| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Konstantin Bloch, Julia Vennäng, Daniel Lazard, Pnina Vard. Different susceptibility of rat pancreatic alpha and beta cells to hypoxia. Histochemistry and cell biology. vol 137. issue 6. 2012-09-24. PMID:22310982. |
in contrast, hypoxia induced an abundance of apoptotic beta cells (61 ± 22%) and had no effect on the level of apoptosis in alpha cells. |
2012-09-24 |
2023-08-12 |
rat |
| Konstantin Bloch, Julia Vennäng, Daniel Lazard, Pnina Vard. Different susceptibility of rat pancreatic alpha and beta cells to hypoxia. Histochemistry and cell biology. vol 137. issue 6. 2012-09-24. PMID:22310982. |
in conclusion, this study demonstrates that hypoxia results in severe functional abnormality in both beta and alpha cells while alpha cells display significantly decreased rate of apoptosis compared to intensive apoptotic injury of beta cells. |
2012-09-24 |
2023-08-12 |
rat |
| A Wong, N Gunasekaran, D P Hancock, G S Denyer, L Meng, J L Radford, I S McGregor, J C Arnol. The major plant-derived cannabinoid Δ(9)-tetrahydrocannabinol promotes hypertrophy and macrophage infiltration in adipose tissue. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme. vol 44. issue 2. 2012-09-11. PMID:22189757. |
we also showed that thc induced macrophage infiltration and increased expression of the inflammatory cytokine tumor necrosis factor alpha (tnf-α) in adipose tissue but did not induce apoptosis as measured by tunel staining. |
2012-09-11 |
2023-08-12 |
rat |
| Romina Scian, Paula Barrionuevo, Carlos A Fossati, Guillermo H Giambartolomei, M Victoria Delpin. Brucella abortus invasion of osteoblasts inhibits bone formation. Infection and immunity. vol 80. issue 7. 2012-08-24. PMID:22547546. |
we demonstrated that supernatants from b. abortus-infected macrophages may also mediate osteoblast apoptosis and inhibit osteoblast function in a process that is dependent on the presence of tumor necrosis factor alpha (tnf-α). |
2012-08-24 |
2023-08-12 |
Not clear |
| Cheng-Der Wu, Yuan-Sung Kuo, Han-Chung Wu, Chin-Tarng Li. MicroRNA-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. Journal of biomedical science. vol 18. 2012-08-17. PMID:22059741. |
microrna-1 induces apoptosis by targeting prothymosin alpha in nasopharyngeal carcinoma cells. |
2012-08-17 |
2023-08-12 |
Not clear |
| Kristina Heyne, Judith Huwer, Vincent Zimmer, Michael Pfreundschuh, Jasmin Teresa Ney, Gunter Assman. Different apoptotic responses of RA synoviocytes depending on different genotypes of the mdm2 SNP T309G. Apoptosis : an international journal on programmed cell death. vol 17. issue 4. 2012-07-30. PMID:22187011. |
the cell-lines genotyped with mdm2 snp 309tt showed a significantly different apoptosis rate in percent compared with gg for both conditions with stimulation (19.4 ± 3.6 vs. 26.9 ± 1.8; p = 0.02) and without stimulation by tnf alpha and il-1beta (27.4 ± 8.8 vs. 43.9 ± 2.4; p = 0.0002). |
2012-07-30 |
2023-08-12 |
Not clear |
| Miroslav Vařecha, Michaela Potěšilová, Pavel Matula, Michal Kozube. Endonuclease G interacts with histone H2B and DNA topoisomerase II alpha during apoptosis. Molecular and cellular biochemistry. vol 363. issue 1-2. 2012-07-02. PMID:22160858. |
endonuclease g interacts with histone h2b and dna topoisomerase ii alpha during apoptosis. |
2012-07-02 |
2023-08-12 |
human |
| Béatrice Dendelé, Xavier Tekpli, Odile Sergent, Marie-Thérèse Dimanche-Boitrel, Jørn A Holme, Laurence Huc, Dominique Lagadic-Gossman. Identification of the couple GSK3α/c-Myc as a new regulator of hexokinase II in benzo[a]pyrene-induced apoptosis. Toxicology in vitro : an international journal published in association with BIBRA. vol 26. issue 1. 2012-05-03. PMID:22100782. |
we show that while glycogen synthase kinase 3 beta (gsk3β) regulated the expression of hkii at the transcriptional level, glycogen synthase kinase 3 alpha (gsk3α) was involved in b[a]p-induced apoptosis via a decrease in c-myc expression. |
