| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thierry Voisin, Aadil El Firar, Christiane Rouyer-Fessard, Valérie Gratio, Marc Laburth. A hallmark of immunoreceptor, the tyrosine-based inhibitory motif ITIM, is present in the G protein-coupled receptor OX1R for orexins and drives apoptosis: a novel mechanism. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 22. issue 6. 2008-07-16. PMID:18198212. |
this is based on the following observations: 1) mutation of y(358) into f abolished orexin-induced tyrosine phosphorylation in itim, orexin-induced apoptosis, and uncoupled ox1r from gq protein in transfected chinese hamster ovary (cho) cells; 2) orexin-induced apoptosis in cho cells expressing recombinant ox1r and in colon cancer cells expressing the native receptor was abolished by treatment with the tyrosine phosphatase inhibitor pao and by transfection with a dominant-negative mutant of shp-2; 3) orexins were unable to promote apoptosis in fibroblast cells invalidated for the g alpha q subunit and transfected with ox1r cdna, whereas they promoted apoptosis in cells equipped with g alpha q and ox1r; and 4) the phospholipase c inhibitor u-73122 blocked orexin-stimulated inositol phosphate formation, whereas it had no effect on orexin-induced apoptosis in cho cells expressing ox1r. |
2008-07-16 |
2023-08-12 |
Not clear |
| Alexey A Matskevich, Karin Moellin. Stimuli-dependent cleavage of Dicer during apoptosis. The Biochemical journal. vol 412. issue 3. 2008-07-16. PMID:18289125. |
here, we have studied the role of dicer, one of the central proteins of the mirna processing machinery during apoptosis, and show that down-regulation of dicer results in accelerated apoptosis of hela cells, triggered by tnfalpha (tumour necrosis factor alpha). |
2008-07-16 |
2023-08-12 |
Not clear |
| Ruth A Bryan, Xianchun Huang, Alfred Morgenstern, Frank Bruchertseifer, Arturo Casadevall, Ekaterina Dadachov. Radiofungicidal effects of external gamma radiation and antibody-targeted beta and alpha radiation on Cryptococcus neoformans. Antimicrobial agents and chemotherapy. vol 52. issue 6. 2008-07-15. PMID:18378712. |
we evaluated the clonogenic survival, membrane permeability, metabolic activity (xtt reduction), and apoptosis (flica binding) of cryptococcus neoformans cells subjected to gamma rays from an external source, and beta and alpha particles delivered to fungal cells by capsule-specific antibody. |
2008-07-15 |
2023-08-12 |
Not clear |
| Un-Ho Jin, Kwon-Ho Song, Muneo Motomura, Ikukatsu Suzuki, Yeun-Hwa Gu, Yun-Jeong Kang, Tae-Chul Moon, Cheorl-Ho Ki. Caffeic acid phenethyl ester induces mitochondria-mediated apoptosis in human myeloid leukemia U937 cells. Molecular and cellular biochemistry. vol 310. issue 1-2. 2008-06-20. PMID:18060475. |
apoptotic action of the cape was accompanied by release of cytochrome c, reduction of bcl-2 expression, increase of bax expression, activation/cleavage of caspase-3 and activation/cleavage of parp in u937 cells, but not by fas protein, an initial mediator in the death signaling, or by phospho-eif2 alpha and chop, crucial mediators in er-mediated apoptosis. |
2008-06-20 |
2023-08-12 |
human |
| Guang Yan, Jiannan Huang, Nancy Ruth Jarbadan, Yixing Jiang, Hua Chen. Sequestration of NF-kappaB signaling complexes in lipid rafts contributes to repression of NF-kappaB in T lymphocytes under hyperthermia stress. The Journal of biological chemistry. vol 283. issue 18. 2008-06-19. PMID:18316375. |
heat stress has been implicated to repress the activation of an inflammatory mediator, nuclear factor of kappab (nf-kappab), which sensitizes cells to apoptosis mediated by inflammatory cytokine, tumor necrosis factor alpha. |
2008-06-19 |
2023-08-12 |
Not clear |
