| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Luisa Riccardi, Emanuela Mazzon, Stefano Bruscoli, Emanuela Esposito, Concetta Crisafulli, Rosanna Di Paola, Rocco Caminiti, Carlo Riccardi, Salvatore Cuzzocre. Peroxisome proliferator-activated receptor-alpha modulates the anti-inflammatory effect of glucocorticoids in a model of inflammatory bowel disease in mice. Shock (Augusta, Ga.). vol 31. issue 3. 2009-03-19. PMID:18665053. |
in particular, dex was less effective in ppar-[alpha]ko compared with wt mice, as evaluated by inhibition of proinflammatory cytokines production, cell migration, oxidative stress, apoptosis, and colon injury. |
2009-03-19 |
2023-08-12 |
mouse |
| J Grosjean-Raillard, M Tailler, L Adès, J-L Perfettini, C Fabre, T Braun, S De Botton, P Fenaux, G Kroeme. ATM mediates constitutive NF-kappaB activation in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene. vol 28. issue 8. 2009-03-18. PMID:19079347. |
inhibition of atm with two distinct pharmacological inhibitors suppressed the activating autophosphorylation of atm, blocked the interaction of atm and nemo, delocalized nemo as well as another putative nf-kappab activator, pidd, from the nucleus, abolished the activating phosphorylation of the catalytic proteins of the ikk complex (ikk1/2 on serines 176/180), enhanced the expression of i kappab alpha and caused the relocalization of nf-kappab from the nucleus to the cytoplasm, followed by apoptosis. |
2009-03-18 |
2023-08-12 |
Not clear |
| Suofu Qin, Yumiko Okawa, Larissa I Atangan, Geoffrey Brown, Roshantha A Chandraratna, Yi Zha. Integrities of A/B and C domains of RXR are required for rexinoid-induced caspase activations and apoptosis. The Journal of steroid biochemistry and molecular biology. vol 112. issue 1-3. 2009-03-06. PMID:18761406. |
here we have delineated regions of the retinoid x receptor alpha (rxralpha) that are required for rexinoid (rxr agonist)-induced growth inhibition and apoptosis. |
2009-03-06 |
2023-08-12 |
Not clear |
| Balakrishna Shankar, Subramanian Krishnan, Vasantha Malladi, Arun Balakrishnan, Peter H William. Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis. International journal of medical microbiology : IJMM. vol 299. issue 2. 2009-03-06. PMID:18771950. |
in this study, outer membrane proteins of wild-type enteropathogenic e. coli and an intimin-deficient mutant are shown to induce apoptosis by up-regulation of tumour necrosis factor alpha and activation of c-jun n-terminal kinase. |
2009-03-06 |
2023-08-12 |
Not clear |
| Balakrishna Shankar, Subramanian Krishnan, Vasantha Malladi, Arun Balakrishnan, Peter H William. Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis. International journal of medical microbiology : IJMM. vol 299. issue 2. 2009-03-06. PMID:18771950. |
proteinase k treatment of outer membrane proteins reduced apoptosis significantly, as did neutralising tumour necrosis factor alpha with specific antibodies. |
2009-03-06 |
2023-08-12 |
Not clear |
| Balakrishna Shankar, Subramanian Krishnan, Vasantha Malladi, Arun Balakrishnan, Peter H William. Outer membrane proteins of wild-type and intimin-deficient enteropathogenic Escherichia coli induce Hep-2 cell death through intrinsic and extrinsic pathways of apoptosis. International journal of medical microbiology : IJMM. vol 299. issue 2. 2009-03-06. PMID:18771950. |
inhibition of c-jun n-terminal kinase, but not inhibition of p38 mitogen-activated protein kinase, resulted in reduction of tumour necrosis factor alpha mrna levels and caspase-3 protein levels, and a reduction in apoptosis as observed by fluorescence-activated cell sorter analysis. |
2009-03-06 |
2023-08-12 |
Not clear |
| Hong Im Kim, Huang Huang, Satish Cheepala, Shile Huang, Jun Chun. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. Cancer prevention research (Philadelphia, Pa.). vol 1. issue 5. 2009-03-05. PMID:19138983. |
