| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Theocharis Panaretakis, Linn Hjortsberg, Katja Pokrovskaja Tamm, Ann-Charlotte Björklund, Bertrand Joseph, Dan Grandé. Interferon alpha induces nucleus-independent apoptosis by activating extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase downstream of phosphatidylinositol 3-kinase and mammalian target of rapamycin. Molecular biology of the cell. vol 19. issue 1. 2008-11-10. PMID:17942603. |
interferon (ifn)alpha induces apoptosis via bak and bax and the mitochondrial pathway. |
2008-11-10 |
2023-08-12 |
Not clear |
| Conny Gysemans, Hanne Callewaert, Lutgart Overbergh, Chantal Mathie. Cytokine signalling in the beta-cell: a dual role for IFNgamma. Biochemical Society transactions. vol 36. issue Pt 3. 2008-11-03. PMID:18481951. |
ifngamma (interferon gamma), a cytokine typically secreted by infiltrating immune cells in insulitis in type 1 diabetes, is by itself not detrimental to beta-cells, but, together with other cytokines, such as il-1beta (interleukin 1beta) and tnfalpha (tumour necrosis factor alpha), or dsrna (double-stranded rna), it induces beta-cell apoptosis. |
2008-11-03 |
2023-08-12 |
mouse |
| F T Billings, Sean W C Chen, Mihwa Kim, Sang Won Park, Joseph H Song, Shuang Wang, Joseph Herman, Vivette D'Agati, H Thomas Le. alpha2-Adrenergic agonists protect against radiocontrast-induced nephropathy in mice. American journal of physiology. Renal physiology. vol 295. issue 3. 2008-10-27. PMID:18579700. |
alpha(2)-agonist-treated mice had reduced plasma creatinine, renal tubular necrosis, renal apoptosis, and renal cortical proximal tubule vacuolization 24 h after iohexol injection. |
2008-10-27 |
2023-08-12 |
mouse |
| Paula Lorenzo, Rosana Alvarez, Maria A Ortiz, Susana Alvarez, F Javier Piedrafita, Angel R de Ler. Inhibition of IkappaB kinase-beta and anticancer activities of novel chalcone adamantyl arotinoids. Journal of medicinal chemistry. vol 51. issue 17. 2008-10-24. PMID:18702457. |
on the basis of the observations that chalcone 7 (mx781) and some related adamantyl arotinoids (adars) inhibit ikappab alpha kinase beta (ikkbeta) activity, inhibit cell growth, and induce apoptosis in cancer cells, a new series of adars structurally related to 7 have been designed and synthesized. |
2008-10-24 |
2023-08-12 |
Not clear |
| Rachel M Snyder, Weiping Yu, Li Jia, Bob G Sanders, Kimberly Klin. Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth. Nutrition and cancer. vol 60. issue 3. 2008-10-20. PMID:18444175. |
alpha -tea alone and together with methylseleninic acid (msa) and trans-resveratrol (t-res) were investigated for ability to induce apoptosis, dna synthesis arrest, and cellular differentiation and inhibit colony formation in human mda-mb-435-f-l breast cancer cells in culture. |
2008-10-20 |
2023-08-12 |
human |
| Rachel M Snyder, Weiping Yu, Li Jia, Bob G Sanders, Kimberly Klin. Vitamin E analog alpha-TEA, methylseleninic acid, and trans-resveratrol in combination synergistically inhibit human breast cancer cell growth. Nutrition and cancer. vol 60. issue 3. 2008-10-20. PMID:18444175. |
furthermore, combinations of alpha -tea, t-res, and msa significantly enhanced levels of apoptosis in human breast (mda-mb-231, mcf7, and t47d) and prostate (lncap, pc-3, and du-145) cancer cell lines as well as in immortalized but nontumorigenic mcf10a cells but not primary cultures of human mammary epithelial cells. |
2008-10-20 |
2023-08-12 |
human |
| Rezan Demiralay, Nesrin Gürsan, Havva Erde. The effects of erdosteine, N-acetylcysteine, and vitamin E on nicotine-induced apoptosis of hippocampal neural cells. Journal of cellular biochemistry. vol 104. issue 5. 2008-10-17. PMID:18348255. |
