| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Bernhard Gillissen, Jana Wendt, Antje Richter, Anja Richter, Annika Müer, Tim Overkamp, Nina Gebhardt, Robert Preissner, Claus Belka, Bernd Dörken, Peter T Danie. Endogenous Bak inhibitors Mcl-1 and Bcl-xL: differential impact on TRAIL resistance in Bax-deficient carcinoma. The Journal of cell biology. vol 188. issue 6. 2010-04-22. PMID:20308427. |
nevertheless, knockdown of mcl-1 but not bcl-xl overcame resistance to trail, cd95/fasl and tumor necrosis factor (alpha) death receptor ligation in bax-deficient cells, and enabled trail to activate bak, indicating that mcl-1 rather than bcl-xl is a major target for sensitization of bax-deficient tumors for death receptor-induced apoptosis via the bak pathway. |
2010-04-22 |
2023-08-12 |
Not clear |
| Xin Qi, Lai Wang, Fenghe D. Novel small molecules relieve prothymosin alpha-mediated inhibition of apoptosome formation by blocking its interaction with Apaf-1. Biochemistry. vol 49. issue 9. 2010-04-21. PMID:20121050. |
in this study, we investigate how bett regulates prothymosin alpha (prot), a nuclear protein previously shown to play essential roles in apoptosis. |
2010-04-21 |
2023-08-12 |
human |
| A Mario Marcondes, Xiang Li, Ted A Gooley, Brian Milless, H Joachim Dee. Identification of DJ-1/PARK-7 as a determinant of stroma-dependent and TNF-alpha-induced apoptosis in MDS using mass spectrometry and phosphopeptide analysis. Blood. vol 115. issue 10. 2010-04-19. PMID:20061558. |
we have shown that marrow stroma-derived signals convey sensitivity to tumor-necrosis-factor alpha (tnf-alpha)-mediated apoptosis in otherwise-resistant kg1a myeloid cells and cd34(+) cells from mds marrow. |
2010-04-19 |
2023-08-12 |
Not clear |
| Pamela Bulzomi, Alessandro Bolli, Paola Galluzzo, Stefano Leone, Filippo Acconcia, Maria Marin. Naringenin and 17beta-estradiol coadministration prevents hormone-induced human cancer cell growth. IUBMB life. vol 62. issue 1. 2010-04-12. PMID:19960539. |
in particular, our previous results indicate that the flavanone naringenin (nar), decoupling estrogen receptor alpha (eralpha) action mechanisms, drives cancer cells to apoptosis. |
2010-04-12 |
2023-08-12 |
human |
| Wei Liang, Chunhua Lu, Jing Li, James Q Yin, Robert Chunhua Zha. p73alpha regulates the sensitivity of bone marrow mesenchymal stem cells to DNA damage agents. Toxicology. vol 270. issue 1. 2010-04-09. PMID:20100536. |
the increase of cellular apoptosis was attributed to enhanced chemosensitivity in p73 alpha infected cells. |
2010-04-09 |
2023-08-12 |
human |
| Ti Zhang, Hui-Chuan Sun, Hong-Yuan Zhou, Jing-Tao Luo, Bai-Lin Zhang, Peng Wang, Lu Wang, Lun-Xiu Qin, Ning Ren, Sheng-Long Ye, Qiang Li, Zhao-You Tan. Interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells. Cancer letters. vol 290. issue 2. 2010-04-07. PMID:19822391. |
interferon alpha inhibits hepatocellular carcinoma growth through inducing apoptosis and interfering with adhesion of tumor endothelial cells. |
2010-04-07 |
2023-08-12 |
mouse |
| Naohisa Kuriyama, Shuji Isaji, Takashi Hamada, Masashi Kishiwada, Ichiro Ohsawa, Masanobu Usui, Hiroyuki Sakurai, Masami Tabata, Tatsuya Hayashi, Koji Suzuk. The cytoprotective effects of addition of activated protein C into preservation solution on small-for-size grafts in rats. Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society. vol 16. issue 1. 2010-03-31. PMID:20035525. |