2012-05-03 |
2023-08-12 |
rat |
| Albert S Jun, Huan Meng, Naren Ramanan, Mario Matthaei, Shukti Chakravarti, Richard Bonshek, Graeme C M Black, Rhonda Grebe, Martha Kimo. An alpha 2 collagen VIII transgenic knock-in mouse model of Fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis. Human molecular genetics. vol 21. issue 2. 2012-04-26. PMID:22002996. |
an alpha 2 collagen viii transgenic knock-in mouse model of fuchs endothelial corneal dystrophy shows early endothelial cell unfolded protein response and apoptosis. |
2012-04-26 |
2023-08-12 |
mouse |
| Yongqin Zhang, Philip E Dubé, M Kay Washington, Fang Yan, D Brent Pol. ErbB2 and ErbB3 regulate recovery from dextran sulfate sodium-induced colitis by promoting mouse colon epithelial cell survival. Laboratory investigation; a journal of technical methods and pathology. vol 92. issue 3. 2012-04-19. PMID:22157714. |
delayed recovery in mice with epithelial deletion of erbb2 or erbb3 was associated with increased colonic expression of tumor necrosis factor alpha and increased epithelial apoptosis. |
2012-04-19 |
2023-08-12 |
mouse |
| Hsueh-Fang Wang, Chien-Yu Tseng, Mu-Hsin Chang, James A Lin, Fu-Jen Tsai, Chang-Hai Tsai, Ying-Chen Lu, Chao-Hung Lai, Chih-Yang Huang, Cheng-Chih Tsa. Anti-inflammatory effects of probiotic Lactobacillus paracasi on ventricles of BALB/C mice treated with ovalbumin. The Chinese journal of physiology. vol 55. issue 1. 2012-04-19. PMID:22242953. |
the inflammatory pathway, including toll-like receptor 4 (tlr4), phospholate-jun-n-terminal kinase (p-jnk), jnk1/2 and tumor necrosis factor- alpha (tnf-α) and the mitochondria-dependent apoptosis phospholate-p38 (p-p38), bcl-2 associated agonist of cell death (bad), bcl-2 associated x (bax) and activated caspase 3, were found to be significant- ly increased in the hearts of allergy mice. |
2012-04-19 |
2023-08-12 |
mouse |
| Guixiang Gan, Ruicheng Hu, Aiguo Dai, Shuangxiang Tan, Qing Ouyang, Daiyan Fu, Dixuan Jian. The role of endoplasmic reticulum stress in emphysema results from cigarette smoke exposure. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. vol 28. issue 4. 2012-04-16. PMID:22178884. |
in our research, we investigated the role of protein kinase rna (pkr)-like er kinase (perk)/ eukaryotic initiation factor 2 alpha (eif2α) pathway, the ccaat enhancer-binding protein-homologous protein (chop) expression, caspase-12 activation and apoptosis in emphysema results from cigarette smoke (cs) exposure. |
2012-04-16 |
2023-08-12 |
rat |
| Sebastian Kummer, Stefanie Jeruschke, Lara Vanessa Wegerich, Andrea Peters, Petra Lehmann, Annette Seibt, Friederike Mueller, Nadezda Koleganova, Elisabeth Halbenz, Claus Peter Schmitt, Markus Bettendorf, Ertan Mayatepek, Marie-Luise Gross-Weissmann, Jun O. Estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo. PloS one. vol 6. issue 11. 2012-04-10. PMID:22096576. |
estrogen receptor alpha expression in podocytes mediates protection against apoptosis in-vitro and in-vivo. |
2012-04-10 |
2023-08-12 |
Not clear |
| Liang Xia, Fang Ding, Jun-Hui Zhu, Guo-Sheng F. Resveratrol attenuates apoptosis of pulmonary microvascular endothelial cells induced by high shear stress and proinflammatory factors. Human cell. vol 24. issue 3. 2012-02-22. PMID:21892612. |
in order to investigate the effects of resveratrol (rsv) on ec apoptosis, we applied high shear stress (hss) with proinflammatory factors [tumor necrosis factor alpha (tnf-α) plus cycloheximide] to human pulmonary microvascular ecs (pmvecs) through an artificial capillary system. |
2012-02-22 |
2023-08-12 |
human |
| Clarence N Ahlem, James M Frincke, Steven K White, Christopher L Reading, Richard J Trauger, Rajkumar Lakshmanaswam. 17α-ethynyl-5α-androstane-3α, 17β-diol treatment of MNU-induced mammary cancer in rats. International journal of breast cancer. vol 2011. 2012-02-14. PMID:22332014. |
