| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Brian G Petrich, Yibin Wan. Stress-activated MAP kinases in cardiac remodeling and heart failure; new insights from transgenic studies. Trends in cardiovascular medicine. vol 14. issue 2. 2004-07-13. PMID:15030789. |
previous studies in neonatal myocytes in culture suggest a critical role for both jnk and p38 in hypertrophy and apoptosis. |
2004-07-13 |
2023-08-12 |
Not clear |
| Abdelkarim Sabri, Hoyt H Hughie, Pamela A Lucches. Regulation of hypertrophic and apoptotic signaling pathways by reactive oxygen species in cardiac myocytes. Antioxidants & redox signaling. vol 5. issue 6. 2004-07-06. PMID:14588146. |
it is now clear that ris act as critical regulators of cardiac myocyte hypertrophy and apoptosis through control of redox-sensitive signaling cascades, such as tyrosine kinases and phosphatases, protein kinase c, and mitogen-activated protein kinases. |
2004-07-06 |
2023-08-12 |
Not clear |
| John J Wielgus, L Corbin Downey, Katelyn W Ewald, Melissa E Hatley, Kathleen C Wilson, Ruth Hill Yeildin. Exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. Brain research. vol 1000. issue 1-2. 2004-06-22. PMID:15053960. |
exposure to low concentrations of nicotine during cranial nerve development inhibits apoptosis and causes cellular hypertrophy in the ventral oculomotor nuclei of the chick embryo. |
2004-06-22 |
2023-08-12 |
chicken |
| L Centurione, C Di Giulio, M Cacchio, M Rapino, D Bosco, G Grifone, N Sabatini, G Bianchi, S Castorina, A Antonucci, A Catald. Correlations between protein kinase C zeta signaling and morphological modifications during rat heart development and aging. Mechanisms of ageing and development. vol 124. issue 8-9. 2004-06-17. PMID:14499501. |
moreover, we propose that pkc zeta may mediate this different response by activating nf-kb pathway and by maintaining the balance between hypertrophic growth and apoptosis involved with remodeling of neonatal heart. |
2004-06-17 |
2023-08-12 |
rat |
| Frank Eefting, Benno Rensing, Jochem Wigman, Willem Jan Pannekoek, Wai Ming Liu, Maarten Jan Cramer, Daniel J Lips, Pieter A Doevendan. Role of apoptosis in reperfusion injury. Cardiovascular research. vol 61. issue 3. 2004-06-04. PMID:14962473. |
in the past 10 years, distinct intracellular pathways important for hypertrophy, apoptosis, cardiac failure, ischemic preconditioning and reperfusion damage have been recognized. |
2004-06-04 |
2023-08-12 |
Not clear |
| Takashi Shimoaka, Satoru Kamekura, Hirotaka Chikuda, Kazuto Hoshi, Ung-Il Chung, Toru Akune, Zenjiro Maruyama, Toshihisa Komori, Michihiro Matsumoto, Wataru Ogawa, Yasuo Terauchi, Takashi Kadowaki, Kozo Nakamura, Hiroshi Kawaguch. Impairment of bone healing by insulin receptor substrate-1 deficiency. The Journal of biological chemistry. vol 279. issue 15. 2004-06-01. PMID:14736890. |
this impairment was because of the suppression of callus formation with a decrease in chondrocyte proliferation and increases in hypertrophic differentiation and apoptosis. |
2004-06-01 |
2023-08-12 |
mouse |
| Brian G Petrich, Benjamin C Eloff, Deborah L Lerner, Attila Kovacs, Jeffrey E Saffitz, David S Rosenbaum, Yibin Wan. Targeted activation of c-Jun N-terminal kinase in vivo induces restrictive cardiomyopathy and conduction defects. The Journal of biological chemistry. vol 279. issue 15. 2004-06-01. PMID:14742426. |
the stress-activated protein kinase, c-jun n-terminal kinase (jnk), has been implicated in the process of cardiac hypertrophy and apoptosis, yet the specific roles of jnk in heart failure are unclear. |
2004-06-01 |
2023-08-12 |
Not clear |
| Kohtaro Abe, Hiroaki Shimokawa, Keiko Morikawa, Toyokazu Uwatoku, Keiji Oi, Yasuharu Matsumoto, Tsuyoshi Hattori, Yutaka Nakashima, Kozo Kaibuchi, Katsuo Sueishi, Akira Takeshi. Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circulation research. vol 94. issue 3. 2004-05-24. PMID:14670839. |
the fasudil treatment improved pulmonary hypertension, right ventricular hypertrophy, and pulmonary vascular lesions with suppression of vsmc proliferation and macrophage infiltration, enhanced vsmc apoptosis, and amelioration of endothelial dysfunction and vsmc hypercontraction. |
2004-05-24 |
2023-08-12 |
rat |
| Zijian Xie, Ting Ca. Na+-K+--ATPase-mediated signal transduction: from protein interaction to cellular function. Molecular interventions. vol 3. issue 3. 2004-05-10. PMID:14993422. |
although ouabain stimulates hypertrophic growth in cardiac myocytes and proliferation in smooth muscle cells, it also induces apoptosis in many malignant cells. |
2004-05-10 |
2023-08-12 |
Not clear |
| Tong Zhang, Shigeki Miyamoto, Joan Heller Brow. Cardiomyocyte calcium and calcium/calmodulin-dependent protein kinase II: friends or foes? Recent progress in hormone research. vol 59. 2004-04-29. PMID:14749501. |
in cardiac muscle, ca(2+) plays a central role in regulating contractility, gene expression, hypertrophy, and apoptosis. |
2004-04-29 |
