| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ni-Huiping Son, Radha Ananthakrishnan, Shuiqing Yu, Raffay S Khan, Hongfeng Jiang, Ruiping Ji, Hirokazu Akashi, Qing Li, Karen O'Shea, Shunichi Homma, Ira J Goldberg, Ravichandran Ramasam. Cardiomyocyte aldose reductase causes heart failure and impairs recovery from ischemia. PloS one. vol 7. issue 9. 2013-02-20. PMID:23029549. |
when the har transgene was crossed onto the ppar alpha knockout background, another example of greater heart glucose oxidation, har expressing mice had increased heart fructose content, cardiac fibrosis, ros, and apoptosis. |
2013-02-20 |
2023-08-12 |
mouse |
| Qinxiang Zheng, Yueping Ren, Radouil Tzekov, Yuanping Zhang, Bo Chen, Jiangping Hou, Chunhui Zhao, Jiali Zhu, Ying Zhang, Xufeng Dai, Shan Ma, Jia Li, Jijing Pang, Jia Qu, Wensheng L. Differential proteomics and functional research following gene therapy in a mouse model of Leber congenital amaurosis. PloS one. vol 7. issue 8. 2013-02-07. PMID:22953002. |
the expression of 3 proteins involved in regulation of apoptosis and neuroptotection (alpha a crystallin, heat shock protein 70 and peroxiredoxin 6) were investigated further. |
2013-02-07 |
2023-08-12 |
mouse |
| M A Rezvanfar, M A Rezvanfar, A Ahmadi, H A Shojaei Saadi, M Baeeri, M Abdollah. Mechanistic links between oxidative/nitrosative stress and tumor necrosis factor alpha in letrozole-induced murine polycystic ovary: biochemical and pathological evidences for beneficial effect of pioglitazone. Human & experimental toxicology. vol 31. issue 9. 2013-02-05. PMID:22076494. |
to determine the role of oxidative stress in pco, the level of cellular lipid peroxidation (lpo), superoxide dismutase (sod), catalase (cat), glutathione peroxidase (gpx), and peroxynitrite (onoo), and tumor necrosis factor alpha (tnf-α) as a marker of inflammation and apoptosis were measured in serum and the ovaries. |
2013-02-05 |
2023-08-12 |
rat |
| Guilherme Fartes, Fabio Lorenzetti, Larissa Beloti Salvador, Valdemar Ortiz, Miriam Dambro. Antioxidant supplementation decreases the cell death rate in the prostatic stromal tissue of long-term castrated rats. International braz j urol : official journal of the Brazilian Society of Urology. vol 38. issue 3. 2013-01-16. PMID:22765858. |
the purpose of this study was to compare the effects of castration on cell death rate of the adult rat prostates and to evaluate the benefic action of alpha tocopherol supplementation to avoid apoptosis post-orchiectomy. |
2013-01-16 |
2023-08-12 |
rat |
| Stancy Joseph, Victoria E Deneke, Karen D Cowden Dah. ARID3B induces tumor necrosis factor alpha mediated apoptosis while a novel ARID3B splice form does not induce cell death. PloS one. vol 7. issue 7. 2013-01-14. PMID:22860069. |
arid3b induces tumor necrosis factor alpha mediated apoptosis while a novel arid3b splice form does not induce cell death. |
2013-01-14 |
2023-08-12 |
Not clear |
| Stancy Joseph, Victoria E Deneke, Karen D Cowden Dah. ARID3B induces tumor necrosis factor alpha mediated apoptosis while a novel ARID3B splice form does not induce cell death. PloS one. vol 7. issue 7. 2013-01-14. PMID:22860069. |
importantly, arid3b fl overexpression results in upregulation of pro-apoptotic bim and induces tumor necrosis factor alpha (tnfα) and tnf-related apoptosis inducing ligand (trail) induced cell death. |
2013-01-14 |
2023-08-12 |
Not clear |
| Lucie Barblu, Kawthar Machmach, Christophe Gras, Jean-François Delfraissy, Faroudy Boufassa, Manuel Leal, Ezequiel Ruiz-Mateos, Olivier Lambotte, Jean-Philippe Herbeuva. Plasmacytoid dendritic cells (pDCs) from HIV controllers produce interferon-α and differentiate into functional killer pDCs under HIV activation. The Journal of infectious diseases. vol 206. issue 5. 2013-01-08. PMID:22693234. |