this study investigated the frequency of apoptosis in rat hippocampal neural cells after intraperitoneal nicotine injection, examining the roles of the inflammatory markers myeloperoxidase (mpo) and tumor necrosis factor alpha (tnf-alpha) in nicotine-induced brain damage and the protective effects of three known antioxidant agents, n-acetylcysteine (nac), erdosteine, and vitamin e. female wistar rats were divided into seven groups, each composed of nine rats: 2 negative control groups, 2 positive control groups, one erdosteine-treated group (500 mg/kg), one nac-treated group (500 mg/kg), and one vitamin e-treated group (500 mg/kg). |
2008-10-17 |
2023-08-12 |
rat |
| Hong-Nu Yu, Young-Rae Lee, Eun-Mi Noh, Kyung-Sun Lee, Jong-Suk Kim, Eun-Kyung Song, Myung-Kwan Han, Yong-Chul Lee, Kang-Beom Kwon, Seung-Jin Lee, Hyun Jo Youn, Sung Hoo Jun. Induction of G1 phase arrest and apoptosis in MDA-MB-231 breast cancer cells by troglitazone, a synthetic peroxisome proliferator-activated receptor gamma (PPARgamma) ligand. Cell biology international. vol 32. issue 8. 2008-10-14. PMID:18474441. |
here we wished to determine whether the ppargamma ligand induces apoptosis and cell cycle arrest of the mda-mb-231 cell, an estrogen receptor alpha negative breast cancer cell line. |
2008-10-14 |
2023-08-12 |
Not clear |
| Hyun-Hee Lee, Christine M Hoeman, John C Hardaway, F Betul Guloglu, Jason S Ellis, Renu Jain, Rohit Divekar, Danielle M Tartar, Cara L Haymaker, Habib Zaghouan. Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity. The Journal of experimental medicine. vol 205. issue 10. 2008-10-14. PMID:18762566. |
during secondary antigen challenge, th2-produced il-4 triggers the apoptosis of th1 cells via il-4r alpha/il-13r alpha 1, thus explaining the th2 bias in neonates. |
2008-10-14 |
2023-08-12 |
Not clear |
| Hyun-Hee Lee, Christine M Hoeman, John C Hardaway, F Betul Guloglu, Jason S Ellis, Renu Jain, Rohit Divekar, Danielle M Tartar, Cara L Haymaker, Habib Zaghouan. Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity. The Journal of experimental medicine. vol 205. issue 10. 2008-10-14. PMID:18762566. |
by day 6 after birth, however, a significant number of cd8 alpha(+)cd4(-) dcs accumulated in the spleen and produced il-12, which triggered the down-regulation of il-13r alpha 1 expression on th1 cells, thus protecting them against il-4-driven apoptosis. |
2008-10-14 |
2023-08-12 |
Not clear |
| Consuelo Amantini, Michela Mosca, Roberta Lucciarini, Marina Cecilia Perfumi, Giorgio Santon. Thiorphan-induced survival and proliferation of rat thymocytes by activation of Akt/survivin pathway and inhibition of caspase-3 activity. The Journal of pharmacology and experimental therapeutics. vol 327. issue 1. 2008-10-08. PMID:18621988. |
in addition, the nep/cd10 inhibitor stimulated interleukin (il)-2 production, il-2 receptor alpha chain expression, and concanavalin a-induced proliferation of cd5(+) thymocytes, and it inhibited spontaneous and nk(1)r-dependent thymocyte apoptosis. |
2008-10-08 |
2023-08-12 |
rat |
| Jian Huang, Lijun Wu, Shin-ichi Tashiro, Satoshi Onodera, Takashi Ikejim. Reactive oxygen species mediate oridonin-induced HepG2 apoptosis through p53, MAPK, and mitochondrial signaling pathways. Journal of pharmacological sciences. vol 107. issue 4. 2008-10-07. PMID:18719315. |
p53, a specific inhibitor of pifithrin alpha (pft alpha), markedly inhibited ros generation and apoptosis, showing that p53 was responsible for the cytotoxity of oridonin through mediation by ros. |
2008-10-07 |
2023-08-12 |
human |
| Hiroaki Kishikawa, Katsuya Kobayashi, Ken Takemori, Tadashi Okabe, Kimiaki Ito, Atsuhiro Sakamot. The effects of dexmedetomidine on human neutrophil apoptosis. Biomedical research (Tokyo, Japan). vol 29. issue 4. 2008-10-06. PMID:18724006. |
