| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yuncheng Wu, Xinqun Li, Wenjie Xie, Joseph Jankovic, Weidong Le, Tianhong Pa. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochemistry international. vol 57. issue 3. 2010-11-04. PMID:20546814. |
our results also showed that deferoxamine attenuated rotenone-induced apoptosis, which was blocked when hif-1 alpha or autophagy related gene beclin 1 was suppressed. |
2010-11-04 |
2023-08-12 |
Not clear |
| Yuncheng Wu, Xinqun Li, Wenjie Xie, Joseph Jankovic, Weidong Le, Tianhong Pa. Neuroprotection of deferoxamine on rotenone-induced injury via accumulation of HIF-1 alpha and induction of autophagy in SH-SY5Y cells. Neurochemistry international. vol 57. issue 3. 2010-11-04. PMID:20546814. |
in summary, the present study indicated that the level of hif-1 alpha was decreased under the situation when mitochondrial complex i was inhibited, and the neuroprotective role of deferoxamine in rotenone-induced apoptosis could be partially explained by its effects on the accumulation of hif-1 alpha and hif-1 alpha-mediated induction of autophagy. |
2010-11-04 |
2023-08-12 |
Not clear |
| Péter Csomor, István Sziklai, Bálint Liktor, László Szabó, József Pytel, József Jóri, Tamás Karos. Otosclerosis: disturbed balance between cell survival and apoptosis. Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. vol 31. issue 6. 2010-11-04. PMID:20684053. |
otosclerosis is an inflammatory bone remodeling disorder of the human otic capsule, which might be characterized by a disturbed balance between cell survival and apoptosis due to an increased expression of inflammatory cytokines, mainly tumor necrosis factor-[alpha] (tnf-[alpha]). |
2010-11-04 |
2023-08-12 |
human |
| Thomas Decker, Christian Bogner, Madlen Oelsner, Christian Peschel, Ingo Ringshause. Antiapoptotic effect of interleukin-2 (IL-2) in B-CLL cells with low and high affinity IL-2 receptors. Annals of hematology. vol 89. issue 11. 2010-10-25. PMID:20544350. |
although b chronic lymphocytic leukemia (b-cll) cells express the alpha chain of the interleukin-2 (il-2) receptor cd25, little is known about the effect of il-2 on apoptosis in b-cll cells. |
2010-10-25 |
2023-08-12 |
Not clear |
| Haifeng Wang, Yinghao Sun, Linhui Wang, Chuanliang Xu, Qing Yang, Bing Liu, Zhiyong Li. Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. Journal of andrology. vol 31. issue 3. 2010-10-18. PMID:20019389. |
in this study, we investigated the expression of the alpha subunit of hypoxia-inducible factor 1 (hif-1 alpha) and determined the apoptosis index (ai) in the testes of rats with varicoceles to study the mechanism by which varicoceles induce infertility. |
2010-10-18 |
2023-08-12 |
rat |
| Haifeng Wang, Yinghao Sun, Linhui Wang, Chuanliang Xu, Qing Yang, Bing Liu, Zhiyong Li. Hypoxia-induced apoptosis in the bilateral testes of rats with left-sided varicocele: a new way to think about the varicocele. Journal of andrology. vol 31. issue 3. 2010-10-18. PMID:20019389. |
furthermore, hif-1 alpha is a useful factor that can be used to predict the degree of germ cell apoptosis in rat testes. |
2010-10-18 |
2023-08-12 |
rat |
| Claudia Bracht, Dominik R J Hauser, Verena Schattel, Wolfgang Albrecht, Stefan A Laufe. Synthesis and biological testing of N-aminoimidazole-based p38alpha MAP kinase inhibitors. ChemMedChem. vol 5. issue 7. 2010-10-18. PMID:20473979. |