apc exerted cytoprotective effects, as evidenced by (1) increased 7-day graft survival; (2) decreased initial portal pressure and improved hepatic microcirculation; (3) decreased levels of aminotransferase and improved histological features of hepatic ischemia-reperfusion injury; (4) suppressed infiltration of neutrophils and monocytes/macrophages; (5) reduced hepatic expression of tumor necrosis factor alpha and interleukin 6; (6) decreased serum levels of hyaluronic acid, which indicated attenuation of sinusoidal endothelial cell injury; (7) increased hepatic levels of nitric oxide via up-regulated hepatic endothelial nitric oxide synthesis expression together with down-regulated hepatic inducible nitric oxide synthase expression; (8) decreased hepatic levels of endothelin 1; and (9) reduced hepatocellular apoptosis by down-regulated caspase-8 and caspase-3 activities. |
2010-03-31 |
2023-08-12 |
rat |
| Xin-Han Zhao, Zhi-Yu Wang, Lin-Lin L. [Expression of ER alpha and SMRT in apoptosis of breast cancer cells induced by tamoxifen]. Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences. vol 37. issue 3. 2010-03-30. PMID:18546531. |
[expression of er alpha and smrt in apoptosis of breast cancer cells induced by tamoxifen]. |
2010-03-30 |
2023-08-12 |
Not clear |
| Yi-Fan Yang, Chau-Chung Wu, Wen-Pin Chen, Ming-Jai S. Transforming growth factor-beta type I receptor/ALK5 contributes to doxazosin-induced apoptosis in H9C2 cells. Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19727674. |
the mechanism of doxazosin-induced apoptosis through alpha(1)-adrenoceptor-independent pathway has been reported in various types of cell models. |
2010-03-30 |
2023-08-12 |
Not clear |
| Natasha Kyprianou, Taylor B Vaughan, Martin C Miche. Apoptosis induction by doxazosin and other quinazoline alpha1-adrenoceptor antagonists: a new mechanism for cancer treatment? Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19904527. |
doxazosin and related, quinazoline-based alpha(1)-adrenoceptor antagonists can induce apoptosis in prostate and various other normal, benign, smooth muscle, endothelial and malignant cells. |
2010-03-30 |
2023-08-12 |
Not clear |
| Natasha Kyprianou, Taylor B Vaughan, Martin C Miche. Apoptosis induction by doxazosin and other quinazoline alpha1-adrenoceptor antagonists: a new mechanism for cancer treatment? Naunyn-Schmiedeberg's archives of pharmacology. vol 380. issue 6. 2010-03-30. PMID:19904527. |
while the high concentrations of doxazosin required to induce apoptosis challenge the use of this and related drugs for clinical optimization of apoptosis induction, such quinazoline structure may represent chemical starting points to develop more potent apoptosis-inducing agents free of alpha(1)-adrenoceptor antagonistic action and suitable for cancer treatment with minimal and well-tolerated side effects. |
2010-03-30 |
2023-08-12 |
Not clear |
| Paola Massari, Jay Gunawardana, Xiuping Liu, Lee M Wetzle. Meningococcal porin PorB prevents cellular apoptosis in a toll-like receptor 2- and NF-kappaB-independent manner. Infection and immunity. vol 78. issue 3. 2010-03-26. PMID:20028813. |
interestingly, porb does not prevent extrinsic apoptosis induced by tumor necrosis factor alpha plus cycloheximide, suggesting a unique mitochondrial pathway specificity. |
2010-03-26 |
2023-08-12 |
Not clear |
| Danielle M Pastor, Rosalyn B Irby, Lisa S Porit. Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. Diseases of the colon and rectum. vol 53. issue 3. 2010-03-23. PMID:20173470. |
tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. |
2010-03-23 |
2023-08-12 |
Not clear |