here we show that curcumin significantly reduced alpha(6)beta(4)-dependent breast cancer cell motility and invasion in a concentration-dependent manner without affecting apoptosis in mda-mb-435/beta4 (beta(4)-integrin transfectants) and mda-mb-231 breast cancer cell lines. |
2009-03-05 |
2023-08-12 |
Not clear |
| Shanhong Ling, Ruizhi Luo, Aozhi Dai, Zhixin Guo, Ruoling Guo, Paul A Komesarof. A pharmaceutical preparation of Salvia miltiorrhiza protects cardiac myocytes from tumor necrosis factor-induced apoptosis and reduces angiotensin II-stimulated collagen synthesis in fibroblasts. Phytomedicine : international journal of phytotherapy and phytopharmacology. vol 16. issue 1. 2009-02-23. PMID:19010649. |
a cardiac myocyte line, h9c2, and primarily cultured fibroblasts from rat hearts were incubated with cp over a broad concentration range (50-800 microg/ml) under normal cultures, conditions of ischemia (serum-free culture), and stimulation by angiotensin ii (aii, 100 nm), hydrogen peroxide (h(2)o(2), 50-200 microm), or tumor necrosis factor alpha (tnfalpha, 40 ng/ml) for 24-48 h. cell growth, apoptosis, dna and collagen synthesis, and expression of relevant genes were assessed via cell number study, morphological examination, annexin-v staining, flow-cytometry, [(3)h]-thymidine or [(3)h]-proline incorporation assay, and western blotting analysis. |
2009-02-23 |
2023-08-12 |
rat |
| Josef Krieglstein, Birgit Hufnagel, Melanie Dworak, Stefanie Schwarz, Tobias Kewitz, Michael Reinbold, Susanne Klump. Influence of various fatty acids on the activity of protein phosphatase type 2C and apoptosis of endothelial cells and macrophages. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. vol 35. issue 5. 2009-02-20. PMID:18812221. |
in previous work we have demonstrated that protein phosphatase type 2c (pp2c) alpha and beta can be activated by mono-unsaturated fatty acids (mufas) leading to apoptosis of cultured endothelial cells. |
2009-02-20 |
2023-08-12 |
human |
| C S Sandström, B Ohlsson, O Melander, U Westin, R Mahadeva, S Janciauskien. An association between Type 2 diabetes and alpha-antitrypsin deficiency. Diabetic medicine : a journal of the British Diabetic Association. vol 25. issue 11. 2009-02-20. PMID:19046232. |
alpha(1)-antitrypsin (aat) is a serine protease inhibitor which recently has been shown to prevent type 1 diabetes development, to prolong islet allograft survival and to inhibit pancreatic b-cell apoptosis in vivo. |
2009-02-20 |
2023-08-12 |
Not clear |
| Usha Gundimeda, Jason Eric Schiffman, Divya Chhabra, Jourdan Wong, Adela Wu, Rayudu Gopalakrishn. Locally generated methylseleninic acid induces specific inactivation of protein kinase C isoenzymes: relevance to selenium-induced apoptosis in prostate cancer cells. The Journal of biological chemistry. vol 283. issue 50. 2009-02-19. PMID:18922790. |
msa inhibited cell growth and induced apoptosis in du145 prostate cancer cells at a concentration that was higher than that needed to inhibit purified pkc alpha but in a range comparable with that required for the inhibition of pkc epsilon. |
2009-02-19 |
2023-08-12 |
Not clear |
| Shufeng Li, Mingyan E, Bo Y. Adriamycin induces myocardium apoptosis through activation of nuclear factor kappaB in rat. Molecular biology reports. vol 35. issue 4. 2009-02-09. PMID:17577680. |
myocardial apoptosis was detected by dna fragmentation assay and tunel assay; location and distribution of p-ikappab alpha was observed by immunohistochemical assay; myocardial expression of p-ikappab alpha protein was assessed by western blot analysis; activity of nf-kappab was evaluated by electrophoretic mobility shift assay. |
2009-02-09 |
2023-08-12 |
rat |
| Shufeng Li, Mingyan E, Bo Y. Adriamycin induces myocardium apoptosis through activation of nuclear factor kappaB in rat. Molecular biology reports. vol 35. issue 4. 2009-02-09. PMID:17577680. |
adriamycin induces myocardium apoptosis through activation of nuclear factor kappab in rat and nf-kappab activation requires ikappab alpha degradation. |