these results suggest that high doses of dexmedetomidine induce apoptosis without alpha(2)-adrenoceptors stimulus and inhibit superoxide production after long-term incubation. |
2008-10-06 |
2023-08-12 |
human |
| R Cursio, C Miele, N Filippa, E Van Obberghen, J Gugenhei. Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. Transplantation proceedings. vol 40. issue 6. 2008-09-30. PMID:18675125. |
liver hif-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. |
2008-09-30 |
2023-08-12 |
rat |
| R Cursio, C Miele, N Filippa, E Van Obberghen, J Gugenhei. Liver HIF-1 alpha induction precedes apoptosis following normothermic ischemia-reperfusion in rats. Transplantation proceedings. vol 40. issue 6. 2008-09-30. PMID:18675125. |
the hypoxia-inducible factor alpha (hif-1alpha) may trigger liver apoptosis following i-r through the induction of hypoxically regulated genes. |
2008-09-30 |
2023-08-12 |
rat |
| Li-Ying Geng, Ming Fang, Jian-Ming Yi, Fei Jiang, Muhammad Moeen-ud-Din, Li-Guo Yan. Effect of overexpression of inhibin alpha (1-32) fragment on bovine granulosa cell proliferation, apoptosis, steroidogenesis, and development of co-cultured oocytes. Theriogenology. vol 70. issue 1. 2008-09-25. PMID:18456314. |
effect of overexpression of inhibin alpha (1-32) fragment on bovine granulosa cell proliferation, apoptosis, steroidogenesis, and development of co-cultured oocytes. |
2008-09-25 |
2023-08-12 |
cattle |
| Li-Ying Geng, Ming Fang, Jian-Ming Yi, Fei Jiang, Muhammad Moeen-ud-Din, Li-Guo Yan. Effect of overexpression of inhibin alpha (1-32) fragment on bovine granulosa cell proliferation, apoptosis, steroidogenesis, and development of co-cultured oocytes. Theriogenology. vol 70. issue 1. 2008-09-25. PMID:18456314. |
the objective was to determine the effects of an inhibin alpha (1-32) fragment gene on proliferation, apoptosis, and steroidogenesis of bovine granulosa cells (gc) isolated from medium and small follicles (diameter >4-8 and 1-4mm, respectively), and the effect of gc, previously transfected with pegisi, on oocyte maturation and in vitro embryo development. |
2008-09-25 |
2023-08-12 |
cattle |
| Ndiya Ogba, Laura J Chaplin, Yong Qiu Doughman, Koh Fujinaga, Monica M Montan. HEXIM1 regulates 17beta-estradiol/estrogen receptor-alpha-mediated expression of cyclin D1 in mammary cells via modulation of P-TEFb. Cancer research. vol 68. issue 17. 2008-09-18. PMID:18757415. |
estrogen receptor alpha (eralpha) plays a key role in mammary gland development and is implicated in breast cancer through the transcriptional regulation of genes linked to proliferation and apoptosis. |
2008-09-18 |
2023-08-12 |
mouse |
| Yeo Kyoung Oh, Hyun Jung Lee, Mi-Hee Jeong, Marie Rhee, Ji-Won Mo, Eun Hyeon Song, Joong-Yeon Lim, Kyung-Hee Choi, Inho Jo, Sang Ick Park, Bin Gao, Yongil Kwon, Won-Ho Ki. Role of activating transcription factor 3 on TAp73 stability and apoptosis in paclitaxel-treated cervical cancer cells. Molecular cancer research : MCR. vol 6. issue 7. 2008-09-16. PMID:18644986. |
in wild-type activating transcription factor 3 (atf3)-overexpressed cells, paclitaxel enhanced apoptosis through increased alpha and beta isoform expression of tap73; however, these events were attenuated in cells containing inactive cooh-terminal-deleted atf3 [atf3(deltac)] or atf3 sirna. |
2008-09-16 |
2023-08-12 |
Not clear |
| Susan A Krum, Myles Brow. Unraveling estrogen action in osteoporosis. Cell cycle (Georgetown, Tex.). vol 7. issue 10. 2008-09-15. PMID:18418063. |
one hypothesis is that estrogen, via rapid non-genomic signaling, induces apoptosis without the need for direct binding of estrogen receptor alpha (eralpha) to dna. |
2008-09-15 |
2023-08-12 |
Not clear |