| Danielle M Pastor, Rosalyn B Irby, Lisa S Porit. Tumor necrosis factor alpha induces p53 up-regulated modulator of apoptosis expression in colorectal cancer cell lines. Diseases of the colon and rectum. vol 53. issue 3. 2010-03-23. PMID:20173470. |
the purpose of the current study was to evaluate the effects of tumor necrosis factor alpha (tnf-alpha) on p53 and p53 up-regulated modulator of apoptosis (puma), a downstream effector of p53 in the apoptotic pathway in colorectal cancer cells. |
2010-03-23 |
2023-08-12 |
Not clear |
| Sung Dae Cho, Syng-Ook Lee, Sudhakar Chintharlapalli, Maen Abdelrahim, Shaheen Khan, Kyungsil Yoon, Ashish M Kamat, Stephen Saf. Activation of nerve growth factor-induced B alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. Molecular pharmacology. vol 77. issue 3. 2010-03-19. PMID:20023005. |
activation of nerve growth factor-induced b alpha by methylene-substituted diindolylmethanes in bladder cancer cells induces apoptosis and inhibits tumor growth. |
2010-03-19 |
2023-08-12 |
mouse |
| Xavier Tekpli, Mary Rissel, Laurence Huc, Daniel Catheline, Odile Sergent, Vincent Rioux, Philippe Legrand, Jørn A Holme, Marie-Thérèse Dimanche-Boitrel, Dominique Lagadic-Gossman. Membrane remodeling, an early event in benzo[a]pyrene-induced apoptosis. Toxicology and applied pharmacology. vol 243. issue 1. 2010-03-10. PMID:19931295. |
the b[alpha]p-induced membrane remodeling resulted in an intracellular alkalinization observed during the early phase of apoptosis. |
2010-03-10 |
2023-08-12 |
rat |
| Shiun-Kwei Chiou, Neil Ho. Up-regulation of GADD45alpha expression by NSAIDs leads to apoptotic and necrotic colon cancer cell deaths. Apoptosis : an international journal on programmed cell death. vol 14. issue 11. 2010-03-09. PMID:19757064. |
growth arrest and dna damage inducible 45 alpha (gadd45alpha) is a central player in mediating apoptosis induced by a variety of stress stimuli and genotoxic agents. |
2010-03-09 |
2023-08-12 |
Not clear |
| Yu-Xiong Feng, Jiang-Sha Zhao, Jing-Jing Li, Tao Wang, Shu-Qun Cheng, Yunfei Yuan, Fudi Wang, Xiao-Fan Wang, Dong Xi. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway. Hepatology (Baltimore, Md.). vol 51. issue 2. 2010-02-22. PMID:19918976. |
in addition, ephrina2 endowed cancer cells with resistance to tumor necrosis factor alpha (tnf-alpha)-induced apoptosis, thus facilitating their survival. |
2010-02-22 |
2023-08-12 |
Not clear |
| Hui Wang, Justin D Lathia, Qiulian Wu, Jialiang Wang, Zhizhong Li, John M Heddleston, Christine E Eyler, Jennifer Elderbroom, Joseph Gallagher, Jesse Schuschu, Jennifer MacSwords, Yiting Cao, Roger E McLendon, Xiao-Fan Wang, Anita B Hjelmeland, Jeremy N Ric. Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. Stem cells (Dayton, Ohio). vol 27. issue 10. 2010-02-17. PMID:19658188. |
targeting il6r alpha or il6 ligand expression in gscs with the use of short hairpin rnas (shrnas) significantly reduces growth and neurosphere formation capacity while increasing apoptosis. |
2010-02-17 |
2023-08-12 |
mouse |
| Phil-Sang Chung, Peijie He, Jang-In Shin, Hee-Jun Hwang, Sang Joon Lee, Jin-Chul Ah. Photodynamic therapy with 9-hydroxypheophorbide alpha on AMC-HN-3 human head and neck cancer cells: induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum. Cancer biology & therapy. vol 8. issue 14. 2010-02-12. PMID:19421004. |
photodynamic therapy with 9-hydroxypheophorbide alpha on amc-hn-3 human head and neck cancer cells: induction of apoptosis via photoactivation of mitochondria and endoplasmic reticulum. |
2010-02-12 |
2023-08-12 |
human |