulate c-Flip/extracellular signal-regulated kinase 1 and 2 antiapoptotic signaling in simple epithelial cells. Molecular and cellular biology. vol 24. issue 16. 2004-09-09. PMID:15282307. |
here we show that upon fas, tumor necrosis factor alpha receptor, or tumor necrosis factor alpha-related apoptosis-inducing ligand receptor stimulation, an inhibition of extracellular signal-regulated kinase 1 and 2 (erk1/2) activation sensitizes wild-type but not k8-null mouse hepatocytes to apoptosis and that a much weaker erk1/2 activation occurs in k8-null hepatocytes. |
2004-09-09 |
2023-08-12 |
mouse |
| Chen Zhao, Enhua Wan. Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. Cellular signalling. vol 16. issue 3. 2004-09-01. PMID:14687661. |
heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of bid in nih3t3 fibroblasts. |
2004-09-01 |
2023-08-12 |
Not clear |
| Chen Zhao, Enhua Wan. Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. Cellular signalling. vol 16. issue 3. 2004-09-01. PMID:14687661. |
our present studies demonstrate that hsp90 can suppress tumor necrosis factor alpha (tnfalpha)-induced apoptosis in stable hsp90-overexpressing nih3t3 cells by preventing the cleavage of bid. |
2004-09-01 |
2023-08-12 |
Not clear |
| Juan L Contreras, Mario Vilatoba, Christopher Eckstein, Guadalupe Bilbao, J Anthony Thompson, Devin E Eckhof. Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. Surgery. vol 136. issue 2. 2004-08-24. PMID:15300206. |
i/r injury is associated with liver apoptosis, which is mediated by death receptors such as fas and tumor necrosis factor alpha (tnf-alpha), and/or mitochondrial dysfunction induced by cellular stress. |
2004-08-24 |
2023-08-12 |
mouse |
| Luca Benetti, Bernard Roizma. Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 25. 2004-08-23. PMID:15192152. |
herpes simplex virus 1 encodes at least four genes whose functions include blocking apoptosis induced by exogenous agents (e.g., sorbitol, fas ligand, and bad protein) or replication-incompetent mutants (e.g., the d120 mutant lacking both copies of the alpha 4 gene). |
2004-08-23 |
2023-08-12 |
Not clear |
| Luca Benetti, Bernard Roizma. Herpes simplex virus protein kinase US3 activates and functionally overlaps protein kinase A to block apoptosis. Proceedings of the National Academy of Sciences of the United States of America. vol 101. issue 25. 2004-08-23. PMID:15192152. |
we report that (i) the pattern of proteins phosphorylated by u(s)3 in transduced cells or in cells infected with wt virus overlaps that of phosphoproteins targeted by pka, (ii) activation of pka blocks apoptosis induced by d120 mutant or by bad protein independently of u(s)3, (iii) u(s)3 protein kinase phosphorylates peptides containing the serine or threonine targeted by pka including that present in the regulatory type ii alpha subunit of pka, and (iv) in wt virus-infected cells the regulatory type ii alpha subunit is phosphorylated in a u(s)3-dependent manner. |
2004-08-23 |
2023-08-12 |
Not clear |
| Oren Tirosh, Betty Schwartz, Igor Zusman, George Kossoy, Shlomo Yahav, Ruth Miski. Long-lived alpha MUPA transgenic mice exhibit increased mitochondrion-mediated apoptotic capacity. Annals of the New York Academy of Sciences. vol 1019. 2004-08-20. PMID:15247062. |
recently, several changes in the alpha mupa liver were noted, at the mitochondrial and cellular level, which consistently pointed to an enhanced capacity to induce apoptosis. |
2004-08-20 |
2023-08-12 |
mouse |
| F V N Din, M G Dunlop, L A Star. Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. British journal of cancer. vol 91. issue 2. 2004-08-19. PMID:15188000. |
we previously reported that aspirin induces signal-specific i kappa b alpha degradation followed by nf kappa b nuclear translocation in crc cells, and that this mechanism contributes substantially to aspirin-induced apoptosis. |
2004-08-19 |
2023-08-12 |
Not clear |
| F V N Din, M G Dunlop, L A Star. Evidence for colorectal cancer cell specificity of aspirin effects on NF kappa B signalling and apoptosis. British journal of cancer. vol 91. issue 2. 2004-08-19. PMID:15188000. |
we found that aspirin induced concentration-dependent i kappa b alpha degradation, nf kappa b nuclear translocation and apoptosis in all crc lines studied. |
2004-08-19 |