| E B Rankin, A J Giacci. The role of hypoxia-inducible factors in tumorigenesis. Cell death and differentiation. vol 15. issue 4. 2008-06-13. PMID:18259193. |
they are heterodimeric transcription factors consisting of an oxygen-sensitive alpha subunit (hif-alpha) and a constitutive beta subunit (hif-beta) that facilitate both oxygen delivery and adaptation to oxygen deprivation by regulating the expression of genes that control glucose uptake, metabolism, angiogenesis, erythropoiesis, cell proliferation, and apoptosis. |
2008-06-13 |
2023-08-12 |
Not clear |
| Judit Marsillach, Natàlia Ferré, Jordi Camps, Anna Rull, Raul Beltran, Jorge Jove. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17938867. |
ccl(4) administration over 12 weeks was associated with significant changes in b-cell leukemia/lymphoma 2, procollagen type i alpha 2, matrix metalloproteinases 3 and 8, tissue inhibitors of metalloproteinases 1, 2, and 3 and the inhibitor of apoptosis 4 gene expressions. |
2008-06-10 |
2023-08-12 |
rat |
| Judit Marsillach, Natàlia Ferré, Jordi Camps, Anna Rull, Raul Beltran, Jorge Jove. Changes in the expression of genes related to apoptosis and fibrosis pathways in CCl4-treated rats. Molecular and cellular biochemistry. vol 308. issue 1-2. 2008-06-10. PMID:17938867. |
recovery after ccl(4) cessation was associated with changes in procollagen type i alpha 2, matrix metalloproteinase 7, tissue inhibitors of metalloproteinases 1 and 2, inhibitor of apoptosis 4, and survivin gene expressions. |
2008-06-10 |
2023-08-12 |
rat |
| Quan-Sheng Zhu, Wenhong Ren, Borys Korchin, Guy Lahat, Adam Dicker, Yiling Lu, Gordon Mills, Raphael E Pollock, Dina Le. Soft tissue sarcoma cells are highly sensitive to AKT blockade: a role for p53-independent up-regulation of GADD45 alpha. Cancer research. vol 68. issue 8. 2008-06-10. PMID:18413758. |
human sts xenografts in nude mice were used for in vivo studies, and immunohistochemistry was used to assess the effect of treatment on gadd45 alpha expression, proliferation, and apoptosis. |
2008-06-10 |
2023-08-12 |
mouse |
| Aparna C Ranganathan, Shishir Ojha, Antonis Kourtidis, Douglas S Conklin, Julio A Aguirre-Ghis. Dual function of pancreatic endoplasmic reticulum kinase in tumor cell growth arrest and survival. Cancer research. vol 68. issue 9. 2008-06-10. PMID:18451152. |
increased perk activation is linked to enhanced p-eif2 alpha levels, translational repression, and a decrease in ki67, ph 3, and cycd1/d3 levels, but not to changes in angiogenesis or apoptosis. |
2008-06-10 |
2023-08-12 |
Not clear |
| Bingong Li, Qiutang Zeng, Hongxiang Wang, Xiaobo Ma. Effect of cytokines secreted by human adipose stromal cells on endothelial cells. Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. vol 26. issue 4. 2008-06-06. PMID:17120730. |
ascs secreted cytokines such as vegf, hgf and sdf-1 alpha so the asc medium could stimulate proliferation and counteract apoptosis of endothelial cells (p < 0.05). |
2008-06-06 |
2023-08-12 |
human |
| Marc Tarrus, Almer M van der Sloot, Kai Temming, Marie Lacombe, Frank Opdam, Wim J Quax, Grietje Molema, Klaas Poelstra, Robbert J Ko. RGD-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of TNF alpha related apoptosis inducing ligand (TRAIL). Apoptosis : an international journal on programmed cell death. vol 13. issue 2. 2008-06-03. PMID:18071905. |
rgd-avidin-biotin pretargeting to alpha v beta 3 integrin enhances the proapoptotic activity of tnf alpha related apoptosis inducing ligand (trail). |
2008-06-03 |
2023-08-12 |
Not clear |
| Jeong-Woong Park, Hong Pyo Kim, Seon-Jin Lee, Xue Wang, Yong Wang, Emeka Ifedigbo, Simon C Watkins, Motoi Ohba, Stefan W Ryter, Yatin M Vyas, Augustine M K Cho. Protein kinase C alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. Journal of immunology (Baltimore, Md. : 1950). vol 180. issue 7. 2008-05-30. PMID:18354190. |