he3235 treatment increased immunohistochemical markers of apoptosis and expression of proapoptotic genes and estrogen receptor beta and decreased expression of antiapoptotic genes, androgen receptor, and estrogen receptor alpha. |
2012-02-14 |
2023-08-12 |
rat |
| Aiping Lan, Xinxue Liao, Liqiu Mo, Chuntao Yang, Zhanli Yang, Xiuyu Wang, Fen Hu, Peixi Chen, Jianqiang Feng, Dongdan Zheng, Liangcan Xia. Hydrogen sulfide protects against chemical hypoxia-induced injury by inhibiting ROS-activated ERK1/2 and p38MAPK signaling pathways in PC12 cells. PloS one. vol 6. issue 10. 2012-02-13. PMID:21998720. |
we observed that cocl(2) induced expression of transcriptional factor hypoxia-inducible factor-1 alpha (hif-1α), decreased cystathionine-β synthase (cbs, a synthase of h(2)s) expression, and increased generation of reactive oxygen species (ros), leading to injuries of the cells, evidenced by decrease in cell viability, dissipation of mitochondrial membrane potential (mmp) , caspase-3 activation and apoptosis, which were attenuated by pretreatment with nahs (a donor of h(2)s) or n-acetyl-l cystein (nac), a ros scavenger. |
2012-02-13 |
2023-08-12 |
Not clear |
| Eun-Ju Chang, Jeongim Ha, Soon-Suk Kang, Zang Hee Lee, Hong-Hee Ki. AWP1 binds to tumor necrosis factor receptor-associated factor 2 (TRAF2) and is involved in TRAF2-mediated nuclear factor-kappaB signaling. The international journal of biochemistry & cell biology. vol 43. issue 11. 2012-01-26. PMID:21810480. |
knockdown of awp1 using small hairpin rna significantly decreased nuclear factor kappab activity but increased tumor necrosis factor alpha (tnfα)-induced apoptosis, presumably by decreasing the induction of nuclear factor kappab-responsive anti-apoptotic molecules, including fice-like inhibitory protein (flip), x-linked inhibitor of apoptosis protein (xiap), bcl-2, and bcl-xl. |
2012-01-26 |
2023-08-12 |
Not clear |
| Chung-Jung Liu, Jeng-Fan Lo, Chia-Hua Kuo, Chun-Hsien Chu, Li-Ming Chen, Fuu-Jen Tsai, Chang-Hai Tsai, Bor-Show Tzang, Wei-Wen Kuo, Chih-Yang Huan. Akt mediates 17beta-estradiol and/or estrogen receptor-alpha inhibition of LPS-induced tumor necresis factor-alpha expression and myocardial cell apoptosis by suppressing the JNK1/2-NFkappaB pathway. Journal of cellular and molecular medicine. vol 13. issue 9B. 2011-12-23. PMID:20196785. |
to identify the cardioprotective effects and precise cellular/molecular mechanisms behind estrogen and estrogen receptors (ers), we investigated the effects of 17beta-estradiol (e(2)) and estrogen receptor alpha (eralpha) on lps-induced apoptosis by analyzing the activation of survival and death signalling pathways in doxycycline (dox)-inducible tet-on/eralpha h9c2 myocardial cells and eralpha-transfected primary cardiomyocytes overexpressing eralpha. |
2011-12-23 |
2023-08-12 |
Not clear |
| Frank Hanses, Sunny Park, Jeremy Rich, Jean C Le. Reduced neutrophil apoptosis in diabetic mice during staphylococcal infection leads to prolonged Tnfα production and reduced neutrophil clearance. PloS one. vol 6. issue 8. 2011-12-23. PMID:21912601. |
decreased apoptosis correlated with impaired clearance of neutrophils by macrophages both in vitro and in vivo and prolonged production of proinflammatory tumor necrosis factor alpha by neutrophils from diabetic mice. |
2011-12-23 |
2023-08-12 |
mouse |
| Lingzhi Zhang, Hongruo Yun, Fiona Murray, Ruilin Lu, Lin Wang, Vivian Hook, Paul A Inse. Cytotoxic T lymphocyte antigen-2 alpha induces apoptosis of murine T-lymphoma cells and cardiac fibroblasts and is regulated by cAMP/PKA. Cellular signalling. vol 23. issue 10. 2011-12-06. PMID:21620962. |
cytotoxic t lymphocyte antigen-2 alpha induces apoptosis of murine t-lymphoma cells and cardiac fibroblasts and is regulated by camp/pka. |
2011-12-06 |
2023-08-12 |
Not clear |