2023-08-12 |
Not clear |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
we found that bleomycin-induced apoptosis was significantly enhanced by nicotine and was blocked by nicotinic acetylcholine receptor antagonists, including alpha-bungarotoxin, a competitive antagonist of alpha 7 nicotinic receptor. |
2004-08-16 |
2023-08-12 |
Not clear |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
among the other agonists tested, 3-[2,4-dimethoxybenzylidene]anabaseine (gts-21)-selective agonist for alpha 7-nicotinic acetylcholine receptor-, but not epibatidine or cytisine, enhanced bleomycin-induced apoptosis. |
2004-08-16 |
2023-08-12 |
Not clear |
| Delphine Gimonet, Regis Grailhe, Paul Coninx, Frank Antonicelli, Bernard Haye, Françoise Liautaud-Roge. Functional role of nicotinic acetylcholine receptors in apoptosis in HL-60 cell line. European journal of pharmacology. vol 482. issue 1-3. 2004-08-16. PMID:14660001. |
in addition to these results, the detectable presence of alpha 7-mrna supports a key role of alpha 7-nicotinic acetylcholine receptors in the modulation of the induced apoptosis by nicotine. |
2004-08-16 |
2023-08-12 |
Not clear |
| Sunghoon Kim, Junghee Kang, B Mark Evers, Dai H Chun. Interferon-gamma induces caspase-8 in neuroblastomas without affecting methylation of caspase-8 promoter. Journal of pediatric surgery. vol 39. issue 4. 2004-08-10. PMID:15065018. |
resistance of neuroblastomas to death-receptor (eg, tumor necrosis factor alpha (tnf-alpha) receptor)--mediated apoptosis is thought to be caused by loss of caspase-8 expression. |
2004-08-10 |
2023-08-12 |
Not clear |
| Anuradha Chakrabarty, Marsha M Danley, Steven M LeVin. Immunohistochemical localization of phosphorylated protein kinase R and phosphorylated eukaryotic initiation factor-2 alpha in the central nervous system of SJL mice with experimental allergic encephalomyelitis. Journal of neuroscience research. vol 76. issue 6. 2004-07-26. PMID:15160394. |
alternatively, phospho-pkr and phospho-eif2 alpha may promote apoptosis as a way to regulate t-cell number in the cns. |
2004-07-26 |
2023-08-12 |
mouse |
| Amelia Cataldi, Giuseppina Bianchi, Cinzia Rapino, Nadia Sabatini, Lucia Centurione, Camillo Di Giulio, Domenico Bosco, Adriano Antonucc. Molecular and morphological modifications occurring in rat heart exposed to intermittent hypoxia: role for protein kinase C alpha. Experimental gerontology. vol 39. issue 3. 2004-07-20. PMID:15036399. |
in hypoxic young heart pkc alpha activation, paralleled by sustained bax homodimerization and caspase-3 activation, along with reduced p-ikbalpha and inhibiting apoptosis protein (iap) expression, suggests that the young early and deeply undergoes the effects of lowered oxygen tension. |
2004-07-20 |
2023-08-12 |
rat |
| Daniel E B Swinson, J Louise Jones, Giles Cox, Donna Richardson, Adrian L Harris, Kenneth J O'Byrn. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. International journal of cancer. vol 111. issue 1. 2004-07-20. PMID:15185341. |
hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. |
2004-07-20 |
2023-08-12 |
Not clear |
| Daniel E B Swinson, J Louise Jones, Giles Cox, Donna Richardson, Adrian L Harris, Kenneth J O'Byrn. Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathways. International journal of cancer. vol 111. issue 1. 2004-07-20. PMID:15185341. |
under different circumstances, hif-1 alpha may promote both tumorigenesis and apoptosis. |
2004-07-20 |
2023-08-12 |
Not clear |
| Enmei Liu, Helen K W Law, Yu-Lung La. Insulin-like growth factor I promotes maturation and inhibits apoptosis of immature cord blood monocyte-derived dendritic cells through MEK and PI 3-kinase pathways. Pediatric research. vol 54. issue 6. 2004-07-19. PMID:12930919. |
furthermore, igf-i inhibited apoptosis of cb dc and increased the production of tumor necrosis factor alpha (tnf-alpha). |
2004-07-19 |
2023-08-12 |
Not clear |
| S T Williams, A N Smith, C D Cianci, J S Morrow, T L Brow. Identification of the primary caspase 3 cleavage site in alpha II-spectrin during apoptosis. Apoptosis : an international journal on programmed cell death. vol 8. issue 4. 2004-07-14. PMID:12815278. |
identification of the primary caspase 3 cleavage site in alpha ii-spectrin during apoptosis. |
2004-07-14 |
2023-08-12 |
Not clear |