after hiv exposure, plasmacytoid dendritic cells (pdcs) produce high levels of interferon alpha (ifn-α) and express the apoptotic ligand trail (tumor necrosis factor-related apoptosis inducing ligand). |
2013-01-08 |
2023-08-12 |
human |
| Jae-Kyo Jeong, Jae-Suk Seo, Myung-Hee Moon, You-Jin Lee, Jae-Won Seol, Sang-Youel Par. Hypoxia-inducible factor-1 α regulates prion protein expression to protect against neuron cell damage. Neurobiology of aging. vol 33. issue 5. 2012-11-23. PMID:22036844. |
based on our previous findings that hypoxia protects neuronal cells from prp (106-126)-induced apoptosis and increases cellular prion protein (prp(c)) expression, we hypothesized that hypoxia-related genes, including hypoxia-inducible factor-1 alpha (hif-1α), may regulate prp(c) expression and that these genes may be involved in prion-related neurodegenerative diseases. |
2012-11-23 |
2023-08-12 |
human |
| Christian Liedtke, Christian Trautwei. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. European journal of cell biology. vol 91. issue 6-7. 2012-11-07. PMID:22153863. |
tumor necrosis factor (tnf) alpha is a pleiotropic cytokine triggering either pro-inflammatory effects via nf-κb related pathways or apoptosis through activation of caspase-8. |
2012-11-07 |
2023-08-12 |
mouse |
| Christian Liedtke, Christian Trautwei. The role of TNF and Fas dependent signaling in animal models of inflammatory liver injury and liver cancer. European journal of cell biology. vol 91. issue 6-7. 2012-11-07. PMID:22153863. |
targeted stimulation of the caspase-8 promoter by interferons alpha and gamma, cytotoxic drugs or p53 can substantially sensitize hepatoma cells for apoptosis, whereas hepatocellular carcinoma frequently present an inactive caspase-8 gene promoter. |
2012-11-07 |
2023-08-12 |
mouse |
| Lian-Qing Sun, Ying-Ying Chen, Xuan Wang, Xiao-Jin Li, Bing Xue, Ling Qu, Ting-Ting Zhang, Yi-Ming Mu, Ju-Ming L. The protective effect of alpha lipoic acid on Schwann cells exposed to constant or intermittent high glucose. Biochemical pharmacology. vol 84. issue 7. 2012-11-01. PMID:22796564. |
the aim of this study was to examine the impact of treatment with alpha lipoic acid (ala) on the intermittent high glucose (ihg) or high glucose (hg)-induced oxidative stress-induced mitochondrial pathway activation and schwann cells (scs) apoptosis in vitro. |
2012-11-01 |
2023-08-12 |
Not clear |
| b' Guowei Gu, Ines Barone, Luca Gelsomino, Cinzia Giordano, Daniela Bonofiglio, Giancarlo Statti, Francesco Menichini, Stefania Catalano, Sebastiano And\\xc3\\xb. Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ER\\xce\\xb1/Sp1-mediated p53 activation. Journal of cellular physiology. vol 227. issue 10. 2012-10-29. PMID:22213398.' |
we observed that od extracts strongly inhibited anchorage-dependent and -independent cell growth and induced apoptosis in estrogen receptor alpha (erα)-positive breast cancer cells, whereas proliferation and apoptotic responses of mcf-10a normal breast epithelial cells were unaffected. |
2012-10-29 |
2023-08-12 |
human |
| Pauline Yoong, Gerald B Pie. Immune-activating properties of Panton-Valentine leukocidin improve the outcome in a model of methicillin-resistant Staphylococcus aureus pneumonia. Infection and immunity. vol 80. issue 8. 2012-10-10. PMID:22665379. |
conversely, pvl lowered the levels of tumor necrosis factor alpha (tnf-α) produced in active pulmonary infection, while low doses induced apoptosis, suggesting that pvl also has the capacity to regulate inflammation. |
2012-10-10 |
2023-08-12 |
mouse |
| Yang Hong, Meng Sang, Chao Shang, Yi-xue Xue, Yun-hui Li. Quantitative analysis of topoisomerase II alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells. Neuroscience letters. vol 518. issue 2. 2012-10-04. PMID:22569122. |