2023-08-12 |
mouse |
| Kelley P Anderso. Sympathetic nervous system activity and ventricular tachyarrhythmias: recent advances. Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc. vol 8. issue 1. 2004-04-23. PMID:12848817. |
the role of long-term elevations of snsa is suggested by animal models of enhanced snsa signaling that results in apoptosis, hypertrophy, and fibrosis, and sympathetic nerve sprouting caused by infusion of nerve growth factor. |
2004-04-23 |
2023-08-12 |
human |
| María A Fortuño, Natalia López, Arantxa González, Javier Díe. Involvement of cardiomyocyte survival-apoptosis balance in hypertensive cardiac remodeling. Expert review of cardiovascular therapy. vol 1. issue 2. 2004-04-23. PMID:15030288. |
accumulating data support a role for cardiomyocyte apoptosis in the development of several cardiac diseases, including the transition from hypertensive compensatory hypertrophy to heart failure. |
2004-04-23 |
2023-08-12 |
Not clear |
| Jan Kajstura, Annarosa Leri, Clotilde Castaldo, Bernardo Nadal-Ginard, Piero Anvers. Myocyte growth in the failing heart. The Surgical clinics of North America. vol 84. issue 1. 2004-04-15. PMID:15053188. |
the recognition that myocyte hypertrophy and regeneration, as well as myocyte necrosis and apoptosis, occur in cardiac diseases has contributed to enhancing our understanding of the plasticity of the human heart. |
2004-04-15 |
2023-08-12 |
human |
| Kanu Chatterje. Congestive heart failure: what should be the initial therapy and why? American journal of cardiovascular drugs : drugs, devices, and other interventions. vol 2. issue 1. 2004-04-14. PMID:14727993. |
activation of the angiotensin and adrenergic systems produces deleterious effects on systemic and coronary hemodynamics, promotes myocyte hypertrophy and fibroblast growth, and myocyte necrosis and apoptosis. |
2004-04-14 |
2023-08-12 |
Not clear |
| Emily J Foulstone, Camille Huser, Anna L Crown, Jeff M P Holly, Claire E H Stewar. Differential signalling mechanisms predisposing primary human skeletal muscle cells to altered proliferation and differentiation: roles of IGF-I and TNFalpha. Experimental cell research. vol 294. issue 1. 2004-03-30. PMID:14980516. |
stimulation with both igf-i and tumour necrosis factor alpha (tnfalpha) increased cellular proliferation but while igf-i subsequently increased myoblast differentiation, via both hyperplasia and hypertrophy, tnfalpha inhibited the initiation of differentiation, but did not induce apoptosis. |
2004-03-30 |
2023-08-12 |
human |
| K Mansfield, B Pucci, C S Adams, I M Shapir. Induction of apoptosis in skeletal tissues: phosphate-mediated chick chondrocyte apoptosis is calcium dependent. Calcified tissue international. vol 73. issue 2. 2004-03-24. PMID:14565598. |
in an earlier study, we have shown that pi induced apoptosis of terminally differentiated hypertrophic chondrocytes. |
2004-03-24 |
2023-08-12 |
chicken |
| Siân V Griffin, Raimund Pichler, Takehiko Wada, Michael Vaughan, Raghu Durvasula, Stuart J Shanklan. The role of cell cycle proteins in Glomerular disease. Seminars in nephrology. vol 23. issue 6. 2004-03-24. PMID:14631565. |
although initially identified and characterized as regulators of the cell cycle and hence proliferation, an extended role for cell cycle proteins has been appreciated more recently in a number of physiologic and pathologic processes, including development, differentiation, hypertrophy, and apoptosis. |
2004-03-24 |
2023-08-12 |
Not clear |
| Klaus Pönicke, Ingrid Heinroth-Hoffmann, Otto-Erich Brodd. Role of beta 1- and beta 2-adrenoceptors in hypertrophic and apoptotic effects of noradrenaline and adrenaline in adult rat ventricular cardiomyocytes. Naunyn-Schmiedeberg's archives of pharmacology. vol 367. issue 6. 2004-03-23. PMID:12750877. |
furthermore, there was a significant negative correlation between catecholamine-evoked apoptosis and catecholamine-induced hypertrophic effects. |
2004-03-23 |
2023-08-12 |
rat |
| Yuichiro J Suzuki, Todd Evan. Regulation of cardiac myocyte apoptosis by the GATA-4 transcription factor. Life sciences. vol 74. issue 15. 2004-03-15. PMID:14761664. |
our recent experiments demonstrate that the gata-4 transcription factor not only mediates cardiac hypertrophy, but also regulates apoptosis and survival of adult cardiac muscle cells. |
2004-03-15 |
2023-08-12 |
Not clear |
| Véronique Moulin, Sébastien Larochelle, Céline Langlois, Isabelle Thibault, Carlos A Lopez-Vallé, Michel Ro. Normal skin wound and hypertrophic scar myofibroblasts have differential responses to apoptotic inductors. Journal of cellular physiology. vol 198. issue 3. 2004-03-12. PMID:14755540. |
we have isolated and cultured human normal wound (wmyo) and hypertrophic scar (hmyo) myofibroblasts and compared their basal apoptotic rates and their sensitivity to serum starvation and fas antibody-induced apoptosis to that obtained for dermal fibroblasts (fb). |
2004-03-12 |
2023-08-12 |
human |