2009-02-09 |
2023-08-12 |
rat |
| Nadia Malagolini, Mariella Chiricolo, Marina Marini, Fabio Dall'Oli. Exposure of alpha2,6-sialylated lactosaminic chains marks apoptotic and necrotic death in different cell types. Glycobiology. vol 19. issue 2. 2009-02-04. PMID:18988689. |
in this work, we show that in cell lines from different histological origin, (colon, breast, pancreas, and bladder cancer) as well as in normal human and mice neutrophils, apoptosis is accompanied by the exposure of sugar chains recognized by the lectin from sambucus nigra (sna), specific for sia alpha 2,6gal/galnac structures. |
2009-02-04 |
2023-08-12 |
mouse |
| A Maver, I Medica, B Salobir, M Tercelj-Zorman, M Sabovic, D Petrovic, B Peterli. Peroxisome proliferator-activated receptor gamma/Pro12Ala polymorphism and peroxisome proliferator-activated receptor gamma coactivator-1 alpha/Gly482Ser polymorphism in patients with sarcoidosis. Sarcoidosis, vasculitis, and diffuse lung diseases : official journal of WASOG. vol 25. issue 1. 2009-02-03. PMID:19070258. |
pparg, together with its transcriptional coactivator peroxisome proliferator-activated receptor gamma coactivator-1 alpha (ppargc1a), has important modulating effects on immune response and apoptosis. |
2009-02-03 |
2023-08-12 |
Not clear |
| Loretta L Hoover, Elizabeth G Burton, Megan L O'Neill, Bonnie A Brooks, Shilpa Sreedharan, Nineveh A Dawson, Steven W Kubala. Retinoids regulate TGFbeta signaling at the level of Smad2 phosphorylation and nuclear accumulation. Biochimica et biophysica acta. vol 1783. issue 12. 2009-01-27. PMID:18773928. |
scott and r.a. shannon, elevated transforming growth factor beta2 enhances apoptosis and contributes to abnormal outflow tract and aortic sac development in retinoic x receptor alpha knockout embryos, development 129 (2002) 733-746.]. |
2009-01-27 |
2023-08-12 |
Not clear |
| Janesh Pillay, Laurien H Ulfman, Leo Koenderma. Comment on "Neutrophil apoptosis: selective regulation by different ligands of integrin alpha M beta 2". Journal of immunology (Baltimore, Md. : 1950). vol 181. issue 12. 2009-01-27. PMID:19050232. |
comment on "neutrophil apoptosis: selective regulation by different ligands of integrin alpha m beta 2". |
2009-01-27 |
2023-08-12 |
Not clear |
| Alessandra Cucina, Andrea Fuso, Pierpaolo Coluccia, Antonino Cavallar. Nicotine inhibits apoptosis and stimulates proliferation in aortic smooth muscle cells through a functional nicotinic acetylcholine receptor. The Journal of surgical research. vol 150. issue 2. 2009-01-23. PMID:18295799. |
apoptosis inhibition as well as the proliferation increase, and basic fibroblast growth factor expression on nicotine-treated smcs were blocked by nicotinic acetylcholine receptor antagonists, including alpha-bungarotoxin, a competitive antagonist of alpha subunits of nicotinic receptor. |
2009-01-23 |
2023-08-12 |
Not clear |
| Gang Song, Yanlin Ming, Yubin Mao, Shideng Bao, Gaoliang Ouyan. Osteopontin prevents curcumin-induced apoptosis and promotes survival through Akt activation via alpha v beta 3 integrins in human gastric cancer cells. Experimental biology and medicine (Maywood, N.J.). vol 233. issue 12. 2009-01-22. PMID:18849546. |
osteopontin prevents curcumin-induced apoptosis and promotes survival through akt activation via alpha v beta 3 integrins in human gastric cancer cells. |
2009-01-22 |
2023-08-12 |
human |
| Liaman K Mamedova, Ruibo Wang, Pedro Besada, Bruce T Liang, Kenneth A Jacobso. Attenuation of apoptosis in vitro and ischemia/reperfusion injury in vivo in mouse skeletal muscle by P2Y6 receptor activation. Pharmacological research. vol 58. issue 3-4. 2009-01-14. PMID:18805489. |
activation of the g(q)-coupled p2y(6) receptor heterologously expressed in astrocytes significantly attenuates apoptosis induced by tumor necrosis factor alpha (tnfalpha). |
2009-01-14 |
2023-08-12 |
mouse |