quantitative analysis of topoisomerase ii alpha and evaluation of its effects on cell proliferation and apoptosis in glioblastoma cancer stem cells. |
2012-10-04 |
2023-08-12 |
Not clear |
| E Weiss, U Vonreyher, W Kittstein, P Moller, P Krammer, F Marks, M Gschwend. Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. International journal of oncology. vol 10. issue 6. 2012-10-02. PMID:21533493. |
suppression of apoptosis in colo 205 cells by the phorbol ester tpa may be mediated by the pkc isoenzyme alpha. |
2012-10-02 |
2023-08-12 |
Not clear |
| E Weiss, U Vonreyher, W Kittstein, P Moller, P Krammer, F Marks, M Gschwend. Suppression of apoptosis in COLO 205 cells by the phorbol ester TPA may be mediated by the PKC isoenzyme alpha. International journal of oncology. vol 10. issue 6. 2012-10-02. PMID:21533493. |
thus, these findings suggest that pkc alpha has an important role in the tpa-induced inhibition of apoptosis. |
2012-10-02 |
2023-08-12 |
Not clear |
| V Damiano, G Diisernia, F Ciardiello, S Pepe, A Bianco, C Bianco, A Ruggiero, G Baldassarre, G Merlo, G Tortor. Overexpression of wild-type p53 overrides the mitogenic effect of ri-alpha subunit of protein-kinase-a in human breast cells. International journal of oncology. vol 7. issue 2. 2012-10-02. PMID:21552843. |
retroviral vector-mediated overexpression of wild-type p53 in the mcf-10a neo and mcf-10a ri alpha cells determined a marked inhibition of ri alpha protein expression in mcf-10a-p53 cells and induced g0/g1 accumulation, cell gowth arrest and changes in cell morphology not due to apoptosis in both mcf-10a-p53 and mcf-10a ri alpha-p53 cells. |
2012-10-02 |
2023-08-12 |
human |
| W Bezwoda, N Mansoor, L Seymou. Combined Cytosine-arabinoside plus interferon-alpha .1. Interferon-alpha potentiates the effect of Cytosine-arabinoside in hl-60 cells by stimulation of apoptosis. International journal of oncology. vol 2. issue 3. 2012-10-02. PMID:21573578. |
addition of interferon alpha in amounts as low as 10 u/ml potentiated the apoptosis inducing effect of cytosine arabinoside and moreover prevented recovery from sublethal toxicity after short duration exposure to the latter drug. |
2012-10-02 |
2023-08-12 |
human |
| Siobhan Bacon, Ma Peyh Kyithar, Jasmin Schmid, Syed R Rizvi, Caroline Bonner, Rolf Graf, Jochen Hm Prehn, Maria M Byrn. Serum levels of pancreatic stone protein (PSP)/reg1A as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (HNF1A-MODY) carriers from the third decade of life onward. BMC endocrine disorders. vol 12. 2012-10-02. PMID:22808921. |
serum levels of pancreatic stone protein (psp)/reg1a as an indicator of beta-cell apoptosis suggest an increased apoptosis rate in hepatocyte nuclear factor 1 alpha (hnf1a-mody) carriers from the third decade of life onward. |
2012-10-02 |
2023-08-12 |
Not clear |
| Naveen Kumar Singhal, Garima Srivastava, Sonal Agrawal, Swatantra Kumar Jain, Mahendra Pratap Sing. Melatonin as a neuroprotective agent in the rodent models of Parkinson's disease: is it all set to irrefutable clinical translation? Molecular neurobiology. vol 45. issue 1. 2012-09-24. PMID:22198804. |
parkinson's disease (pd), a neurodegenerative disorder, is characterized by the selective degeneration of the nigrostriatal dopaminergic neurons, continuing or permanent deficiency of dopamine, accretion of an abnormal form of alpha synuclein in the adjacent neurons, and dysregulation of ubiquitin proteasomal system, mitochondrial metabolism, permeability and integrity, and cellular apoptosis resulting in rigidity, bradykinesia, resting tremor, and postural instability. |
2012-09-24 |
2023-08-12 |
Not clear |