the p38 mitogen-activated protein (map) kinase alpha plays a central role in the regulation of cellular responses such as differentiation, proliferation, apoptosis, and inflammation. |
2010-10-18 |
2023-08-12 |
Not clear |
| E Law, S Lu, T J Kieffer, G L Warnock, Z Ao, M Woo, L Marzba. Differences between amyloid toxicity in alpha and beta cells in human and mouse islets and the role of caspase-3. Diabetologia. vol 53. issue 7. 2010-08-27. PMID:20369225. |
we used human and transgenic mouse islets in culture to examine whether deletion of caspase-3 protects islets from apoptosis induced by endogenously produced and exogenously applied hiapp and compared hiapp toxicity in islet alpha and beta cells. |
2010-08-27 |
2023-08-12 |
mouse |
| Zhor Bouizar, Bruno Ragazzon, Lucie Viou, Mariuccia Hortane, Jerôme Bertherat, Marthe Rizk-Rabi. 8Cl-cAMP modifies the balance between PKAR1 and PKAR2 and modulates the cell cycle, growth and apoptosis in human adrenocortical H295R cells. Journal of molecular endocrinology. vol 44. issue 6. 2010-08-24. PMID:20237143. |
r2b silencing reduced the apoptosis induced by tumour necrosis factor alpha and transforming growth factor beta. |
2010-08-24 |
2023-08-12 |
human |
| Anna Kilbey, Anne Terry, Alma Jenkins, Gillian Borland, Qifeng Zhang, Michael J O Wakelam, Ewan R Cameron, James C Nei. Runx regulation of sphingolipid metabolism and survival signaling. Cancer research. vol 70. issue 14. 2010-08-24. PMID:20587518. |
runx expression also opposed the activation of c-jun-nh(2)-kinase and p38(mapk), key mediators of ceramide-induced death, and suppressed the onset of apoptosis in response to exogenous tumor necrosis factor alpha. |
2010-08-24 |
2023-08-12 |
mouse |
| Wei Zhu, Honghua Zheng, Xinli Shao, Wei Wang, Qing Yao, Zhengli L. Excitotoxicity of TNFalpha derived from KA activated microglia on hippocampal neurons in vitro and in vivo. Journal of neurochemistry. vol 114. issue 2. 2010-08-23. PMID:20438614. |
we use electrophysiological techniques, elisa, western-blot, rt-pcr assay and tunel method to explore whether over-produced tumor necrosis factor alpha (tnfalpha) released from activated microglia results in neuronal injuries, and further causes apoptosis through increasing excitotoxicity of hippocampal neurons. |
2010-08-23 |
2023-08-12 |
rat |
| Francesco Caiazza, Brian J Harvey, Warren Thoma. Cytosolic phospholipase A2 activation correlates with HER2 overexpression and mediates estrogen-dependent breast cancer cell growth. Molecular endocrinology (Baltimore, Md.). vol 24. issue 5. 2010-08-17. PMID:20211985. |
pharmacological blockade of cpla(2)alpha using a specific antagonist suppressed the growth of both mcf-7 and skbr3 cells by reducing e2-induced proliferation and by stimulating cellular apoptosis and necrosis. |
2010-08-17 |
2023-08-12 |
Not clear |
| C M Greene, S D W Miller, T P Carroll, I K Oglesby, F Ahmed, M O'Mahony, C C Taggart, N G McElvaney, S J O'Neil. Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells. The European respiratory journal. vol 35. issue 5. 2010-08-13. PMID:19840955. |
herein, we investigate the effects of mutant z alpha(1)-at (zaat) expression on apoptosis in a human bronchial epithelial cell line (16hbe14o-) and delineate the mechanisms involved. |
2010-08-13 |
2023-08-12 |
human |
| C M Greene, S D W Miller, T P Carroll, I K Oglesby, F Ahmed, M O'Mahony, C C Taggart, N G McElvaney, S J O'Neil. Anti-apoptotic effects of Z alpha1-antitrypsin in human bronchial epithelial cells. The European respiratory journal. vol 35. issue 5. 2010-08-13. PMID:19840955. |