protein kinase c alpha and zeta differentially regulate death-inducing signaling complex formation in cigarette smoke extract-induced apoptosis. |
2008-05-30 |
2023-08-12 |
human |
| Myung Kuk Joe, Hyo Jung Lee, Young Ho Suh, Kyu Lee Han, Joo Hyun Lim, Jihyun Song, Je Kyung Seong, Myeong Ho Jun. Crucial roles of neuronatin in insulin secretion and high glucose-induced apoptosis in pancreatic beta-cells. Cellular signalling. vol 20. issue 5. 2008-05-23. PMID:18289831. |
therefore, to investigate the possible functions that nnat may serve in pancreatic beta-cells, two nnat isotypes (alpha and beta) were expressed using adenoviruses in murine min6n8 pancreatic beta-cells, and the cellular fates and the effects of nnat on insulin secretion, high glucose-induced apoptosis, and functional impairment were examined. |
2008-05-23 |
2023-08-12 |
Not clear |
| Nobuhiro Kanemura, Hisashi Tsurumi, Masataka Okuno, Rie Matsushima-Nishiwaki, Masahito Shimizu, Hisataka Moriwak. Retinoid X receptor alpha is highly phosphorylated in retinoic acid-resistant HL-60R cells and the combination of 9-cis retinoic acid plus MEK inhibitor induces apoptosis in the cells. Leukemia research. vol 32. issue 6. 2008-05-22. PMID:18082883. |
retinoid x receptor alpha is highly phosphorylated in retinoic acid-resistant hl-60r cells and the combination of 9-cis retinoic acid plus mek inhibitor induces apoptosis in the cells. |
2008-05-22 |
2023-08-12 |
Not clear |
| Cécilie Dufour, Xavier Holy, Pierre J Mari. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18378961. |
continuous administration of tgf-beta2 using osmotic minipumps prevented the decreased alpha(5)beta(1)-integrin expression and the reduced pi3k/akt signaling in unloaded bone, resulting in the prevention of osteoblast apoptosis. |
2008-05-22 |
2023-08-12 |
rat |
| Cécilie Dufour, Xavier Holy, Pierre J Mari. Transforming growth factor-beta prevents osteoblast apoptosis induced by skeletal unloading via PI3K/Akt, Bcl-2, and phospho-Bad signaling. American journal of physiology. Endocrinology and metabolism. vol 294. issue 4. 2008-05-22. PMID:18378961. |
these results identify a protective role for tgf-beta2 in osteoblast apoptosis induced by mechanical unloading via the alpha(5)beta(1)/pi3k/akt signaling cascade and downstream bcl-2 and phospho-bad survival proteins. |
2008-05-22 |
2023-08-12 |
rat |
| Desheng Xiao, Kuansong Wang, Jianhua Zhou, Huiqiu Cao, Zhenghao Deng, Yongbin Hu, Xiahui Qu, Jifang We. Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401527. |
inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase c alpha activation and subcellular translocation of smac in human small cell lung cancer cells. |
2008-05-14 |
2023-08-12 |
human |
| Desheng Xiao, Kuansong Wang, Jianhua Zhou, Huiqiu Cao, Zhenghao Deng, Yongbin Hu, Xiahui Qu, Jifang We. Inhibition of fibroblast growth factor 2-induced apoptosis involves survivin expression, protein kinase C alpha activation and subcellular translocation of Smac in human small cell lung cancer cells. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401527. |
thus, survivin, smac, and pkc alpha might play important roles in the inhibition of apoptosis by fgf-2 in human small cell lung cancer cells. |
2008-05-14 |
2023-08-12 |
human |
| Yanbin Zhao, Xuesong Chen, Li Cai, Yanmei Yang, Guangjie Sui, Jin W. Angiotensin II suppresses adriamycin-induced apoptosis through activation of phosphatidylinositol 3-kinase/Akt signaling in human breast cancer cells. Acta biochimica et biophysica Sinica. vol 40. issue 4. 2008-05-14. PMID:18401528. |
treatment of human breast cancer mcf-7 cells with adriamycin, a dna topoisomerase ii alpha inhibitor, caused apoptosis. |
2008-05-14 |
2023-08-12 |
human |