control, m variant alpha(1)-at (maat)- or zaat-expressing cells were assessed for apoptosis, caspase-3 activity, cell viability, phosphorylation of bad, nuclear factor (nf)-kappab activation and induced expression of a selection of pro- and anti-apoptotic genes. |
2010-08-13 |
2023-08-12 |
human |
| Ryoichi Shirai, Rikiya Gotou, Fumiyasu Hirano, Kiyoshi Ikeda, Seiji Inou. Autologous extracellular cytochrome c is an endogenous ligand for leucine-rich alpha2-glycoprotein and beta-type phospholipase A2 inhibitor. The Journal of biological chemistry. vol 285. issue 28. 2010-08-12. PMID:20442399. |
beta-type phospholipase a(2) inhibitory protein (plibeta) from the serum of the venomous snake gloydius brevicaudus neutralizes basic phospholipase a(2) (pla(2)) from its own venom, and it has 33% sequence homology with human leucine-rich alpha(2)-glycoprotein (lrg), which has been recently reported to bind cytochrome c (cyt c) (cummings, c., walder, j., treeful, a., and jemmerson, r. (2006) apoptosis 11, 1121-1129). |
2010-08-12 |
2023-08-12 |
human |
| Ulrike Olszewski, Gerhard Hamilto. Mechanisms of cytotoxicity of anticancer titanocenes. Anti-cancer agents in medicinal chemistry. vol 10. issue 4. 2010-08-02. PMID:20380637. |
differences observed in transcript levels indicated downregulation of dna unwinding by topoisomerases i and ii alpha and activation of responses to dna damage and cellular stress as well as shutdown of energy metabolism and, finally, apoptosis. |
2010-08-02 |
2023-08-12 |
Not clear |
| Roberta F Saldanha-Gama, João A Moraes, Andrea Mariano-Oliveira, Ana Lucia Coelho, Erin M Walsh, Cezary Marcinkiewicz, Christina Barja-Fidalg. alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of Bcl-2 family members. Biochimica et biophysica acta. vol 1803. issue 7. 2010-07-27. PMID:20362630. |
alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of bcl-2 family members. |
2010-07-27 |
2023-08-12 |
human |
| Roberta F Saldanha-Gama, João A Moraes, Andrea Mariano-Oliveira, Ana Lucia Coelho, Erin M Walsh, Cezary Marcinkiewicz, Christina Barja-Fidalg. alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of Bcl-2 family members. Biochimica et biophysica acta. vol 1803. issue 7. 2010-07-27. PMID:20362630. |
however, there are no detailed studies on how alpha(9)beta(1) integrin-coupled signaling pathways interact and how they converge to finally modulate spontaneous apoptosis in neutrophils. |
2010-07-27 |
2023-08-12 |
human |
| Roberta F Saldanha-Gama, João A Moraes, Andrea Mariano-Oliveira, Ana Lucia Coelho, Erin M Walsh, Cezary Marcinkiewicz, Christina Barja-Fidalg. alpha(9)beta(1) integrin engagement inhibits neutrophil spontaneous apoptosis: involvement of Bcl-2 family members. Biochimica et biophysica acta. vol 1803. issue 7. 2010-07-27. PMID:20362630. |
using vlo5, a snake venom disintegrin shown to bind to alpha(9)beta(1) integrin in neutrophils, we demonstrate that alpha(9)beta(1) integrin engagement leads to the activation of integrin signaling pathways and potently reduces neutrophil spontaneous apoptosis. |
2010-07-27 |
2023-08-12 |
human |
| Anja Schindler, Edan Fole. A functional RNAi screen identifies hexokinase 1 as a modifier of type II apoptosis. Cellular signalling. vol 22. issue 9. 2010-07-15. PMID:20460151. |
tumor necrosis factor alpha (tnf-alpha) signals through nf-kappab, jnk, and caspase modules to drive physiological responses that range from inflammation to apoptosis. |
2010-07-15 |
2023-08-12 |
human |